Projekte
We are currently working on the following areas:

Genetic regulation of molecular and immune phenotypes
We study how genetic variation affects molecular and immune phenotypes such as gene expression, metabolites and cytokine responses to stimulations in health and patient cohort (T1D, HIV and Lyme etc). We develop computational methods and algorithms for fully exploit high-throughput datasets from the most recent profiling technologies, e.g., causal inference and deconvolution of the overall genetic regulation effects of gene expression into relevant cell types.
Publications
Integration of multi-omics & Single cell genomics
Publications
Genetic regulation of molecular and immune phenotypes
Li Y, Oosting M, Smeekens SP, Jaeger M, Aguirre-Gamboa R, Le KTT, Deelen P, Ricano-Ponce I, Schoffelen T, Jansen AFM, Swertz MA, Withoff S, van de Vosse E, van Deuren M, van de Veerdonk F, Zhernakova A, van der Meer JWM, Xavier RJ, Franke L, Joosten LAB, Wijmenga C, Kumar V, Netea MG (2016) A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell 167(4): 1099-1110 e1014.
Integration of multi-omics & Single cell genomics
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, Domenico ED, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Jarcy LB de, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, Kalle C von, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE, DC19O Initiative (DeCOI) (2020) Suppressive myeloid cells are a hallmark of severe COVID-19. medRxiv 2020.06.03.20119818; doi: doi.org/10.1101/2020.06.03.20119818.
Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Vosa U, Withoff S, Netea-Maier RT, Koenen H, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y (2018) Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nat Immunol 19(7): 776-786.
Li Y, Oosting M, Deelen P, Ricano-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG (2016) Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nat Med 22(8): 952-960.