Publikationen

Publikationen

    2024

    • Costa B, Becker J, Krammer T, Mulenge F, Duran V, Pavlou A, Gern OL, Chu X, Li Y, Cicin-Sain L, Eiz-Vesper B, Messerle M, Dölken L, Saliba AE, Erhard F, Kalinke U (2024) Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells. Nat Commun 15(1): 1745.

    • Passos V, Henkel LM, Wang J, Zapatero‐Belinchón FJ, Möller R, Sun G, Waltl I, Schneider T, Wachs A, Ritter B, Kropp KA, Zhu S, Deleidi M, Kalinke U, Schulz TF, Höglinger G, Gerold G, Wegner F, Viejo‐Borbolla A (2024) Innate immune response to SARS‐CoV‐2 infection contributes to neuronal damage in human iPSC‐derived peripheral neurons. J Med Virol 96(2).

    • Chiyyeadu A, Asgedom G, Bruhn M, Rocha C, Schlegel TU, Neumann T, Galla M, Barbosa PV, Hoffmann M, Ehrhardt K, Ha TC, Morgan M, Schoeder CT, Pöhlmann S, Kalinke U, Schambach A (2024) A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants. Clin Immunol 260(n/a): 109902.

    • Manoharan J, Rana R, Kuenze G, Gupta D, Elwakiel A, Ambreen S, Wang H, Banerjee K, Zimmermann S, Singh K, Gupta A, Fatima S, Kretschmer S, Schaefer L, Zeng-Brouwers J, Schwab C, Al-Dabet MM, Gadi I, Altmann H, Koch T, Poitz DM, Baber R, Kohli S, Shahzad K, Geffers R, Lee-Kirsch MA, Kalinke U, Meiler J, Mackman N, Isermann B (2024) Tissue factor binds to and inhibits interferon-α receptor 1 signaling. Immunity 57(1): 68-85 e11.

    • Stankov MV, Hoffmann M, Gutierrez Jauregui R, Cossmann A, Morillas Ramos G, Graalmann T, Winter EJ, Friedrichsen M, Ravens I, Ilievska T, Ristenpart J, Schimrock A, Willenzon S, Ahrenstorf G, Witte T, Forster R, Kempf A, Pohlmann S, Hammerschmidt SI, Dopfer-Jablonka A, Behrens GMN (2024) Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination. Lancet Infect Dis 24(1): e1-e3.

    • Bruhn M, Obara M, Chiyyeadu A, Costa B, Salam A, Ziegler A, Waltl I, Pavlou A, Bonifacius A, Hoffmann M, Graalmann T, Pöhlmann S, Eiz-Vesper B, Schambach A, Kalinke U (2024) Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation. J Infect 88(1): 171-187 e14.

    2023

    • Akmatov MK, Beisheeva NJ, Nurmatov AZ, Gulsunai SJ, Saikal KN, Derkenbaeva AA, Abdrahmanova ZO, Prokein J, Klopp N, Illig T, Kasymov OT, Nurmatov ZS, Pessler F (2023) The Changing Epidemiology of Viral Hepatitis in a Post-Soviet Country-The Case of Kyrgyzstan. Pathogens 12(8): 989.

    • Al-Mekhlafi A, Waqas FH, Krueger M, Klawonn F, Akmatov MK, Muller-Vahl K, Trebst C, Skripuletz T, Stangel M, Suhs KW, Pessler F (2023) Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation. J Transl Med 21(1): 776.

    • Atschekzei F, Fedchenko M, Elsayed A, Dubrowinskaja N, Graalmann T, Ringshausen FC, Witte T, Sogkas G (2023) Rituximab to treat prolidase deficiency due to a novel pathogenic copy number variation in PEPD. RMD Open 9(4).

    • Barends M, Koller N, Scholz C, Duran V, Bosnjak B, Becker J, Doring M, Blees H, Forster R, Kalinke U, Tampe R (2023) Dynamic interactome of the MHC I peptide loading complex in human dendritic cells. Proc Natl Acad Sci U S A 120(25): e2219790120.

    • Buhler M, Li D, Li L, Runft S, Waltl I, Pavlou A, Kalinke U, Ciurkiewicz M, Huehn J, Floess S, Beineke A, Baumgartner W, Gerhauser I (2023) IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler's murine encephalomyelitis virus. J Neuroinflammation 20(1): 58.

    • Camarao AAR, Gern OL, Stegmann F, Mulenge F, Costa B, Saremi B, Jung K, Lepenies B, Kalinke U, Steffen I (2023) Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions. Microbiol Spectr 11(5): e0219223.

    • Chen F, Yalcin I, Zhao M, Chen C, Blankenfeldt W, Pessler F, Büssow K (2023) Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1. Sci Rep 13(1): 10360.

    • Fneish Z, Becker J, Mulenge F, Costa B, Krajewski L, Duran V, Ziegler A, Sommer V, Traidl-Hoffmann C, Gilles S, Kalinke U (2023) Birch pollen extract enhances human cytomegalovirus replication in monocyte-derived dendritic cells. Allergy 78(2): 543-546.

    • Harit K, Bhattacharjee R, Matuschewski K, Becker J, Kalinke U, Schlüter D, Nishanth G (2023) The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. Cell Death Dis 14(7).

    • Merkert S, Haase A, Dahlmann J, Göhring G, Waqas FH, Pessler F, Martin U, Olmer R (2023) Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing. Stem Cell Res 69(n/a): 103090.

    • Rahim MI, Waqas SF, Lienenklaus S, Willbold E, Eisenburger M, Stiesch M (2023) Effect of titanium implants along with silver ions and tetracycline on type I interferon-beta expression during implant-related infections in co-culture and mouse model. Front Bioeng Biotechnol 11(n/a): 1227148.

    • Schröder LJ, Mulenge F, Pavlou A, Skripuletz T, Stangel M, Gudi V, Kalinke U (2023) Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination. Glia 71(11): 2573-2590.

    • Tischer-Zimmermann S, Bonifacius A, Santamorena MM, Mausberg P, Stoll S, Döring M, Kalinke U, Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B (2023) Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab. Front Immunol 14(n/a): 878953.

    • Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmasheva N, Begnini F, Kiib AE, Dahlmann J, Chen C, Pavlou A, Poulsen TB, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch AKH, Pleschka S, Pessler F (2023) NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner. PLOS Pathogens 19(7): 1-24.

    2022

    • Arshad H, Siokis A, Franke R, Habib A, Alfonso JCL, Poliakova Y, Lücke E, Michaelis K, Brönstrup M, Meyer-Hermann M, Bilitewski U, Vila J, Abel L, Illig T, Schreiber J, Pessler F (2022) Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease. Cells 11(15): 2283.

    • Becker J, Kalinke U (2022) Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19. EMBO J 41(10): e111208.

    • Bühler M, Runft S, Li D, Götting J, Detje CN, Nippold V, Stoff M, Beineke A, Schulz T, Kalinke U, Baumgärtner W, Gerhauser I (2022) IFN-beta deficiency results in fatal or demyelinating disease in C57BL/6 mice infected with Theiler's murine encephalomyelitis viruses. Front Immunol 13(n/a).

    • Chen F, Elgaher WAM, Winterhoff M, Bussow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bahre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F (2022) Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nat Metab 4(5): 534-546.

    • Démoulins T, Baron ML, Gauchat D, Kettaf N, Reed SJ, Charpentier T, Kalinke U, Lamarre A, Ahmed R, Sekaly RP, Sarkar S, Kalia V (2022) Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection. Virology 567(n/a): 77-86.

    • Gruenwald M, Chen F, Bähre H, Pessler F (2022) Itaconate Isomers in Bread. Antioxidants (Basel) 11(7): 1382.

    • Kalinke U, Barouch DH, Rizzi R, Lagkadinou E, Türeci Ö, Pather S, Neels P (2022) Clinical development and approval of COVID-19 vaccines. Expert Rev Vaccines 21(5): 609-619.

    • Knop L, Spanier J, Larsen PK, Witte A, Bank U, Dunay IR, Kalinke U, Schüler T (2022) IFNAR signaling in fibroblastic reticular cells can modulate CD8(+) memory fate decision. Eur J Immunol 52(6): 895-906.

    • Koller N, Hollthaler P, Barends M, Doring M, Spahn C, Duran V, Costa B, Becker J, Heilemann M, Kalinke U, Tampe R (2022) Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells. Cell Mol Life Sci 79(9): 477.

    • Lu D, Chatterjee S, Xiao K, Riedel I, Huang CK, Costa A, Cushman S, Neufeldt D, Rode L, Schmidt A, Juchem M, Leonardy Ju, Büchler G, Blume J, Gern OL, Kalinke U, Tan WLW, Foo R, Vink A, van Laake LW, van der Meer P, Bär C, Thum T (2022) A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity. Eur Heart J 43(42): 4496-4511.

    • Malik MNH, Waqas SF, Zeitvogel J, Cheng J, Geffers R, Gouda ZAE, Elsaman AM, Radwan AR, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner LM, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F (2022) Congenital deficiency reveals critical role of ISG15 in skin homeostasis. J Clin Invest 132(3).

    • Michaely LM, Schuwerk L, Allnoch L, Schön K, Waltl I, Larsen PK, Pavlou A, Prajeeth CK, Rimmelzwaan GF, Becker SC, Kalinke U, Baumgärtner W, Gerhauser I (2022) Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice. Int J Mol Sci 23(20): 12492.

    • Pais TF, Ali H, Moreira da Silva J, Duarte N, Neres R, Chhatbar C, Acurcio RC, Guedes RC, Strano Moraes MC, Costa-Silva B, Kalinke U, Penha-Goncalves C (2022) Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response. Proc Natl Acad Sci U S A 119(36): e2206327119.

    • Riese P, Trittel S, Akmatov MK, May M, Prokein J, Illig T, Schindler C, Sawitzki B, Elfaki Y, Floess S, Huehn J, Blazejewski AJ, Strowig T, Hernandez-Vargas EA, Geffers R, Zhang B, Li Y, Pessler F, Guzmàn CA (2022) Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly. Nat Commun 13(1): 6894.

    • Schwerk J, Kemper L, Bussey KA, Lienenklaus S, Weiss S, Cicin-Sain L, Kröger A, Kalinke U, Collins CM, Speck SH, Messerle M, Wirth D, Brinkmann MM, Hauser H, Köster M (2022) Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo. Pathogens 11(12): 1554.

    • Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas F, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F (2022) Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLOS Pathog 18(1): 1-40.

    • Waltl Inken, Kalinke Ulrich (2022) Beneficial and detrimental functions of microglia during viral encephalitis. Trends Neurosci 45(2): 158-170.

    • Waqas SF, Sohail A, Nguyen AHH, Usman A, Ludwig T, Wegner A, Malik MNH, Schuchardt S, Geffers R, Winterhoff M, Merkert S, Martin U, Olmer R, Lachmann N, Pessler F (2022) ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives. Clin Transl Med 12(7): e931.

    • Yang X, Ali S, Zhao M, Richter L, Schäfer V, Schliehe-Diecks J, Frank M, Qi J, Larsen PK, Skerra J, Islam H, Wachtmeister T, Alter C, Huang A, Bhatia S, Köhrer K, Kirschning C, Weighardt H, Kalinke U, Kalscheuer R, Uhrberg M, Scheu S (2022) The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway. Front Immunol 13(n/a): 856230.

    2021

    • Al-Mekhlafi A, Sühs KW, Schuchardt S, Kuhn M, Müller-Vahl K, Trebst C, Skripuletz T, Klawonn F, Stangel M, Pessler F (2021) Elevated Free Phosphatidylcholine Levels in Cerebrospinal Fluid Distinguish Bacterial from Viral CNS Infections. Cells 10(5): 1115.

    • Bosnjak B, Odak I, Ritter C, Stahl K, Graalmann T, Steinbrück L, Blasczyk R, Falk CS, Schulz TF, Wedemeyer HH, Cornberg M, Ganser A, Förster R, Koenecke C (2021) Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy. Front Immunol 12(n/a): 721738.

    • Duran V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro JT, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Lepenies B, Tampe R, Förster R, Bosnjak B, Furch M, Graalmann T, Kalinke U (2021) Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells. J Control Release 334(n/a): 201-212.

    • Franz S, Pott F, Zillinger T, Schuler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Dohner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C (2021) Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction. Life Sci Alliance 4(7).

    • Gern OL, Mulenge F, Pavlou A, Ghita L, Steffen I, Stangel M, Kalinke U (2021) Toll-like Receptors in Viral Encephalitis. Viruses 13(10): 2065.

    • Ghita L, Breitkopf V, Mulenge F, Pavlou A, Gern OL, Durán V, Prajeeth CK, Kohls M, Jung K, Stangel M, Steffen I, Kalinke U (2021) Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. J Neurosci Res 99(10): 2478-2492.

    • Ghita L, Spanier J, Chhatbar C, Mulenge F, Pavlou A, Larsen PK, Waltl I, Lueder Y, Kohls M, Jung K, Best SM, Forster R, Stangel M, Schreiner D, Kalinke U (2021) MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS. Sci Immunol 6(60).

    • Graalmann T, Borst K, Manchanda H, Vaas L, Bruhn M, Graalmann L, Koster M, Verboom M, Hallensleben M, Guzman CA, Sutter G, Schmidt RE, Witte T, Kalinke U (2021) B cell depletion impairs vaccination-induced CD8(+) T cell responses in a type I interferon-dependent manner. Ann Rheum Dis 80(12): 1537-1544.

    • Gussarow D, Bonifacius A, Cossmann A, Stankov MV, Mausberg P, Tischer-Zimmermann S, Gödecke N, Kalinke U, Behrens GMN, Blasczyk R, Eiz-Vesper B (2021) Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?. Front Med 8(n/a).

    • Iampietro M, Dumont C, Mathieu C, Spanier J, Robert J, Charpenay A, Dupichaud S, Dhondt KP, Aurine N, Pelissier R, Ferren M, Mely S, Gerlier D, Kalinke U, Horvat B (2021) Activation of cGAS/STING pathway upon paramyxovirus infection. iScience 24(6): 102519.

    • Kreissl S, Hendler S, Akmatov MK, von Meien M, Range U, Pessler F, Vogelberg C (2021) Reduced exhaled breath condensate pH and severity of allergic sensitization predict school age asthma. J Allergy Clin Immunol Pract 9(4): 1570-1577.

    • Krenn V, Bosone C, Burkard TR, Spanier J, Kalinke U, Calistri A, Salata C, Christoff RR, Garcez PP, Mirazimi A, Knoblich JA (2021) Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell 28(8): 1362-1379 e1367.

    • Luo Y, Möhn N, Skripuletz T, Senel M, Tumani H, Pessler F, Sühs KW, Stangel M (2021) Differentiation of viral and autoimmune central nervous system inflammation by kynurenine pathway. Ann Clin Transl Neurol 8(12): 2228-2234.

    • Malik MNH, Waqas SFH, Zeitvogel J, Cheng J, Geffers R, Gouda ZAE, Elsaman AM, Radwan AR, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner LM, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F (2021) Congenital deficiency reveals critical role of ISG15 in skin homeostasis. J Clin Invest 39(3): 276-280.

    • Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schluter D (2021) The deubiquitinase OTUB1 augments NF-kappaB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13. Cell Mol Immunol 18(6): 1512-1527.

    • Pezoldt J, Wiechers C, Erhard F, Rand U, Bulat T, Beckstette M, Brendolan A, Huehn J, Kalinke U, Mueller M, Strobl B, Deplancke B, Cicin-Sain L, Sitnik KM (2021) Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection. Commun Biol 4(12): 1355.

    • Prior S, Metcalfe C, Hufton SE, Wadhwa M, Schneider CK, Burns C (2021) Maintaining `standards' for biosimilar monoclonal antibodies. Nat Biotechnol 39(3): 276-280.

    • Ramli SR, Bunk B, Spröer C, Geffers R, Jarek M, Bhuju S, Goris M, Mustakim S, Pessler F (2021) Complete Genome Sequencing of Leptospira interrogans Isolates from Malaysia Reveals Massive Genome Rearrangement but High Conservation of Virulence-Associated Genes. Pathogens 10(9): 1198.

    • Winterhoff M, Chen F, Sahini N, Ebensen T, Kuhn M, Kaever V, Bähre H, Pessler F (2021) Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate. Metabolites 11(5): 270.

    • de Araujo LS, Ribeiro-Alves M, Wipperman MF, Vorkas CK, Pessler F, Saad MHF (2021) Transcriptomic Biomarkers for Tuberculosis: Validation of NPC2 as a Single mRNA Biomarker to Diagnose TB, Predict Disease Progression, and Monitor Treatment Response. Cells 10(10): 2704.

    2020

    • Behrens GMN, Cossmann A, Stankov MV, Schulte B, Streeck H, Förster R, Bosnjak B, Willenzon S, Boeck AL, Thu Tran A, Thiele T, Graalmann T, Kayser MZ, Zychlinsky Scharff A, Dopfer C, Horke A, Pink I, Witte T, Wetzke M, Ernst D, Jablonka A, Happle C (2020) Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals. Infect Dis Ther 9(4): 837-849.

    • Borst K, Flindt S, Blank P, Larsen PK, Chhatbar C, Skerra J, Spanier J, Hirche C, König M, Alanentalo T, Hafner M, Waibler Z, Pfeffer K, Sexl V, Sutter G, Müller W, Graalmann T, Kalinke U (2020) Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection. PLOS Pathog 16(2): 1-19.

    • Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Dohner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen PK, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C (2020) Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Proc Natl Acad Sci U S A 117(32): 19475-19486.

    • Forster D, Schwarz JH, Brosinski K, Kalinke U, Sutter G, Volz A (2020) Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection. Viruses 12(1): 72.

    • Freuer D, Linseisen J, Waterboer T, Pessler F, Guzmán CA, Wawro N, Peters A, Meisinger C (2020) Seropositivity of selected chronic infections and different measures of obesity. PLoS One 15(4): 1-16.

    • Gamrekelashvili J, Kapanadze T, Sablotny S, Ratiu C, Dastagir K, Lochner M, Karbach S, Wenzel P, Sitnow A, Fleig S, Sparwasser T, Kalinke U, Holzmann B, Haller H, Limbourg FP (2020) Notch and TLR signaling coordinate monocyte cell fate and inflammation. eLife 9(n/a).

    • Haake K, Neehus AL, Buchegger T, Kühnel MP, Blank P, Philipp F, Oleaga-Quintas C, Schulz A, Grimley M, Goethe R, Jonigk D, Kalinke U, Boisson-Dupuis S, Casanova JL, Bustamante J, Lachmann N (2020) Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-gamma Responsive Pathway. Cells 9(2): 483.

    • Hahn K, Pollmann L, Nowak J, Nguyen AHH, Haake K, Neehus AL, Waqas SFH, Pessler F, Baumann U, Hetzel M, Casanova JL, Schulz A, Bustamante J, Ackermann M, Lachmann N (2020) Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-gammaR1 Deficiency. Mol Ther Methods Clin Dev 17(n/a): 785-795.

    • Hosseini S, Michaelsen-Preusse K, Grigoryan G, Chhatbar C, Kalinke U, Korte M (2020) Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS. Cell Rep 31(7): 107666.

    • Iampietro M, Aurine N, Dhondt KP, Dumont C, Pelissier R, Spanier J, Vallve A, Raoul H, Kalinke U, Horvat B (2020) Control of Nipah Virus infection in mice by the host adaptors mitochondrial antiviral signaling protein (MAVS) and Myeloid differentiation primary response 88 (MyD88). J Infect Dis 221((Supplement_4)): S401-S406.

    • Knop L, Deiser K, Bank U, Witte A, Mohr J, Philipsen L, Fehling HJ, Müller AJ, Kalinke U, Schüler T (2020) IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival. Euro J Immunol 50(6): 846-857.

    • Luo Y, Möhn N, Al-Mekhlafi A, Schuchardt S, Skripuletz T, Sühs W, Pessler F, Stangel M (2020) Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy. PLoS One 15(11): 1-10.

    • Martin-Fernandez M, Garcia-Morato MariaBravo, Gruber Conor, Loza SaraMurias, Malik MuhammadNasirHayat, Alsohime Fahad, Alakeel Abdullah, Valdez Rita, Buta Sofija, Buda Guadalupe, Marti MarceloA., Larralde Margarita, Boisson Bertrand, Rodriguez MartaFeito, Qiu Xueer, Chrabieh Maya, Ayed MohammedAl, Muhsen SalehAl, Desai JigarV., Ferre EliseM.N., Rosenzweig SergioD., Amador-Borrero Blanca, Bravo-Gallego LuzYadira, Olmer Ruth, Merkert Sylvia, Bret Montserrat, Sood AmikaK., Al rabiaah Abdulkarim, Temsah MohamadHani, Halwani Rabih, Hernandez Michelle, Pessler Frank, Casanova Jean-Laurent, Bustamante Jacinta, Lionakis MichailS., Bogunovic Dusan (2020) Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions. Cell Rep 31(6): 107633.

    • Merkert S, Jaboreck MC, Engels L, Malik MNH, Göhring G, Pessler F, Martin U, Olmer R (2020) Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing. Stem Cell Res 50(n/a): 102135.

    • Namineni S, O`Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M (2020) A dual role for hepatocyte-intrinsic canonical NF-$\upkappa$B signaling in virus control. J Hepatol 72(5): 960-975.

    • Page M, Almond N, Rose NJ, Schneider CK (2020) Diagnostics and the coronavirus: don't let the standards slip. Nat Biotechnol 38(6): 673-674.

    • Reinke S, Linge M, Diebner HH, Luksch H, Glage S, Gocht A, Robertson AAB, Cooper MA, Hofmann SR, Naumann R, Sarov M, Behrendt R, Roers A, Pessler F, Roesler J, Rösen-Wolff A, Winkler S (2020) Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-alpha-Mediated Inflammation In Vivo. Cell Rep 30(8): 2501-2511.e5.

    • Samir M, Vidal RO, Abdallah F, Capece V, Seehusen F, Geffers R, Hussein A, Ali AAH, Bonn S, Pessler F (2020) Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1). RNA Biol 17(1): 112-124.

    • Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC (2020) Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Cell 181(5): 1080-1096 e19.

    • Seelbinder B, Wallstabe J, Marischen L, Weiss E, Wurster S, Page L, Löffler C, Bussemer L, Schmitt AL, Wolf T, Linde J, Cicin-Sain L, Becker J, Kalinke U, Vogel J, Panagiotou G, Einsele H, Westermann AJ, Schäuble S, Loeffler J (2020) Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model. Cell Rep 33(7): 108389.

    • Vardi A, Ben-Dor S, Cho SM, Kalinke U, Spanier J, Futerman AH (2020) Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease. J Neuroinflammation 17(1): 265.

    • de Araujo LS, Pessler K, Suhs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Muller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F (2020) Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis. J Transl Med 18(1): 9.

    2019

    • Akmatov MK, Riese P, Trittel S, May M, Prokein J, Illig T, Schindler C, Guzman CA, Pessler F (2019) Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly. BMC Infect Dis 19(1): 656.

    • Arshad H, Alfonso JCL, Franke R, Michaelis K, Araujo L, Habib A, Zboromyrska Y, Lucke E, Strungaru E, Akmatov MK, Hatzikirou H, Meyer-Hermann M, Petersmann A, Nauck M, Bronstrup M, Bilitewski U, Abel L, Sievers J, Vila J, Illig T, Schreiber J, Pessler F (2019) Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia. J Transl Med 17(1): 365.

    • Borst K, Graalmann T, Kalinke U (2019) Reply to: "Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic Inflammation". J Hepatol 70(4): 815-816.

    • Borst K, Graalmann T, Kalinke U (2019) Reply to: Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers. J Hepatol 71(3): 633-635.

    • Caputo M, Horn J, Karch A, Akmatov MK, Becher H, Braun B, Brenner H, Castell S, Fischer B, Giani G, Gunther K, Hoffmann B, Jockel KH, Keil T, Kluppelholz B, Krist L, Leitzmann MF, Lieb W, Linseisen J, Meisinger C, Moebus S, Obi N, Pischon T, Schipf S, Schmidt B, Sievers C, Steinbrecher A, Volzke H, Mikolajczyk R (2019) Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort. BMC Infect Dis 19(1): 19.

    • Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Bussow K, Pessler F (2019) Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A 116(41): 20644-20654.

    • Doring M, Blees H, Koller N, Tischer-Zimmermann S, Musken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampe R, Kalinke U (2019) Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation. Blood Adv 3(6): 839-850.

    • Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr CM (2019) Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells. Nanomedicine 21:(n/a): 102073.

    • Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonovic N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotic A, Jonjic S, Muller M, Strobl B (2019) Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep 26(9): 2394-2406 e5.

    • Heidegger S, Kreppel D, Bscheider M, Stritzke F, Nedelko T, Wintges A, Bek S, Fischer JC, Graalmann T, Kalinke U, Bassermann F, Haas T, Poeck H (2019) RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade. EBioMedicine 41:(n/a): 146-155.

    • Hensel N, Raker V, Forthmann B, Detering NT, Kubinski S, Buch A, Katzilieris-Petras G, Spanier J, Gudi V, Wagenknecht S, Kopfnagel V, Werfel TA, Stangel M, Beineke A, Kalinke U, Paludan SR, Sodeik B, Claus P (2019) HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. J Neuroinflammation 16(1): 248.

    • Kalodimou G, Veit S, Jany S, Kalinke U, Broder CC, Sutter G, Volz A (2019) A soluble version of Nipah Virus glycoprotein G delivered by vaccinia virus MVA activates specific CD8 and CD4 T cells in mice. Viruses 12(1): 26.

    • Knop L, Frommer C, Stoycheva D, Deiser K, Kalinke U, Blankenstein T, Kammertoens T, Dunay IR, Schüler T (2019) Interferon-gamma Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4(+) T Cells in Chronic Lymphopenic Mice. Front Immunol 10:(n/a): 140.

    • Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Majek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvar-Kozma Maria, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A (2019) Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. Immunity 51(6): 1074-1087.e9.

    • Ramli SR, Moreira GMSG, Zantow J, Goris MGA, Nguyen VK, Novoselova N, Pessler F, Hust M (2019) Discovery of Leptospira spp. seroreactive peptides using ORFeome phage display. PLoS Negl Trop Dis 13(1): 1-18.

    • Ratuszny D, Suhs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M (2019) Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis. Int J Mol Sci 20(2).

    • Ruangkiattikul N, Rys D, Abdissa K, Rohde M, Semmler T, Tegtmeyer PK, Kalinke U, Schwarz C, Lewin A, Goethe R (2019) Type I interferon induced by TLR2-TLR4-MyD88-TRIF-IRF3 controls Mycobacterium abscessus subsp. abscessus persistence in murine macrophages via nitric oxide. Int J Med Microbiol 309(5): 307-318.

    • Sohail MU, Yassine HM, Sohail A, Al Thani AA (2019) Impact of Physical Exercise on Gut Microbiome, Inflammation, and the Pathobiology of Metabolic Disorders. Rev Diabet Stud 15(1): 35-48.

    • Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M, Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen BE, Wagner H, Lang KS, Sparwasser TD (2019) TLR7 Controls VSV Replication in CD169 (+) SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol 10:(n/a): 466.

    • Springer A, Heuer L, Janecek-Erfurth E, Beineke A, Strube C (2019) Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model. Parasitol Res 118(9): 2591-2600.

    • Suhs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Muller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F (2019) Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections. J Infect Dis 220(1): 127-138.

    • Tegtmeyer PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Doering M, Ruzsics Z, Kalinke U (2019) STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Nat Commun 10(1): 2830.

    • Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR, Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD (2019) Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis. J Hepatol 70(4): 722-734.

    • Waindok P, Özbakis-Beceriklisoy G, Janecek-Erfurth E, Springer A, Pfeffer M, Leschnik M, Strube C (2019) Parasites in brains of wild rodents (Arvicolinae and Murinae) in the city of Leipzig, Germany. Int J Parasitol Parasites Wildl 10(n/a): 211-217.

    • Wawro N, Amann U, Butt J, Meisinger C, Akmatov MK, Pessler F, Peters A, Rathmann W, Kääb S, Waterboer T, Linseisen J (2019) Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study. Front Public Health 7:(n/a): 96.

    • Ziegler A, Hinz T, Kalinke U (2019) RNA-Based Adjuvants: Immunoenhancing Effect on Antiviral Vaccines and Regulatory Considerations. Crit Rev Immunol 39(1): 1-14.

    • de Araujo LS, Ribeiro-Alves M, Leal-Calvo T, Leung J, Duran V, Samir M, Talbot S, Tallam A, Mello FCQ, Geffers R, Saad MHF, Pessler F (2019) Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection. mBio(10): 6.

    2018

    • Akmatov MK, Rübsamen N, Deyneko IV, Karch A, Mikolajczyk RT (2018) Poor knowledge of vaccination recommendations and negative attitudes towards vaccinations are independently associated with poor vaccination uptake among adults – Findings of a population-based panel study in Lower Saxony, Germany. Vaccine 36(18): 2417-2426.

    • Becker J, Kinast V, Doring M, Lipps C, Duran V, Spanier J, Tegtmeyer PK, Wirth D, Cicin-Sain L, Alcami A, Kalinke U (2018) Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines. Virulence 9(1): 1669-1684.

    • Bieling M, Tischer S, Kalinke U, Blasczyk R, Buus S, Maecker-Kolhoff B, Eiz-Vesper B (2018) Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes. Oncotarget 9(4): 4737-4757.

    • Borst K, Frenz T, Spanier J, Tegtmeyer PK, Chhatbar C, Skerra J, Ghita L, Namineni S, Lienenklaus S, Köster M, Heikenwaelder M, Sutter G, Kalinke U (2018) Type I interferon receptor-signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis. J Hepatol 68(4): 682-690.

    • Chen YL, Jing J, Mo YQ, Ma JD, Yang LJ, Chen LF, Zhang X, Yan T, Zheng DH, Pessler F, Dai L (2018) Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis. Arthritis Res Ther 20(1): 130.

    • Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Jordao MJC, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U (2018) Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis. Cell Rep 25(1): 118-129.e4.

    • Herzmann C, Dallenga T, Kalinke U (2018) Pulmonale Immunitat bei Tuberkulose. Pneumologie 72(7): 493-502.

    • Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kuhnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgartner W, Bange FC, Goethe R, Jonigk D, Forster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N (2018) Hematopoietic stem cell gene therapy for IFNgammaR1 deficiency protects mice from mycobacterial infections. Blood 131(5): 533-545.

    • Kaufer C, Chhatbar C, Broer S, Waltl I, Ghita L, Gerhauser I, Kalinke U, Loscher W (2018) Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures. Proc Natl Acad Sci U S A 115(38): E8929-E8938.

    • Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgartner W, Wacker F, Kalinke U (2018) Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLoS Pathog 14(8): e1007235.

    • Kuhn M, Suhs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F (2018) Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. J Neuroinflammation 15(1): 20.

    • Loof TG, Sohail A, Bahgat MM, Tallam A, Arshad H, Akmatov MK, Pils MC, Heise U, Beineke A, Pessler F (2018) Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection. Front Cell Infect Microbiol 8:(n/a): 101.

    • Mzinza DT, Fleige H, Laarmann K, Willenzon S, Ristenpart J, Spanier J, Sutter G, Kalinke U, Valentin-Weigand P, Förster R (2018) Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice. Cellular & Molecular Immunology 15(10): 875-887.

    • Narendra SC, Chalise JP, Biggs S, Kalinke U, Magnusson M (2018) Regulatory T-Cells Mediate IFN-alpha-Induced Resistance against Antigen-Induced Arthritis. Front Immunol 9:(n/a): 285.

    • Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kuhnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N (2018) Impaired IFNgamma-Signaling and Mycobacterial Clearance in IFNgammaR1-Deficient Human iPSC-Derived Macrophages. Stem Cell Reports 10(1): 7-16.

    • Olmer R, Engels L, Usman A, Menke S, Malik MNH, Pessler F, Göhring G, Bornhorst D, Bolten S, Abdelilah-Seyfried S, Scheper T, Kempf H, Zweigerdt R, Martin U (2018) Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports 10(5): 1657-1672.

    • Petersen H, Mostafa A, Tantawy MA, Iqbal AA, Hoffmann D, Tallam A, Selvakumar B, Pessler F, Beer M, Rautenschlein S, Pleschka S (2018) NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems. Front Microbiol 9:(n/a): 526.

    • Pägelow D, Chhatbar C, Beineke A, Liu X, Nerlich A, van Vorst K, Rohde M, Kalinke U, Förster R, Halle S, Valentin-Weigand P, Hornef MW, Fulde M (2018) The olfactory epithelium as a port of entry in neonatal neurolisteriosis. Nat Commun 9(1): 4269.

    • Samir M, Hamed M, Abdallah F, Kinh Nguyen V, Hernandez-Vargas EA, Seehusen F, Baumgartner W, Hussein A, Ali AAH, Pessler F (2018) An Egyptian HPAI H5N1 isolate from clade 2.2.1.2 is highly pathogenic in an experimentally infected domestic duck breed (Sudani duck). Transbound Emerg Dis 65(3): 859-873.

    • Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C (2018) Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection. Frontiers in Immunology 9:(n/a): 79.

    • Skripuletz T, Pars K, Schulte A, Schwenkenbecher P, Yildiz O, Ganzenmueller T, Kuhn M, Spreer A, Wurster U, Pul R, Stangel M, Suhs KW, Trebst C (2018) Varicella zoster virus infections in neurological patients: a clinical study. BMC Infect Dis 18(1): 238.

    • Strehlitz A, Goldmann O, Pils MC, Pessler F, Medina E (2018) An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia. Frontiers in Immunology 9:(n/a): 1424.

    • Tappe KA, Budida R, Stankov MV, Frenz T, H R.Shah, Volz A, Sutter G, Kalinke U, Behrens GMN (2018) Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8(+) T cell proliferation. Eur J Immunol 48(12): 2042-2054.

    • Vendelova E, Ashour D, Blank P, Erhard F, Saliba AE, Kalinke U, Lutz MB (2018) Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells. Front Immunol 9:(n/a): 333.

    • Waltl I, Käufer C, Bröer S, Chhatbar C, Ghita L, Gerhauser I, Anjum M, Kalinke U, Löscher W (2018) Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis. Neurobiol Dis 110:(n/a): 192-205.

    • Waltl I, Käufer C, Gerhauser I, Chhatbar C, Ghita L, Kalinke U, Löscher W (2018) Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage. Brain Behav Immun 74:(n/a): 186-204.

    2017

    • Akmatov MK, Jentsch L, Riese P, May M, Ahmed MW, Werner D, Rosel A, Prokein J, Bernemann I, Klopp N, Prochnow B, Illig T, Schindler C, Guzman CA, Pessler F (2017) Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination. BMC Med Res Methodol 17(1): 18.

    • Akmatov MK, Koch N, Vital M, Ahrens W, Flesch-Janys D, Fricke J, Gatzemeier A, Greiser H, Günther K, Illig T, Kaaks R, Krone B, Kühn A, Linseisen J, Meisinger C, Michels K, Moebus S, Nieters A, Obi N, Schultze A, Six-Merker J, Pieper DH, Pessler F (2017) Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study – findings from Pretest 1 of the German National Cohort. Sci Rep 7(1): 1855.

    • Akmatov MK, Riese P, May M, Jentsch L, Ahmed MW, Werner D, Rösel A, Tyler M, Pessler K, Prokein J, Bernemann I, Klopp N, Prochnow B, Trittel S, Tallam A, Illig T, Schindler C, Guzmán CA, Pessler F (2017) Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population. Hum Vaccin Immunother 0 1-10.

    • Akmatov MK, Rober N, Ahrens W, Flesch-Janys D, Fricke J, Greiser H, Gunther K, Kaaks R, Kemmling Y, Krone B, Linseisen J, Meisinger C, Moebus S, Obi N, Guzman CA, Conrad K, Pessler F (2017) Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study. Arthritis Res Ther 19(1): 127.

    • Bongartz H, Rübsamen N, Raupach-Rosin H, Akmatov MK, Mikolajczyk RT (2017) Why do people participate in health-related studies?. Int J Public Health 62(9): 1059-1062.

    • Borchers S, Babaei R, Klimpel C, Duque Escobar J, Schröder S, Blume R, Malik MNH, Oetjen E (2017) TNFalpha-induced DLK activation contributes to apoptosis in the beta-cell line HIT. Naunyn Schmiedebergs Arch Pharmacol 390(8): 813-825.

    • De Jaime-Soguero A, Aulicino F, Ertaylan G, Griego A, Cerrato A, Tallam A, del Sol A, Cosma MP, Lluis F (2017) Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus. PLoS Genet 13(3): 1-27.

    • Filomena A, Pessler F, Akmatov MK, Krause G, Duffy D, Gärtner B, Gerhard M, Albert ML, Joos TO, Schneiderhan-Marra N (2017) Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori. High-Throughput 6(4): 14.

    • Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM, Poeck H (2017) RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci Transl Med 9(386).

    • González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A (2017) Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. PLoS Pathog 13(5): 1-28.

    • Hinz T, Kallen K, Britten CM, Flamion B, Granzer U, Hoos A, Huber C, Khleif S, Kreiter S, Rammensee HG, Sahin U, Singh-Jasuja H, Tureci O, Kalinke U (2017) The European Regulatory Environment of RNA-Based Vaccines. Methods Mol Biol 1499(n/a): 203--222.

    • Hirche C, Frenz T, Haas SF, Doring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U (2017) Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In~Vivo. Cell Rep 19(11): 2345--2356.

    • Hoffmann M, Crone L, Dietzel E, Paijo J, Gonzalez-Hernandez M, Nehlmeier I, Kalinke U, Becker S, Pohlmann S (2017) A polymorphism within the internal fusion loop of the Ebola virus glycoprotein modulates host cell entry. J Virol 91(9).

    • Ivin M, Dumigan A, de Vasconcelos FN, Ebner F, Borroni M, Kavirayani A, Przybyszewska KN, Ingram RJ, Lienenklaus S, Kalinke U, Stoiber D, Bengoechea JA, Kovarik P (2017) Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection. PLOS Pathog 13(11): 1-29.

    • Karabaev BB, Beisheeva NJ, Satybaldieva AB, Ismailova AD, Pessler F, Akmatov MK (2017) Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015). Infect Dis Poverty 6(1): 45.

    • Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V’kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJM, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V (2017) Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathog 13(2): 1-26.

    • Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Casadonte R, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Sunitsch S, Tikhilov R, Morawietz L (2017) 15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics. Pathol Res Pract 213(8): 874-881.

    • Lirussi D, Ebensen T, Schulze K, Trittel S, Duran V, Liebich I, Kalinke U, Guzman CA (2017) Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation. EBioMedicine n/a(22): 100-111.

    • Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A (2017) A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle. Sci Rep 7(1): 2933.

    • Paijo J, Kaever V, Kalinke U (2017) cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry. Methods Mol Biol n/a(1656): 153-166.

    • Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJP, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JMV, Steinmann E (2017) Immune protection against reinfection with nonprimate hepacivirus. Proceedings of the National Academy of Sciences 114(12): E2430-E2439.

    • Preusse M, Schughart K, Pessler F (2017) Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection. Front Immunol 8(n/a): 246.

    • Ruangkiattikul N, Nerlich A, Abdissa K, Lienenklaus S, Suwandi A, Janze N, Laarmann K, Spanier J, Kalinke U, Weiss S, Goethe R (2017) cGAS-STING-TBK1-IRF3/7 Induced Interferon-β Contributes to the Clearing of Non Tuberculous Mycobacterial Infection in Mice. Virulence n/a(n/a): 1-13.

    • Rubsamen N, Akmatov MK, Castell S, Karch A, Mikolajczyk RT (2017) Factors associated with attrition in a longitudinal online study: results from the HaBIDS panel. BMC Med Res Methodol 17(1): 132.

    • Rubsamen N, Akmatov MK, Castell S, Karch A, Mikolajczyk RT (2017) Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design. Emerg Themes Epidemiol 14(n/a): 4.

    • Selvakumar TA, Bhushal S, Kalinke U, Wirth D, Hauser H, Köster M, Hornef MW (2017) Identification of a Predominantly Interferon-$\uplambda$-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells. Front Immunol 8(n/a): 1302.

    • Speth MT, Repnik U, Müller E, Spanier J, Kalinke U, Corthay A, Griffiths G (2017) Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette–Guérin (BCG) via Synergistic Activation of Innate Immune Receptors. Mol Pharm 14(11): 4098-4112.

    • Tantawy MA, Nafie MS, Elmegeed GA, Ali IAI (2017) Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs. Bioorg Chem 73(n/a): 128-146.

    • Thiemann S, Smit N, Roy U, Lesker TR, Galvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T (2017) Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. Cell Host Microbe 21(6): 682--694.e5.

    • Zhao Y, Stepto H, Schneider CK (2017) Development of the First WHO Lentiviral Vector Standard: Towards the Production Control and Standardisation of Lentivirus based Gene Therapy Products. Hum Gene Ther Methods 28(4): 205-214.

    • Ziegler A, Soldner C, Lienenklaus S, Spanier J, Trittel S, Riese P, Kramps T, Weiss S, Heidenreich R, Jasny E, Guzman CA, Kallen KJ, Fotin-Mleczek M, Kalinke U (2017) A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects. J Immunol 198(4): 1595-1605.

    2016

    • Abou-El-Enein M, Schneider CK (2016) Deciphering the EU clinical trials regulation. Nat Biotechnol 34(3): 231-233.

    • Akmatov MK, Stumme M, Pessler F (2016) Real-life practice of methotrexate toxicity monitoring in juvenile idiopathic arthritis in Germany, Switzerland and Austria: results of a cross-sectional assessment conducted in 2012. Clin Exp Rheumatol 34(3): 548-553.

    • Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S (2016) Growing tumors induce a local STING dependent type I IFN response in dendritic cells. International Journal of Cancer 139(6): 1350-1357.

    • Blank T, Detje CN, Spiess A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zoller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Muller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M (2016) Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity 44(4): 901-912.

    • Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, Dambock U, Kroger A, Weiss S, Knapp S, Jamieson AM, Kirschning C, Kalinke U, Strobl B, Muller M, Stoiber D, Lienenklaus S, Kovarik P (2016) Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19(3): 375-387.

    • De Beuckelaer A, Pollard C, van Lint S, Roose K, van Hoecke L, Naessens T, Udhayakumar VK, Smet M, Sanders N, Lienenklaus S, Saelens X, Weiss S, Vanham G, Grooten J, De Koker S (2016) Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses. Mol Ther 24(11): 2012--2020.

    • Elsaman AM, Muhammad EM, Pessler F (2016) Sonographic Findings in Gouty Arthritis: Diagnostic Value and Association with Disease Duration. Ultrasound Med Biol 42(6): 1330-1336.

    • Frenz T, Grabski E, Buschjäger D, Vaas LAI, Burgdorf N, Schmidt RE, Witte T, Kalinke U (2016) CD4+ T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol 138(2): 586-589 e10.

    • Grine L, Steeland S, Van Ryckeghem S, Ballegeer M, Lienenklaus S, Weiss S, Sanders NN, Vandenbroucke RE, Libert C (2016) Topical imiquimod yields systemic effects due to unintended oral uptake. Sci Rep 6(n/a): 20134.

    • Hendel N, Akmatov MK, Hamel J, Vogelberg C, Pessler F (2016) Exhaled breath analysis in childhood rheumatic disorders-a longitudinal study. J Breath Res 10(2): 021001.

    • Kochs G, Anzaghe M, Kronhart S, Wagner V, Gogesch P, Scheu S, Lienenklaus S, Waibler Z (2016) In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection. J Virol 90(20): 9330-9337.

    • Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kroger A, Overby AK (2016) Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. J Neuroinflammation 13(n/a): 22.

    • Lambricht L, Vanvarenberg K, De Beuckelaer A, Van Hoecke L, Grooten J, Ucakar B, Lipnik P, Sanders NN, Lienenklaus S, Preat V, Vandermeulen G (2016) Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines. Mol Ther 24(9): 1686-1696.

    • Luckoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T (2016) Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med 8(6): 670-678.

    • Maier BB, Hladik A, Lakovits K, Korosec A, Martins R, Kral JB, Mesteri I, Strobl B, Müller M, Kalinke U, Merad M, Knapp S (2016) Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. Eur J Immunol 46(9): 2175-2186.

    • Mehraj J, Witte W, Akmatov MK, Layer F, Werner G, Krause G (2016) Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community. 398(n/a): 55-87.

    • Namasivayam AA, Morales AF, Lacave AMF, Tallam A, Simovic B, Alfaro DG, Bobbili DR, Martin F, Androsova G, Shvydchenko I, Park J, Calvo JV, Hoeng J, Peitsch MC, Racero MGV, Biryukov M, Talikka M, Pérez MB, Rohatgi N, Díaz-Díaz N, Mandarapu R, Ruiz RA, Davidyan S, Narayanasamy S, Boue S, Guryanova S, Arbas SM, Menon S, Xiang Y (2016) Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications. Gene Regul Syst Bio 10(n/a): 51-66.

    • Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer ACD, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG (2016) pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation. Proceedings of the National Academy of Sciences 113(29): 8098-8103.

    • Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U (2016) cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog 12(4): e1005546.

    • Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Gunther C, Muller W, Knobeloch KP, Prinz M, Roers A, Behrendt R (2016) Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity. J Immunol 197(6): 2157-2166.

    • Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T (2016) Hepatitis C Virus Stimulates Murine CD8alpha-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog 12(7): e1005736.

    • Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl A A, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T (2016) Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep 17(4): 1113 - 1127.

    • Samir M, Pessler F (2016) Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications. Front. Vet. Sci. 3(n/a): 22.

    • Samir M, Vaas LAI, Pessler F (2016) MicroRNAs in the Host Response to Viral Infections of Veterinary Importance. Front Vet Sci 3(n/a): 86.

    • Schlett CL, Hendel T, Hirsch J, Weckbach S, Caspers S, Schulz-Menger J, Ittermann T, von Knobelsdorff-Brenkenhoff F, Ladd SC, Moebus S, Stroszczynski C, Fischer B, Leitzmann M, Kuhl C, Pessler F, Hartung D, Kemmling Y, Hetterich H, Amunts K, Günther M, Wacker F, Rummeny E, Kauczor HU, Forsting M, Völzke H, Hosten N, Reiser MF, Bamberg F (2016) Quantitative, Organ-Specific Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a Multicenter, Multivendor Study. Invest Radiol 51(4): 255-265.

    • Schweitzer A, Pessler F, Akmatov MK (2016) Impact of rotavirus vaccination on coverage and timing of pentavalent vaccination – Experience from 2 Latin American countries. Human Vaccines & Immunotherapeutics 0 1-7.

    • Weissmuller S, Kronhart S, Kreuz D, Schnierle B, Kalinke U, Kirberg J, Hanschmann KM, Waibler Z (2016) TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model. PLoS One 11(3): e0149093.

    • de Araujo LS, Vaas LA, Ribeiro-Alves M, Geffers R, Mello FC, de Almeida AS, Moreira AD, Kritski AL, Lapa E.SilvaJR, Moraes MO, Pessler F, Saad MH (2016) Transcriptomic Biomarkers for Tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA Expression in Peripheral Blood. Front Microbiol 7(n/a): 1586.

    2015

    • Abd-Elshafy DN, Muller-Ladner U, Neumann E, Anggakusuma., Bahgat MM, Pessler F, Behrendt P (2015) Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 5(n/a): 18043.

    • Abd-Elshafy DN, Muller-Ladner U, Neumann E, Anggakusuma., Bahgat MM, Pessler F, Behrendt P (2015) Erratum: Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 6(n/a): 21441.

    • Akmatov MK, Kimani-Murage E, Pessler F, Guzman CA, Krause G, Kreienbrock L, Mikolajczyk RT (2015) Evaluation of invalid vaccine doses in 31 countries of the WHO African Region. Vaccine 33(7): 892-901.

    • Akmatov MK, Rubsamen N, Schultze A, Kemmling Y, Obi N, Gunther K, Ahrens W, Pessler F, Krause G, Mikolajczyk RT (2015) Diverse recruitment strategies result in different participation percentages in a web-based study, but in similar compliance. Int J Public Health 60(8): 937-943.

    • Brinkmann MM, Dag F, Hengel H, Messerle M, Kalinke U, Cicin-Sain L (2015) Cytomegalovirus immune evasion of myeloid lineage cells. Med Microbiol Immunol 204(3): 367-382.

    • Crouse J, Kalinke U, Oxenius A (2015) Regulation of antiviral T cell responses by type I interferons. Nat Rev Immunol 15(4): 231-242.

    • Detje CN, Lienenklaus S, Chhatbar C, Spanier J, Prajeeth CK, Soldner C, Tovey MG, Schluter D, Weiss S, Stangel M, Kalinke U (2015) Upon intranasal VSV infection astrocytes in the olfactory bulb are important IFN-beta producers that protect from lethal encephalitis. J Virol 89(5): 2731-2738.

    • Fischbach H, Doring M, Nikles D, Lehnert E, Baldauf C, Kalinke U, Tampe R (2015) Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets. Nat Commun 6(n/a): 6199.

    • Frenz T, Grabski E, Duran V, Hozsa C, Stepczynska A, Furch M, Gieseler RK, Kalinke U (2015) Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers. Eur J Pharm Biopharm 97(Pt A): 13-17.

    • Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells. J Virol 89(6): 3200-3208.

    • Luciani F, Galluzzo S, Gaggioli A, Kruse NA, Venneugues P, Schneider CK, Pini C, Melchiorri D (2015) Implementing quality by design for biotech products: are regulators on track?. MAbs 7(3): 451-455.

    • Malczyk AH, Kupke A, Prufer S, Scheuplein VA, Hutzler S, Kreuz D, Beissert T, Bauer S, Hubich-Rau S, Tondera C, Shams Eldin H, Schmidt J, Vergara-Alert J, Suzer Y, Seifried J, Hanschmann KM, Kalinke U, Herold S, Sahin U, Cichutek K, Waibler Z, Eickmann M, Becker S, Muhlebach MD (2015) A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform. J Virol 89(22): 11654-11667.

    • Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P (2015) Abortively infected astrocytes appear to represent the main source of interferon-β in the virus-infected brain. J Virol 90(4): 2031-2038.

    • Preusse M, Schughart K, Wilk E, Klawonn F, Pessler F (2015) Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains. BMC Res Notes 8(n/a): 225.

    • Salmikangas P, Menezes-Ferreira M, Reischl I, Tsiftsoglou A, Kyselovic J, Borg JJ, Ruiz S, Flory E, Trouvin J, Celis P, Ancans J, Timon M, Pante G, Sladowski D, Lipnik-Stangelj M, Schneider CK (2015) Manufacturing, characterization and control of cell-based medicinal products: challenging paradigms toward commercial use. Regen Med 10(1): 65-78.

    • Schneider CK, Weise M (2015) Regulatorische Aspekte zu Biosimilars: Mythen und Fakten. Z Rheumatol 74(8): 695-700.

    • Schweitzer A, Akmatov MK, Kindler F, Kemmling Y, Kreienbrock L, Krause G, Pessler F (2015) The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort. BMJ Open 5(8): e007461.

    • Schweitzer A, Della Beffa C, Akmatov MK, Narchi H, Abaev YK, Sherry DD, Pessler F (2015) Primary Osteomyelitis of the Sternum in the Pediatric Age Group: Report of a New Case and Comprehensive Analysis of Seventy-four Cases. Pediatr Infect Dis J 34(4): e92-e101.

    • Schweitzer A, Krause G, Pessler F, Akmatov MK (2015) Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan. BMC Public Health 155(1): 798.

    • Skripuletz T, Salinas Tejedor L, Prajeeth CK, Hansmann F, Chhatbar C, Kucman V, Zhang N, Raddatz BB, Detje CN, Suhs KW, Pul R, Gudi V, Kalinke U, Baumgartner W, Stangel M (2015) The antiviral drug ganciclovir does not inhibit microglial proliferation and activation. Sci Rep 5(n/a): 14935.

    • Vogel S, Grabski E, Buschjager D, Klawonn F, Doring M, Wang J, Fletcher E, Bechmann I, Witte T, Durisin M, Schraven B, Mangsbo SM, Schonfeld K, Czeloth N, Kalinke U (2015) Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells. Sci Rep 5(n/a): 18308.

    • Waffarn EE, Hastey CJ, Dixit N, Choi YS, Cherry S, Kalinke U, Simon SI, Baumgarth N (2015) Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation. Nature Communications 6(n/a): 8991.

    • Wang H, El Maadidi S, Fischer J, Grabski E, Dickhofer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Loffler MW, Wiese M, Pichulik T, Mullhaupt B, Semela D, Dufour JF, East German, Swiss Hepatitis C.VirusStudyGroups, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN (2015) A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance. Hepatol 62(5): 1375-1387.

    • Wenzel UA, Fernandez-Santoscoy M, Tam MA, Tegtmeyer P, Wick MJ (2015) Synergy between CD40 and MyD88 Does Not Influence Host Survival to Salmonella Infection. Front Immunol 6(n/a): 460.

    2014

    • Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider CK (2014) A roadmap toward clinical translation of genetically-modified stem cells for treatment of HIV. Trends Mol Med d20(11): 632-642.

    • Akmatov MK, Mehraj J, Gatzemeier A, Strompl J, Witte W, Krause G, Pessler F (2014) Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany. Int J Infect Dis 25(n/a): 4-10.

    • Arnold P, Himmels P, Weiss S, Decker TM, Markl J, Gatterdam V, Tampe R, Bartholomaeus P, Dietrich U, Durr R (2014) Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. Retrovirology 11(n/a): 42.

    • Bald T, Landsberg J, Lopez-Ramos D, Renn M, Glodde N, Jansen P, Gaffal E, Steitz J, Tolba R, Kalinke U, Limmer A, Jonsson G, Holzel M, Tuting T (2014) Immune-cell poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov 4(6): 674-687.

    • Bartholomaeus P, Semmler LY, Bukur T, Boisguerin V, Romer PS, Tabares P, Chuvpilo S, Tyrsin DY, Matskevich A, Hengel H, Castle J, Hunig T, Kalinke U (2014) Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response. J Immunol 192(5): 2091-2098.

    • Borg JJ, Serracino-Inglott A, Azzopardi LM, Schneider CK (2014) Comment On: "EU's New Pharmacovigilance Legislation: Considerations for Biosimilars". Drug Saf 37(2): 123-124.

    • Castell S, Akmatov MK, Obi N, Flesh-Janys D, Nieters A, Kemmling Y, Pessler F, Krause G (2014) Test-retest reliability of an infectious disease questionnaire and evaluation of self-assessed vulnerability to infections : Findings of Pretest 2 of the German National Cohort. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 57(11): 1300-1307.

    • Conrad E, Resch TK, Gogesch P, Kalinke U, Bechmann I, Bogdan C, Waibler Z (2014) Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice. Hepatology 59(4): 1555-1563.

    • Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, Kalinke U, Vivier E, Jonjic S, Oxenius A (2014) Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity 40(6): 961-973.

    • Doring M, Lessin I, Frenz T, Spanier J, Kessler A, Tegtmeyer P, Dag F, Thiel N, Trilling M, Lienenklaus S, Weiss S, Scheu S, Messerle M, Cicin-Sain L, Hengel H, Kalinke U (2014) M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plasmacytoid dendritic cells. J Virol 88(23): 13638-13650.

    • Fleige H, Ravens S, Moschovakis GL, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R (2014) IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 211(4): 643-651.

    • Frentzen A, Kusuma A, Guerlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kroger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T (2014) Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology 59(1): 78-88.

    • Frenz T, Graalmann L, Detje CN, Doring M, Grabski E, Scheu S, Kalinke U (2014) Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus. J Immunol 193(5): 2496-2503.

    • Gabaev I, Elbasani E, Ameres S, Steinbruck L, Stanton R, Doring M, Lenac Rovis T, Kalinke U, Jonjic S, Moosmann A, Messerle M (2014) Expression of the Human Cytomegalovirus UL11 Glycoprotein in Viral Infection and Evaluation of its Effect on Virus-Specific CD8 T Cells. J Virol 88(24): 14326-14339.

    • Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Renia L, Ruedl C, Macdonald KP, Hill GR, Engwerda CR (2014) Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest 124(6): 2483-2496.

    • Kuhn A, Nieters A, Kottgen A, Goek ON, Michels K, Nothlings U, Jacobs G, Meisinger C, Pessler F, Akmatov MF, Kuhnisch J, Moebus S, Glocker E, Naus S, Keimling M, Leitzmann M, Linseisen J, Sarioglu H, von Toerne C, Hauck SM, Wallaschofski H, Wichmann HE, Illig T (2014) Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1255-1263.

    • Lebel ME, Daudelin JF, Chartrand K, Tarrab E, Kalinke U, Savard P, Labrecque N, Leclerc D, Lamarre A (2014) Nanoparticle Adjuvant Sensing by TLR7 Enhances CD8+ T Cell-Mediated Protection from Listeria Monocytogenes Infection. J Immunol 192(3): 1071-1078.

    • Liehl P, Zuzarte-Luis V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Muller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudencio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigario AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM (2014) Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20(1): 47-53.

    • Mall S, Akmatov MK, Schultze A, Ahrens W, Obi N, Pessler F, Krause G (2014) Web-based questionnaires to capture acute infections in long-term cohorts : Findings of a feasibility study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1308-1314.

    • Mehraj J, Akmatov MK, Strompl J, Gatzemeier A, Layer F, Werner G, Pieper DH, Medina E, Witte W, Pessler F, Krause G (2014) Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Nasal Carriage in a Random Sample of Non-Hospitalized Adult Population in Northern Germany. PLoS One 9(9): e107937.

    • Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Koster M, Kalinke U, Hauser H, Kroger A (2014) Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathog 10(3): e1003999.

    • Narayanan G, Cossu G, Galli MC, Flory E, Ovelgonne H, Salmikangas P, Schneider CK, Trouvin JH (2014) Clinical development of gene therapy needs a tailored approach: a regulatory perspective from the European union. Hum Gene Ther Clin Dev 25(1): 1-6.

    • Novoselova N, Beffa CD, Wang J, Li J, Pessler F, Klawonn F (2014) HUM Calculator and HUM package for R: easy-to-use software tools for multicategory receiver operating characteristic analysis. Bioinformatics 30(11): 1635-1636.

    • Pessler F, Ogdie AR, Mayer CT, Kretzschmar WW, Dai L, Elsaman AM, Einhorn E, Krenn V, Schumacher HR (2014) Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells. Amyloid 21(1): 28-34.

    • Schultze A, Akmatov MK, Andrzejak M, Karras N, Kemmling Y, Maulhardt A, Wieghold S, Ahrens W, Gunther K, Schlenz H, Krause G, Pessler F (2014) Comparison of stool collection on site versus at home in a population-based study : Feasibility and participants' preference in Pretest 2 of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1264-1269.

    • Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Gunther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F, Krause G (2014) Collection of vaccination data in the German National Cohort : Findings of a feasibility study in three study centers. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1292-1299.

    • Shankar G, Arkin S, Cocea L, Devanarayan V, Kirshner S, Kromminga A, Quarmby V, Richards S, Schneider CK, Subramanyam M, Swanson S, Verthelyi D, Yim S (2014) Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides-Harmonized Terminology and Tactical Recommendations. Aaps J 16(4): 658-673.

    • Sievers C, Akmatov MK, Kreienbrock L, Hille K, Ahrens W, Gunther K, Flesch-Janys D, Obi N, Michels KB, Fricke J, Greiser KH, Kaaks R, Peter HH, Pessler F, Nieters A, Krause G (2014) Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : Findings of a multicenter study. Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : Findings of a multicenter study 57(11): 1283-1291.

    • Spanier J, Lienenklaus S, Paijo J, Kessler A, Borst K, Heindorf S, Baker DP, Kroger A, Weiss S, Detje CN, Staeheli P, Kalinke U (2014) Concomitant TLR/RLH Signaling of Radioresistant and Radiosensitive Cells Is Essential for Protection against Vesicular Stomatitis Virus Infection. J Immunol 193(6): 3045-3054.

    • Svitek N, Gerhauser I, Goncalves C, Grabski E, Doring M, Kalinke U, Anderson DE, Cattaneo R, von Messling V (2014) Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but not STAT1 for Canine Distemper Virus Virulence in Ferrets. J Virol 88(5): 2941-2950.

    • Volz A, Langenmayer M, Jany S, Kalinke U, Sutter G (2014) Rapid expansion of CD8+ T cells in wildtype and type I interferon receptor deficient mice correlates with protection after low-dose emergency immunization with Modified Vaccinia virus Ankara. J Virol 88(18): 10946-10957.

    • Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Overby AK, Kroger A (2014) Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local anti-viral response. J Virol 88(21): 12202-12212.

    • Weise M, Kurki P, Wolff-Holz E, Bielsky MC, Schneider CK (2014) Biosimilars: the science of extrapolation. Blood 124(22): 3191-3196.

    • Zheng LS, Hitoshi S, Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for Interferon-alpha-Induced Depression and Neural Stem Cell Dysfunction. Stem cell reports 3(1): 73-84.

    • Zust R, Toh YX, Valdes I, Cerny D, Heinrich J, Hermida L, Marcos E, Guillen G, Kalinke U, Shi PY, Fink K (2014) Type I IFN signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines. J Virol 88(13): 7276-7285.

    • van Aerts LA, De Smet K, Reichmann G, Willem van der Laan J, Schneider CK (2014) Biosimilars entering the clinic without animal studies: A paradigm shift in the European Union. mAbs 6(5).

    2013

    • Aiuti A, Cossu G, de Felipe P, Galli MC, Narayanan G, Renner M, Stahlbom A, Schneider CK, Voltz-Girolt C (2013) The Committee for Advanced Therapies' (CAT) reflection paper on management of clinical risks deriving from insertional mutagenesis. Hum Gene Ther Clin Dev 24(2): 47-54.

    • Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Buscher D, Fibbe W, Foussat A, Kwa M, Lantz O, Maciulaitis R, Palomaki T, Schneider CK, Sensebe L, Tachdjian G, Tarte K, Tosca L, Salmikangas P (2013) Risk of tumorigenicity in mesenchymal stromal cell-based therapies-Bridging scientific observations and regulatory viewpoints. Cytotherapy 15(7): 753-759.

    • Beffa CD, Slansky E, Pommerenke C, Klawonn F, Li J, Dai L, Schumacher Jr HR, Pessler F (2013) The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. PLoS One 8(8): e72494.

    • Britten CM, Singh-Jasuja H, Flamion B, Hoos A, Huber C, Kallen KJ, Khleif SN, Kreiter S, Nielsen M, Rammensee HG, Sahin U, Hinz T, Kalinke U (2013) The regulatory landscape for actively personalized cancer immunotherapies. Nat Biotechnol 31(10): 880-882.

    • Bunse CE, Borchers S, Varanasi PR, Tischer S, Figueiredo C, Immenschuh S, Kalinke U, Kohl U, Goudeva L, Maecker-Kolhoff B, Ganser A, Blasczyk R, Weissinger EM, Eiz-Vesper B (2013) Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor. PLoS One 8(12): e77925.

    • Eichler HG, Bloechl-Daum B, Brasseur D, Breckenridge A, Leufkens H, Raine J, Salmonson T, Schneider CK, Rasi G (2013) The risks of risk aversion in drug regulation. Nat Rev Drug Discov 12(12): 907-916.

    • Elsaman AM, Radwan AR, Akmatov MK, Della Beffa C, Walker A, Mayer CT, Dai L, Nativ S, Rygg M, Atsali E, Saijo K, Ogdie AR, Srinivasulu N, Fathi N, Ralph Schumacher H, Pessler F (2013) Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases. Semin Arthritis Rheum 43(3): 405-412.

    • Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, Qureshi S, Lamarre A, Haddad EK, Sekaly RP, Peri S, Balachandran S, Lin R, Hiscott J (2013) Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. PLoS pathogens 9(4): e1003298.

    • Hogner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlohner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S (2013) Macrophage-expressed IFN-beta Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia. PLoS Pathog 9(2): e1003188.

    • Hogner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlohner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S (2013) Correction: Macrophage-expressed IFN-beta Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia. PLoS Pathog 12(6): e1005716.

    • Joshi R, Feldmann V, Koestner W, Detje C, Gottschalk S, Mayer HA, Sauer MG, Engelmann J (2013) Multifunctional silica nanoparticles for optical and magnetic resonance imaging. Biol Chem 394(1): 125-135.

    • Melchiorri D, Pani L, Gasparini P, Cossu G, Ancans J, Borg JJ, Drai C, Fiedor P, Flory E, Hudson I, Leufkens HG, Muller-Berghaus J, Narayanan G, Neugebauer B, Pokrotnieks J, Robert JL, Salmonson T, Schneider CK (2013) Regulatory evaluation of Glybera in Europe - two committees, one mission. Nat Rev Drug Discov 12(9): 719.

    • Prete F, Catucci M, Labrada M, Gobessi S, Castiello MC, Bonomi E, Aiuti A, Vermi W, Cancrini C, Metin A, Hambleton S, Bredius R, Notarangelo LD, van der Burg M, Kalinke U, Villa A, Benvenuti F (2013) Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells. J Exp Med 210(2): 355-374.

    • Preusse M, Tantawy MA, Klawonn F, Schughart K, Pessler F (2013) Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice. BMC Microbiol 13(n/a): 293.

    • Schneider CK (2013) Biosimilars in rheumatology: the wind of change. Ann Rheum Dis 72(3): 315-318.

    • Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, Weber M, Kalinke U, Hofer MJ, Hatesuer B, Schughart K, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Weber F, Hornef MW, Autenrieth IB, Bohn E (2013) IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-alpha Secretion and LPS-Induced Endotoxin Shock. J Immunol 191(7): 3913-3921.

    • Tsiftsoglou AS, Ruiz S, Schneider CK (2013) Development and regulation of biosimilars: current status and future challenges. BioDrugs 27(3): 203-211.

    • Vestergaard HT, Apote LD, Schneider CK, Herberts C (2013) The evolution of nonclinical regulatory science: advanced therapy medicinal products as a paradigm. Mol Ther 21(7): 1294-1296.

    2012

    • Bache C, Spreitzer I, Becker B, Loeschner B, Rosskopf U, Hanschmann KM, Schwanig M, Schneider CK, Lieb B, Montag T (2012) Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood. Med Microbiol Immunol 201(3): 327-335.

    • Baranek T, Manh TP, Alexandre Y, Maqbool MA, Cabeza JZ, Tomasello E, Crozat K, Bessou G, Zucchini N, Robbins SH, Vivier E, Kalinke U, Ferrier P, Dalod M (2012) Differential responses of immune cells to type I interferon contribute to host resistance to viral infection. Cell Host Microbe 12(4): 571-584.

    • Ejaz A, Steinmann E, Banki Z, Anggakusuma, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H (2012) Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus. PLoS One 7(9): e45770.

    • Kalinke U, Prinz M (2012) Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS. Immunol Cell Biol 90(5): 505-509.

    • Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, Reichart U, Reizis B, Kalinke U, Jamieson A, Mueller M, Decker T (2012) Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection. PLoS Pathog 8(6): e1002763.

    • Kremer M, Suezer Y, Volz A, Frenz T, Majzoub M, Hanschmann KM, Lehmann MH, Kalinke U, Sutter G (2012) Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox. PLoS pathogens 8(3): e1002557.

    • Maciulaitis R, D'Apote L, Buchanan A, Pioppo L, Schneider CK (2012) Clinical development of advanced therapy medicinal products in europe: evidence that regulators must be proactive. Mol Ther 20(3): 479-482.

    • Mizutani T, Neugebauer N, Putz EM, Moritz N, Simma O, Zebedin-Brandl E, Gotthardt D, Warsch W, Eckelhart E, Kantner HP, Kalinke U, Lienenklaus S, Weiss S, Strobl B, Muller M, Sexl V, Stoiber D (2012) Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1(7): 1027-1037.

    • Schneider CK, Borg JJ, Ehmann F, Ekman N, Heinonen E, Ho K, Hoefnagel MH, van der Plas RM, Ruiz S, van der Stappen AJ, Thorpe R, Tiitso K, Tsiftsoglou AS, Vleminckx C, Waxenecker G, Welin M, Weise M, Trouvin JH (2012) In support of the European Union biosimilar framework. Nat Biotechnol 30(8): 745-748.

    • Schneider CK, Vleminckx C, Gravanis I, Ehmann F, Trouvin JH, Weise M, Thirstrup S (2012) Setting the stage for biosimilar monoclonal antibodies. Nat Biotechnol 30(12): 1179-1185.

    • Schwandt T, Schumak B, Gielen GH, Jungerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JM, Knolle PA, Limmer A (2012) Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. Embo J 31(1): 201-213.

    • Weise M, Bielsky MC, De Smet K, Ehmann F, Ekman N, Giezen TJ, Gravanis I, Heim HK, Heinonen E, Ho K, Moreau A, Narayanan G, Kruse NA, Reichmann G, Thorpe R, van Aerts L, Vleminckx C, Wadhwa M, Schneider CK (2012) Biosimilars: what clinicians should know. Blood 120(26): 5111-5117.

    • Weissmueller S, Semmler LY, Kalinke U, Christians S, Mueller-Berghaus J, Waibler Z (2012) ICOS-LICOS interaction is critically involved in TGN1412-mediated T cell activation. Blood 119(26): 6268-6277.

    2011

    • Arico E, Monque DM, D'Agostino G, Moschella F, Venditti M, Kalinke U, Allen DJ, Nash AA, Belardelli F, Ferrantini M (2011) MHV-68 producing mIFNalpha1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68.. Vaccine 29(23): 3935-3944.

    • Buttel IC, Chamberlain P, Chowers Y, Ehmann F, Greinacher A, Jefferis R, Kramer D, Kropshofer H, Lloyd P, Lubiniecki A, Krause R, Mire-Sluis A, Platts-Mills T, Ragheb JA, Reipert BM, Schellekens H, Seitz R, Stas P, Subramanyam M, Thorpe R, Trouvin JH, Weise M, Windisch J, Schneider CK (2011) Taking immunogenicity assessment of therapeutic proteins to the next level.. Biologicals 39(2): 100-109.

    • Chopy D, Detje CN, Lafage M, Kalinke U, Lafon M (2011) The type I interferon response bridles rabies virus infection and reduces pathogenicity.. J Neurovirol 17(4): 353-367.

    • Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M (2011) Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15(1): 98-106.

    • Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, Lee H, Arthur CD, White JM, Kalinke U, Murphy KM, Schreiber RD (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors.. J Exp Med 208(10): 1989-2003.

    • Dominguez PM, Lopez-Bravo M, Kalinke U, Ardavin C (2011) Statins inhibit iNOSmediated microbicidal potential of activated monocyte-derived dendritic cells by an IFNbeta-dependent mechanism.. Eur J Immunol 41(11): 3330-3339.

    • Eichler HG, Abadie E, Breckenridge A, Flamion B, Gustafsson LL, Leufkens H, Rowland M, Schneider CK, Bloechl-Daum B (2011) Bridging the efficacy-effectiveness gap: a regulator's perspective on addressing variability of drug response.. Nat Rev Drug Discov 10(7): 495-506.

    • Grabski E, Waibler Z, Schule S, Kloke BP, Sender LY, Panitz S, Cichutek K, Schweizer M, Kalinke U (2011) Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems.. Mol Biotechnol 47(3): 262-269.

    • Gratz MS, Suezer Y, Kremer M, Volz A, Majzoub M, Hanschmann KM, Kalinke U, Schwantes A, Sutter G (2011) N1L is an ectromelia virus virulence factor and essential for in vivo spread upon respiratory infection.. J Virol 85(7): 3557-3569.

    • Kalinke U, Bechmann I, Detje CN (2011) Host strategies against virus entry via the olfactory system.. Virulence 2(4): 367-370.

    • Reiss M, Buttel IC, Schneider CK (2011) Report from the Committee for Advanced Therapies (CAT). Pitfalls on the way from concept to medical treatment with advanced therapy medicinal products.. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54(7): 822-830.

    • Schulke S, Burggraf M, Waibler Z, Wangorsch A, Wolfheimer S, Kalinke U, Vieths S, Toda M, Scheurer S (2011) A fusion protein of flagellin and ovalbumin suppresses the T(H)2 response and prevents murine intestinal allergy.. J Allergy Clin Immunol 128(6): 1340-1348 e1312.

    • Weise M, Bielsky MC, De Smet K, Ehmann F, Ekman N, Narayanan G, Heim HK, Heinonen E, Ho K, Thorpe R, Vleminckx C, Wadhwa M, Schneider CK (2011) Biosimilars-why terminology matters.. Nat Biotechnol 29(8): 690-693.

    • Williams SK, Fairless R, Weise J, Kalinke U, Schulz-Schaeffer W, Diem R (2011) Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis.. Am J Pathol 178(6): 2823-2831.

    2010

    • Al Moussawi K, Ghigo E, Kalinke U, Alexopoulou L, Mege JL, Desnues B (2010) Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.. PLoS Pathog 6(1): e1000722.

    • Buttel IC, Voller K, Schneider CK (2010) Immunogenicity and its Impact on Benefit/Risk Considerations in the Authorisation of Biopharmaceuticals.. Curr Drug Saf 5(4): 287-292.

    • Frenz T, Waibler Z, Hofmann J, Hamdorf M, Lantermann M, Reizis B, Tovey MG, Aichele P, Sutter G, Kalinke U (2010) Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. Eur J Immunol 40(10): 2769-2777.

    • Goetz KB, Pfleiderer M, Schneider CK (2010) First-in-human clinical trials with vaccines-what regulators want.. Nat Biotechnol 28(9): 910-916.

    • Goossens P, Gijbels MJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJ, Kalinke U, Weber C, Lutgens E, de Winther MP (2010) Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12(2): 142-153.

    • Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M (2010) Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II.. J Allergy Clin Immunol 125(1): 175-183, e171-111.

    • Kern M, Popov A, Scholz K, Schumak B, Dandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA (2010) Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.. Gastroenterology 138(1): 336-46.

    • Kochs G, Bauer S, Vogt C, Frenz T, Tschopp J, Kalinke U, Waibler Z (2010) Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells.. J Virol 84(23): 12344-12350.

    • Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Rooijen NVan, Kalinke U, Ludewig B, Hengartner H, Harris N, Häussinger D, Ohashi PS, Zinkernagel RM, Lang KS (2010) Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.. Hepatology 51(1): 25-32.

    • Malinarich FH, Grabski E, Worbs T, Chennupati V, Haas JD, Schmitz S, Candia E, Quera R, Malissen B, Forster R, Hermoso M, Prinz I (2010) Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial gammadelta T cells is functional in vivo. Eur J Immunol 40(12): 3378-88.

    • Murikinati S, Juttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M (2010) Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.. FASEB J 24(3): 788-798.

    • Prinz M, Kalinke U (2010) New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.. Trends Mol Med 16(8): 379-386.

    • Schneider CK, Salmikangas P, Jilma B, Flamion B, Todorova LR, Paphitou A, Haunerova I, Maimets T, Trouvin JH, Flory E, Tsiftsoglou A, Sarkadi B, Gudmundsson K, O'Donovan M, Migliaccio G, Ancans J, Maciulaitis R, Robert JL, Samuel A, Ovelgonne JH, Hystad M, Fal AM, Lima BS, Moraru AS, Turcani P, Zorec R, Ruiz S, Akerblom L, Narayanan G, Kent A, Bignami F, Dickson JG, Niederwieser D, Figuerola-Santos MA, Reischl IG, Beuneu C, Georgiev R, Vassiliou M, Pychova A, Clausen M, Methuen T, Lucas S, Schussler-Lenz M, Kokkas V, Buzas Z, MacAleenan N, Galli MC, Line A, Gulbinovic J, Berchem G, Fraczek M, Menezes-Ferreira M, Vilceanu N, Hrubisko M, Marinko P, Timon M, Cheng W, Crosbie GA, Meade N, di Paola ML, VandenDriessche T, Ljungman P, D'Apote L, Oliver-Diaz O, Buttel I, Celis P (2010) Challenges with advanced therapy medicinal products and how to meet them.. Nat Rev Drug Discov 9(3): 195-201 Review.

    • Schussler-Lenz M, Schneider CK (2010) Clinical trials with advanced therapy medicinal products.. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53(1): 68-74 Review.

    • Sender LY, Gibbert K, Suezer Y, Radeke HH, Kalinke U, Waibler Z (2010) CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals.. Mol Immunol 47(6): 1255-1261.

    2009

    • Aly S, Mages J, Reiling N, Kalinke U, Decker T, Lang R, Ehlers S (2009) Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13(8B): 2069-2082.

    • Anz D, Thaler R, Stephan N, Waibler Z, Trauscheid MZ, Scholz C, Kalinke U, Barchet W, Endres S, Bourquin C (2009) Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10): 6044-6050.

    • Bach P, Tschape JA, Kopietz F, Braun G, Baade JK, Wiederhold KH, Staufenbiel M, Prinz M, Deller T, Kalinke U, Buchholz CJ, Muller UC (2009) Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice. J Immunol 182(12): 7613-7624.

    • Cervantes-Barragan L, Kalinke U, Zust R, Konig M, Reizis B, Lopez-Macias C, Thiel V, Ludewig B (2009) Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2): 1099-1106.

    • Cucak H, Yrlid U, Reizis B, Kalinke U, Johansson-Lindbom B (2009) Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3): 491-501.

    • Dauber B, Martinez-Sobrido L, Schneider J, Hai R, Waibler Z, Kalinke U, Garcia-Sastre A, Wolff T (2009) Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR. PLoS Pathog 5(6): e1000473.

    • Detje CN, Meyer T, Schmidt H, Kreuz D, Rose JK, Bechmann I, Prinz M, Kalinke U (2009) Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol 182(4): 2297-2304.

    • Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A (2009) IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 458(7240): 904-908.

    • Jahn EM, Schneider CK (2009) How to systematically evaluate immunogenicity of therapeutic proteins - regulatory considerations. N Biotechnol 25(5): 280-286.

    • Paran N, Suezer Y, Lustig S, Israely T, Schwantes A, Melamed S, Katz L, Preuss T, Hanschmann KM, Kalinke U, Erez N, Levin R, Velan B, Lower J, Shafferman A, Sutter G (2009) Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox. J Infect Dis 199(1): 39-48.

    • Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, von Gabain A, Stoiber D, Sexl V, Kolbe T, Rulicke T, Muller M, Decker T, Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, von Gabain A, Stoiber D, Sexl V, Kolbe T, Rulicke T, Muller M, Decker T (2009) Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4): 2286-2293.

    • Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH (2009) Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol 182(7): 4183-4191.

    • Schneider CK, Papaluca M, Kurki P (2009) A European perspective on immunogenicity evaluation. Nat Biotechnol 27(6): 507-508.

    • Stockinger S, Kastner R, Kernbauer E, Pilz A, Westermayer S, Reutterer B, Soulat D, Stengl G, Vogl C, Frenz T, Waibler Z, Taniguchi T, Rulicke T, Kalinke U, Muller M, Decker T (2009) Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog 5(3): e1000355.

    • Waibler Z, Anzaghe M, Frenz T, Schwantes A, Pohlmann C, Ludwig H, Palomo-Otero M, Alcami A, Sutter G, Kalinke U (2009) Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components. J Virol 83(4): 1563-1571.

    2008

    • Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J (2008) TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28(5): 651-661.

    • Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tuting T, Hartmann G (2008) 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11): 1256-1263.

    • Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U (2008) Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5): 675-686.

    • Schneider CK, Kalinke U (2008) Toward biosimilar monoclonal antibodies. Nat Biotechnol 26(9): 985-990 Review.

    • Schraven B, Kalinke U (2008) CD28 superagonists: what makes the difference in humans?. Immunity 28(5): 591-595.

    • Waibler Z, Anzaghe M, Konur A, Akira S, Muller W, Kalinke U (2008) Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC. Eur J Immunol 38(11): 3127-3137.

    • Waibler Z, Sender LY, Kamp C, Muller-Berghaus J, Liedert B, Schneider CK, Lower J, Kalinke U (2008) Toward experimental assessment of receptor occupancy: TGN1412 revisited. J Allergy Clin Immunol 122(5): 890-892.

    • Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B (2008) Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies. PLoS One 3(3): e1708.

    2007

    • Bach P, Kamphuis E, Odermatt B, Sutter G, Buchholz CJ, Kalinke U (2007) Vesicular stomatitis virus glycoprotein displaying retrovirus-like particles induce a type I IFN receptor-dependent switch to neutralizing IgG antibodies. J Immunol 178(9): 5839-5847.

    • Blakqori G, Delhaye S, Habjan M, Blair CD, Sanchez-Vargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F (2007) La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol 81(10): 4991-4999.

    • Demirel O, Waibler Z, Kalinke U, Grunebach F, Appel S, Brossart P, Hasilik A, Tampe R, Abele R (2007) Identification of a lysosomal peptide transport system induced during dendritic cell development. J Biol Chem 282(52): 37836-37843.

    • Koerner I, Kochs G, Kalinke U, Weiss S, Staeheli P (2007) Protective role of beta interferon in host defense against influenza A virus. J Virol 81(4): 2025-2030.

    • Liedert B, Bassus S, Schneider CK, Kalinke U, Lower J (2007) Safety of phase I clinical trials with monoclonal antibodies in Germany--the regulatory requirements viewed in the aftermath of the TGN1412 disaster. Int J Clin Pharmacol Ther 45(1): 1-9.

    • Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M (2007) Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem 282(7): 4669-4680.

    • Schleicher U, Liese J, Knippertz I, Kurzmann C, Hesse A, Heit A, Fischer JA, Weiss S, Kalinke U, Kunz S, Bogdan C (2007) NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4): 893-906.

    • Schneider CK, Kalinke U (2007) After the TGN1412 incident. Principles for assessment of first-in-man trials with monoclonal antibodies by the Paul Ehrlich Institute. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50(10): 1213-1220.

    • Waibler Z, Anzaghe M, Ludwig H, Akira S, Weiss S, Sutter G, Kalinke U (2007) Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses. J Virol 81(22): 12102-12110.

    • Waibler Z, Detje CN, Bell JC, Kalinke U (2007) Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells. Immunobiology 212(9-10): 887-894.

    • Waibler Z, Kalinke U, Will J, Juan MH, Pfeilschifter JM, Radeke HH (2007) TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol Immunol 44(7): 1483-1489.

    2006

    • Aichele P, Unsoeld H, Koschella M, Schweier O, Kalinke U, Vucikuja S (2006) CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J Immunol 176(8): 4525-4529.

    • Buchholz CJ, Bach P, Nikles D, Kalinke U (2006) Prion protein-specific antibodies for therapeutic intervention of transmissible spongiform encephalopathies. Expert Opin Biol Ther 6(3): 293-300.

    • Gerlach N, Schimmer S, Weiss S, Kalinke U, Dittmer U (2006) Effects of type I interferons on Friend retrovirus infection. J Virol 80(7): 3438-3444.

    • Hinz T, Buchholz CJ, van der Stappen T, Cichutek K, Kalinke U (2006) Manufacturing and quality control of cell-based tumor vaccines: a scientific and a regulatory perspective. J Immunother 29(5): 472-476.

    • Kalinke U, Bach P, Konig M, Buchholz CJ (2006) Vaccination against prion diseases. Discov Med 6(31): 29-34.

    • Kamphuis E, Junt T, Waibler Z, Forster R, Kalinke U (2006) Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10): 3253-3261.

    • Le Bon A, Durand V, Kamphuis E, Thompson C, Bulfone-Paus S, Rossmann C, Kalinke U, Tough DF (2006) Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J Immunol 176(8): 4682-4689.

    • Le Bon A, Thompson C, Kamphuis E, Durand V, Rossmann C, Kalinke U, Tough DF (2006) Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4): 2074-2078.

    • Ludwig H, Suezer Y, Waibler Z, Kalinke U, Schnierle BS, Sutter G (2006) Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara. J Gen Virol 87(Pt 5): 1145-1155.

    • Schneider CK, Kalinke U, Lower J (2006) TGN1412--a regulator's perspective. Nat Biotechnol 24(5): 493-496.

    • Schule S, Steidl S, Panitz S, Coulibaly C, Kalinke U, Cichutek K, Schweizer M (2006) Selective gene transfer to T lymphocytes using coreceptor-specific MLV(HIV) pseudotype vectors in a transgenic mouse model. Virology 351(1): 237-247.

    • Staib C, Suezer Y, Kisling S, Kalinke U, Sutter G (2006) Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara. J Gen Virol 87(Pt 10): 2917-2921.

    2005

    • Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B (2005) Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35): 30797-30806.

    • Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ (2005) Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. J Virol 79(7): 4033-4042.

    • Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Muller M (2005) Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6): 4000-4008.

    2004

    • Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004) A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation. Gene 338(2): 197-207.

    2003

    • Hangartner L, Senn BM, Ledermann B, Kalinke U, Seiler P, Bucher E, Zellweger RM, Fink K, Odermatt B, Burki K, Zinkernagel RM, Hengartner H (2003) Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.. Proc Natl Acad Sci U S A 100(22): 12883-12888.

    • Senn BM, Lopez-Macias C, Kalinke U, Lamarre A, Isibasi A, Zinkernagel RM, Hengartner H (2003) Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.. Eur J Immunol 33(4): 950-961.

    2002

    • Barchet W, Cella M, Odermatt B, Asselin-Paturel C, Colonna M, Kalinke U (2002) Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.. J Exp Med 195(4): 507-516.

    • Scheu S, Alferink J, Potzel T, Barchet W, Kalinke U, Pfeffer K (2002) Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.. J Exp Med 195(12): 1613-1624.

    2001

    • Heppner FL, Arrighi I, Kalinke U, Aguzzi A (2001) Immunity against prions?. Trends Mol Med 7(11): 477-479.

    • Heppner FL, Musahl C, Arrighi I, Klein MA, Rulicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A (2001) Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294(5540): 178-182.

    • Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A (2001) Complement facilitates early prion pathogenesis. Nat Med 7(4): 488-492.

    • Zinkernagel RM, LaMarre A, Ciurea A, Hunziker L, Ochsenbein AF, McCoy KD, Fehr T, Bachmann MF, Kalinke U, Hengartner H (2001) Neutralizing antiviral antibody responses. Adv Immunol n/a(79): 1-53.

    2000

    • Kalinke U, Oxenius A, Lopez-Macias C, Zinkernagel RM, Hengartner H (2000) Virus neutralization by germ-line vs. hypermutated antibodies. Proc Natl Acad Sci U S A 97(18): 10126-10131.

    • Karrer U, Lopez-Macias C, Oxenius A, Odermatt B, Bachmann MF, Kalinke U, Bluethmann H, Hengartner H, Zinkernagel RM (2000) Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice. J Immunol 164(2): 768-778.

    • Seiler P, Senn BM, Klenerman P, Kalinke U, Hengartner H, Zinkernagel RM (2000) Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence. J Virol 74(13): 5896-5901.

    1999

    • Lopez-Macias C, Kalinke U, Cascalho M, Wabl M, Hengartner H, Zinkernagel RM, Lamarre A (1999) Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses. J Exp Med 189(11): 1791-1798.

    • Seiler P, Senn BM, Brundler MA, Zinkernagel RM, Hengartner H, Kalinke U (1999) In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody. J Immunol 162(8): 4536-4541.

    1998

    • Funk GA, Barbour AD, Hengartner H, Kalinke U (1998) Mathematical model of a virus-neutralizing immunglobulin response. J Theor Biol 195(1): 41-52.

    • Seiler P, Kalinke U, Rulicke T, Bucher EM, Bose C, Zinkernagel RM, Hengartner H (1998) Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. J Virol 72(3): 2253-2258.

    1997

    • Bachmann MF, Kalinke U, Althage A, Freer G, Burkhart C, Hoost H, Aguet M, Hengartner H, Zinkernagel RM (1997) The role of antibody concentration and avidity in antiviral protection. Science 276(5321): 2024-2027.

    • Fehr T, Bachmann MF, Bucher E, Kalinke U, Di Padova FE, Lang AB, Hengartner H, Zinkernagel RM (1997) Role of repetitive antigen patterns for induction of antibodies against antibodies. J Exp Med 185(10): 1785-1792.

    • Hammami-Hauasli N, Kalinke DU, Schumann H, Kalinke U, Pontz BF, Anton-Lamprecht I, Pulkkinen L, Zimmermann M, Uitto J, Bruckner-Tuderman L (1997) A combination of a common splice site mutation and a frameshift mutation in the COL7A1 gene: absence of functional collagen VII in keratinocytes and skin. J Invest Dermatol 109(3): 384-389.

    • Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390(6661): 687-690.

    1996

    • Battegay M, Fiedler P, Kalinke U, Brombacher F, Zinkernagel RM, Peter HH, Kohler G, Eibel H (1996) Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mic. Eur J Immuno 26(1): 250-258.

    • Kalinke U, Bucher EM, Ernst B, Oxenius A, Roost HP, Geley S, Kofler R, Zinkernagel RM, Hengartner H (1996) The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis viru. Immunity 5(6): 639-652.

    • Kalinke U, Krebber A, Krebber C, Bucher E, Pluckthun A, Zinkernagel RM, Hengartner H (1996) Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection. Eur J Immuno 26(12): 2801-2806.

    1995

    • Gilfillan S, Bachmann M, Trembleau S, Adorini L, Kalinke U, Zinkernagel R, Benoist C, Mathis D (1995) Efficient immune responses in mice lacking N-region diversity. Eur J Immunol 25(11): 3115-3122.

    • Roost HP, Bachmann MF, Haag A, Kalinke U, Pliska V, Hengartner H, Zinkernagel RM (1995) Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity. Proc Natl Acad Sci 92(5): 1257-1261.

    1994

    • Kalinke DU, Kalinke U, Winberg JO, Konig A, Lauharanta J, Christiano AM, Uitto J, Bruckner-Tuderman L (1994) Collagen VII in severe recessive dystrophic epidermolysis bullosa: expression of mRNA but lack of intact protein product in skin and cutaneous cells in vitro. J Invest Dermatol 102(2): 260-262.

    1991

    • Schonrich G, Kalinke U, Momburg F, Malissen M, Schmitt-Verhulst AM, Malissen B, Hammerling GJ, Arnold B (1991) Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductio. Cell 65(2): 293-304.

    1990

    • Kalinke U, Arnold B, Hammerling GJ (1990) Strong xenogeneic HLA response in transgenic mice after introducing an alpha 3 domain into HLA B27. Nature 348(6302): 642-644.