Publikationen

Publikationen

Eine vollständige Publikationsliste unserer Wissenschaftler

    2017

    • Joean O, Hueber A, Feller F, Jirmo AC, Lochner M, Dittrich AM, Albrecht Melanie (2017) Suppression of Th17-polarized airway inflammation by rapamycin. Sci Rep 7(1): 15336.

    • Selvakumar TA, Bhushal S, Kalinke U, Wirth D, Hauser H, Köster M, Hornef MW (2017) Identification of a Predominantly Interferon-$\uplambda$-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells. Front Immunol 8 1302.

    • Ivin M, Dumigan A, de Vasconcelos FN, Ebner F, Borroni M, Kavirayani A, Przybyszewska KN, Ingram RJ, Lienenklaus S, Kalinke U, Stoiber D, Bengoechea JA, Kovarik P (2017) Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection. PLOS Pathog 13(11): 1-29.

    • Bohm K, Filomena A, Schneiderhan-Marra N, Krause G, Sievers C (2017) Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology. Vaccine 35(43): 5883--5889.

    • Müsken M, Klimmek K, Sauer-Heilborn A, Donnert M, Sedlacek L, Suerbaum S, Häussler S (2017) Towards individualized diagnostics of biofilm-associated infections: a case study. npj Biofilms and Microbiomes 3 22.

    • Ducroux A, Goffinet C (2017) cGAS, an antiviral weapon: role in the recognition of HIV-1 transmitted from cell to cell. Med Sci (Paris) 33(8-9): 732-734.

    • Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meulemann P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T (2017) Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry. Antiviral Res 147 19-28.

    • Speth MT, Repnik U, Müller E, Spanier J, Kalinke U, Corthay A, Griffiths G (2017) Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette–Guérin (BCG) via Synergistic Activation of Innate Immune Receptors. Mol Pharm 14(11): 4098-4112.

    • Sgodda M, Dai Z, Zweigerdt R, Sharma AD, Ott M, Cantz T (2017) A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features. Stem Cells and Development 26(20): 1490-1504.

    • Schniederjans M, Koska M, Häussler S (2017) Transcriptional and mutational profiling of an aminoglycoside resistant Pseudomonas aeruginosa small colony variant. Antimicrobial Agents and Chemotherapy 61(11).

    • Paijo J, Kaever V, Kalinke U (2017) cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry. Methods Mol Biol (1656): 153-166.

    • Seidel K, Balakrishnan A, Alexiou C, Janko C, Komoll RM, Wang LL, Kirschning A, Ott M (2017) Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates—Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. Chemistry 23(50): 12326-12337.

    • van Duuren JBJH, Musken M, Karge B, Tomasch J, Wittmann C, Haussler S, Bronstrup M (2017) Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa. Sci Rep 7(1): 5223.

    • Zischke J, Mamareli P, Pokoyski C, Gabaev I, Buyny S, Jacobs R, Falk CS, Lochner M, Sparwasser T, Schulz TF, Kay-Fedorov PC (2017) The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. PLoS Pathog 13(6): 1-26.

    • Reichert C, Campe A, Walter S, Pfaender S, Welsch K, Ruddat I, Sieme H, Feige K, Steinmann E, Cavalleri JMV (2017) Frequent occurrence of nonprimate hepacivirus infections in Thoroughbred breeding horses - A cross-sectional study for the occurrence of infections and potential risk factors. Vet Microbiol 203 315--322.

    • Bartenschlager R, Cornberg M, Pietschmann T (2017) Maßgeschneiderte Therapie der Virushepatitis der Gegenwart und Zukunft. Der Internist 58(7): 666-674.

    • Weller R, Hueging K, Brown RJP, Todt D, Joecks S, Vondran FWR, Pietschmann T (2017) Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions. J Virol 91(18).

    • Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Casadonte R, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Sunitsch S, Tikhilov R, Morawietz L (2017) 15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics. Pathol Res Pract 213(8): 874-881.

    • Zhao Y, Stepto H, Schneider CK (2017) Development of the First WHO Lentiviral Vector Standard: Towards the Production Control and Standardisation of Lentivirus based Gene Therapy Products. Hum Gene Ther Methods 28(4): 205-214.

    • Hirche C, Frenz T, Haas SF, Doring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U (2017) Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In~Vivo. Cell Rep 19(11): 2345--2356.

    • Lirussi D, Ebensen T, Schulze K, Trittel S, Duran V, Liebich I, Kalinke U, Guzman CA (2017) Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation. EBioMedicine (22): 100-111.

    • Thiemann S, Smit N, Roy U, Lesker TR, Galvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T (2017) Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. Cell Host Microbe 21(6): 682--694.e5.

    • Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P (2017) Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest 127(7): 2789-2804.

    • Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A (2017) Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology 14(1): 34.

    • Akmatov MK, Rober N, Ahrens W, Flesch-Janys D, Fricke J, Greiser H, Gunther K, Kaaks R, Kemmling Y, Krone B, Linseisen J, Meisinger C, Moebus S, Obi N, Guzman CA, Conrad K, Pessler F (2017) Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study. Arthritis Res Ther 19(1): 127.

    • Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A (2017) A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle. Sci Rep 7(1): 2933.

    • González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A (2017) Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. PLoS Pathog 13(5): 1-28.

    • Vasiliauskaite I, Owsianka A, England P, Khan AG, Cole S, Bankwitz D, Foung SKH, Pietschmann T, Marcotrigiano J, Rey FA, Patel AH, Krey T (2017) Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. mBio 8(3).

    • Akmatov MK, Koch N, Vital M, Ahrens W, Flesch-Janys D, Fricke J, Gatzemeier A, Greiser H, Günther K, Illig T, Kaaks R, Krone B, Kühn A, Linseisen J, Meisinger C, Michels K, Moebus S, Nieters A, Obi N, Schultze A, Six-Merker J, Pieper DH, Pessler F (2017) Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study – findings from Pretest 1 of the German National Cohort. Sci Rep 7(1): 1855.

    • Friedrich C, Mamareli P, Thiemann S, Kruse F, Wang Z, Holzmann B, Strowig T, Sparwasser T, Lochner M (2017) MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium. PLOS Pathogens 13(5): 1-26.

    • Popovic B, Golemac M, Podlech J, Zeleznjak J, Bilic-Zulle L, Lukic ML, Cicin-Sain L, Reddehase MJ, Sparwasser T, Krmpotic A, Jonjic S (2017) IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection. PLoS Pathog 13(4): 1-23.

    • van der Vlugt L, Obieglo K, Ozir-Fazalalikhan A, Sparwasser T, Haeberlein S, Smits HH (2017) Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol 47(9): 545-554.

    • Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T (2017) Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity. J Hepatol 67(3): 480-489.

    • Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM, Poeck H (2017) RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci Transl Med 9(386).

    • Ruangkiattikul N, Nerlich A, Abdissa K, Lienenklaus S, Suwandi A, Janze N, Laarmann K, Spanier J, Kalinke U, Weiss S, Goethe R (2017) cGAS-STING-TBK1-IRF3/7 Induced Interferon-β Contributes to the Clearing of Non Tuberculous Mycobacterial Infection in Mice. Virulence 1-13.

    • Akmatov MK, Riese P, May M, Jentsch L, Ahmed MW, Werner D, Rösel A, Tyler M, Pessler K, Prokein J, Bernemann I, Klopp N, Prochnow B, Trittel S, Tallam A, Illig T, Schindler C, Guzmán CA, Pessler F (2017) Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population. Hum Vaccin Immunother 0 1-10.

    • Preusse M, Schughart K, Pessler F (2017) Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection. Front Immunol 8 246.

    • Kommerein N, Stumpp SN, Müsken M, Ehlert N, Winkel A, Häussler S, Behrens P, Buettner FFR, Stiesch M (2017) An oral multispecies biofilm model for high content screening applications. PLoS One 12(3): 1-21.

    • Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S (2017) Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. mBio 8(1).

    • Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJP, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JMV, Steinmann E (2017) Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A 114(12): E2430-E2439.

    • Hoffmann M, Crone L, Dietzel E, Paijo J, Gonzalez-Hernandez M, Nehlmeier I, Kalinke U, Becker S, Pohlmann S (2017) A polymorphism within the internal fusion loop of the Ebola virus glycoprotein modulates host cell entry. J Virol 91(9).

    • Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJP, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JMV, Steinmann E (2017) Immune protection against reinfection with nonprimate hepacivirus. Proceedings of the National Academy of Sciences 114(12): E2430-E2439.

    • Karabaev BB, Beisheeva NJ, Satybaldieva AB, Ismailova AD, Pessler F, Akmatov MK (2017) Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015). Infect Dis Poverty 6(1): 45.

    • Akmatov MK, Jentsch L, Riese P, May M, Ahmed MW, Werner D, Rosel A, Prokein J, Bernemann I, Klopp N, Prochnow B, Illig T, Schindler C, Guzman CA, Pessler F (2017) Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination. BMC Med Res Methodol 17(1): 18.

    • Wang LL, Balakrishnan A, Bigall NC, Candito D, Miethe JF, Seidel K, Xie Y, Ott M, Kirschning A (2017) A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. Chemistry 23(10): 2265-2270.

    • Kirchhoff L, Olsowski M, Zilmans K, Dittmer S, Haase G, Sedlacek L, Steinmann E, Buer J, Rath PM, Steinmann J (2017) Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents. Sci Rep 7 42886.

    • Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, Yang J, Engelmann M, Todt D, Windisch MP, Brill FH, Steinmann J, Steinmann J, Becker S, Alves MP, Pietschmann T, Eickmann M, Thiel V, Steinmann E (2017) Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses. J Infect Dis 215(6): 902-906.

    • Becker B, Bischoff B, Brill FHH, Steinmann E, Steinmann J (2017) Virucidal efficacy of a sonicated hydrogen peroxide system (trophon® EPR) following European and German test methods. GMS Hyg Infect Control 12 Doc02.

    • Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V’kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJM, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V (2017) Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathog 13(2): 1-26.

    • Todt D, Schlevogt B, Deterding K, Grundhoff A, Manns MP, Wedemeyer H, Fischer N, Cornberg M, Steinmann E (2017) Successful retreatment of a patient with chronic hepatitis C genotype 2k/1b virus with ombitasvir/paritaprevir/ritonavir plus dasabuvir. J Antimicrob Chemother 72(5): 1541-1543.

    • Gerold G, Bruening J, Weigel B, Pietschmann T (2017) Protein interactions during the flavivirus and hepacivirus life cycle. Mol Cell Proteomics 16(4 suppl 1): S75-S91.

    • Ziegler A, Soldner C, Lienenklaus S, Spanier J, Trittel S, Riese P, Kramps T, Weiss S, Heidenreich R, Jasny E, Guzman CA, Kallen KJ, Fotin-Mleczek M, Kalinke U (2017) A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects. J Immunol 198(4): 1595-1605.

    • Khera T, Todt D, Vercauteren K, McClure CP, Verhoye L, Farhoudi A, Bhuju S, Geffers R, Baumert TF, Steinmann E, Meuleman P, Pietschmann T, Brown RJP (2017) Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy. Antiviral Research 139 129 - 137.

    • Hinz T, Kallen K, Britten CM, Flamion B, Granzer U, Hoos A, Huber C, Khleif S, Kreiter S, Rammensee HG, Sahin U, Singh-Jasuja H, Tureci O, Kalinke U (2017) The European Regulatory Environment of RNA-Based Vaccines. Methods Mol Biol 1499 203--222.

    • Minarrieta L, Ghorbani P, Sparwasser T, Berod L (2017) Metabolites: deciphering the molecular language between DCs and their environment. Semin Immunopathol 39(2): 177-198.

    • Behrendt P, Lüth S, Dammermann W, Drave S, Brown RJP, Todt D, Schnoor U, Steinmann E, Wedemeyer H, Pischke S, Iking-Konert C (2017) Exacerbation of hepatitis E virus infection during anti-TNFα treatment. Joint Bone Spine 84(2): 217-219.

    • Pfaender S, Vielle NJ, Ebert N, Steinmann E, Alves MP, Thiel V (2017) Inactivation of Zika virus in human breast milk by prolonged storage or pasteurization. Virus Res 228 58 - 60.

    • Pietschmann T (2017) Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases. J Virol 91(2).

    • Walter S, Rasche A, Moreira-Soto A, Pfaender S, Bletsa M, Corman VM, Aguilar-Setien A, García-Lacy F, Hans A, Todt D, Schuler G, Shnaiderman-Torban A, Steinman A, Roncoroni C, Veneziano V, Rusenova N, Sandev N, Rusenov A, Zapryanova D, García-Bocanegra I, Jores J, Carluccio A, Veronesi MC, Cavalleri JMV, Drosten C, Lemey P, Steinmann E, Drexler JF (2017) Differential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeys. J Virol 91(1).

    in press

    • Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kühnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann B, Schambach A, Roesler J, Lachmann N (in press) Impaired IFNy-signaling and mycobacterial clearance in IFNyR1 deficient human iPSC-derived Macrophages. Stem cell Rep n/a(n/a): n/a.

    • Singpiel A, Kramer J, Maus R, Stolper J, Bittersohl LF, Gauldie J, Kolb M, Welte T, Sparwasser T, Maus UA (in press) Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells. Immunobiology n/a(n/a): n/a.

    • Junge N, Sharma AD, Ott M (in press) About cytokeratin 19 and the drivers of liver regeneration. J Hepatol n/a(n/a): n/a.

    • Semitekolou M, Morianos I, Banos A, Konstantopoulos D, Adamou-Tzani M, Sparwasser T, Xanthou G (in press) Dendritic cells conditioned by activin-A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma. J Allergy Clin Immunol n/a(n/a): n/a.

    2016

    • Abou-El-Enein M, Schneider CK (2016) Deciphering the EU clinical trials regulation. Nat Biotechnol 34(3): 231-233.

    • Akmatov MK, Stumme M, Pessler F (2016) Real-life practice of methotrexate toxicity monitoring in juvenile idiopathic arthritis in Germany, Switzerland and Austria: results of a cross-sectional assessment conducted in 2012. Clin Exp Rheumatol 34(3): 548-553.

    • Almeida L, Lochner M, Berod L, Sparwasser T (2016) Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol 28(5): 514 - 524.

    • Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S (2016) Growing tumors induce a local STING dependent type I IFN response in dendritic cells. International Journal of Cancer 139(6): 1350-1357.

    • Anggakusuma, Brown RJ, Banda D, Todt D, Vieyres G, Steinmann E, Pietschmann T (2016) Hepaciviral NS3/4A proteases interfere with MAVS signalling of their cognate animal hosts and also with human MAVS: implications for zoonotic transmission. J Virol 90(23): 10670-10681.

    • Bankwitz D, Pietschmann T (2016) Hepatitis C virus plays hide and seek with neutralizing antibodies. Hepatology 64(6): 1840-1842.

    • Behrendt P, Bremer B, Todt D, Brown RJP, Heim A, Manns MP, Steinmann E, Wedemeyer H (2016) Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection. J Infect Dis 214(3): 361-368.

    • Berod L, Sparwasser T (2016) pDCs Take a Deep Breath to Fight Viruses. Immunity 44(6): 1246-1248.

    • Binder SC, Eckweiler D, Schulz S, Bielecka A, Nicolai T, Franke R, Haussler S, Meyer-Hermann M (2016) Functional modules of sigma factor regulons guarantee adaptability and evolvability. Sci Rep 6 22212.

    • Blank T, Detje CN, Spiess A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zoller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Muller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M (2016) Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity 44(4): 901-912.

    • Buettner M, Lochner M (2016) Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon. Front Immunol 7 342.

    • Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, Dambock U, Kroger A, Weiss S, Knapp S, Jamieson AM, Kirschning C, Kalinke U, Strobl B, Muller M, Stoiber D, Lienenklaus S, Kovarik P (2016) Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19(3): 375-387.

    • De Beuckelaer A, Pollard C, van Lint S, Roose K, van Hoecke L, Naessens T, Udhayakumar VK, Smet M, Sanders N, Lienenklaus S, Saelens X, Weiss S, Vanham G, Grooten J, De Koker S (2016) Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses. Mol Ther 24(11): 2012--2020.

    • Drave SA, Debing Y, Walter S, Todt D, Engelmann M, Friesland M, Wedemeyer H, Neyts J, Behrendt P, Steinmann E (2016) Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. Journal of Viral Hepatitis 23(7): 512-521.

    • Dudek M, Puttur F, Arnold-Schrauf C, Kuhl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T (2016) Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol 9(5): 1288-1302.

    • Elsaman AM, Muhammad EM, Pessler F (2016) Sonographic Findings in Gouty Arthritis: Diagnostic Value and Association with Disease Duration. Ultrasound Med Biol 42(6): 1330-1336.

    • Freitag J, Berod L, Kamradt T, Sparwasser T (2016) Immunometabolism and autoimmunity. Immunol Cell Biol 94(10): 925-934.

    • Frenz T, Grabski E, Buschjäger D, Vaas LAI, Burgdorf N, Schmidt RE, Witte T, Kalinke U (2016) CD4+ T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol 138(2): 586-589 e10.

    • Gather T, Walter S, Pfaender S, Todt D, Feige K, Steinmann E, Cavalleri JM (2016) Acute and chronic infections with nonprimate hepacivirus in young horses. Vet Res 47(1): 97.

    • Gather T, Walter S, Todt D, Pfaender S, Brown RJ, Postel A, Becher P, Moritz A, Hansmann F, Baumgaertner W, Feige K, Steinmann E, Cavalleri JV (2016) Vertical transmission of hepatitis C virus-like nonprimate hepacivirus in horses. J Gen Virol 97(10): 2540-2551.

    • Gerold G, Bruening J, Pietschmann T (2016) Decoding protein networks during virus entry by quantitative proteomics. Virus Res 218 25-39.

    • Ghanbari A, Dehghany J, Schwebs T, Musken M, Haussler S, Meyer-Hermann M (2016) Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms. Sci Rep 6.

    • Goffinet C (2016) Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. Curr HIV Res 14(3): 211-216.

    • Grine L, Steeland S, Van Ryckeghem S, Ballegeer M, Lienenklaus S, Weiss S, Sanders NN, Vandenbroucke RE, Libert C (2016) Topical imiquimod yields systemic effects due to unintended oral uptake. Sci Rep 6 20134.

    • Heidrich B, Steinmann E, Plumeier I, Kirschner J, Sollik L, Ziegert S, Engelmann M, Lehmann P, Manns MP, Pieper DH, Wedemeyer H (2016) Frequent detection of HCV RNA and HCVcoreAg in stool of patients with chronic hepatitis C. J Clin Virol 80 1 - 7.

    • Hendel N, Akmatov MK, Hamel J, Vogelberg C, Pessler F (2016) Exhaled breath analysis in childhood rheumatic disorders-a longitudinal study. J Breath Res 10(2): 021001.

    • Ionidis G, Hübscher J, Jack T, Becker B, Bischoff B, Todt D, Hodasa V, Brill FHH, Steinmann E, Steinmann J (2016) Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid. BMC Infect Dis 16(1).

    • Khaledi A, Schniederjans M, Pohl S, Rainer R, Bodenhofer U, Xia B, Klawonn F, Bruchmann S, Preusse M, Eckweiler D, Dötsch A, Häussler S (2016) Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa. Antimicrob Agents and Chemother 66(8): 4722-4733.

    • Klotz U, Schmidt D, Willinger B, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria. Mycoses 59(5): 312-318.

    • Knuschke T, Rotan O, Bayer W, Sokolova V, Hansen W, Sparwasser T, Dittmer U, Epple M, Buer J, Westendorf AM (2016) Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology 13(1).

    • Kochs G, Anzaghe M, Kronhart S, Wagner V, Gogesch P, Scheu S, Lienenklaus S, Waibler Z (2016) In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection. J Virol 90(20): 9330-9337.

    • Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S (2016) Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa. Environ Microbiol 18(10): 3583-3592.

    • Krull M, Klare I, Ross B, Trenschel R, Beelen DW, Todt D, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation. Antimicrob Resist Infect Control 5 31.

    • Lambricht L, Vanvarenberg K, De Beuckelaer A, Van Hoecke L, Grooten J, Ucakar B, Lipnik P, Sanders NN, Lienenklaus S, Preat V, Vandermeulen G (2016) Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines. Mol Ther 24(9): 1686-1696.

    • Lorenz A, Pawar V, Häussler S, Weiss S (2016) Insights into host–pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections. FEBS Letters 590(21): 3941-3959.

    • Luckoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T (2016) Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med 8(6): 670-678.

    • Maier BB, Hladik A, Lakovits K, Korosec A, Martins R, Kral JB, Mesteri I, Strobl B, Müller M, Kalinke U, Merad M, Knapp S (2016) Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. Eur J Immunol 46(9): 2175-2186.

    • Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Kohrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K (2016) Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8(362): 362ra146.

    • Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med 8(362): 362ra143.

    • Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer ACD, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG (2016) pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation. Proceedings of the National Academy of Sciences 113(29): 8098-8103.

    • Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U (2016) cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog 12(4): e1005546.

    • Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LAM, Schetters STT, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JMM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WWJ (2016) Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proc Natl Acad Sci U S A 113(12): 3329-3334.

    • Perin PM, Haid S, Brown RJP, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FWR, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology 63(1): 49--62.

    • Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Gunther C, Muller W, Knobeloch KP, Prinz M, Roers A, Behrendt R (2016) Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity. J Immunol 197(6): 2157-2166.

    • Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T (2016) Hepatitis C Virus Stimulates Murine CD8alpha-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog 12(7): e1005736.

    • Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T (2016) Hepatitis C Virus Stimulates Murine CD8alpha-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog 12(7): e1005736.

    • Pfaender S, von Hahn T, Steinmann J, Ciesek S, Steinmann E (2016) Prevention strategies for blood-borne viruses—in the Era of vaccines, direct acting antivirals and antiretroviral therapy. Rev Med Virol 26(5): 330-339.

    • Postel A, Cavalleri JM, Pfaender S, Walter S, Steinmann E, Fischer N, Feige K, Haas L, Becher P (2016) Frequent presence of hepaci and pegiviruses in commercial equine serum pools. Vet Microbiol 182 8 - 14.

    • Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl A A, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T (2016) Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via \TLR9\ and MyD88 Signaling. Cell Reports 17(4): 1113 - 1127.

    • Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl A A, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T (2016) Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep 17(4): 1113 - 1127.

    • Raha S, Raud B, Oberdörfer L, Castro CN, Schreder A, Freitag J, Longerich T, Lochner M, Sparwasser T, Berod L, Koenecke C, Prinz I (2016) Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Eur J Immunol 46(9): 2233-2238.

    • Samir M, Pessler F (2016) Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications. Front. Vet. Sci. 3 22.

    • Samir M, Vaas LAI, Pessler F (2016) MicroRNAs in the Host Response to Viral Infections of Veterinary Importance. Front Vet Sci 3 86.

    • Schlett CL, Hendel T, Hirsch J, Weckbach S, Caspers S, Schulz-Menger J, Ittermann T, von Knobelsdorff-Brenkenhoff F, Ladd SC, Moebus S, Stroszczynski C, Fischer B, Leitzmann M, Kuhl C, Pessler F, Hartung D, Kemmling Y, Hetterich H, Amunts K, Günther M, Wacker F, Rummeny E, Kauczor HU, Forsting M, Völzke H, Hosten N, Reiser MF, Bamberg F (2016) Quantitative, Organ-Specific Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a Multicenter, Multivendor Study. Invest Radiol 51(4): 255-265.

    • Schweitzer A, Pessler F, Akmatov MK (2016) Impact of rotavirus vaccination on coverage and timing of pentavalent vaccination – Experience from 2 Latin American countries. Human Vaccines & Immunotherapeutics 0 1-7.

    • Siddharta A, Pfaender S, Malassa A, Doerrbecker J, Anggakusuma, Engelmann M, Nugraha B, Steinmann J, Todt D, Vondran FW, Mateu-Gelabert P, Goffinet C, Steinmann E (2016) Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. Sci Rep 6 36619.

    • Smith KA, Filbey KJ, Reynolds LA, Hewitson JP, Harcus Y, Boon L, Sparwasser T, Hammerling G, Maizels RM (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol 9(2): 428-443.

    • Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer B M, Araúzo-Bravo M J, Steinemann D, Luedde T, Schwabe R F, Manns M P, Schöler H R, Schambach A, Cantz T, Ott M, Sharma A D (2016) Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell 18(6): 797-808.

    • Stohr S, Costa R, Sandmann L, Westhaus S, Pfaender S, Anggakusuma, Dazert E, Meuleman P, Vondran FW, Manns MP, Steinmann E, von Hahn T, Ciesek S (2016) Host cell mTORC1 is required for HCV RNA replication. Gut 65(12): 2017-2028.

    • Tata M, Wolfinger MT, Amman F, Roschanski N, Dötsch A, Sonnleitner E, Häussler S, Bläsi U (2016) RNASeq Based Transcriptional Profiling of Pseudomonas aeruginosa PA14 after Short- and Long-Term Anoxic Cultivation in Synthetic Cystic Fibrosis Sputum Medium. PLoS One 11(1): e0147811.

    • Todt D, Gisa A, Radonic A, Nitsche A, Behrendt P, Suneetha PV, Pischke S, Bremer B, Brown RJP, Manns MP, Cornberg M, Bock CT, Steinmann E, Wedemeyer H (2016) In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 65(10): 1733-1743.

    • Todt D, Walter S, Brown RJP, Steinmann E (2016) Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations. Viruses 8(10): 283.

    • Todt D., Francois C., Kusuma A, Behrendt P, Engelmann M, Knegendorf L, Vieyres G, Wedemeyer H, Hartmann R, Pietschmann T, Duverlie G, Steinmann E (2016) Antiviral activity of different interferon (sub-) types against hepatitis E virus replication. Antimicrobial Agents and Chemotherapy 60(4): 2132-2139.

    • Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P (2016) Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Gut 65(12): 2029-2034.

    • Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FWR, Kaderali L, Pietschmann T (2016) ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production. PLoS Pathog 12(4): e1005568.

    • Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E (2016) Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7. J Virol 90(10): 5075-5089.

    • Weissmuller S, Kronhart S, Kreuz D, Schnierle B, Kalinke U, Kirberg J, Hanschmann KM, Waibler Z (2016) TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model. PLoS One 11(3): e0149093.

    • Weller R, Todt D, Engelmann M, Friesland M, Wedemeyer H, Pietschmann T, Steinmann E (2016) Apolipoprotein E polymorphisms and their protective effect on Hepatitis E virus replication. Hepatology 64(6): 2274-2276.

    • Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T (2016) In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. Eur J Immunol 46(5): 1193-1202.

    • Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C (2016) cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Cell Host & Microbe 20(4): 443-457.

    • Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C (2016) cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Cell Host & Microbe 20(4): 443 - 457.

    • Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M (2016) Foxp3 T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol 9(2): 444-457.

    • Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD (2016) MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun 7 11916.

    • de Araujo LS, Vaas LA, Ribeiro-Alves M, Geffers R, Mello FC, de Almeida AS, Moreira AD, Kritski AL, Lapa E.SilvaJR, Moraes MO, Pessler F, Saad MH (2016) Transcriptomic Biomarkers for Tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA Expression in Peripheral Blood. Front Microbiol 7 1586.

    • von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A (2016) Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. MBio 7(6).

    2015

    • Abd-Elshafy DN, Muller-Ladner U, Neumann E, Anggakusuma., Bahgat MM, Pessler F, Behrendt P (2015) Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 5 18043.

    • Abd-Elshafy DN, Muller-Ladner U, Neumann E, Anggakusuma., Bahgat MM, Pessler F, Behrendt P (2015) Erratum: Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 6 21441.

    • Abd-Elshafy DN, Pietschmann T, Muller-Ladner U, Neumann E, Anggakusuma, M BahgatM, Pessler F, Behrendt P (2015) Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 5 18043.

    • Akeus P, Langenes V, Kristensen J, von Mentzer A, Sparwasser T, Raghavan S, Quiding-Jarbrink M (2015) Treg-cell depletion promotes chemokine production and accumulation of CXCR3 conventional T cells in intestinal tumors. Eur J Immunol 45(6): 1654-1666.

    • Akmatov MK, Kimani-Murage E, Pessler F, Guzman CA, Krause G, Kreienbrock L, Mikolajczyk RT (2015) Evaluation of invalid vaccine doses in 31 countries of the WHO African Region. Vaccine 33(7): 892-901.

    • Akmatov MK, Rubsamen N, Schultze A, Kemmling Y, Obi N, Gunther K, Ahrens W, Pessler F, Krause G, Mikolajczyk RT (2015) Diverse recruitment strategies result in different participation percentages in a web-based study, but in similar compliance. Int J Public Health 60(8): 937-943.

    • Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grun JR, Grutzkau A, Verginis P (2015) De Novo-Induced Self-Antigen-Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes. J Immunol 194(12): 5812-5824.

    • Anggakusuma, Frentzen A, Gurlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Hornung V, Kuehnel F, Pietschmann T (2015) Control of HCV replication in mouse liver derived cells by MAVS-dependent production of type-I and -III interferons. J Virol 89(7): 3833-3845.

    • Anggakusuma, Frentzen A, Gurlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Hornung V, Kuehnel F, Pietschmann T (2015) Control of HCV replication in mouse liver derived cells by MAVS-dependent production of type-I and -III interferons. J Virol 98(7): 3833-3845.

    • Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl AA, Siegmund B, Lochner M, Schmitz I (2015) IkappaBNS Regulates Murine Th17 Differentiation during Gut Inflammation and Infection. J Immunol 194(6): 2888-2898.

    • Arnold-Schrauf C, Berod L, Sparwasser T (2015) Dendritic cell-specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 45(1): 32-39.

    • Bielecki P, Jensen V, Schulze W, Godeke J, Strehmel J, Eckweiler D, Nicolai T, Bielecka A, Wille T, Gerlach RG, Haussler S (2015) Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa. Nucleic Acids Res 43(13): 6413-6425.

    • Blanka A, Duvel J, Dotsch A, Klinkert B, Abraham WR, Kaever V, Ritter C, Narberhaus F, Haussler S (2015) Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition. Sci Signal 8(372): ra36.

    • Bolton HA, Zhu E, Terry AM, Guy TV, Koh WP, Tan SY, Power CA, Bertolino P, Lahl K, Sparwasser T, Shklovskaya E, de St. Groth BF (2015) Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 125(9): 3627-3641.

    • Brinkmann MM, Dag F, Hengel H, Messerle M, Kalinke U, Cicin-Sain L (2015) Cytomegalovirus immune evasion of myeloid lineage cells. Med Microbiol Immunol 204(3): 367-382.

    • Bruchmann S, Muthukumarasamy U, Pohl S, Preusse M, Bielecka A, Nicolai T, Hamann I, Hillert R, Kola A, Gastmeier P, Eckweiler D, Haussler S (2015) Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain- and sequence type-specific adaptation. Environ Microbiol 17(11): 4690-4710.

    • Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U (2015) Stromal cells as trend-setters for cells migrating into the lymph node. Mucosal Immunol 8(3): 640-649.

    • Casilag F, Lorenz A, Krüger J, Klawonn F, Weiss S, Häussler S (2015) The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition. Infect Immun 84(1): 162-171.

    • Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T (2015) Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 68(2 Pt C): 575-584.

    • Crouse J, Kalinke U, Oxenius A (2015) Regulation of antiviral T cell responses by type I interferons. Nat Rev Immunol 15(4): 231-242.

    • Detje CN, Lienenklaus S, Chhatbar C, Spanier J, Prajeeth CK, Soldner C, Tovey MG, Schluter D, Weiss S, Stangel M, Kalinke U (2015) Upon intranasal VSV infection astrocytes in the olfactory bulb are important IFN-beta producers that protect from lethal encephalitis. J Virol 89(5): 2731-2738.

    • Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M (2015) Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J 34(10): 1336-1348.

    • Dotsch A, Schniederjans M, Khaledi A, Hornischer K, Schulz S, Bielecka A, Eckweiler D, Pohl S, Haussler S (2015) The Pseudomonas aeruginosa Transcriptional Landscape Is Shaped by Environmental Heterogeneity and Genetic Variation. MBio 6(4): e00749.

    • Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch Lothar, Herberg FriedrichW., Frank Ronald, Häussler Susanne (2015) Application of synthetic peptide arrays to uncover c-di-GMP binding motifs. Journal of Bacteriology 198(1): 138-146.

    • Fischbach H, Doring M, Nikles D, Lehnert E, Baldauf C, Kalinke U, Tampe R (2015) Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets. Nat Commun 6 6199.

    • Frenz T, Grabski E, Duran V, Hozsa C, Stepczynska A, Furch M, Gieseler RK, Kalinke U (2015) Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers. Eur J Pharm Biopharm 97(Pt A): 13-17.

    • Garcia-Risco MR, Vazquez E, Sheldon J, Steinmann E, Riebesehl N, Fornari T, Reglero G (2015) Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of the extracts. Virus Res 198 9-14.

    • Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T (2015) Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Cell Rep 12(5): 864-878.

    • Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells. J Virol 89(6): 3200-3208.

    • Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells. J Virol 89(6): 3200-3208.

    • Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T (2015) Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor by using a novel lentiviral pseudotype (hRSVpp) system. J Virol 90(6): 3065-3073.

    • Hedenstierna M, Weiland O, Brass A, Bankwitz D, Behrendt P, Uhnoo I, Aleman S, Cardell K, Fryden A, Norkrans G, Eilard A, Glaumann H, Pietschmann T, Sallberg M, Brenndorfer ED (2015) Long-term follow-up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure. Aliment Pharmacol Ther 41(6): 532-543.

    • Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wolk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T (2015) Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. PLoS One 10(7): e0134529.

    • Junge N, Mingozzi F, Ott M, Baumann U (2015) Adeno-associated Virus Vector Based Gene Therapy for Monogenetic Metabolic Diseases of the Liver. J Pediatr Gastroenterol Nutr 60(4): 433-440.

    • Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG (2015) Ligation of TLR7 on CD19 CD1d B cells suppresses allergic lung inflammation via regulatory T cells. Eur J Immunol 45(6): 1842-1854.

    • Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG (2015) PD-L1(hi) B cells are critical regulators of humoral immunity. Nat Commun 6 5997.

    • Koutsoudakis G, Romero-Brey I, Berger C, Perez-Vilaro G, Perin PM, Vondran FW, Kalesse M, Harmrolfs K, Muller R, Martinez JP, Pietschmann T, Bartenschlager R, Bronstrup M, Meyerhans A, Diez J (2015) Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. J Hepatol 63(4): 813-821.

    • Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Hepatology 62(3): 702-714.

    • Lassak J, Keilhauer E, Furst M, Wuichet K, Godeke J, Starosta AL, Chen JM, Sogaard-Andersen L, Rohr J, Wilson DN, Haussler S, Mann M, Jung K (2015) Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nat Chem Biol 11(4): 266-270.

    • Lauber C, Vieyres G, Terczynska-Dyla E, Anggakusuma, Dijkman R, Gad HH, Akhtar H, Geffers R, Vondran FW, Thiel V, Kaderali L, Pietschmann T, Hartmann R (2015) Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells. Genes Immun 16(6): 414-421.

    • Legoux FP, Lim JB, Cauley A W, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way S S, Moon JJ (2015) CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity 43(5): 896 - 908.

    • Lochner M, Berod L, Sparwasser T (2015) Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36(2): 81-91.

    • Lochner M, Wang Z, Sparwasser T (2015) Chapter Five - The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells. 136 99 - 129.

    • Luciani F, Galluzzo S, Gaggioli A, Kruse NA, Venneugues P, Schneider CK, Pini C, Melchiorri D (2015) Implementing quality by design for biotech products: are regulators on track?. MAbs 7(3): 451-455.

    • Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Sturzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klarner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Munch J (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife 4.

    • Mahapatra S, Albrecht M, Baru AM, Sparwasser T, Herrick C, Dittrich AM (2015) Superior Suppressive Capacity of Skin Tregs Compared to Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol 135(10): 2418-2426.

    • Malczyk AH, Kupke A, Prufer S, Scheuplein VA, Hutzler S, Kreuz D, Beissert T, Bauer S, Hubich-Rau S, Tondera C, Shams Eldin H, Schmidt J, Vergara-Alert J, Suzer Y, Seifried J, Hanschmann KM, Kalinke U, Herold S, Sahin U, Cichutek K, Waibler Z, Eickmann M, Becker S, Muhlebach MD (2015) A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform. J Virol 89(22): 11654-11667.

    • Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD (2015) MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells. J Hepatol 62(1): 101-110.

    • Molina MA, Diaz AM, Hesse C, Ginter W, Gentilini MV, Nunez GG, Canellada AM, Sparwasser T, Berod L, Castro MS, Manghi MA (2015) Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production. PLoS One 10(5): e0127262.

    • Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R (2015) Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol 195(4): 1753-1762.

    • Oumeraci T, Jensen V, Talbot SR, Hofmann W, Kostrzewa M, Schlegelberger B, von Neuhoff N, Haussler S (2015) Comprehensive MALDI-TOF Biotyping of the Non-Redundant Harvard Pseudomonas aeruginosa PA14 Transposon Insertion Mutant Library. PLoS One 10(2): e0117144.

    • Pawar V, Komor U, Kasnitz N, Bielecki P, Pils MC, Gocht B, Moter A, Rohde M, Weiss S, Haussler S (2015) In vivo efficacy of antimicrobials against biofilm producing Pseudomonas aeruginosa. Antimicrob Agents Chemother 59(8): 4974-4981.

    • Pfaender S, Brinkmann J, Todt D, Riebesehl N, Steinmann J, Steinmann J, Pietschmann T, Steinmann E (2015) Mechanisms of viral inactivation methods against hepatitis C virus. Appl Environ Microbiol 81(5): 1616-1621.

    • Pfaender S, Cavalleri JM, Walter S, Doerrbecker J, Campana B, Brown RJ, Burbelo PD, Postel A, Hahn K, Kusuma A, Riebesehl N, Baumgartner W, Becher P, Heim MH, Pietschmann T, Feige K, Steinmann E (2015) Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses. Hepatology 61(2): 448-459.

    • Pfaender S, Walter S, Todt D, Behrendt P, Doerrbecker J, Woelk B, Engelmann M, Gravemann U, Seltsam A, Steinmann J, Burbelo PD, Klawonn F, Feige K, Pietschmann T, Cavalleri JM, Steinmann E (2015) Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure. J Gen Virol 96(9): 2636-2642.

    • Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P (2015) Abortively infected astrocytes appear to represent the main source of interferon-β in the virus-infected brain. J Virol 90(4): 2031-2038.

    • Preusse M, Schughart K, Wilk E, Klawonn F, Pessler F (2015) Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains. BMC Res Notes 8 225.

    • Pustelny C, Komor U, Pawar V, Lorenz A, Bielecka A, Moter A, Gocht B, Eckweiler D, Grothe C, Lunsdorf H, Weiss S, Haussler S (2015) Contribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system. Infect Immun 83(1): 417-429.

    • Rabenau HF, Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 493-504.

    • Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2015) Reply: PCR assay for pathogen detection in ventriculostomy-related meningitis in neurosurgery patients: unanswered questions?. Infection 43(2): 251-252.

    • Salmikangas P, Menezes-Ferreira M, Reischl I, Tsiftsoglou A, Kyselovic J, Borg JJ, Ruiz S, Flory E, Trouvin J, Celis P, Ancans J, Timon M, Pante G, Sladowski D, Lipnik-Stangelj M, Schneider CK (2015) Manufacturing, characterization and control of cell-based medicinal products: challenging paradigms toward commercial use. Regen Med 10(1): 65-78.

    • Schneider CK, Weise M (2015) Regulatorische Aspekte zu Biosimilars: Mythen und Fakten. Z Rheumatol 74(8): 695-700.

    • Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C (2015) CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35(1): 6-10.

    • Schulz S, Eckweiler D, Bielecka A, Nicolai T, Franke R, Dotsch A, Hornischer K, Bruchmann S, Duvel J, Haussler S (2015) Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk. PLoS Pathog 11(3): e1004744.

    • Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, von Rheinbaben F, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P, Rabenau HF (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 491-491.

    • Schweitzer A, Akmatov MK, Kindler F, Kemmling Y, Kreienbrock L, Krause G, Pessler F (2015) The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort. BMJ Open 5(8): e007461.

    • Schweitzer A, Della Beffa C, Akmatov MK, Narchi H, Abaev YK, Sherry DD, Pessler F (2015) Primary Osteomyelitis of the Sternum in the Pediatric Age Group: Report of a New Case and Comprehensive Analysis of Seventy-four Cases. Pediatr Infect Dis J 34(4): e92-e101.

    • Schweitzer A, Krause G, Pessler F, Akmatov MK (2015) Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan. BMC Public Health 155(1): 798.

    • Skripuletz T, Salinas Tejedor L, Prajeeth CK, Hansmann F, Chhatbar C, Kucman V, Zhang N, Raddatz BB, Detje CN, Suhs KW, Pul R, Gudi V, Kalinke U, Baumgartner W, Stangel M (2015) The antiviral drug ganciclovir does not inhibit microglial proliferation and activation. Sci Rep 5 14935.

    • Steinmann J, Becker B, Bischoff B, Steinmann E (2015) Alcohol hand rub or soap and water for removal of norovirus from hands – the debate continues. Journal of Hospital Infection 91(4): 371 - 372.

    • Tarr AW, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, Brown RJ (2015) Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design. Viruses 7(7): 3995-4046.

    • Tebartz C, Horst SA, Sparwasser T, Huehn J, Beineke A, Peters G, Medina E (2015) A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection. J Immunol 194(3): 1100-1111.

    • Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Forster R, Pabst O, Hornef MW (2015) Active suppression of intestinal CD4TCRalphabeta T-lymphocyte maturation during the postnatal period. Nat Commun 6 7725.

    • Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y (2015) Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression. Oncoimmunology 4(8): e970462.

    • Vercammen K, Wei Q, Charlier D, Dotsch A, Haussler S, Schulz S, Salvi F, Gadda G, Spain J, Levin Rybtke M, Tolker-Nielsen T, Dingemans J, Ye L, Cornelis P (2015) Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene encoding a nitronate monooxygenase. J Bacteriol 197(6): 1026-1039.

    • Vogel S, Grabski E, Buschjager D, Klawonn F, Doring M, Wang J, Fletcher E, Bechmann I, Witte T, Durisin M, Schraven B, Mangsbo SM, Schonfeld K, Czeloth N, Kalinke U (2015) Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells. Sci Rep 5 18308.

    • Waffarn EE, Hastey CJ, Dixit N, Choi YS, Cherry S, Kalinke U, Simon SI, Baumgarth N (2015) Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation. Nature Communications 6 8991.

    • Walker A, Skibbe K, Steinmann E, Pfaender S, Kuntzen T, Megger D.A., Groten S, Sitek B, Lauer G.M., Kim A.Y., Pietschmann T, Allen T.M., Timm J. (2015) Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing. J Virol doi: 10.1128/JVI.01993-15.

    • Wang H, El Maadidi S, Fischer J, Grabski E, Dickhofer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Loffler MW, Wiese M, Pichulik T, Mullhaupt B, Semela D, Dufour JF, East German, Swiss Hepatitis C.VirusStudyGroups, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN (2015) A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance. Hepatol 62(5): 1375-1387.

    • Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J (2015) Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43(3): 1537-1548.

    • Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata KI (2015) Foxp3+ Regulatory T Cells Play a Protective Role in Angiotensin II-Induced Aortic Aneurysm Formation in Mice. Hypertension 65(4): 889-895.

    2014

    • Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider CK (2014) A roadmap toward clinical translation of genetically-modified stem cells for treatment of HIV. Trends Mol Med d20(11): 632-642.

    • Akmatov MK, Mehraj J, Gatzemeier A, Strompl J, Witte W, Krause G, Pessler F (2014) Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany. Int J Infect Dis 25 4-10.

    • Anggakusuma A, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63(7): 1137-1149.

    • Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63(7): 1137-1149.

    • Arnold P, Himmels P, Weiss S, Decker TM, Markl J, Gatterdam V, Tampe R, Bartholomaeus P, Dietrich U, Durr R (2014) Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. Retrovirology 11 42.

    • Arnold-Schrauf C, Dudek M, Dielmann A, Pace L, Swallow M, Kruse F, Kuhl AA, Holzmann B, Berod L, Sparwasser T (2014) Dendritic Cells Coordinate Innate Immunity via MyD88 Signaling to Control Listeria monocytogenes Infection. Cell Rep 6(4): 698-708.

    • Bald T, Landsberg J, Lopez-Ramos D, Renn M, Glodde N, Jansen P, Gaffal E, Steitz J, Tolba R, Kalinke U, Limmer A, Jonsson G, Holzel M, Tuting T (2014) Immune-cell poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov 4(6): 674-687.

    • Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, Haid S, Catanese MT, Zeisel MB, Nicosia A, Baumert TF, Kaderali L, Pietschmann T (2014) Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins. J Virol 88(21): 12644-12655.

    • Barbier M, Damron FH, Bielecki P, Suarez-Diez M, Puchalka J, Alberti S, Dos Santos VM, Goldberg JB (2014) From the Environment to the Host: Re-Wiring of the Transcriptome of Pseudomonas aeruginosa from 22 degrees C to 37 degrees C. PLoS One 9(2): e89941.

    • Bartholomaeus P, Semmler LY, Bukur T, Boisguerin V, Romer PS, Tabares P, Chuvpilo S, Tyrsin DY, Matskevich A, Hengel H, Castle J, Hunig T, Kalinke U (2014) Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response. J Immunol 192(5): 2091-2098.

    • Behrendt P, Steinmann E, Manns MP, Wedemeyer H (2014) The impact of hepatitis E in the liver transplant setting. Journal of hepatology 61(6): 1418-1429.

    • Berneman-Zeitouni D, Molakandov K, Elgart M, Mor E, Fornoni A, Dominguez MR, Kerr-Conte J, Ott M, Meivar-Levy I, Ferber S (2014) The temporal and hierarchical control of transcription factors-induced liver to pancreas transdifferentiation. PLoS One 9(2): 387812.

    • Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20(11): 1327-1333.

    • Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini MV, Freitag J, Holzmann B, Sparwasser T (2014) MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol 44(5): 1399-1409.

    • Berod L, Stuve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Holscher C, Sparwasser T (2014) Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity. PLoS One 9(7): e102804.

    • Bielecki P, Muthukumarasamy U, Eckweiler D, Bielecka A, Pohl S, Schanz A, Niemeyer U, Oumeraci T, von Neuhoff N, Ghigo JM, Haussler S (2014) In vivo mRNA profiling of uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene expression profiles. MBio 5(4): e01075-14.

    • Blanka A, Schulz S, Eckweiler D, Franke R, Bielecka A, Nicolai T, Casilag F, Duvel J, Abraham WR, Kaever V, Haussler S (2014) Identification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity. J Bacteriol 196(2): 345-356.

    • Blankenhaus B, Reitz M, Brenz Y, Eschbach ML, Hartmann W, Haben I, Sparwasser T, Huehn J, Kuhl A, Feyerabend TB, Rodewald HR, Breloer M (2014) Foxp3(+) Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice. PLoS Pathog 10(2): e1003913.

    • Borg JJ, Serracino-Inglott A, Azzopardi LM, Schneider CK (2014) Comment On: "EU's New Pharmacovigilance Legislation: Considerations for Biosimilars". Drug Saf 37(2): 123-124.

    • Borrero-de Acuna JM, Bielecka A, Haussler S, Schobert M, Jahn M, Wittmann C, Jahn D, Poblete-Castro I (2014) Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida. Microb Cell Fact 13(1): 88.

    • Brouwer S, Pustelny C, Ritter C, Klinkert B, Narberhaus F, Haussler S (2014) The PqsR and RhlR transcriptional regulators determine the level of PQS synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms. J Bacteriol 196(23): 4163-4171.

    • Brown RJ, Koutsoudakis G, Urbanowicz RA, Mirza D, Ginkel C, Riebesehl N, Calland N, Albecka A, Price L, Hudson N, Descamps V, Backx M, McClure CP, Duverlie G, Pecheur EI, Dubuisson J, Perez-Del-Pulgar S, Forns X, Steinmann E, Tarr AW, Pietschmann T, Ball JK (2014) Analysis of serine codon conservation reveals diverse phenotypic constraints on Hepatitis C Virus glycoprotein evolution. J Virol 88(1): 667-678.

    • Cabot G, Bruchmann S, Mulet X, Zamorano L, Moya B, Juan C, Haussler S, Oliver A (2014) Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC. Antimicrob Agents Chemother 58(6): 3091-3099.

    • Castell S, Akmatov MK, Obi N, Flesh-Janys D, Nieters A, Kemmling Y, Pessler F, Krause G (2014) Test-retest reliability of an infectious disease questionnaire and evaluation of self-assessed vulnerability to infections : Findings of Pretest 2 of the German National Cohort. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 57(11): 1300-1307.

    • Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P (2014) HIV Nef Expression Favors the Relative Preservation of CD4+ T Regulatory Cells That Retain Some Important Suppressive Functions. J Immunol 192(4): 1681-1692.

    • Conrad E, Resch TK, Gogesch P, Kalinke U, Bechmann I, Bogdan C, Waibler Z (2014) Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice. Hepatology 59(4): 1555-1563.

    • Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, Kalinke U, Vivier E, Jonjic S, Oxenius A (2014) Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity 40(6): 961-973.

    • Deest M, Westhaus S, Steinmann E, Manns MP, von Hahn T, Ciesek S (2014) Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization. Antiviral Res 101 37-44.

    • Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Behrendt P, Brown RJ, Ciesek S, Wedemeyer H, Sarrazin C, Kaderali L, Pietschmann T, Steinmann E (2014) Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology 60(2): 508-520.

    • Doring M, Lessin I, Frenz T, Spanier J, Kessler A, Tegtmeyer P, Dag F, Thiel N, Trilling M, Lienenklaus S, Weiss S, Scheu S, Messerle M, Cicin-Sain L, Hengel H, Kalinke U (2014) M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plasmacytoid dendritic cells. J Virol 88(23): 13638-13650.

    • Eckweiler D, Bunk B, Sproer C, Overmann J, Haussler S (2014) Complete Genome Sequence of Highly Adherent Pseudomonas aeruginosa Small-Colony Variant SCV20265. Genome Announc 2(1).

    • Ehrlich A, Moreno Castilho T, Goldsmith-Pestana K, Chae WJ, Bothwell AL, Sparwasser T, McMahon-Pratt D (2014) The Immunotherapeutic Role of Regulatory T Cells in Leishmania (Viannia) panamensis Infection. J Immunol 193(6): 2961-2970.

    • Espinoza Mora Mdel R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B, Jacobs T (2014) Depletion of Regulatory T Cells Augments a Vaccine-Induced T Effector Cell Response against the Liver-Stage of Malaria but Fails to Increase Memory. PLoS One 9(8): e104627.

    • Fleige H, Ravens S, Moschovakis GL, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R (2014) IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 211(4): 643-651.

    • Fleige H, Ravens S, Moschovakis GL, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R (2014) IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 211(4): 643-651.

    • Frentzen A, Anggakusuma, Guerlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kroger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T (2014) Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology 59(1): 78-88.

    • Frentzen A, Kusuma A, Guerlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kroger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T (2014) Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology 59(1): 78-88.

    • Frenz T, Graalmann L, Detje CN, Doring M, Grabski E, Scheu S, Kalinke U (2014) Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus. J Immunol 193(5): 2496-2503.

    • Gabaev I, Elbasani E, Ameres S, Steinbruck L, Stanton R, Doring M, Lenac Rovis T, Kalinke U, Jonjic S, Moosmann A, Messerle M (2014) Expression of the Human Cytomegalovirus UL11 Glycoprotein in Viral Infection and Evaluation of its Effect on Virus-Specific CD8 T Cells. J Virol 88(24): 14326-14339.

    • Ganesh V, Baru AM, Hesse C, Friedrich C, Glage S, Gohmert M, Janke C, Sparwasser T (2014) Salmonella Typhimurium Infection Induced CD11b+Gr1+ Cells Ameliorate Allergic Airway Inflammation. Infect Immun 82(3): 1052-1063.

    • Gerold G, Pietschmann T (2014) A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication. Hepatology 59(2): 363-365.

    • Gerold G, Pietschmann T (2014) The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets. Dig Dis 32(5): 525-537.

    • Haid S, Grethe C, Dill MT, Heim M, Kaderali L, Pietschmann T (2014) Isolate-dependent use of Claudins for cell entry by hepatitis C virus. Hepatology 59(1): 24-34.

    • Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Renia L, Ruedl C, Macdonald KP, Hill GR, Engwerda CR (2014) Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest 124(6): 2483-2496.

    • Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wolk B, Kaderali L, Pietschmann T (2014) Apolipoprotein E co-determines tissue-tropism of hepatitis C virus and it is crucial for viral cell-to-cell transmission by contributing to a post-envelopment step of assembly. J Virol 88(3): 1433-1446.

    • Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ (2014) Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res 110c 52-59.

    • Jost NH, Abel S, Hutzler M, Sparwasser T, Zimmermann A, Roers A, Muller W, Klopfleisch R, Hengel H, Westendorf AM, Buer J, Hansen W (2014) Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunol Cell Biol 92(10): 860-871.

    • Kuhn A, Nieters A, Kottgen A, Goek ON, Michels K, Nothlings U, Jacobs G, Meisinger C, Pessler F, Akmatov MF, Kuhnisch J, Moebus S, Glocker E, Naus S, Keimling M, Leitzmann M, Linseisen J, Sarioglu H, von Toerne C, Hauck SM, Wallaschofski H, Wichmann HE, Illig T (2014) Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1255-1263.

    • Lange M, Fiedler M, Bankwitz D, Osburn W, Viazov S, Brovko O, Zekri AR, Khudyakov Y, Nassal M, Pumpens P, Pietschmann T, Timm J, Roggendorf M, Walker A (2014) Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies. PLoS One 9(7): e102235.

    • Lebel ME, Daudelin JF, Chartrand K, Tarrab E, Kalinke U, Savard P, Labrecque N, Leclerc D, Lamarre A (2014) Nanoparticle Adjuvant Sensing by TLR7 Enhances CD8+ T Cell-Mediated Protection from Listeria Monocytogenes Infection. J Immunol 192(3): 1071-1078.

    • Liehl P, Zuzarte-Luis V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Muller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudencio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigario AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM (2014) Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20(1): 47-53.

    • Lindenberg M, Solmaz G, Puttur F, Sparwasser T (2014) Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. J Virol 11 145.

    • Mall S, Akmatov MK, Schultze A, Ahrens W, Obi N, Pessler F, Krause G (2014) Web-based questionnaires to capture acute infections in long-term cohorts : Findings of a feasibility study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1308-1314.

    • Mayer CT, Ghorbani P, Kuhl AA, Stuve P, Hegemann M, Berod L, Gershwin ME, Sparwasser T (2014) Few Foxp3 regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Euro J Immunol 44(10): 2990-3002.

    • Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stuve P, Puttur F, Merad M, Sparwasser T (2014) Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 124(20): 3081-3091.

    • Mayer CT, Lahl K, Milanez-Almeida P, Watts D, Dittmer U, Fyhrquist N, Huehn J, Kopf M, Kretschmer K, Rouse B, Sparwasser T (2014) Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Immun Inflamm Dis 2(3): 162-165.

    • Mayer CT, Sparwasser T (2014) Assessing the suppressive activity of foxp3(+) regulatory T cells. Methods Mol Biol 1193 85-96.

    • Mayer CT, Tian L, Hesse C, Kuhl AA, Swallow M, Kruse F, Thiele M, Gershwin ME, Liston A, Sparwasser T (2014) Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 50 23-32.

    • Mehraj J, Akmatov MK, Strompl J, Gatzemeier A, Layer F, Werner G, Pieper DH, Medina E, Witte W, Pessler F, Krause G (2014) Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Nasal Carriage in a Random Sample of Non-Hospitalized Adult Population in Northern Germany. PLoS One 9(9): e107937.

    • Meyer Zu Horste G, Cordes S, Mausberg AK, Zozulya AL, Wessig C, Sparwasser T, Mathys C, Wiendl H, Hartung HP, Kieseier BC (2014) FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies. PLoS One 9(10): e108756.

    • Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Koster M, Kalinke U, Hauser H, Kroger A (2014) Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathog 10(3): e1003999.

    • Narayanan G, Cossu G, Galli MC, Flory E, Ovelgonne H, Salmikangas P, Schneider CK, Trouvin JH (2014) Clinical development of gene therapy needs a tailored approach: a regulatory perspective from the European union. Hum Gene Ther Clin Dev 25(1): 1-6.

    • Novoselova N, Beffa CD, Wang J, Li J, Pessler F, Klawonn F (2014) HUM Calculator and HUM package for R: easy-to-use software tools for multicategory receiver operating characteristic analysis. Bioinformatics 30(11): 1635-1636.

    • Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sackaguchi S, Roers A, Muller W, Hansen W, Buer J, Westendorf AM (2014) Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res 74(16): 4258-4269.

    • Pawar V, Crull K, Komor U, Kasnitz N, Frahm M, Kocijancic D, Westphal K, Leschner S, Wolf K, Loessner H, Rohde M, Haussler S, Weiss S (2014) Murine solid tumours as a novel model to study bacterial biofilm formation in vivo. J Intern Med 276(2): 130-139.

    • Perez F, Hujer AM, Marshall SH, Ray AJ, Rather PN, Suwantarat N, Dumford, D 3rd, O'Shea P, Domitrovic TN, Salata RA, Chavda KD, Chen L, Kreiswirth BN, Vila AJ, Haussler S, Jacobs MR, Bonomo RA (2014) Extensively Drug Resistant (XDR) Pseudomonas aeruginosa Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: A New Genetic Resistance Determinant in Northeast Ohio. Antimicrob Agents Chemother 58(10): 5929-5935.

    • Pessler F, Ogdie AR, Mayer CT, Kretzschmar WW, Dai L, Elsaman AM, Einhorn E, Krenn V, Schumacher HR (2014) Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells. Amyloid 21(1): 28-34.

    • Pessler F, Ogdie AR, Mayer CT, Kretzschmar WW, Dai L, Elsaman AM, Einhorn E, Krenn V, Schumacher HR (2014) Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells. Amyloid 21(1): 28-34.

    • Petzold C, Steinbronn N, Gereke M, Strasser RH, Sparwasser T, Bruder D, Geffers R, Schallenberg S, Kretschmer K (2014) Fluorochrome-based definition of naturally occurring Foxp3 regulatory T cells of intra- and extrathymic origin. Euro J Immunol 44(12): 3632-3645.

    • Pietschmann T (2014) In sero veritas: what serum markers teach us about HCV infection of primary human hepatocytes. Gut 63(9): 1375-1377.

    • Pohl S, Klockgether J, Eckweiler D, Khaledi A, Schniederjans M, Chouvarine P, Tummler B, Haussler S (2014) The extensive set of accessory Pseudomonas aeruginosa genomic components. FEMS Microbiol Lett 356(2): 235-241.

    • Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2014) Value of multiplex PCR using cerebrospinal fluid for the diagnosis of ventriculostomy-related meningitis in neurosurgery patients. Infection 42(2): 621-627.

    • Schmidt A, Belaaouaj A, Bissinger R, Koller G, Malleret L, D'Orazio C, Facchinelli M, Schulte-Hubbert B, Molinaro A, Holst O, Hammermann J, Schniederjans M, Meyer KC, Damkiaer S, Piacentini G, Assael B, Bruce K, Haussler S, Lipuma JJ, Seelig J, Worlitzsch D, Doring G (2014) Neutrophil elastase-mediated increase in airway temperature during inflammation. J Cyst Fibros 58(10): 5929-5935.

    • Schultze A, Akmatov MK, Andrzejak M, Karras N, Kemmling Y, Maulhardt A, Wieghold S, Ahrens W, Gunther K, Schlenz H, Krause G, Pessler F (2014) Comparison of stool collection on site versus at home in a population-based study : Feasibility and participants' preference in Pretest 2 of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1264-1269.

    • Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Gunther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F, Krause G (2014) Collection of vaccination data in the German National Cohort : Findings of a feasibility study in three study centers. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(11): 1292-1299.

    • Schulz S, Haussler S (2014) Chromatin Immunoprecipitation for ChIP-chip and ChIP-seq. Methods Mol Biol 1149 591-605.

    • Schulze B, Piehler D, Eschke M, von Buttlar H, Kohler G, Sparwasser T, Alber G (2014) CD4 FoxP3 regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. European Journal of Immnuology 44(12): 3596-3604.

    • Shankar G, Arkin S, Cocea L, Devanarayan V, Kirshner S, Kromminga A, Quarmby V, Richards S, Schneider CK, Subramanyam M, Swanson S, Verthelyi D, Yim S (2014) Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides-Harmonized Terminology and Tactical Recommendations. Aaps J 16(4): 658-673.

    • Sievers C, Akmatov MK, Kreienbrock L, Hille K, Ahrens W, Gunther K, Flesch-Janys D, Obi N, Michels KB, Fricke J, Greiser KH, Kaaks R, Peter HH, Pessler F, Nieters A, Krause G (2014) Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : Findings of a multicenter study. Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : Findings of a multicenter study 57(11): 1283-1291.

    • Spanier J, Lienenklaus S, Paijo J, Kessler A, Borst K, Heindorf S, Baker DP, Kroger A, Weiss S, Detje CN, Staeheli P, Kalinke U (2014) Concomitant TLR/RLH Signaling of Radioresistant and Radiosensitive Cells Is Essential for Protection against Vesicular Stomatitis Virus Infection. J Immunol 193(6): 3045-3054.

    • Svitek N, Gerhauser I, Goncalves C, Grabski E, Doring M, Kalinke U, Anderson DE, Cattaneo R, von Messling V (2014) Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but not STAT1 for Canine Distemper Virus Virulence in Ferrets. J Virol 88(5): 2941-2950.

    • Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P (2014) Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. Hepatology 9(7): e102235.

    • Vidigal PG, Dittmer S, Steinmann E, Buer J, Rath PM, Steinmann J (2014) Adaptation of Stenotrophomonas maltophilia in cystic fibrosis: Molecular diversity, mutation frequency and antibiotic resistance. Int J Med Microbiol 304(5-6): 613-619.

    • Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J (2014) Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm. PLoS One 9(4): e92876.

    • Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J (2014) Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm. PLoS One 9(4): e92876.

    • Vieyres G, Dubuisson J, Pietschmann T (2014) Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion. Viruses 6(3): 1149-1187.

    • Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA (2014) Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 6(258): 258ra142.

    • Volz A, Langenmayer M, Jany S, Kalinke U, Sutter G (2014) Rapid expansion of CD8+ T cells in wildtype and type I interferon receptor deficient mice correlates with protection after low-dose emergency immunization with Modified Vaccinia virus Ankara. J Virol 88(18): 10946-10957.

    • Wang Y, Sparwasser T, Figlin R, Kim HL (2014) Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 74(8): 2217-2228.

    • Wang Z, Friedrich C, Hagemann SC, Korte WH, Goharani N, Cording S, Eberl G, Sparwasser T, Lochner M (2014) Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium. Mucosal Immunol 7(6): 1290-1301.

    • Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Overby AK, Kroger A (2014) Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local anti-viral response. J Virol 88(21): 12202-12212.

    • Weise M, Kurki P, Wolff-Holz E, Bielsky MC, Schneider CK (2014) Biosimilars: the science of extrapolation. Blood 124(22): 3191-3196.

    • Zheng LS, Hitoshi S, Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for Interferon-alpha-Induced Depression and Neural Stem Cell Dysfunction. Stem cell reports 3(1): 73-84.

    • Zust R, Toh YX, Valdes I, Cerny D, Heinrich J, Hermida L, Marcos E, Guillen G, Kalinke U, Shi PY, Fink K (2014) Type I IFN signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines. J Virol 88(13): 7276-7285.

    • van Aerts LA, De Smet K, Reichmann G, Willem van der Laan J, Schneider CK (2014) Biosimilars entering the clinic without animal studies: A paradigm shift in the European Union. mAbs 6(5).

    2013

    • Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Munch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schuttrumpf J, Muller UC, Seppen J, Ott M, Buchholz CJ (2013) Specific gene delivery to liver sinusoidal and artery endothelial cells. Blood 122(12): 2030-2038.

    • Ahmad I, Wigren E, Le Guyon S, Vekkeli S, Blanka A, El Mouali Y, Anwar N, Chuah ML, Lunsdorf H, Frank R, Rhen M, Liang ZX, Lindqvist Y, Romling U (2013) The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium. Mol Microbiol 90(6): 1216-1232.

    • Aiuti A, Cossu G, de Felipe P, Galli MC, Narayanan G, Renner M, Stahlbom A, Schneider CK, Voltz-Girolt C (2013) The Committee for Advanced Therapies' (CAT) reflection paper on management of clinical risks deriving from insertional mutagenesis. Hum Gene Ther Clin Dev 24(2): 47-54.

    • Akhmetzyanova I, Zelinskyy G, Schimmer S, Brandau S, Altenhoff P, Sparwasser T, Dittmer U (2013) Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother 62(2): 257-271.

    • Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Buscher D, Fibbe W, Foussat A, Kwa M, Lantz O, Maciulaitis R, Palomaki T, Schneider CK, Sensebe L, Tachdjian G, Tarte K, Tosca L, Salmikangas P (2013) Risk of tumorigenicity in mesenchymal stromal cell-based therapies-Bridging scientific observations and regulatory viewpoints. Cytotherapy 15(7): 753-759.

    • Beffa CD, Slansky E, Pommerenke C, Klawonn F, Li J, Dai L, Schumacher Jr HR, Pessler F (2013) The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. PLoS One 8(8): e72494.

    • Behrendt P, Doerrbecker J, Riebesehl N, Wilhelm C, Ciesek S, Erichsen TJ, Steinmann J, Ott M, Manns MP, Pietschmann T, Steinmann E (2013) Stability and transmission of hepatitis C virus in different anesthetic agents. Am J Infect Control 41(10): 942-943.

    • Behrendt P, Doerrbecker J, Riebesehl N, Wilhelm C, Ciesek S, Erichsen TJ, Steinmann J, Ott M, Manns MP, Pietschmann T, Steinmann E (2013) Stability and transmission of hepatitis C virus in different anesthetic agents. Am J Infect Control 41(10): 942-943.

    • Bielecki P, Komor U, Bielecka A, Musken M, Puchalka J, Pletz MW, Ballmann M, Martins Dos Santos VA, Weiss S, Haussler S (2013) Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites. Environ Microbiol 15(2): 570-587.

    • Bobadilla Fazzini RA, Skindersoe ME, Bielecki P, Puchalka J, Givskov M, Martins Dos Santos VA (2013) Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response. Environ Microbiol 15(1): 111-120.

    • Britten CM, Singh-Jasuja H, Flamion B, Hoos A, Huber C, Kallen KJ, Khleif SN, Kreiter S, Nielsen M, Rammensee HG, Sahin U, Hinz T, Kalinke U (2013) The regulatory landscape for actively personalized cancer immunotherapies. Nat Biotechnol 31(10): 880-882.

    • Bruchmann S, Dotsch A, Nouri B, Chaberny IF, Haussler S (2013) Quantitative contribution of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance. Antimicrob Agents Chemother 57(3): 1361-1368.

    • Bunse CE, Borchers S, Varanasi PR, Tischer S, Figueiredo C, Immenschuh S, Kalinke U, Kohl U, Goudeva L, Maecker-Kolhoff B, Ganser A, Blasczyk R, Weissinger EM, Eiz-Vesper B (2013) Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor. PLoS One 8(12): e77925.

    • Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rulicke T, Stein JV, Hehlgans T, Ludewig B (2013) Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity. Immunity 38(5): 1013-1024.

    • Doerrbecker J, Behrendt P, Mateu-Gelabert P, Ciesek S, Riebesehl N, Wilhelm C, Steinmann J, Pietschmann T, Steinmann E (2013) Transmission of Hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment. J Infect Dis 207(2): 281-287.

    • Doerrbecker J., Meuleman P., Kang J., Riebesehl N., Wilhelm C., Friesland M., Pfaender S., Steinmann J., Pietschmann T., Steinmann E. (2013) Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. J Virol Hepat 20(7): 478-485.

    • Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T (2013) Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med 2(9): 641-654. * ebenfalls TWINCORE Beteiligung.

    • Eichler HG, Bloechl-Daum B, Brasseur D, Breckenridge A, Leufkens H, Raine J, Salmonson T, Schneider CK, Rasi G (2013) The risks of risk aversion in drug regulation. Nat Rev Drug Discov 12(12): 907-916.

    • Elsaman AM, Radwan AR, Akmatov MK, Della Beffa C, Walker A, Mayer CT, Dai L, Nativ S, Rygg M, Atsali E, Saijo K, Ogdie AR, Srinivasulu N, Fathi N, Ralph Schumacher H, Pessler F (2013) Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases. Semin Arthritis Rheum 43(3): 405-412.

    • Elsaman AM, Radwan AR, Akmatov MK, Della Beffa C, Walker A, Mayer CT, Dai L, Nativ S, Rygg M, Atsali E, Saijo K, Ogdie AR, Srinivasulu N, Fathi N, Ralph Schumacher H, Pessler F (2013) Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases. Semin Arthritis Rheum 43(3): 405-412.

    • Fernandez MA, Yu U, Zhang G, White R, Sparwasser T, Alexander SI, Jones CA (2013) Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology 447(1-2): 9-20.

    • Gentzsch J, Brohm C, Steinmann E, Friesland M, Menzel N, Vieyres G, Perin PM, Frentzen A, Kaderali L, Pietschmann T (2013) Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment. PLoS pathogens 9(5): e1003355.

    • Gerold G, Pietschmann T (2013) Hepatitis C virus NS5B polymerase primes innate immune signaling. Hepatology 57(3): 1275-1277.

    • Godeke J, Pustelny C, Haussler S (2013) Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase counteracts Azithromycin-mediated effects on Pseudomonas aeruginosa. Antimicrob Agents Chemother 57(4): 1617-1624.

    • Goncalves Vidigal P, Schmidt D, Stehling F, Mellies U, Steinmann E, Buer J, Rath PM, Steinmann J (2013) Development of a quantitative immunofluorescence assay for detection of Stenotrophomonas maltophilia antibodies in patients with cystic fibrosis. J Cyst Fibros 12(6): 651-654.

    • Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, Qureshi S, Lamarre A, Haddad EK, Sekaly RP, Peri S, Balachandran S, Lin R, Hiscott J (2013) Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. PLoS pathogens 9(4): e1003298.

    • Hamming OJ, Terczynska-Dyla E, Vieyres G, Dijkman R, Jorgensen SE, Akhtar H, Siupka P, Pietschmann T, Thiel V, Hartmann R (2013) Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses. Embo J 32(23): 3055-3065.

    • Haussler S, Fuqua C (2013) Biofilms 2012: New Discoveries and Significant Wrinkles in a Dynamic Field. J Bacteriol 195(13): 2947-2958.

    • Hesse C, Ginter W, Forg T, Mayer CT, Baru AM, Arnold-Schrauf C, Unger WW, Kalay H, van Kooyk Y, Berod L, Sparwasser T (2013) In vivo targeting of human DC-SIGN drastically enhances CD8 T-cell-mediated protective immunity. Eur J Immunol 43(10): 2543-2553.

    • Hogner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlohner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S (2013) Macrophage-expressed IFN-beta Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia. PLoS Pathog 9(2): e1003188.

    • Hogner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlohner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S (2013) Correction: Macrophage-expressed IFN-beta Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia. PLoS Pathog 12(6): e1005716.

    • Hu M, Wang C, Zhang G, Saito M, Wang Y, Fernandez M, Qian Y, Wang Y, Sawyer A, Hawthorne W, Jones C, Sparwasser T, Bishop A, Sharland A, O'Connell P, Alexander S (2013) Graft Infiltrating Foxp3 Tregs in Spontaneously Tolerant Renal A Allografts Express High Levels of CXCR3 and BLIMP-1. Am J Transplant 13(11): 2819-2830.

    • Joshi R, Feldmann V, Koestner W, Detje C, Gottschalk S, Mayer HA, Sauer MG, Engelmann J (2013) Multifunctional silica nanoparticles for optical and magnetic resonance imaging. Biol Chem 394(1): 125-135.

    • Kanjarawi R, Dy M, Bardel E, Sparwasser T, Dubois B, Mecheri S, Kaiserlian D (2013) Regulatory CD4(+)Foxp3(+) T Cells Control the Severity of Anaphylaxis. PLoS One 8(7): e69183.

    • Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4): 679-691.

    • Klingenberg R, Gerdes N, Badeau RM, Gistera A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Luscher TF, Jauhiainen M, Sparwasser T, Hansson GK (2013) Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123(3): 1323-1334.

    • Kuhlhorn F, Rath M, Schmoeckel K, Cziupka K, Nguyen HH, Hildebrandt P, Hunig T, Sparwasser T, Huehn J, Potschke C, Broker BM (2013) Foxp3(+) regulatory T cells are required for recovery from severe sepsis. PLoS One 8(5): e65109.

    • Layland LE, Straubinger K, Ritter M, Loffredo-Verde E, Garn H, Sparwasser T, Prazeres da Costa C (2013) Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3(+) Treg Cells. PLoS Negl Trop Dis 7(8): e2379.

    • Lodermeyer V, Suhr K, Schrott N, Kolbe C, Sturzel CM, Krnavek D, Munch J, Dietz C, Waldmann T, Kirchhoff F, Goffinet C (2013) 90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1. Retrovirology 10(1): 111.

    • Martin B, Auffray C, Delpoux A, Pommier A, Durand A, Charvet C, Yakonowsky P, de Boysson H, Bonilla N, Audemard A, Sparwasser T, Salomon BL, Malissen B, Lucas B (2013) Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun 4 2209.

    • Mayer CT, Huntenburg J, Nandan A, Schmitt E, Czeloth N, Sparwasser T (2013) CD4 blockade directly inhibits mouse and human CD4 T cell functions independent of Foxp3 Tregs. J Autoimmun 47 73-82.

    • Melchiorri D, Pani L, Gasparini P, Cossu G, Ancans J, Borg JJ, Drai C, Fiedor P, Flory E, Hudson I, Leufkens HG, Muller-Berghaus J, Narayanan G, Neugebauer B, Pokrotnieks J, Robert JL, Salmonson T, Schneider CK (2013) Regulatory evaluation of Glybera in Europe - two committees, one mission. Nat Rev Drug Discov 12(9): 719.

    • Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kroger A (2013) Hepatitis C Virus Replication in Mouse Cells is Restricted by IFN-Dependent and -Independent Mechanisms. Gastroenterology 145(6): 1414-1423e1.

    • Norenberg A, Heinz S, Scheller K, Hewitt NJ, Braspenning J, Ott M (2013) Optimization of upcyte human hepatocytes for the in vitro micronucleus assay. Mutat Res 758(1-2): 69-79 * ebenfalls TWINCORE Beteiligung.

    • Pasquet L, Douet JY, Sparwasser T, Romagnoli P, van Meerwijk JP (2013) Long term prevention of chronic allograft rejection by regulatory T cell immunotherapy involves host Foxp3-expressing T cells. Blood 121(21): 4303-4310.

    • Petzold C, Riewaldt J, Watts D, Sparwasser T, Schallenberg S, Kretschmer K (2013) Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res 2013 940710.

    • Pfaender S, Heyden J, Friesland M, Ciesek S, Ejaz A, Steinmann J, Malarski A, Stoiber H, Tsiavaliaris G, Bader W, Jahreis G, Pietschmann T, Steinmann E (2013) Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk. J Infect Dis 208(12): 1943-1952.

    • Prete F, Catucci M, Labrada M, Gobessi S, Castiello MC, Bonomi E, Aiuti A, Vermi W, Cancrini C, Metin A, Hambleton S, Bredius R, Notarangelo LD, van der Burg M, Kalinke U, Villa A, Benvenuti F (2013) Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells. J Exp Med 210(2): 355-374.

    • Preusse M, Tantawy MA, Klawonn F, Schughart K, Pessler F (2013) Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice. BMC Microbiol 13 293.

    • Pustelny C, Brouwer S, Musken M, Bielecka A, Dotsch A, Nimtz M, Haussler S (2013) The peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental adaptation of Pseudomonas aeruginosa PA14. Environ Microbiol 15(2): 597-609.

    • Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T (2013) Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance. PLoS Pathog 9(9): e1003648.

    • Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M (2013) Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents. Hepatology 58(1): 397-408.

    • Rosalia RA, Stepanek I, Pollakova V, Simova J, Bieblova J, Indrova M, Moravcova S, Pribylova H, Bontkes HJ, Bubenik J, Sparwasser T, Reinis M (2013) Administration of anti-CD25 mAb leads to impaired alpha-galactosylceramide-mediated induction of IFN-gamma production in a murine model. Immunobiology 218(6): 851-859.

    • Schemuth H, Dittmer S, Lackner M, Sedlacek L, Hamprecht A, Steinmann E, Buer J, Rath PM, Steinmann J (2013) In vitro activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis. Mycoses 56(3): 297-303.

    • Schmitz I, Schneider C, Frohlich A, Frebel H, Christ D, Leonard WJ, Sparwasser T, Oxenius A, Freigang S, Kopf M (2013) IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection. PLoS Pathog 9(5): e1003362.

    • Schneider CK (2013) Biosimilars in rheumatology: the wind of change. Ann Rheum Dis 72(3): 315-318.

    • Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T (2013) Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med 13(5): 842-855.

    • Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, Weber M, Kalinke U, Hofer MJ, Hatesuer B, Schughart K, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Weber F, Hornef MW, Autenrieth IB, Bohn E (2013) IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-alpha Secretion and LPS-Induced Endotoxin Shock. J Immunol 191(7): 3913-3921.

    • Steinmann E, Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Hillung J, Gentzsch J, Lauber C, Brown R, Frentzen A, Pietschmann T (2013) Characterization of hepatitis C virus intra- and inter-genotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol 87(24): 13297-13306.

    • Steinmann E, Gravemann U, Friesland M, Doerrbecker J, Muller TH, Pietschmann T, Seltsam A (2013) Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products. Transfusion 53(5): 1010-1018.

    • Steinmann E, Pietschmann T (2013) Cell culture systems for hepatitis C virus. Curr Top Microbiol Immunol 369 17-48.

    • Steinmann J, Becker B, Bischoff B, Magulski T, Steinmann E (2013) Virucidal activity of Formulation I of the World Health Organization's alcohol-based handrubs: impact of changes in key ingredient levels and test parameters. Antimicrob Resist Infect Control 2(1): 34.

    • Steinmann J, Buer J, Pietschmann T, Steinmann E (2013) Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of Green Tea. Br J Pharmacol 168(5): 1059-1073.

    • Tsiftsoglou AS, Ruiz S, Schneider CK (2013) Development and regulation of biosimilars: current status and future challenges. BioDrugs 27(3): 203-211.

    • Vestergaard HT, Apote LD, Schneider CK, Herberts C (2013) The evolution of nonclinical regulatory science: advanced therapy medicinal products as a paradigm. Mol Ther 21(7): 1294-1296.

    • Vieyres G, Brohm C, Friesland M, Gentzsch J, Wolk B, Roingeard P, Steinmann E, Pietschmann T (2013) Subcellular localization and function of an epitope-tagged p7 in hepatitis C virus-producing cells. J Virol 87(3): 1664-1678.

    • Vieyres G, Pietschmann T (2013) Entry and replication of recombinant hepatitis C viruses in cell culture. Methods 59(2): 233-248.

    • Westhaus S, Bankwitz D, Ernst S, Rohrmann K, Wappler I, Agne C, Luchtefeld M, Schieffer B, Sarrazin C, Manns MP, Pietschmann T, Ciesek S, von Hahn T (2013) Characterization of the inhibition of hepatitis C virus entry by in vitro generated and patient derived oxidized low density lipoprotein. Hepatology 57(5): 1716-1724.

    • Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA (2013) Loss of the TGFbeta-Activating Integrin alphavbeta8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity. PLoS Pathog 9(10): e1003675.

    • Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L (2013) A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration. Cell 153(2): 389-401.

    • Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD (2013) MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology 57(1): 299-310.

    • Zahid MN, Turek M, Xiao F, Thi VL, Guerin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F, Baumert TF, Zeisel MB (2013) The post-binding activity of scavenger receptor BI mediates initiation of hepatitis C virus infection and viral dissemination. Hepatology 57(2): 492-504.

    2012

    • Abel S, Luckheide N, Westendorf AM, Geffers R, Roers A, Muller W, Sparwasser T, Matuschewski K, Buer J, Hansen W (2012) Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection. J Immunol 188(11): 5467-5477.

    • Auriemma M, Brzoska T, Klenner L, Kupas V, Goerge T, Voskort M, Zhao Z, Sparwasser T, Luger TA, Loser K (2012) alpha-MSH-Stimulated Tolerogenic Dendritic Cells Induce Functional Regulatory T Cells and Ameliorate Ongoing Skin Inflammation. J Invest Dermatol 132(7): 1814-1824.

    • Bache C, Spreitzer I, Becker B, Loeschner B, Rosskopf U, Hanschmann KM, Schwanig M, Schneider CK, Lieb B, Montag T (2012) Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood. Med Microbiol Immunol 201(3): 327-335.

    • Baranek T, Manh TP, Alexandre Y, Maqbool MA, Cabeza JZ, Tomasello E, Crozat K, Bessou G, Zucchini N, Robbins SH, Vivier E, Kalinke U, Ferrier P, Dalod M (2012) Differential responses of immune cells to type I interferon contribute to host resistance to viral infection. Cell Host Microbe 12(4): 571-584.

    • Barbier J, Wegner J, Benson S, Gentzsch J, Pietschmann T, Kirschning A (2012) Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition. Chemistry 18(29): 9083-9090.

    • Baru AM, Ganesh V, Krishnaswamy JK, Hesse C, Untucht C, Glage S, Behrens G, Mayer CT, Puttur F, Sparwasser T (2012) Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. PLoS One 7(10): e47102.

    • Baru AM, Untucht C, Ganesh V, Hesse C, Mayer CT, Sparwasser T (2012) Optimal Isolation of Functional Foxp3(+) Induced Regulatory T Cells Using DEREG Mice. PLoS One 7(9): e44760.

    • Berod L, Puttur F, Huehn J, Sparwasser T (2012) Tregs in infection and vaccinology: heroes or traitors?. Microb Biotechnol 5(2): 260-269.

    • Bieback K, Wuchter P, Besser D, Franke W, Becker M, Ott M, Pacher M, Ma N, Stamm C, Kluter H, Muller A, Ho AD (2012) Mesenchymal stromal cells (MSCs): science and f(r)iction. J Mol Med (Berl) 90(7): 773-782.

    • Bielecki P, Lukat P, Husecken K, Dotsch A, Steinmetz H, Hartmann RW, Muller R, Haussler S (2012) Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa. Chembiochem 13(16): 2339-2345.

    • Cervantes-Barragan L, Firner S, Bechmann I, Waisman A, Lahl K, Sparwasser T, Thiel V, Ludewig B (2012) Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 188(8): 3678-3685.

    • Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P, Lohmann V, Pietschmann T (2012) Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. PloS One 7(4): e36029.

    • Dotsch A, Eckweiler D, Schniederjans M, Zimmermann A, Jensen V, Scharfe M, Geffers R, Haussler S (2012) The Pseudomonas aeruginosa transcriptome in planktonic cultures and static biofilms using RNA sequencing. PloS One 7(2): e31092.

    • Duvel J, Bertinetti D, Moller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jansch L, Herberg FW, Haussler S (2012) A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. J Microbiol Methods 88(2): 229-236.

    • Eberlein J, Davenport B, Nguyen TT, Victorino F, Sparwasser T, Homann D (2012) Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol 86(4): 1955-1970.

    • Ejaz A, Steinmann E, Banki Z, Anggakusuma, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H (2012) Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus. PLoS One 7(9): e45770.

    • Ejaz A, Steinmann E, Banki Z, Kusuma A, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H (2012) Specific Acquisition of Functional CD59 but Not CD46 or CD55 by Hepatitis C Virus. PLoS One 7(9): e45770.

    • Fofana I, Fafi-Kremer S, Carolla P, Fauvelle C, Zahid MN, Turek M, Heydmann L, Cury K, Hayer J, Combet C, Cosset FL, Pietschmann T, Hiet MS, Bartenschlager R, Habersetzer F, Doffoel M, Keck ZY, Foung SK, Zeisel MB, Stoll-Keller F, Baumert TF (2012) Mutations that Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies. Gastroenterology 143(1): 223-233.e9.

    • Frentzen A, Hueging K, Bitzegeio J, Pietschmann T, Steinmann E (2012) Two methods of heterokaryon formation to discover HCV restriction factors. J Vis Exp (65): e4029.

    • Fyhrquist N, Lehtimaki S, Lahl K, Savinko T, Lappetelainen AM, Sparwasser T, Wolff H, Lauerma A, Alenius H (2012) Foxp3+ cells control th2 responses in a murine model of atopic dermatitis. J Invest Dematol 132(6): 1672-1680.

    • Gomez de Aguero M, Vocanson M, Hacini-Rachinel F, Taillardet M, Sparwasser T, Kissenpfennig A, Malissen B, Kaiserlian D, Dubois B (2012) Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells. J Clin Invest 122(5): 1700-1711.

    • Haid S, Novodomska A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Ponisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg A, Wong-Staal F, Davioud-Charvet E, Pietschmann T (2012) A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes. Gastroenterology 143(1): 213-222.e5.

    • Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I (2012) Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 209(11): 2001-2016.

    • Hansen W, Hutzler M, Abel S, Stockmann C, Albert J, Sparwasser T, Sakaguchi S, Westendorf A, Schadendorf D, Buer J, Helfrich I (2012) Neuropilin-1 deficiency on CD4+Foxp3+regulatory T cells impaires tumor growth in melanoma. Exp Dermatol 22(3): E38-E38.

    • Hellingman AA, van der Vlugt LE, Lijkwan MA, Bastiaansen AJ, Sparwasser T, Smits HH, Hamming JF, Quax PH (2012) A limited role for regulatory T cells in post-ischemic neovascularization. J Cell Mol Med 16(2): 328-336.

    • Kafert-Kasting S, Schneider A, Attaran M, Priesner C, Barthold M, Perrier AL, Kriegbaum H, Ott M, Meyburg J (2012) Safety assessment of intraportal liver cell application in New Zealand white rabbits under GLP conditions. Arch Toxicol 86(9): 1413-1422.

    • Kalinke U, Prinz M (2012) Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS. Immunol Cell Biol 90(5): 505-509.

    • Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, Reichart U, Reizis B, Kalinke U, Jamieson A, Mueller M, Decker T (2012) Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection. PLoS Pathog 8(6): e1002763.

    • Komor U, Bielecki P, Loessner H, Rohde M, Wolf K, Westphal K, Weiss S, Haussler S (2012) Biofilm formation by Pseudomonas aeruginosa in solid murine tumors - a novel model system. Microbes Infect 14(11): 951-958.

    • Kremer M, Suezer Y, Volz A, Frenz T, Majzoub M, Hanschmann KM, Lehmann MH, Kalinke U, Sutter G (2012) Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox. PLoS pathogens 8(3): e1002557.

    • Krishnaswamy JK, Jirmo AC, Baru AM, Ebensen T, Guzman CA, Sparwasser T, Behrens GM (2012) TLR2 Agonist-Allergen Coupling Efficiently Redirects Th2 Cell Responses and Inhibits Allergic Airway Eosinophilia. Am J Respir Cell Mol Biol 47(6): 852-863.

    • Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J (2012) High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. J Biol Chem 287(46): 39224-39232.

    • Lehtimaeki S, Savinko T, Lahl K, Sparwasser T, Wolff H, Lauerma A, Alenius H, Fyhrquist N (2012) The Temporal and Spatial Dynamics of Foxp3+ Treg Cell-Mediated Suppression during Contact Hypersensitivity Responses in a Murine Model. J Invest Dermatol 132(12): 2744-2751.

    • Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster KE, Sprent J, Culley FJ, Johansson C, Openshaw PJ (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5(2): 161-172.

    • Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Musken M, Haussler S, Steinbach A, Hartmann RW (2012) Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa. Chem Biol 19(3): 381-390.

    • Maazi H, Shirinbak S, Willart M, Hammad HM, Cabanski M, Boon L, Ganesh V, Baru AM, Hansen G, Lambrecht BN, Sparwasser T, Nawijn MC, van Oosterhout AJ (2012) Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 42(10): 1519-1528.

    • Maciulaitis R, D'Apote L, Buchanan A, Pioppo L, Schneider CK (2012) Clinical development of advanced therapy medicinal products in europe: evidence that regulators must be proactive. Mol Ther 20(3): 479-482.

    • Malone JG, Jaeger T, Manfredi P, Dotsch A, Blanka A, Bos R, Cornelis GR, Haussler S, Jenal U (2012) The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways. PLoS Pathog 8(6): e1002760.

    • Mayer CT, Berod L, Sparwasser T (2012) Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol 3 183.

    • Mayer CT, Kuhl AA, Loddenkemper C, Sparwasser T (2012) Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice. Blood 119(5): 1314-1315.

    • Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, Haid S, Gentzsch J, Kaderali L, Bartenschlager R, Pietschmann T (2012) MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles. PLoS Pathog 8(7): e1002829.

    • Mizutani T, Neugebauer N, Putz EM, Moritz N, Simma O, Zebedin-Brandl E, Gotthardt D, Warsch W, Eckelhart E, Kantner HP, Kalinke U, Lienenklaus S, Weiss S, Strobl B, Muller M, Sexl V, Stoiber D (2012) Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1(7): 1027-1037.

    • Navid F, Boniotto M, Walker C, Ahrens K, Proksch E, Sparwasser T, Muller W, Schwarz T, Schwarz A (2012) Induction of regulatory T cells by a murine beta-defensin. J Immunol 188(2): 735-743.

    • Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S (2012) T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development. Immunity 37(5): 785-799.

    • Pace L, Tempez A, Arnold-Schrauf C, Lemaitre F, Bousso P, Fetler L, Sparwasser T, Amigorena S (2012) Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338(6106): 532-536.

    • Panzer M, Sitte S, Wirth S, Drexler I, Sparwasser T, Voehringer D (2012) Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J Immunol 188(2): 615-623.

    • Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gomez-Lechon MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A (2012) Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 21(1): 1-10.

    • Rath PM, Saner F, Paul A, Lehmann N, Steinmann E, Buer J, Steinmann J (2012) Multiplex PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients. J Clin Microbiol 50(6): 2069-2071.

    • Reuter D, Sparwasser T, Hunig T, Schneider-Schaulies J (2012) Foxp3+ regulatory T cells control persistence of viral CNS infection. PloS One 7(3): e33989.

    • Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U (2012) Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes. Gene Ther 19(4): 425-434.

    • Ruhl M, Chhatwal P, Strathmann H, Kuntzen T, Bankwitz D, Skibbe K, Walker A, Heinemann FM, Horn PA, Allen TM, Hoffmann D, Pietschmann T, Timm J (2012) Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope. J Virol 86(2): 991-1000.

    • Sandmann L, Wilson M, Back D, Wedemeyer H, Manns MP, Steinmann E, Pietschmann T, von Hahn T, Ciesek S (2012) Antiretroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro. Antiviral Res 96(1): 51-58.

    • Schallenberg S, Petzold C, Tsai PY, Sparwasser T, Kretschmer K (2012) Vagaries of fluorochrome reporter gene expression in foxp3(+) regulatory T cells. PLoS One 7(8): e41971.

    • Schneider CK, Borg JJ, Ehmann F, Ekman N, Heinonen E, Ho K, Hoefnagel MH, van der Plas RM, Ruiz S, van der Stappen AJ, Thorpe R, Tiitso K, Tsiftsoglou AS, Vleminckx C, Waxenecker G, Welin M, Weise M, Trouvin JH (2012) In support of the European Union biosimilar framework. Nat Biotechnol 30(8): 745-748.

    • Schneider CK, Vleminckx C, Gravanis I, Ehmann F, Trouvin JH, Weise M, Thirstrup S (2012) Setting the stage for biosimilar monoclonal antibodies. Nat Biotechnol 30(12): 1179-1185.

    • Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kuhl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I (2012) IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor. Immunity 37(6): 998-1008.

    • Schwandt T, Schumak B, Gielen GH, Jungerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JM, Knolle PA, Limmer A (2012) Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. Embo J 31(1): 201-213.

    • Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T (2012) 1,25-Dihydroxyvitamin D Exerts Similar Immunosuppressive Effects as UVR but Is Dispensable for Local UVR-Induced Immunosuppression. J Invest Dermatol 132(12): 2762-2769.

    • Selezska K, Kazmierczak M, Musken M, Garbe J, Schobert M, Haussler S, Wiehlmann L, Rohde C, Sikorski J (2012) Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure. Environ Microbiol 14(8): 1952-1967.

    • Sharma AD, Rittelmeyer I, Cantz T, Ott M (2012) Regenerative therapies for liver diseases. Stem Cell Biology and Regenerative Medicine 2013(doi: 10.1007/978-1-62703-098-4_10): 203-231.

    • Stegmann KA, Bjorkstrom NK, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, Malinski P, Dustin LB, Rice CM, Manns MP, Pietschmann T, Cornberg M, Ljunggren HG, Wedemeyer H (2012) Interferon alpha-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1. J Infect Dis 205(9): 1351-1362.

    • Steinmann J, Paulmann D, Becker B, Bischoff B, Steinmann E (2012) Comparison of virucidal activity of alcohol-based hand sanitizers versus antimicrobial hand soaps in vitro and in vivo. J Hosp Infect 82(4): 277-280.

    • Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Musken M, Haussler S, Steinbach A, Hartmann RW (2012) Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors. J Am Chem Soc 134(39): 16143-16146.

    • Stross L, Gunther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U (2012) Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute, experimental hepatitis B virus infection. Hepatology 56(3): 873-883.

    • Veiga-Parga T, Suryawanshi A, Mulik S, Gimenez F, Sharma S, Sparwasser T, Rouse BT (2012) On the Role of Regulatory T Cells during Viral-Induced Inflammatory Lesions. J Immunol 189(12): 5924-5933.

    • Waern JM, Yuan Q, Rudrich U, Becker PD, Schulze K, Strick-Marchand H, Huntington ND, Zacher BJ, Wursthorn K, Di Santo JP, Guzman CA, Manns MP, Ott M, Bock M (2012) Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice. Hepatology 56(4): 1479-1788.

    • Wei Q, Minh PN, Dotsch A, Hildebrand F, Panmanee W, Elfarash A, Schulz S, Plaisance S, Charlier D, Hassett D, Haussler S, Cornelis P (2012) Global regulation of gene expression by OxyR in an important human opportunistic pathogen. Nucleic Acids Res 40(10): 4320-4333.

    • Weise M, Bielsky MC, De Smet K, Ehmann F, Ekman N, Giezen TJ, Gravanis I, Heim HK, Heinonen E, Ho K, Moreau A, Narayanan G, Kruse NA, Reichmann G, Thorpe R, van Aerts L, Vleminckx C, Wadhwa M, Schneider CK (2012) Biosimilars: what clinicians should know. Blood 120(26): 5111-5117.

    • Weissmueller S, Semmler LY, Kalinke U, Christians S, Mueller-Berghaus J, Waibler Z (2012) ICOS-LICOS interaction is critically involved in TGN1412-mediated T cell activation. Blood 119(26): 6268-6277.

    • Zaoui C, Overhage J, Lons D, Zimmermann A, Musken M, Bielecki P, Pustelny C, Becker T, Nimtz M, Haussler S (2012) An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa. Mol Microbiol 83(3): 536-547.

    • Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller ET, Zou W (2012) Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology 1(2): 152-161.

    • van der Vlugt LE, Labuda LA, Ozir-Fazalalikhan A, Lievers E, Gloudemans AK, Liu KY, Barr TA, Sparwasser T, Boon L, Ngoa UA, Feugap EN, Adegnika AA, Kremsner PG, Gray D, Yazdanbakhsh M, Smits HH (2012) Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PloS One 7(2): e30883.

    • von Hahn T, Schiene-Fischer C, Van ND, Pfander S, Karavul B, Steinmann E, Potthoff A, Strassburg C, Hamdi N, Abdelaziz AI, Sarrazin C, Muller T, Berg T, Trepo E, Wedemeyer H, Manns MP, Pietschmann T, Ciesek S (2012) Hepatocytes that Express Variants of Cyclophilin A are Resistant to HCV Infection and Replication. Gastroenterology 143(2): 439-447e1.

    2011

    • Arico E, Monque DM, D'Agostino G, Moschella F, Venditti M, Kalinke U, Allen DJ, Nash AA, Belardelli F, Ferrantini M (2011) MHV-68 producing mIFNalpha1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68.. Vaccine 29(23): 3935-3944.

    • Arnold I, Lee J, Amieva M, Roers A, Flavell R, Sparwasser T, Muller A (2011) Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140(1): 199-209.

    • Baru AM, Krishnaswamy JK, Rathinasamy A, Scherr M, Eder M, Behrens GM (2011) Dendritic cells derived from HOXB4-immortalized hematopoietic bone marrow cells.. Exp Biol Med (Maywood) 236(11): 1291-1297.

    • Berod L, Heinemann C, Heink S, Escher A, Stadelmann C, Drube S, Wetzker R, Norgauer J, Kamradt T (2011) PI3Kgamma deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.. Eur J Immunol 41(3): 833-844.

    • Beyer M, Thabet Y, Muller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schonfeld EA, Bottcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL (2011) Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.. Nat Immunol 12(9): 898-907.

    • Bielecki P, Puchalka J, Wos-Oxley ML, Loessner H, Glik J, Kawecki M, Nowak M, Tummler B, Weiss S, Dos Santos VA (2011) In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs. PLos One 6(9): e24235.

    • Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kuhl AA, Loddenkemper C, Jacobs T, Breloer M (2011) Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.. J Immunol 186(7): 4295-4305.

    • Burgel B, Friesland M, Koch A, Manns MP, Wedemeyer H, Weissenborn K, Schulz-Schaeffer WJ, Pietschmann T, Steinmann E, Ciesek S (2011) Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration. J Viral Hepat 18(8): 562-570.

    • Buttel IC, Chamberlain P, Chowers Y, Ehmann F, Greinacher A, Jefferis R, Kramer D, Kropshofer H, Lloyd P, Lubiniecki A, Krause R, Mire-Sluis A, Platts-Mills T, Ragheb JA, Reipert BM, Schellekens H, Seitz R, Stas P, Subramanyam M, Thorpe R, Trouvin JH, Weise M, Windisch J, Schneider CK (2011) Taking immunogenicity assessment of therapeutic proteins to the next level.. Biologicals 39(2): 100-109.

    • Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR (2011) Gut-tropic T Cells that Express Integrin alpha4beta7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice.. Gastroenterology 141(6): 2109-18.

    • Chopy D, Detje CN, Lafage M, Kalinke U, Lafon M (2011) The type I interferon response bridles rabies virus infection and reduces pathogenicity.. J Neurovirol 17(4): 353-367.

    • Ciesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, Hamdi N, Abdelaziz AI, Strassburg CP, Wedemeyer H, Manns MP, Pietschmann T, von Hahn T (2011) Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles. J Virol 85(15): 7613-7621.

    • Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry.. Hepatology 54(6): 1947-1955.

    • Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry. Hepatology 54(6): 1947-1955.

    • Ciesek S, von Hahn T, Manns MP (2011) Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 15(3): 597-609.

    • Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M (2011) Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15(1): 98-106.

    • Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, Lee H, Arthur CD, White JM, Kalinke U, Murphy KM, Schreiber RD (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors.. J Exp Med 208(10): 1989-2003.

    • Dietze KK, Zelinskyy G, Gibbert K, Schimmer S, Francois S, Myers L, Sparwasser T, Hasenkrug KJ, Dittmer U (2011) Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Nate Acad Sci 108(6): 2420-2425.

    • Doerrbecker J, Friesland M, Ciesek S, Erichsen TJ, Mateu-Gelabert P, Steinmann J, Pietschmann T, Steinmann E (2011) Inactivation and survival of hepatitis C virus on inanimate surfaces. J Infect Dis 204(12): 1830-1838.

    • Dominguez PM, Lopez-Bravo M, Kalinke U, Ardavin C (2011) Statins inhibit iNOSmediated microbicidal potential of activated monocyte-derived dendritic cells by an IFNbeta-dependent mechanism.. Eur J Immunol 41(11): 3330-3339.

    • Eichler HG, Abadie E, Breckenridge A, Flamion B, Gustafsson LL, Leufkens H, Rowland M, Schneider CK, Bloechl-Daum B (2011) Bridging the efficacy-effectiveness gap: a regulator's perspective on addressing variability of drug response.. Nat Rev Drug Discov 10(7): 495-506.

    • Frentzen A, Huging K, Bitzegeio J, Friesland M, Haid S, Gentzsch J, Hoffmann M, Lindemann D, Zimmer G, Zielecki F, Weber F, Steinmann E, Pietschmann T (2011) Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog 7(4): e1002029.

    • Gentzsch J, Hinkelmann B, Kaderali L, Irschik H, Jansen R, Sasse F, Frank R, Pietschmann T (2011) Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res 89(2): 136-148.

    • Gentzsch J, Hinkelmann B, Kaderali L, Irschik H, Jansen R, Sasse F, Frank R, Pietschmann T (2011) Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res 89(2): 136-148.

    • Grabski E, Waibler Z, Schule S, Kloke BP, Sender LY, Panitz S, Cichutek K, Schweizer M, Kalinke U (2011) Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems.. Mol Biotechnol 47(3): 262-269.

    • Gratz MS, Suezer Y, Kremer M, Volz A, Majzoub M, Hanschmann KM, Kalinke U, Schwantes A, Sutter G (2011) N1L is an ectromelia virus virulence factor and essential for in vivo spread upon respiratory infection.. J Virol 85(7): 3557-3569.

    • Hackl D, Loschko J, Sparwasser T, Reindl W, Krug AB (2011) Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs.. Eur J Immunol 41(5): 1334-1343.

    • Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, Muller W, Sparwasser T, Forster R, Pabst O (2011) Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.. Immunity 34(2): 237-246.

    • Iacob R, Rudrich U, Rothe M, Kirsch S, Maasoumy B, Narain N, Verfaillie CM, Sancho-Bru P, Iken M, Popescu I, Schambach A, Manns MP, Bock M (2011) Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors.. Stem Cell Res 6(3): 251-261.

    • Kalinke U, Bechmann I, Detje CN (2011) Host strategies against virus entry via the olfactory system.. Virulence 2(4): 367-370.

    • Kang TW, Yevsa T, Woller N, Hoenicke L, Gereke M, Wuestefeld T, Dauch D, Hohmeyer A, Potapova A, Bruder D, Schirmacher P, Longerich T, Kubicka S, Ott M, Iken M, Luedde T, Rudalska R, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Manns MP, Tacke F (2011) Senescence surveillance of premalignant hepatocytes limits liver cancer development.. Nature 479(7374): 547-551.

    • Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN (2011) Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction.. J Immunol 187(6): 3186-3197.

    • Koenig S, Yuan Q, Krause P, Christiansen H, Rave-Fraenk M, Kafert-Kasting S, Kriegbaum H, Schneider A, Ott M, Meyburg J (2011) Regional transient portal ischemia and irradiation as preparative regimen for hepatocyte transplantation.. Cell Transplant 20(2): 303-311.

    • Lahl K, Sparwasser T (2011) In vivo depletion of Foxp3+ Tregs using the DEREG mouse model. Methods Mol Biol 707 157-172.

    • Lo Re S, Lecocq M, Uwambayinema F, Yakoub Y, Delos M, Demoulin JB, Lucas S, Sparwasser T, Renauld JC, Lison D, Huaux F (2011) PDGF-Producing CD4+ Foxp3+ Regulatory T Lymphocytes Promote Lung Fibrosis.. Am J Respir Crit Care Med 184(11): 1270-1281.

    • Lochner M (2011) Tertiary lymphoid tissues in the colon: friend and foe.. Gut Microbes 2(3): 193-197.

    • Lochner M, Berard M, Sawa S, Hauer S, Gaboriau-Routhiau V, Fernandez TD, Snel J, Bousso P, Cerf-Bensussan N, Eberl G (2011) Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. J Immunol 186(3): 1531-1537.

    • Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G (2011) Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgt and LTi cells. J Exp Med 208(1): 125-134.

    • Lupberger J, Zeisel MB, Xiao F, Thumann C, zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF (2011) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 17(5): 589-595.

    • Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T (2011) CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 41(3): 716-725.

    • McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ (2011) CD4+CD25+regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.. Proc Natl Acad Sci U S A 108(18): 7529-7534.

    • Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari A, Cazareth J, Sparwasser T, Dombrowicz D, Glaichenhaus N, Julia V (2011) The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 4(1): 53-65.

    • Ohnmacht C, Marques R, Presley L, Sawa S, Lochner M, Eberl G (2011) Intestinal microbiota, evolution of the immune system and the bad reputation of proinflammatory immunity.. Cell Microbiol 13(5): 653-659.

    • Olivier A, Sainz-Perez A, Dong H, Sparwasser T, Majlessi L, Leclerc C (2011) The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.. Eur J Immunol 41(8): 2303-2313.

    • Onder L, Scandella E, Chai Q, Firner S, Mayer CT, Sparwasser T, Thiel V, Rülicke T, Burkhard L (2011) Assessing stromal cell antigen presentation in a novel podoplanin: Cre-recombinase BAC-transgenic mouse model.. Front Immunol 2 50.

    • Paulmann D, Steinmann J, Becker B, Bischoff B, Steinmann E (2011) Virucidal activity of different alcohols against murine norovirus, a surrogate of human norovirus. J Hosp Infect 79(4): 378-379.

    • Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik J, DePinho RA, Basta S, Ohashi PS, Mak TW (2011) IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144(4): 601-613.

    • Reiss M, Buttel IC, Schneider CK (2011) Report from the Committee for Advanced Therapies (CAT). Pitfalls on the way from concept to medical treatment with advanced therapy medicinal products.. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54(7): 822-830.

    • Sancho-Bru P, Roelandt P, Narain N, Pauwelyn K, Notelaers T, Shimizu T, Ott M, Verfaillie C (2011) Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells.. J Hepatol 54(1): 98-107.

    • Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, Cua D, Di Santo JP, Eberl G (2011) RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.. Nat Immunol 12(4): 320-326.

    • Schmidt J, Musken M, Becker T, Magnowska Z, Bertinetti D, Moller S, Zimmermann B, Herberg FW, Jansch L, Haussler S (2011) The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling. PLoS One 6(3): e18184.

    • Schulke S, Burggraf M, Waibler Z, Wangorsch A, Wolfheimer S, Kalinke U, Vieths S, Toda M, Scheurer S (2011) A fusion protein of flagellin and ovalbumin suppresses the T(H)2 response and prevents murine intestinal allergy.. J Allergy Clin Immunol 128(6): 1340-1348 e1312.

    • Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T (2011) In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity.. J Allergy Clin Immunol 128(4): 826-833.

    • Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD (2011) Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.. J Immunol 186(12): 6830-6838.

    • Sharma AD, Narain N, Handel EM, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T (2011) MicroRNA-221 regulates FAS-induced fulminant liver failure.. Hepatology 53(5): 1651-1661.

    • Stagg J, Divisekera U, Duret H, Sparwasser T, Teng MW, Darcy PK, Smyth MJ (2011) CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.. Cancer Res 71(8): 2892-2900.

    • Steinmann E, Ciesek S, Friesland M, Erichsen TJ, Pietschmann T (2011) Prolonged Survival of Hepatitis C Virus in the Anesthetic Propofol. Clin Infect Dis 53(9): 963-964.

    • Steinmann J, Kaase M, Gatermann S, Popp W, Steinmann E, Damman M, Paul A, Saner F, Buer J, Path P (2011) Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. Euro Surveill 16(33): pii: 19944.

    • Straub BK, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, Ott M, Schirmacher P, Franke WW (2011) E:N-cadherin heterodimers define a novel kind of adherens junction connecting certain endoderm-derived normal and tumor cells. J Cell Biol 195(5): 873-887.

    • Tacken PJ, Ginter W, Berod L, Cruz LJ, Joosten B, Sparwasser T, Figdor CG, Cambi A (2011) Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. Blood 118(15): 4111-4119.

    • Tse BW, Russell PJ, Lochner M, Forster I, Power CA (2011) IL-18 Inhibits Growth of Murine Orthotopic Prostate Carcinomas via Both Adaptive and Innate Immune Mechanisms.. PLoS One 6(9): e24241.

    • Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hunig T, Serfling E, Bodor J (2011) Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 108(6): 2480-2485.

    • Wei Q, Tarighi S, Dotsch A, Haussler S, Musken M, Wright VJ, Camara M, Williams P, Haenen S, Boerjan B, Bogaerts A, Vierstraete E, Verleyen P, Schoofs L, Willaert R, De Groote VN, Michiels J, Vercammen K, Crabbe A, Cornelis P (2011) Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa. PLoS One 6(12): e29276.

    • Weise M, Bielsky MC, De Smet K, Ehmann F, Ekman N, Narayanan G, Heim HK, Heinonen E, Ho K, Thorpe R, Vleminckx C, Wadhwa M, Schneider CK (2011) Biosimilars-why terminology matters.. Nat Biotechnol 29(8): 690-693.

    • Weiss EM, Schmidt A, Vobis D, Garbi N, Lahl K, Mayer CT, Sparwasser T, Ludwig A, Suri-Payer E, Oberle N, Krammer PH (2011) Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells.. J Immunol 187(4): 1684-1691.

    • Wheeler K, Tardif S, Rival C, Luu B, Bui E, Del Rio R, Teuscher C, Sparwasser T, Hardy D, Tung KS (2011) Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.. Proc Natl Acad Sci U S A 108(18): 7511-7516.

    • Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H, Stockinger B (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.. Nat Immunol 12(11): 1071-1077.

    • Williams SK, Fairless R, Weise J, Kalinke U, Schulz-Schaeffer W, Diem R (2011) Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis.. Am J Pathol 178(6): 2823-2831.

    • Woller N, Knocke S, Mundt B, Gurlevik E, Struver N, Kloos A, Boozari B, Schache P, Manns MP, Malek NP, Sparwasser T, Zender L, Wirth TC, Kubicka S, Kuhnel F (2011) Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.. J Clin Invest 121(7): 2570-2582.

    • Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T (2011) Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells. PLoS Biol 9(7): e1001099.

    • von Hahn T, Schulze A, Chicano Wust I, Heidrich B, Becker T, Steinmann E, Helfritz FA, Rohrmann K, Urban S, Manns MP, Pietschmann T, Ciesek S (2011) The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. PLoS One 6(9): e24142.

    2010

    • Al Moussawi K, Ghigo E, Kalinke U, Alexopoulou L, Mege JL, Desnues B (2010) Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.. PLoS Pathog 6(1): e1000722.

    • Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S (2010) Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 184(2): 939-946.

    • Asgari S, Pournasr B, Salekdeh GH, Ghodsizadeh A, Ott M, Baharvand H (2010) Induced pluripotent stem cells: a new era for hepatology. J Hepatol 53(4): 738-751.

    • Bankwitz D, Steinmann E, Bitzegeio J, Ciesek S, Friesland M, Herrmann E, Zeisel MB, Baumert TF, Keck ZY, Foung SK, Pecheur EI, Pietschmann T (2010) Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84(11): 5751-5763.

    • Baru AM, Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H, Yildirim A, Garn H, Renz H, Behrens G, Sparwasser T (2010) Selective depletion of Foxp3+ regulatory T cells during sensitization phase aggravates experimental allergic airway inflammation. J Immunol 40(8): 2259-2266.

    • Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H (2010) Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One 5(10): e13137.

    • Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB, Herrmann E, Iken M, Ott M, Baumert TF, Pietschmann T (2010) Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog 6 e1000978.

    • Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB, Herrmann E, Iken M, Ott M, Baumert TF, Pietschmann T (2010) Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog 6 e1000978.

    • Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet F, Kissenpfennig A, Sparwasser T*, Malissen B, Fetler L, Amigorenga S (2010) FoxP3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 32(2): 266-278.

    • Buttel IC, Voller K, Schneider CK (2010) Immunogenicity and its Impact on Benefit/Risk Considerations in the Authorisation of Biopharmaceuticals.. Curr Drug Saf 5(4): 287-292.

    • Ciesek S, Friesland M, Steinmann J, Becker B, Wedemeyer H, Manns MP, Pietschmann T, Steinmann E (2010) How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201(12): 1859-1866.

    • Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA, Wappler I, Manns MP, Wedemeyer H, Pietschmann T (2010) Glucocorticosteroids increase cell entry by hepatitis C virus.. Gastroenterology 138(5): 1875-1884.

    • Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA, Wappler I, Manns MP, Wedemeyer H, Pietschmann T (2010) Glucocorticosteroids increase cell entry by hepatitis C virus. Gastroenterology 138(5): 1875-1884.

    • Dotsch A, Klawonn F, Jarek M, Scharfe M, Blocker H, Haeussler S (2010) Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. BMC Genomics 11 234.

    • Engel D, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle P, Kalff J, Kurts C (2010) Th1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 16(12): 1407-1713.

    • Frenz T, Waibler Z, Hofmann J, Hamdorf M, Lantermann M, Reizis B, Tovey MG, Aichele P, Sutter G, Kalinke U (2010) Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. Eur J Immunol 40(10): 2769-2777.

    • Goetz KB, Pfleiderer M, Schneider CK (2010) First-in-human clinical trials with vaccines-what regulators want.. Nat Biotechnol 28(9): 910-916.

    • Goossens P, Gijbels MJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJ, Kalinke U, Weber C, Lutgens E, de Winther MP (2010) Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12(2): 142-153.

    • Haeussler S (2010) Multicellular signalling and growth of Pseudomonas aeruginosa. Int J Med Microbiol 300(8): 544-548.

    • Haeussler S, Parsek MR (2010) Biofilms 2009: new perspectives at the heart of surface-associated microbial communities. J Bacteriol 192(12): 2941-2949.

    • Hahn T, Steinmann E, Ciesek S, Pietschmann T (2010) Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches. Expert Rev Gastroenterol Hepatol 4(1): 63-79.

    • Haid S, Windisch MP, Bartenschlager R, Pietschmann T (2010) Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line. J Virol 84(2): 964-975.

    • Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, Labastida FD, Sparwasser T, Hill GR, Engwerda CR (2010) CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PloS Pathogens 6(12): e1001221.

    • Hettwer M, Reis-Fernandes MA, Iken M, Ott M, Steinberg P, Nau H (2010) Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.. Reprod Toxicol 30(1): 113-120.

    • Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S (2010) Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2/P2X7 pathway.. JEM 207(12): 2561-2568.

    • Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M (2010) Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II.. J Allergy Clin Immunol 125(1): 175-183, e171-111.

    • Kern M, Popov A, Scholz K, Schumak B, Dandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA (2010) Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.. Gastroenterology 138(1): 336-46.

    • Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T (2010) Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Research 70(20): 7788-7799.

    • Kochs G, Bauer S, Vogt C, Frenz T, Tschopp J, Kalinke U, Waibler Z (2010) Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells.. J Virol 84(23): 12344-12350.

    • Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Rooijen NVan, Kalinke U, Ludewig B, Hengartner H, Harris N, Häussinger D, Ohashi PS, Zinkernagel RM, Lang KS (2010) Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.. Hepatology 51(1): 25-32.

    • Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS, Tellinghuisen TL, Symons J, Furman PA (2010) Development of novel therapies for hepatitis C. Antiviral Res 86(1): 79-92.

    • Malinarich FH, Grabski E, Worbs T, Chennupati V, Haas JD, Schmitz S, Candia E, Quera R, Malissen B, Forster R, Hermoso M, Prinz I (2010) Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial gammadelta T cells is functional in vivo. Eur J Immunol 40(12): 3378-88.

    • Montserret R, Saint N, Vanbelle C, Salvay AG, Simorre JP, Ebel C, Sapay N, Renisio JG, Bockmann A, Steinmann E, Pietschmann T, Dubuisson J, Chipot C, Penin F (2010) NMR structure and ion channel activity of the p7 protein from hepatitis C virus. Biol Chem 285(41): 31446-31461.

    • Muesken M, Di Fiore S, Dotsch A, Fischer R, Haussler S (2010) Genetic determinants of Pseudomonas aeruginosa biofilm establishment. Microbiology 156(Pt 2): 431-441.

    • Muesken M, Di Fiore S, Romling U, Haussler S (2010) A 96-well-plate-based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing. Nat Protoc 5(8): 1460-1469.

    • Murikinati S, Juttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M (2010) Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.. FASEB J 24(3): 788-798.

    • Pechloff K, Holch J, Ferch U, Schweneker M, Kremer M, Sparwasser T, Quintanilla-Martinez L, Gewies A, Peschel C, Ruland J (2010) The fusion kinase ITK-SYK mimics a T-cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T-cell lymphoma. J Exp Med 207(5): 1031-1044.

    • Pommerenke C, Muesken M, Becker T, Dotsch A, Klawonn F, Haeussler S (2010) Global genotype-phenotype correlations in Pseudomonas aeruginosa. PLoS Pathog 6(8): e1001074.

    • Prinz M, Kalinke U (2010) New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.. Trends Mol Med 16(8): 379-386.

    • Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G (2010) Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science 330(6004): 665-669.

    • Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T*, Probst HC*, van den Broek M* (2010) FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T cell tolerance induced by steady state dendritic cells. Proc Nate Acad Sci 107(1): 199-203.

    • Schneider CK, Salmikangas P, Jilma B, Flamion B, Todorova LR, Paphitou A, Haunerova I, Maimets T, Trouvin JH, Flory E, Tsiftsoglou A, Sarkadi B, Gudmundsson K, O'Donovan M, Migliaccio G, Ancans J, Maciulaitis R, Robert JL, Samuel A, Ovelgonne JH, Hystad M, Fal AM, Lima BS, Moraru AS, Turcani P, Zorec R, Ruiz S, Akerblom L, Narayanan G, Kent A, Bignami F, Dickson JG, Niederwieser D, Figuerola-Santos MA, Reischl IG, Beuneu C, Georgiev R, Vassiliou M, Pychova A, Clausen M, Methuen T, Lucas S, Schussler-Lenz M, Kokkas V, Buzas Z, MacAleenan N, Galli MC, Line A, Gulbinovic J, Berchem G, Fraczek M, Menezes-Ferreira M, Vilceanu N, Hrubisko M, Marinko P, Timon M, Cheng W, Crosbie GA, Meade N, di Paola ML, VandenDriessche T, Ljungman P, D'Apote L, Oliver-Diaz O, Buttel I, Celis P (2010) Challenges with advanced therapy medicinal products and how to meet them.. Nat Rev Drug Discov 9(3): 195-201 Review.

    • Schussler-Lenz M, Schneider CK (2010) Clinical trials with advanced therapy medicinal products.. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53(1): 68-74 Review.

    • Sender LY, Gibbert K, Suezer Y, Radeke HH, Kalinke U, Waibler Z (2010) CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals.. Mol Immunol 47(6): 1255-1261.

    • Stange MA, Tutarel O, Pischke S, Schneider A, Strassburg CP, Becker T, Barg-Hock H, Basturk M, Wursthorn K, Cornberg M, Ott M, Greten TF, Manns MP, Wedemeyer H (2010) Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab. Z Gastroenterol 48(2): 258-263.

    • Stegmann KA, Bjorkstrom NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V., Fytili P., Cornberg M., Manns MP., Geffers R., Pietschmann T., Guzman CA., Ljunggren HG., Wedemeyer H. (2010) Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 138(5): 1885-1897.

    • Steinmann E, Pietschmann T (2010) Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses 2(9): 2078-2095 (Review).

    • Steinmann J, Becker B, Bischoff B, Paulmann D, Friesland M, Pietschmann T, Steinmann E (2010) Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization. Am J Infect Control 38(1): 66-68.

    • Suttner K, Depner M, Klopp N, von Mutius E, Illig T, Sparwasser T, Kabesch M (2010) Genetic variants harbouring the FOXP3 locus increase hay fever risk. J Allergy Clin Immunol 125(6): 1395-1399.

    • Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, Smyth MJ (2010) Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth.. Cancer Research 70(20): 7800-7809.

    2009

    • Aly S, Mages J, Reiling N, Kalinke U, Decker T, Lang R, Ehlers S (2009) Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13(8B): 2069-2082.

    • Anz D, Thaler R, Stephan N, Waibler Z, Trauscheid MZ, Scholz C, Kalinke U, Barchet W, Endres S, Bourquin C (2009) Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10): 6044-6050.

    • Bach P, Tschape JA, Kopietz F, Braun G, Baade JK, Wiederhold KH, Staufenbiel M, Prinz M, Deller T, Kalinke U, Buchholz CJ, Muller UC (2009) Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice. J Immunol 182(12): 7613-7624.

    • Bohn YS, Brandes G, Rakhimova E, Horatzek S, Salunkhe P, Munder A, van Barneveld A, Jordan D, Bredenbruch F, Haussler S, Riedel K, Eberl L, Jensen PO, Bjarnsholt T, Moser C, Hoiby N, Tummler B, Wiehlmann L (2009) Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection. Mol Microbiol 71(3): 730-747.

    • Brohm C, Steinmann E, Friesland M, Lorenz IC, Patel A, Penin F, Bartenschlager R, Pietschmann T (2009) Characterization of determinants important for hepatitis C virus p7 function in morphogenesis using trans-complementation. J Virol 83(22): 11682-11693.

    • Cervantes-Barragan L, Kalinke U, Zust R, Konig M, Reizis B, Lopez-Macias C, Thiel V, Ludewig B (2009) Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2): 1099-1106.

    • Ciesek S, Steinmann E, Wedemeyer H, Manns MP, Neyts J, Tautz N, Madan V, Bartenschlager R, von Hahn T, Pietschmann T (2009) Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology 50(5): 1638-1645.

    • Cucak H, Yrlid U, Reizis B, Kalinke U, Johansson-Lindbom B (2009) Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3): 491-501.

    • Dauber B, Martinez-Sobrido L, Schneider J, Hai R, Waibler Z, Kalinke U, Garcia-Sastre A, Wolff T (2009) Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR. PLoS Pathog 5(6): e1000473.

    • Detje CN, Meyer T, Schmidt H, Kreuz D, Rose JK, Bechmann I, Prinz M, Kalinke U (2009) Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol 182(4): 2297-2304.

    • Dotsch A, Becker T, Pommerenke C, Magnowska Z, Jansch L, Haeussler S (2009) Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 53(6): 2522-2531.

    • Dotsch A, Pommerenke C, Bredenbruch F, Geffers R, Haussler S (2009) Evaluation of a microarray-hybridization based method applicable for discovery of single nucleotide polymorphisms (SNPs) in the Pseudomonas aeruginosa genome. BMC Genomics 10 29.

    • Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A (2009) IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 458(7240): 904-908.

    • Haddad A, Jensen V, Becker T, Haeussler S (2009) The Pho regulon influences biofilm formation and type three secretion in Pseudomonas aeruginosA. Environmental Microbiology reports 1(6): 488-494.

    • Haid S, Pietschmann T, Pecheur EI (2009) Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition, and density of virus particles. Pecheur EI Haid S 284(26): 17657-17667.

    • Hamm S, Latz E, Hangel D, Mueller T, Yu P, Golenbock D, Sparwasser T, Wagner H, Bauer S (2009) Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215(7): 559-569.

    • Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Norder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M (2009) Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.. Am J Pathol 175(4): 1483-1492.

    • Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M (2009) A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4): 295-308.

    • Jahn EM, Schneider CK (2009) How to systematically evaluate immunogenicity of therapeutic proteins - regulatory considerations. N Biotechnol 25(5): 280-286.

    • Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, Deroos P, Rudensky A, Sparwasser T (2009) Cutting Edge: Depletion of Foxp3+ Cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 183(12): 7631-7634.

    • Lahl K, Mayer C, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T (2009) Nonfunctional regulatory T cells and defective control of Th2 Cytokine production in natural scurfy mutant mice. J Immunol 183(9): 5662-5672.

    • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P (2009) Humanized mice for modeling human infectious disease: challenges, progress, and outlook.. Cell Host Microbe 6(1): 5-9. Review.

    • Meyburg J, Das AM, Hoerster F, Lindner M, Kriegbaum H, Engelmann G, Schmidt J, Ott M, Pettenazzo A, Luecke T, Bertram H, Hoffmann GF, Burlina A (2009) One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects.. Transplantation 87(5): 636-641.

    • Moya B, Dotsch A, Juan C, Blazquez J, Zamorano L, Haussler S, Oliver A (2009) Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog 5(3): e1000353.

    • Paran N, Suezer Y, Lustig S, Israely T, Schwantes A, Melamed S, Katz L, Preuss T, Hanschmann KM, Kalinke U, Erez N, Levin R, Velan B, Lower J, Shafferman A, Sutter G (2009) Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox. J Infect Dis 199(1): 39-48.

    • Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW (2009) Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 15(5): 528-536.

    • Pietschmann T (2009) Full-length infectious HCV chimeras. Methods Mol Biol 510 347-359.

    • Pietschmann T (2009) Regulation of hepatitis C virus replication by microRNAs. J Hepatol 50(50(3)): 441-444.

    • Pietschmann T (2009) Virology: Final entry key for hepatitis C. Nature 457(7231): 797-798.

    • Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R (2009) Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog 5(6): e1000475.

    • Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, von Gabain A, Stoiber D, Sexl V, Kolbe T, Rulicke T, Muller M, Decker T, Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, von Gabain A, Stoiber D, Sexl V, Kolbe T, Rulicke T, Muller M, Decker T (2009) Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4): 2286-2293.

    • Rausch S, Huehn J, Loddenkemper C, Hepworth MR, Klotz C, Sparwasser T, Hamann A, Lucius R, Hartmann S (2009) Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) Cells. Eur J Immunol 39(11): 3066-3077.

    • Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH (2009) Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol 182(7): 4183-4191.

    • Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M (2009) Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?. Gut 58(4): 594-603.

    • Schneider CK, Papaluca M, Kurki P (2009) A European perspective on immunogenicity evaluation. Nat Biotechnol 27(6): 507-508.

    • Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg MA, Fejer G, Buttner M, Koehler G, Kirschning CJ, Sparwasser T, Alber G (2009) Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 83(18): 9411-9422.

    • Singh S, Stephani J, Schaefer M, Kalay H, Garcia-Vallejo JJ, den Haan J, Saeland E, Sparwasser T, van Kooyk Y (2009) Targeting glycan modified OVA to murine DC-SIGN-transgenic dendritic cells enhances MHC class I and II presentation. Molecular Immunol 47(2-3): 164-174.

    • Steeg C, Adler G, Sparwasser T, Fleischer B, Jacobs T (2009) Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria. J Immunol 183(11): 7014-7022.

    • Stockinger S, Kastner R, Kernbauer E, Pilz A, Westermayer S, Reutterer B, Soulat D, Stengl G, Vogl C, Frenz T, Waibler Z, Taniguchi T, Rulicke T, Kalinke U, Muller M, Decker T (2009) Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog 5(3): e1000355.

    • Waibler Z, Anzaghe M, Frenz T, Schwantes A, Pohlmann C, Ludwig H, Palomo-Otero M, Alcami A, Sutter G, Kalinke U (2009) Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components. J Virol 83(4): 1563-1571.

    • Witteveldt J, Evans MJ, Bitzegeio J, Koutsoudakis G, Owsianka AM, Angus AG, Keck ZY, Foung SK, Pietschmann T, Rice CM, Patel AH (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. J Gen Virol 90(Pt 1): 48-58.

    • Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haeussler S, Blankenfeldt W (2009) Structure Elucidation and Preliminary Assessment of Hydrolase Activity of PqsE, the Pseudomonas Quinolone Signal (PQS) Response Protein. Biochemistry 48(43): 10298-10307.

    • Zelinskyy G, Dietze K, Huesecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U (2009) The regulatory T cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T cell response. Blood 114(15): 3199-3207.

    • Zelinskyy G, Dietze K, Sparwasser T, Dittmer U (2009) Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PloS Pathogens 5(8): e1000406.

    • von Allmen CE, Schmitz N, Bauer M, Hinton HJ, Kurrer M, Buser RB, Gwerder M, Muntwiler S, Sparwasser T, Beerli RR, Bachmann MF (2009) Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Nate Acad Sci 106(28): 11673-11678.

    2008

    • Balke B, Schmoldt S, Haussler S, Suerbaum S, Heesemann J, Hogardt M (2008) A German external quality survey of diagnostic microbiology of respiratory tract infections in patients with cystic fibrosis. J Cyst Fibros 7(1): 7-14.

    • Cantz T, Manns MP, Ott M (2008) Stem cells in liver regeneration and therapy. Cell Tissue Res 331(1): 271-282 Review.

    • Ciesek S, Steinmann E, Manns MP, Wedemeyer H, Pietschmann T (2008) The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis 198(7): 1091-1093.

    • Dietrich CF, Ignee A, Braden B, Barreiros AP, Ott M, Hocke M (2008) Improved differentiation of pancreatic tumors using contrast-enhanced endoscopic ultrasound. Clin Gastroenterol Hepatol 6(5): 590-597 e1.

    • Haridass D, Narain N, Ott M (2008) Hepatocyte transplantation: waiting for stem cells. Curr Opin Organ Transplant 13(6): 627-632 Review.

    • Haussler S, Becker T (2008) The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations. PLoS Pathog 4(9): e1000166.

    • Heit A, Gebhardt F, Lahl K, Neuenhahn M, Schmitz F, Anderl F, Wagner H, Sparwasser T*, Busch DH, Kastenmuller K* (2008) Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38(6): 1585-1597.

    • Jirasko V, Montserret R, Appel N, Janvier A, Eustachi L, Brohm C, Steinmann E, Pietschmann T, Penin F, Bartenschlager R (2008) Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem 283(42): 28546-28562.

    • Kwon HS, Ott M (2008) The ups and downs of SIRT1. Trends Biochem Sci 33(11): 517-525 Review.

    • Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J (2008) TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28(5): 651-661.

    • Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis E, Sousa C (2008) DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 38(12): 3274-3281.

    • Ott M (2008) A symphony of techniques for liver cell therapy, only applicable to rats?. J Hepatol 49(1): 6-8.

    • Pietschmann T, Steinmann E, Ciesek S (2008) Hepatitis C virus cell culture models--new perspectives for research and clinic. Dtsch Med Wochenschr 133(30): 1580-1584.

    • Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tuting T, Hartmann G (2008) 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11): 1256-1263.

    • Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U (2008) Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5): 675-686.

    • Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim AO, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T (2008) Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol 180(10): 6836-6845.

    • Schneider CK, Kalinke U (2008) Toward biosimilar monoclonal antibodies. Nat Biotechnol 26(9): 985-990 Review.

    • Schraven B, Kalinke U (2008) CD28 superagonists: what makes the difference in humans?. Immunity 28(5): 591-595.

    • Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M (2008) Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplant 17(3): 313-323.

    • Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T (2008) Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol 82(14): 7034-7046.

    • Waibler Z, Anzaghe M, Konur A, Akira S, Muller W, Kalinke U (2008) Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC. Eur J Immunol 38(11): 3127-3137.

    • Waibler Z, Sender LY, Kamp C, Muller-Berghaus J, Liedert B, Schneider CK, Lower J, Kalinke U (2008) Toward experimental assessment of receptor occupancy: TGN1412 revisited. J Allergy Clin Immunol 122(5): 890-892.

    • Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B (2008) Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies. PLoS One 3(3): e1708.

    2007

    • Bach P, Kamphuis E, Odermatt B, Sutter G, Buchholz CJ, Kalinke U (2007) Vesicular stomatitis virus glycoprotein displaying retrovirus-like particles induce a type I IFN receptor-dependent switch to neutralizing IgG antibodies. J Immunol 178(9): 5839-5847.

    • Blakqori G, Delhaye S, Habjan M, Blair CD, Sanchez-Vargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F (2007) La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol 81(10): 4991-4999.

    • Demirel O, Waibler Z, Kalinke U, Grunebach F, Appel S, Brossart P, Hasilik A, Tampe R, Abele R (2007) Identification of a lysosomal peptide transport system induced during dendritic cell development. J Biol Chem 282(52): 37836-37843.

    • Koerner I, Kochs G, Kalinke U, Weiss S, Staeheli P (2007) Protective role of beta interferon in host defense against influenza A virus. J Virol 81(4): 2025-2030.

    • Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J, Sparwasser T (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204(1): 57-63.

    • Liedert B, Bassus S, Schneider CK, Kalinke U, Lower J (2007) Safety of phase I clinical trials with monoclonal antibodies in Germany--the regulatory requirements viewed in the aftermath of the TGN1412 disaster. Int J Clin Pharmacol Ther 45(1): 1-9.

    • Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M (2007) Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem 282(7): 4669-4680.

    • Schleicher U, Liese J, Knippertz I, Kurzmann C, Hesse A, Heit A, Fischer JA, Weiss S, Kalinke U, Kunz S, Bogdan C (2007) NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4): 893-906.

    • Schneider CK, Kalinke U (2007) After the TGN1412 incident. Principles for assessment of first-in-man trials with monoclonal antibodies by the Paul Ehrlich Institute. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50(10): 1213-1220.

    • Sparwasser T, Eberl G (2007) BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells. Immunology 121(3): 308-313.

    • Waibler Z, Anzaghe M, Ludwig H, Akira S, Weiss S, Sutter G, Kalinke U (2007) Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses. J Virol 81(22): 12102-12110.

    • Waibler Z, Detje CN, Bell JC, Kalinke U (2007) Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells. Immunobiology 212(9-10): 887-894.

    • Waibler Z, Kalinke U, Will J, Juan MH, Pfeilschifter JM, Radeke HH (2007) TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol Immunol 44(7): 1483-1489.

    2006

    • Aichele P, Unsoeld H, Koschella M, Schweier O, Kalinke U, Vucikuja S (2006) CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J Immunol 176(8): 4525-4529.

    • Buchholz CJ, Bach P, Nikles D, Kalinke U (2006) Prion protein-specific antibodies for therapeutic intervention of transmissible spongiform encephalopathies. Expert Opin Biol Ther 6(3): 293-300.

    • Gerlach N, Schimmer S, Weiss S, Kalinke U, Dittmer U (2006) Effects of type I interferons on Friend retrovirus infection. J Virol 80(7): 3438-3444.

    • Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442(7103): 651-656.

    • Hinz T, Buchholz CJ, van der Stappen T, Cichutek K, Kalinke U (2006) Manufacturing and quality control of cell-based tumor vaccines: a scientific and a regulatory perspective. J Immunother 29(5): 472-476.

    • Kalinke U, Bach P, Konig M, Buchholz CJ (2006) Vaccination against prion diseases. Discov Med 6(31): 29-34.

    • Kamphuis E, Junt T, Waibler Z, Forster R, Kalinke U (2006) Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10): 3253-3261.

    • Klemm S, Gutermuth J, Hultner L, Sparwasser T, Behrendt H, Peschel C, Mak TW, Jakob T, Ruland J (2006) The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.. J Exp Med 203(2): 337-347.

    • Le Bon A, Durand V, Kamphuis E, Thompson C, Bulfone-Paus S, Rossmann C, Kalinke U, Tough DF (2006) Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J Immunol 176(8): 4682-4689.

    • Le Bon A, Thompson C, Kamphuis E, Durand V, Rossmann C, Kalinke U, Tough DF (2006) Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4): 2074-2078.

    • Ludwig H, Suezer Y, Waibler Z, Kalinke U, Schnierle BS, Sutter G (2006) Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara. J Gen Virol 87(Pt 5): 1145-1155.

    • Schneider CK, Kalinke U, Lower J (2006) TGN1412--a regulator's perspective. Nat Biotechnol 24(5): 493-496.

    • Schule S, Steidl S, Panitz S, Coulibaly C, Kalinke U, Cichutek K, Schweizer M (2006) Selective gene transfer to T lymphocytes using coreceptor-specific MLV(HIV) pseudotype vectors in a transgenic mouse model. Virology 351(1): 237-247.

    • Staib C, Suezer Y, Kisling S, Kalinke U, Sutter G (2006) Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara. J Gen Virol 87(Pt 10): 2917-2921.

    • von Meyenn F, Schaefer M, Weighardt H, Bauer S, Kirschning CJ, Wagner H, Sparwasser T (2006) Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211(6-8): 557-565.

    2005

    • Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B (2005) Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35): 30797-30806.

    • Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ (2005) Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. J Virol 79(7): 4033-4042.

    • Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Muller M (2005) Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6): 4000-4008.

    2004

    • Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004) A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation. Gene 338(2): 197-207.

    • Sparwasser T, Gong S, Li JY, Eberl G (2004) General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis 38(1): 39-50.

    2003

    • Hangartner L, Senn BM, Ledermann B, Kalinke U, Seiler P, Bucher E, Zellweger RM, Fink K, Odermatt B, Burki K, Zinkernagel RM, Hengartner H (2003) Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.. Proc Natl Acad Sci U S A 100(22): 12883-12888.

    • Senn BM, Lopez-Macias C, Kalinke U, Lamarre A, Isibasi A, Zinkernagel RM, Hengartner H (2003) Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.. Eur J Immunol 33(4): 950-961.

    2002

    • Barchet W, Cella M, Odermatt B, Asselin-Paturel C, Colonna M, Kalinke U (2002) Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.. J Exp Med 195(4): 507-516.

    • Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17(2): 211-220.

    • Scheu S, Alferink J, Potzel T, Barchet W, Kalinke U, Pfeffer K (2002) Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.. J Exp Med 195(12): 1613-1624.

    2001

    • Baribaud F, Pohlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW (2001) Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol 75(21): 10281-10289.

    • Heppner FL, Arrighi I, Kalinke U, Aguzzi A (2001) Immunity against prions?. Trends Mol Med 7(11): 477-479.

    • Heppner FL, Musahl C, Arrighi I, Klein MA, Rulicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A (2001) Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294(5540): 178-182.

    • Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A (2001) Complement facilitates early prion pathogenesis. Nat Med 7(4): 488-492.

    • Zinkernagel RM, LaMarre A, Ciurea A, Hunziker L, Ochsenbein AF, McCoy KD, Fehr T, Bachmann MF, Kalinke U, Hengartner H (2001) Neutralizing antiviral antibody responses. Adv Immunol (79): 1-53.

    2000

    • Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H, Peschel C (2000) Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 95(3): 999-1006.

    • Kalinke U, Oxenius A, Lopez-Macias C, Zinkernagel RM, Hengartner H (2000) Virus neutralization by germ-line vs. hypermutated antibodies. Proc Natl Acad Sci U S A 97(18): 10126-10131.

    • Karrer U, Lopez-Macias C, Oxenius A, Odermatt B, Bachmann MF, Kalinke U, Bluethmann H, Hengartner H, Zinkernagel RM (2000) Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice. J Immunol 164(2): 768-778.

    • Lipford GB, Sparwasser T (2000) Hematopoietic remodeling triggered by CpG DNA. Curr Top Microbiol Immunol 247 119-129 Review.

    • Lipford GB, Sparwasser T, Zimmermann S, Heeg K, Wagner H (2000) CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J Immunol 165(3): 1228-1235.

    • Seiler P, Senn BM, Klenerman P, Kalinke U, Hengartner H, Zinkernagel RM (2000) Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence. J Virol 74(13): 5896-5901.

    • Sparwasser T, Lipford GB (2000) Consequences of bacterial CpG DNA-driven activation of antigen-presenting cells. Curr Top Microbiol Immunol 247 59-75 Review.

    • Sparwasser T, Vabulas RM, Villmow B, Lipford GB, Wagner H (2000) Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Curr Top Microbiol Immunol 30(12): 3591-3597.

    1999

    • Lopez-Macias C, Kalinke U, Cascalho M, Wabl M, Hengartner H, Zinkernagel RM, Lamarre A (1999) Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses. J Exp Med 189(11): 1791-1798.

    • Seiler P, Senn BM, Brundler MA, Zinkernagel RM, Hengartner H, Kalinke U (1999) In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody. J Immunol 162(8): 4536-4541.

    • Sparwasser T, Hultner L, Koch ES, Luz A, Lipford GB, Wagner H (1999) Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J Immunol 162(4): 2368-74.

    1998

    • Funk GA, Barbour AD, Hengartner H, Kalinke U (1998) Mathematical model of a virus-neutralizing immunglobulin response. J Theor Biol 195(1): 41-52.

    • Hacker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo J 17(21): 6230-6240.

    • Heeg K, Sparwasser T, Lipford GB, Hacker H, Zimmermann S, Wagner H (1998) Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 17(7): 464-469.

    • Seiler P, Kalinke U, Rulicke T, Bucher EM, Bose C, Zinkernagel RM, Hengartner H (1998) Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. J Virol 72(3): 2253-2258.

    • Sparwasser T, Koch ES, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, Wagner H (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28(6): 2045-2054.

    1997

    • Bachmann MF, Kalinke U, Althage A, Freer G, Burkhart C, Hoost H, Aguet M, Hengartner H, Zinkernagel RM (1997) The role of antibody concentration and avidity in antiviral protection. Science 276(5321): 2024-2027.

    • Fehr T, Bachmann MF, Bucher E, Kalinke U, Di Padova FE, Lang AB, Hengartner H, Zinkernagel RM (1997) Role of repetitive antigen patterns for induction of antibodies against antibodies. J Exp Med 185(10): 1785-1792.

    • Hammami-Hauasli N, Kalinke DU, Schumann H, Kalinke U, Pontz BF, Anton-Lamprecht I, Pulkkinen L, Zimmermann M, Uitto J, Bruckner-Tuderman L (1997) A combination of a common splice site mutation and a frameshift mutation in the COL7A1 gene: absence of functional collagen VII in keratinocytes and skin. J Invest Dermatol 109(3): 384-389.

    • Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390(6661): 687-690.

    • Lipford GB, Sparwasser T, Bauer M, Zimmermann S, Koch ES, Heeg K, Wagner H (1997) Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 27(12): 3420-3426.

    • Sparwasser T, Miethke T, Lipford G, Borschert K, Hacker H, Heeg K, Wagner H (1997) Bacterial DNA causes septic shock. Nature 386(6623): 336-337.

    • Sparwasser T, Miethke T, Lipford GB, Erdmann A, Hacker H, Heeg K, Wagner H (1997) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27(7): 1671-1679.

    1996

    • Battegay M, Fiedler P, Kalinke U, Brombacher F, Zinkernagel RM, Peter HH, Kohler G, Eibel H (1996) Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mic. Eur J Immuno 26(1): 250-258.

    • Kalinke U, Bucher EM, Ernst B, Oxenius A, Roost HP, Geley S, Kofler R, Zinkernagel RM, Hengartner H (1996) The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis viru. Immunity 5(6): 639-652.

    • Kalinke U, Krebber A, Krebber C, Bucher E, Pluckthun A, Zinkernagel RM, Hengartner H (1996) Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection. Eur J Immuno 26(12): 2801-2806.

    1995

    • Gilfillan S, Bachmann M, Trembleau S, Adorini L, Kalinke U, Zinkernagel R, Benoist C, Mathis D (1995) Efficient immune responses in mice lacking N-region diversity. Eur J Immunol 25(11): 3115-3122.

    • Roost HP, Bachmann MF, Haag A, Kalinke U, Pliska V, Hengartner H, Zinkernagel RM (1995) Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity. Proc Natl Acad Sci 92(5): 1257-1261.

    1994

    • Kalinke DU, Kalinke U, Winberg JO, Konig A, Lauharanta J, Christiano AM, Uitto J, Bruckner-Tuderman L (1994) Collagen VII in severe recessive dystrophic epidermolysis bullosa: expression of mRNA but lack of intact protein product in skin and cutaneous cells in vitro. J Invest Dermatol 102(2): 260-262.

    1991

    • Schonrich G, Kalinke U, Momburg F, Malissen M, Schmitt-Verhulst AM, Malissen B, Hammerling GJ, Arnold B (1991) Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductio. Cell 65(2): 293-304.

    1990

    • Kalinke U, Arnold B, Hammerling GJ (1990) Strong xenogeneic HLA response in transgenic mice after introducing an alpha 3 domain into HLA B27. Nature 348(6302): 642-644.