Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026The Lancet. Infectious Diseases : S1473-3099(26)00407-X
Pseudovirus-based analysis of host cell entry and vaccine-induced neutralisation of Bundibugyo virus
Hoffmann M, Shandheep A, Pavlou A, Rahmel-Stein K, Ly M, Chen N, Moor N, Moldenhauer A, Drosten C, Kalinke U, Addo M, Pöhlmann S
2026Journal of Translational Medicine : 10.1186/s12967-026-08651-8
Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia
Pashai Fakhri M, Börner F, Held J, Sivaraman K, Fuge J, Rupp J, Barten-Neiner G, Pletz M, Witzenrath M, Rohde G, Rademacher J, Hinze C, Janciauskiene S, CAPNETZ Study Group
2026Plos Pathogens22 (7) : e1014355
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
Ruijten S, Dos Santos J, Rios-Vazquez V, Navas A, Maas H, Groenendijk A, Blaauw M, van Eekeren L, Vos W, Knoll R, Kumar Gupta M, Ter Horst R, Botey-Bataller J, van Unen N, Li Y, Aschenbrenner A, Schultze J, Xu C, Netea M, van der Ven A, Matzaraki V
Kalinke Lab
Immunology
Regulation of acute hepatitis
The project investigates immune reactions in viral hepatitis, in particular the role of hepatocytes and myeloid cells. The aim is to understand immune processes in the liver and to develop diagnostic approaches for the clinic.
Pietschmann Lab
Virology
Antiviral agents against HCV, RSV and coronavirus
We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.
Lauber Lab
Virology
Pandemic preparedness: assessing spill-over risk of RNA viruses
The CoViPa consortium uses computer-assisted high-throughput virus discovery and evolutionary analyses to identify RNA viruses with high spillover risk and potential animal host reservoirs and to investigate new pathogenicity factors.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Science and Society
Science and Society
Ralf Meister, Bishop of the Evangelical-Lutheran Church of Hanover
“Participation and Resilience at the Interface between Science and Society”
Symposium
TWINCORE & CiiM Symposium 2026
Pathways to Infection Resilience
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
