New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Controlled Release : Official Journal of the Controlled Release Society : 115509
Overcoming technological and biological barriers to pulmonary mRNA delivery with lipid-polymer hybrid nanoparticles
Biesel A, Shandheep A, Pavlou A, Busker L, Koch M, Kopliku V, Maisel K, Boese A, Skerra J, Schröder L, Neubert L, Schneider-Daum N, Loretz B, Kalinke U, Lehr C
2026European Journal of Immunology56 (10) : e70306
Tolerogenic Programming Promotes Human Cytomegalovirus Permissiveness in Dendritic Cells
Rahmel-Stein K, Becker J, Lange B, Krajewski L, Eiz-Vesper B, Kalinke U
2026Journal of Market Access & Health Policy14 (4) : 61
Improving Patient Access to New Treatment Modalities in European Cancer Care
Schneider C, Morjaria H, Wissink S, Deroose C, Galvao V, Grünwald V, Kiß O, Symeonides S
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Bartsch Lab
Immunology
Protective anti-viral immunity – learning from natural examples
In this project, antibodies that help to ward off infections are being investigated in more detail. The aim is to find characteristics that have a protective effect against certain pathogens by comparing different antibody profiles in infections and vaccinations.
Pietschmann Lab
Virology
Determinants of protective immunity in HCV: A gold standard for vaccine development
We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.
Kalinke Lab
Bartsch Lab
Behrendt Lab
Pietschmann Lab
Immunology
Platform for the rapid development of new pathogen-directed humanized or fully human monoclonal antibody candidates (MEMUMAB)
Monoclonal antibodies are transforming modern medicine. At Helmholtz Infection Medicine at MHH, bringing together TWINCORE and CiiM, advanced technologies and AI drive the development of next-generation human antibodies against major infectious diseases.
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Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
