New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Proceedings of the National Academy of Sciences of the United States of America123 (40) : e2615985123
Dynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa
Frommeyer Y, Sun J, Wu J, Kennepohl B, Witte J, Gomez N, Battermann J, Becker L, Cetraro P, Verstraten R, Tomasch J, Pich A, Depledge D, Dedon P, Häussler S
2026Respiratory Research27 (1) : 374
The Tie-2 agonist PMC-403 inhibits endothelial damage induced by e-cigarette vapor or LPS
Pape T, Pak O, Graalmann T, Ehlers C, Deutscher J, Spiegelberg D, Horn P, Stahl K, Hoeper M, David S, Sommer N, Seeliger B
2026Journal of Virology : e0111726
Arp2/3 complex-dependent actin remodeling is required for efficient RSV uncoating in A549 cells
Xie E, Schubert M, Reeb J, Seligmann B, Schaks M, Müsken M, Steffen A, Stradal T, Haid S, Rottner K, Sieben C
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Kalinke Lab
Immunology
Towards the development of novel cell therapy options for MSMD patients
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Seminar
TWINCORE Seminar - Systems Immunology
Dr. Verónica Durán
Stanford University School of Medicine, Stanford
"Age-dependent immune landscape in dengue infection and disease progression"
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Prof. Shirit Einav
Stanford University School of Medicine, Stanford
"Targeting an understudied lipid kinase to restore lysosomal function in viral infection and neurodegeneration"
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
