New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Mbio : e0155126
Role of O-specific antigen expression in Pseudomonas aeruginosa pathogenicity
Hartmann O, Preusse M, Heroven A, Felgner S, Gür M, Kordes A, Wolff Bengtsen V, Roghanian M, Zhao X, Müsken M, Gomez N, Häussler S
2026Proceedings of the National Academy of Sciences of the United States of America123 (40) : e2615985123
Dynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa
Frommeyer Y, Sun J, Wu J, Kennepohl B, Witte J, Gomez N, Battermann J, Becker L, Cetraro P, Verstraten R, Tomasch J, Pich A, Depledge D, Dedon P, Häussler S
2026Respiratory Research27 (1) : 374
The Tie-2 agonist PMC-403 inhibits endothelial damage induced by e-cigarette vapor or LPS
Pape T, Pak O, Graalmann T, Ehlers C, Deutscher J, Spiegelberg D, Horn P, Stahl K, Hoeper M, David S, Sommer N, Seeliger B
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Kalinke Lab
Immunology
Towards the development of novel cell therapy options for MSMD patients
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Pessler Lab
Immunology
Functional Biomarkers for respiratory infections
This project focuses on lung infections such as influenza, COVID-19, pneumonia and tuberculosis in order to improve diagnostics, patient stratification and therapy. RNA molecules and metabolites are being investigated as biomarkers and complementary therapies.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
