Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Translational Medicine : 10.1186/s12967-026-08651-8
Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia
Pashai Fakhri M, Börner F, Held J, Sivaraman K, Fuge J, Rupp J, Barten-Neiner G, Pletz M, Witzenrath M, Rohde G, Rademacher J, Hinze C, Janciauskiene S, CAPNETZ Study Group
2026Plos Pathogens22 (7) : e1014355
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
Ruijten S, Dos Santos J, Rios-Vazquez V, Navas A, Maas H, Groenendijk A, Blaauw M, van Eekeren L, Vos W, Knoll R, Kumar Gupta M, Ter Horst R, Botey-Bataller J, van Unen N, Li Y, Aschenbrenner A, Schultze J, Xu C, Netea M, van der Ven A, Matzaraki V
2026Biomarker Research14 (1) : 82
Interleukin-10 enhances IgG galactosylation and sialylation
Lunding H, Wasynczuk A, Bartsch Y, Buhre J, Nouta J, Leliavski A, Lehrian S, Becker A, Manzhula K, Köcher P, Mehlfeld J, Rahmöller J, Wuhrer M, Ehlers M
Bartsch Lab
Immunology
Harnessing antibody Fc effector functions as therapeutic target
The project is researching how the effect of monoclonal antibodies can be improved. These antibodies are already being used successfully against viruses. The aim is to optimize the so-called Fc effector functions in order to fight infections even more effectively.
Pessler Lab
Immunology
Functional Biomarkers for respiratory infections
This project focuses on lung infections such as influenza, COVID-19, pneumonia and tuberculosis in order to improve diagnostics, patient stratification and therapy. RNA molecules and metabolites are being investigated as biomarkers and complementary therapies.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Galardini Lab
Bacteriology
Genotype to phenotype studies in bacteria
By applying statistical genetics methods to pathogen genome sequences, we aim to identify and validate genetic determinants of phenotypes such as pathogenicity, virulence and antibiotic resistance, e.g. in E. coli and P. aeruginosa.
Science and Society
Science and Society
Ralf Meister, Bishop of the Evangelical-Lutheran Church of Hanover
“Participation and Resilience at the Interface between Science and Society”
Symposium
TWINCORE & CiiM Symposium 2026
Pathways to Infection Resilience
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
