New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Molecular Therapy : The Journal of the American Society of Gene Therapy : S1525-0016(26)00933-0
AAV-mediated expression of a SARS-CoV-2 neutralizing antibody in monocyte-derived dendritic cells and human airway epithelial cells
Obara M, Shandheep A, Rahmel-Stein K, Bruhn M, Costa B, Sujariyakul P, Pavlou A, Busker L, Hook S, Tamm S, Lange B, Schröder L, Kamp J, Stanke F, Ott M, Kalinke U
2026Critical Care (london, England)30 (1) : 563
Distinct transcriptomic signatures discriminate hyperinflammation from immune paralysis in sepsis: a single-cell RNA sequencing study
Grondman I, Koeken V, Couwenbergh T, Karageorgos A, Li W, Antonakos N, Zhang B, Damoraki G, van der Heijden W, Xu C, Giamarellos-Bourboulis E, Li Y, Netea M
2027Journal of Hepatology : S0168-8278(26)02935-1
Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency
Krooss S, Yang T, Yuan Q, Drick N, Sgodda M, Held J, Behrendt P, Hartleben B, Koczulla R, Ma X, Liu Y, Wedemeyer H, Janciauskiene S, Di Donato N, Cantz T, Wang Z, Wu Y, Hoeper M, Xia Q, Ott M
Pietschmann Lab
Virology
Principles of HCV assembly and entry and their role in virus persistence
We are investigating how the association of HCV with lipoproteins contributes to the persistence of the virus by influencing entry into liver cells and protecting against antibodies. The aim is to gain new insights for the development of an HCV vaccine.
Pietschmann Lab
Virology
Mechanisms of HCV tissue and species tropism: A guide for development of animal models
The project investigates the factors that determine the species barrier mechanism of HCV and make it impossible to study the infection in animal models. The aim is to use genetic screening systems to develop in vivo models for vaccine research.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
There are currently no events.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
