Experimental Virology

Viruses are vehicles that transport biological information and reprogram the functions of human, animal or plant cells in order to replicate. They are very small and usually have a very simple structure. Enveloped viruses consist only of a layer of proteins filled with genetic material and surrounded by a thin shell of lipids in which viral proteins are embedded. Nevertheless, viral pathogens such as HIV or hepatitis C virus (HCV) threaten the health of millions of people. In addition to HCV, important human pathogens in the group of the RNA viruses include respiratory syncytial virus (RSV) and SARS-CoV-2, the virus responsible for the current COVID-19 pandemic.

In our institute three research groups are working on hepatitis viruses (HCV, HEV), RSV and since 2020 also SARS-CoV-2. We combine molecular and cell biological approaches with bioinformatics and computational methods to understand viral replication mechanisms and to develop new therapeutic and preventive measures.  



Job announcement: PhD Student (f/m/d)

The Institute for Experimental Virology (Director: Prof. Thomas Pietschmann) is recruiting a PhD Student (m/f/d) for SARS-CoV-2 drug discovery. Ple…

A precise measure of protective immunity

New tool aims to make HCV vaccine search easier

Two murine restriction factors limiting hepatitis C infection described

Research team at TWINCORE, with international collaborators, clarifies why mice are not susceptible to infection with hepatitis C virus


New research group “Computational Virology” at TWINCORE

Group leader Chris Lauber funded by RESIST


Fraunhofer Research consortium iCAIR® makes use of synergies to develop new medications against SARS-CoV-2

With its rapid spread around the world, the new coronavirus SARS-CoV-2 has triggered a public health emergency of international concern. To date,…