TWINCORE mourns the death of Michael P. Manns
Long-time companion passes away at the age of 73
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Joint TWINCORE & SLS Europe Symposium 2025
This year's symposium will take place on 18 and 19 September in collaboration with SLS Europe.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025Mabs17 (1) : 2465391
Combinatorial Fc modifications for complementary antibody functionality
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
2025Gut Microbes17 (1) : 2487209
Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation
Buttler L, Velázquez-Ramírez D, Tiede A, Conradi A, Woltemate S, Geffers R, Bremer B, Spielmann V, Kahlhöfer J, Kraft A, Schlüter D, Wedemeyer H, Cornberg M, Falk C, Vital M, Maasoumy B
2025Oncoimmunology14 (1) : 2547271
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors
Möhn N, Narten E, Duzzi L, Thomas J, Grote-Levi L, Beutel G, Fröhlich T, Bollmann B, Wirth T, von Wasielewski I, Gutzmer R, Heidel F, Pessler F, Zobl W, Schuchardt S, Ivanyi P, Nay S, Skripuletz T
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Galardini Lab
Bacteriology
Genotype to phenotype studies in bacteria
By applying statistical genetics methods to pathogen genome sequences, we aim to identify and validate genetic determinants of phenotypes such as pathogenicity, virulence and antibiotic resistance, e.g. in E. coli and P. aeruginosa.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
