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Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Nature Immunology : 10.1038/s41590-025-02387-1
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss S, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft A, Cornberg M, Koczulla A, Pink I, Hoeper M, Xu C, Häussler S, Wiestler M, Netea M, Illig T, Sun J, Li Y
2026Infection and Immunity : e0045325
Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes
Bosc L, Sécher T, Ball G, Le Pennec D, Tribout M, Ba M, Bai Y, Ouerdane L, Arnoux P, Denis Y, Lei X, Bordi C, Heuzé-Vourc'h N, Häussler S, Gomez N, Voulhoux R
2026Respiratory Research : 10.1186/s12931-026-03497-6
Clinical implications of traction bronchiectasis in IPF and fibrotic RA-ILD - a retrospective single-center cohort study
Raith J, Ruwisch J, Schupp J, Graalmann T, Drick N, Hoeper M, Prasse A, Fuge J, Ringshausen F, Knegendorf L, Rademacher J, Dettmer S, Seeliger B
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Galardini Lab
Bacteriology
Genotype to phenotype studies in bacteria
By applying statistical genetics methods to pathogen genome sequences, we aim to identify and validate genetic determinants of phenotypes such as pathogenicity, virulence and antibiotic resistance, e.g. in E. coli and P. aeruginosa.
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Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
