
Project manager of the immune defence in the brain
How immune cells in the brain coordinate their work
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
This year's symposium will take place on 18 and 19 September in collaboration with SLS Europe.
How immune cells in the brain coordinate their work
New insights into the infection strategy of Pseudomonas aeruginosa
Research team from Bochum and Hannover shows that the hepatitis E virus also attacks organs other than the liver
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
Buttler L, Velázquez-Ramírez D, Tiede A, Conradi A, Woltemate S, Geffers R, Bremer B, Spielmann V, Kahlhöfer J, Kraft A, Schlüter D, Wedemeyer H, Cornberg M, Falk C, Vital M, Maasoumy B
Hrabal I, Aliabadi E, Weber S, Ssebyatika G, Krey T, Holicki C, Schmid L, Dinkelborg K, Schröder C, Fast C, Behrendt P, Groschup M, Eiden M
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
In collaboration with the Department of Neurology and the Metabolomics Department, the project is investigating metabolic products in cerebrospinal fluid in order to identify biomarkers for CNS infections and cell damage and to distinguish long COVID and viral from autoimmune diseases.
Together with the Department of Structural Biology at the University of Lübeck, human, strongly neutralizing antibodies against HEV were identified and characterized for the first time. These showed a protective effect in the mouse model and are currently being further developed for clinical application, including mRNA-based application methods.
Using high-performance computers, we analyze NGS data to discover unknown viruses in the human and animal virome that could influence disease risks. We investigate the virome as a factor for infections and diseases such as cancer and immunodeficiencies.
There are currently no events.