Key message
Using the ReFRAME repurposing drug library, we identified novel candidates for broad-spectrum coronavirus antivirals and revealed novel potentially druggable viral host dependency factors used by diverse coronaviruses.
Translational perspective
In this study, we identified molecules with antiviral activity against different coronaviruses. This knowledge can be used for further development of drug candidates and the development of novel host-targeting antiviral therapies.
Original publication
Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen T-T, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.
Antimicrob Agents Chemother. 2024 Feb 6:e0121023.
DOI: https://doi.org/10.1128/aac.01210-23