Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis

Leonardo Silva de Araujo


Searching for cerebrospinal fluid biomarkers for improved early diagnosis of bacterial meningitis, we found that concentrations of the glycerophospholipid PC ae C44:6 were significantly higher in bacterial meningitis than in several other infectious and non-infectious CNS orders. When added to a diagnostic algorithm containing CSF leukocyte count and lactate concentration, it enabled the identification of a subgroup of bacterial meningitis cases that were missed by the other two parameters. 

Translational significance

Free PC ae C44:6 in CSF is a promising additional biomarker for the correct diagnosis of bacterial meningitis in patients with an unusually low degree of neuroinflammation, such as immunocompromised individuals.