Key message
We investigated moDC susceptibility to HCMV infection by scRNA-seq. We show that HCMV can infect different subsets of moDC to different extents and that the intrinsic levels of STING are determinants of infection outcome.
Translational perspective
We identified potential new HCMV anti- and pro-viral genes for therapeutic approaches.
Original publication
Bibiana Costa, Jennifer Becker, Tobias Krammer, Felix Mulenge, Verónica Durán, Andreas Pavlou, Olivia Luise Gern, Xiaojing Chu, Yang Li, Luka Čičin-Šain, Britta Eiz-Vesper, Martin Messerle, Lars Dölken, Antoine-Emmanuel Saliba, Florian Erhard & Ulrich Kalinke
Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells
Nature Communications volume 15, Article number: 1745 (2024)
DOI: https://doi.org/10.1038/s41467-024-45614-3