Key message:
Our research demonstrates that detecting hepatitis E virus (HEV) antigen in urine is more sensitive than in patients' blood, which can be attributed to antibodies present in blood but absent in urine, that may interfere with HEV antigen detection.
Translational perspective:
The results of this study may help to reliably detect previously undiagnosable HEV infections and to better monitor existing infections.
Original publication:
Yannick Stahl, Iyad Kabar, Hauke Heinzow, Benjamin Maasoumy, Birgit Bremer, Heiner Wedemeyer, Hartmut H.-J. Schmidt, Thomas Pietschmann, Bernhard Schlevogt & Patrick Behrendt
Enhanced Monitoring and Detection of Recent Genotype 3 Hepatitis E Virus Infection through Urine Antigen Testing.
Emerging Microbes & Infections, 2023.
DOI: https://doi.org/10.1080/22221751.2023.2251598