Recent publications in a nutshell

Recent publications in a nutshell

From April 2017 our scientists condense their new publications for you. You receive the key message and the translational perspective of the publication at a glance.

Publications

Diversification of the VH3-53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS-CoV-2 virus variants

Matthias Bruhn et. al

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Bibiana Costa

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Svenja M. Sake

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.

Sibylle Haid, Alina Matthaei, Melina Winkler et al.

Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes

Nicoletta Schwermann

Reduced ambiguity and improved interpretability of bacterial genome-wide associations using gene-cluster-centric k-mers

Hannes Sommer

Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

Matthias Bruhn

Enhanced Monitoring and Detection of Recent Genotype 3 Hepatitis E Virus Infection through Urine Antigen Testing

Yannick Stahl

Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes.

Frauke Lange

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Birch pollen extract enhances human cytomegalovirus replication in monocyte-derived dendritic cells

Zeinab Fneish

The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection

Birthe Reinecke

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Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies

Dorothea Bankwitz

B cell depletion impairs vaccination-induced CD8+ T cell responses in a type I interferon-dependent manner

Theresa Graalmann

MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS

Luca Ghita

Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells

Verónica Durán & Theresa Graalmann

Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Moritz Winterhoff

Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

Theresa Graalmann

Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis

Leonardo Silva de Araujo

Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection

Leonardo Silva de Araujo

Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses

Rebecca Moeller

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Haroon Arshad

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis

Fangfang Chen

The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates

Jelena Erdmann

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Pia Tegtmeyer

Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Matthias Lochner

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

Dominic H. Banda

During viral encephalitis type I interferon receptor signaling of neurons and astrocytes regulates microglia activation

Chintan Chhatbar

Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures

Chintan Chhatbar

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

Julia Spanier

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

Lisa Lasswitz

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

Gisa Gerold

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-SIGN Receptor Induces Strong T-Helper 1 Immune Responses

Lis Velasquez

Early lymphocyte loss and increased granulocyte/lymphocyte ratio predict systemic spread of Streptococcus pyogenes in a mouse model of acute skin infection

Aaqib Sohail

Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella-zoster virus reactivation

Frank Pessler

Hepatitis E Virus Replication and Interferon Responses in Human Placental Cells

Leonhard Knegendorf

Type I interferon receptor-signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis

Katharina Borst

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections

Patrick Blank

Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates—Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo

Asha Balakrishnan

Transcriptional and mutational profiling of an aminoglycoside resistant Pseudomonas aeruginosa small colony variant

Michal Koska

Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders—findings of a multicenter population-based study

Frank Pessler; Manas Akmatov

Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study – findings from Pretest 1 of the German National Cohort

Manas Akmatov

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

Theresa Frenz, Christoph Hirche

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium

Panagiota Mamareli

Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity

Dorothea Bankwitz

Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population

Manas Akmatov

Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection

Frank Pessler; Matthias Preusse