Publications
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Lauber C, Zhang X, Vaas J, Klingler F, Mutz P, Dubin A, Pietschmann T, Roth O, Neuman BW, Gorbalenya AE, Bartenschlager R, Seitz S (2024) Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates. PLoS Pathog 20(4): 1-32.
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Pink I, Hennigs JK, Ruhl L, Sauer A, Boblitz L, Huwe M, Fuge J, Falk CS, Pietschmann T, de Zwaan M, Prasse A, Kluge S, Klose H, Hoeper MM, Welte T (2024) Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19. Infection 52(2): 513-524.
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Gömer A, Dinkelborg K, Klöhn M, Jagst M, Wißing MH, Frericks N, Nörenberg P, Behrendt P, Cornberg M, Wedemeyer H, Steinmann E, Maasoumy B, Todt D (2024) Dynamic evolution of the sofosbuvir-associated variant A1343V in HEV-infected patients under concomitant sofosbuvir-ribavirin treatment. JHEP Rep 6(3): 100989.
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Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR, Steinmann E, Pietschmann T, Sheldon J (2024) Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes. J Virol 98(3): e0192123.
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Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen TT, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T (2024) Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets. Antimicrob Agents Chemother 68(3): e0121023.
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Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, F EleouetJ, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T (2024) Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Nat Commun 15(1): 1173.
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Matthaei A, Joecks S, Frauenstein A, Bruening J, Bankwitz D, Friesland M, Gerold G, Vieyres G, Kaderali L, Meissner F, Pietschmann T (2024) Landscape of protein-protein interactions during hepatitis C virus assembly and release. Microbiol Spectr 12(2): e0256222.
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Pink I, Hennigs JK, Ruhl L, Sauer A, Boblitz L, Huwe M, Fuge J, Falk CS, Pietschmann T, de Zwaan M, Prasse A, Kluge S, Klose H, Hoeper MM, Welte T (in press) Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19. Infection n/a(n/a): n/a.
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Vieyres G, Pietschmann T (in press) The role of human lipoproteins for hepatitis C virus persistence. Curr Opin Virol 60(n/a): 101327.
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Aghebatrafat AA, Lauber C, Merkel K, Fruth B, Langergraber K, Robbins MM, Wittig RM, Leendertz FH, Calvignac-Spencer S (2023) Evolutionary Insight into the Association between New Jersey Polyomavirus and Humans. Viruses 15(11): 2248.
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Behrendt P, Gouttenoire J (2023) Editorial in Hepatology Urine: A place where HEV cannot hide!. Hepatology 77(5): 1475-1477.
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Carriqui-Madronal B, Lasswitz L, von Hahn T, Gerold G (2023) Genetic and pharmacological perturbation of hepatitis-C virus entry. Curr Opin Virol 62(n/a): 101362.
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Carriquí-Madroñal B, Sheldon J, Duven M, Stegmann C, Cirksena K, Wyler E, Zapatero-Belinchón FJ, Vondran FlorianWR, Gerold G (2023) The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity. PLoS Pathog 19(11): 1-24.
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Chong LC, Lauber C (2023) Viroid-like RNA-dependent RNA polymerase-encoding ambiviruses are abundant in complex fungi. Front Micobiol 14(n/a): 1144003.
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Dinkelborg K, Kahlhöfer J, Dörge P, Yurdaydin C, Hardtke S, Caruntu FA, Curescu MG, Yalcin K, Akarca US, Gürel S, Zeuzem S, Erhardt A, Lüth S, Papatheodoridis GV, Keskin O, Port K, Radu M, Celen MK, Idilman R, Weber K, Stift J, Wittkop U, Heidrich B, Mederacke I, von der Leyen H, Dienes HP, Cornberg M, Koch A, Manns MP, Wedemeyer H, Deterding K (2023) Quality-of-life scores improve after 96 weeks of PEG-IFNa-2a treatment of hepatitis D: An analysis of the HIDIT-II trial. Liver Int 43(8): 1663-1676.
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Gömer A, Klöhn M, Jagst Michelle, Nocke Maximilian, Pischke Sven, Horvatits T, zur Wiesch JS, Müller T, Hardtke S, Cornberg M, Wedemeyer H, Behrendt P, Steinmann E, Todt D (2023) Emergence of resistance-associated variants during sofosbuvir treatment in chronically infected hepatitis E patients. Hepatology 78(6): 1882-1895.
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Göttig L, Weiss C, Stubbe M, Hanrieder L, Hofmann S, Grodziecki A, Stadler D, Carpentier A, Protzer U, Schreiner S (2023) Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression. mBio 14(3): e0347822.
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Hofmann S, Plank V, Groitl P, Skvorc N, Hofmann K, Luther J, Ko C, Zimmerman P, Bruss V, Stadler D, Carpentier A, Rezk S, Nassal M, Protzer U, Schreiner S (2023) SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA. Microbiol Spectr 11(3): e0044623.
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Keller L, Oueis E, Kaur A, Safaei N, Kirsch SH, Gunesch AP, Haid S, Rand U, Cicin-Sain L, Fu C, Wink J, Pietschmann T, Müller R (2023) Persicamidines- Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses. Angew Chem Int Ed Engl 62(6): e202214595.
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Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E (2023) Janus kinase-inhibition modulates hepatitis E virus infection. Antiviral Res 217(n/a): 105690.
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Lange F, Garn J, Anagho HA, Vondran FWR, von Hahn T, Pietschmann T, Carpentier A (2023) Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes. Liver Int 43(10): 2116-2129.
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Liang TJ, Law JLM, Pietschmann T, Ray SC, Bukh J, Bull R, Chung RT, Tyrrell DL, Houghton M, Rice CM (2023) Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model. Clinical Infectious Diseases 77(Supplement 3): S257-S261.
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Meister TL, Friesland M, Frericks N, Wetzke M, Haid S, Steinmann J, Todt D, Pietschmann T, Steinmann E (2023) Virucidal activity of oral, hand and surface disinfectants against respiratory syncytial virus. J Hosp Infect 141(n/a): 25-32.
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Mhlekude B, Postmus D, Stenzel S, Weiner, J 3rd, Jansen J, Zapatero-Belinchon FJ, Olmer R, Richter A, Heinze J, Heinemann N, Muhlemann B, Schroeder S, Jones TC, Muller MA, Drosten C, Pich A, Thiel V, Martin U, Niemeyer D, Gerold G, Beule D, Goffinet C (2023) Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection. PLoS Pathog 19(9): e1011657.
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Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Thi VLD, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E (2023) Epidermal growth factor receptor modulates hepatitis e virus entry in human hepatocytes -HEP-22-1113. Hepatology 77(6): 2104-2117.
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Stahl Y, Kabar I, Heinzow H, Maasoumy B, Bremer B, Wedemeyer H, Schmidt HHJ, Pietschmann T, Schlevogt B, Behrendt P (2023) Enhanced Monitoring and Detection of Recent Genotype 3 Hepatitis E Virus Infection through Urine Antigen Testing. Emerg Microbes Infect 12(2): 2251598.
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Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J, Schwartz RE, tenOever BR, Evans T, Chen S (2023) A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nat Cell Biol 25(3): 381-389.
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Tergast TL, Schulte B, Griemsmann M, Kahlhöfer J, Dörge P, Hinrichs JB, Kraft ARM, Schmidt JJ, Behrendt P, Wedemeyer H, Cornberg M, Maasoumy B (2023) Application of CT contrast medium is not associated with an increased risk for acute kidney injury in patients with decompensated cirrhosis. Aliment Pharmacol Ther 57(1): 136-145.
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Yang Q, Elz AE, Panis M, Liu T, Nilsson-Payant BE, Blanco-Melo D (2023) Modulation of Influenza A virus NS1 expression reveals prioritization of host response antagonism at single-cell resolution. Front Microbiol 14(n/a): 1267078.
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Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M, Caliskan N, Brown RJP, Steinmann E, Pietschmann T (2023) Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses. Microbiol Spectr 11(4): e0128423.
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Alejo-Valle O, Weigert K, Bhayadia R, Ng M, Issa H, Beyer C, Emmrich S, Schuschel K, Ihling C, Sinz A, Zimmermann M, Wickenhauser C, Flasinski M, Regenyi E, Labuhn M, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH (2022) The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis. Blood 139(5): 651-665.
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Badenhorst M, de Heus P, Auer A, Tegtmeyer B, Stang A, Dimmel K, Tichy A, Kubacki J, Bachofen C, Steinmann E, Cavalleri JMV (2022) Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age. Equine Vet J 54(2): 379-389.
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Bader CD, Panter F, Garcia R, Tchesnokov EP, Haid S, Walt C, Spröer C, Kiefer AF, Götte M, Overmann J, Pietschmann T, Müller R (2022) Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium. Chemistry 28(10): e202104484.
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Baier C, Huang J, Reumann K, Indenbirken D, Thol F, Koenecke C, Ebadi E, Heim A, Bange FC, Haid S, Pietschmann T, Fischer N (2022) Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients. Antimicrob Resist Infect Control 11(1): 88.
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Bankwitz D, Krey T, Pietschmann T (2022) Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 65(2): 183-191.
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Behrendt P, Friesland M, Wißmann JE, Kinast V, Stahl Y, Praditya D, Hueffner L, Nörenberg PM, Bremer B, Maasoumy B, Steinmann J, Becker B, Paulmann D, Brill FHH, Steinmann J, Ulrich RG, Brüggemann Y, Wedemeyer H, Todt D, Steinmann E (2022) Hepatitis E virus is highly resistant to alcohol-based disinfectants. J Hepatol 76(5): 1062-1069.
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Behrendt P, Traidl S, Boker KWH, Wedemeyer H, Deterding K (2022) T-cell driven allergic cutaneous reaction complicating treatment of hepatitis delta virus infection with bulevirtide. Liver Int 42(8): 1770-1771.
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Burkard T, Proske N, Resner K, Collignon L, Knegendorf L, Friesland M, Verhoye L, Sayed IM, Brüggemann Y, Nocke MK, Behrendt P, Wedemeyer H, Meuleman P, Todt D, Steinmann E (2022) Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems. Cells 11(6): 927.
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Gomer A, Brown RJP, Pfaender S, Deterding K, Reuter G, Orton R, Seitz S, Bock CT, Cavalleri JMV, Pietschmann T, Wedemeyer H, Steinmann E, Todt D (2022) Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance. Virus Evol 8(1): veac007.
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Gomer A, Delarocque J, Puff C, Nocke MK, Reinecke B, Baumgartner W, Cavalleri JMV, Feige K, Steinmann E, Todt D (2022) Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response. Microbiol Spectr 10(5): e0168622.
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Gomer A, Puff C, Reinecke B, Bracht S, Conze M, Baumgartner W, Steinmann J, Feige K, Cavalleri JMV, Steinmann E, Todt D (2022) Experimental cross-species infection of donkeys with equine hepacivirus and analysis of host immune signatures. One Health Outlook 4(1): 9.
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Gorbalenya AE, Lauber C (2022) Bioinformatics of virus taxonomy: foundations and tools for developing sequence-based hierarchical classification. Curr Opin Virol 52(n/a): 48-56.
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Gravemann U, Engelmann M, Kinast V, Burkard T, Behrendt P, Schulze TJ, Todt D, Steinmann E (2022) Hepatitis E virus is effectively inactivated by methylene blue plus light treatment. Transfusion 62(11): 2200-2204.
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Haack PA, Harmrolfs K, Bader CD, Garcia R, Gunesch AP, Haid S, Popoff A, Voltz A, Kim H, Bartenschlager R, Pietschmann T, Müller R (2022) Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors. Angew Chem Int Ed Engl 61(52): e202212946.
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Kazmierski J, Elsner C, Dohner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Loffler MW, Weber ANR, Sodeik B, Goffinet C (2022) A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. J Immunol 209(3): 535-547.
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Lasswitz L, Zapatero-Belinchon FJ, Moeller R, Hulskotter K, Laurent T, Carlson LA, Goffinet C, Simmons G, Baumgartner W, Gerold G (2022) The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication. mBio 13(3): e0073122.
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Lauber C, Gerl MJ, Klose C, Ottosson F, Melander O, Simons K (2022) Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort. PLoS Biol 20(3): 1-23.
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Lauber C, Seitz S (2022) Opportunities and Challenges of Data-Driven Virus Discovery. Biomolecules 12(8).
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Marek K, Armando F, Nippold VM, Rohn K, Plattet P, Brogden G, Gerold G, Baumgartner W, Puff C (2022) Persistent Infection of a Canine Histiocytic Sarcoma Cell Line with Attenuated Canine Distemper Virus Expressing Vasostatin or Granulocyte-Macrophage Colony-Stimulating Factor. Int J Mol Sci 23(11): 6156.
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Meister TL, Arroyo LG, Shanahan R, Papapetrou MA, Reinecke B, Brüggemann Y, Todt D, Stang A, Hazlett M, Baird JD, Steinmann E (2022) Infection of young foals with Equine Parvovirus-Hepatitis following a fatal non-biologic case of Theiler's disease. Vet Microbiol 274(n/a): 109557.
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Messaoudi O, Steinmann E, Praditya D, Bendahou M, Wink J (2022) Taxonomic Characterization, Antiviral Activity and Induction of Three New Kenalactams in Nocardiopsis sp. CG3. Curr Microbiol 79(9): 284.
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Paulsen M, Scharff AZ, de Cassan K, Sugianto RI, Blume C, Blume H, Christmann M, Hauss C, Illig T, Jonczyk R, Klopp N, Kopfnagel V, Lichtinghagen R, Lucas H, Luhr A, Mutschler F, Pietschmann T, Pott PC, Prokein J, Schaefer P, Stahl F, Stanislawski N, von der Born J, Schmidt BMW, Heiden S, Stiesch M, Memaran N, Melk A (2022) Children and Adolescents' Behavioral Patterns in Response to Escalating COVID-19 Restriction Reveal Sex and Age Differences. Journal of Adolescent Health 70(3): 378-386.
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Reinecke B, Frericks N, Lauber C, Dinkelborg K, Matthaei A, Vondran FWR, Behrendt P, Haid S, Brown RJP, Pietschmann T (2022) The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. J Virol 96(7): e0199521.
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Rosendal E, Mihai IS, Becker M, Das D, Frangsmyr L, Persson BD, Rankin GD, Groning R, Trygg J, Forsell M, Ankarklev J, Blomberg A, Henriksson J, Overby AK, Lenman A (2022) Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections. mBio 13(3): e0089222.
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Sake SM, Kosch C, Blockus S, Haid S, Gunesch AP, Zhang X, Friesland M, Trummer SB, Grethe C, Kühnel A, Rückert J, Duprex WP, Huang J, Rameix-Welti MA, Empting M, Fischer N, Hirsch AKH, Schulz TF, Pietschmann T (2022) Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages. Antimicrob Agents Chemother 66(12): e0103222.
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Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S (2022) Differential interferon-alpha subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A 119(8).
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Taubert R, Engel B, Diestelhorst J, Hupa-Breier KL, Behrendt P, Baerlecken NT, Sühs KW, Janik MK, Zachou K, Sebode M, Schramm C, Londono MC, Habes S, Oo YH, Lalanne C, Pape S, Schubert M, Hust M, Dübel S, Thevis M, Jonigk D, Beimdiek J, Buettner FFR, Drenth JPH, Muratori L, Adams DH, Dyson JK, Renand A, Graupera I, Lohse AW, Dalekos GN, Milkiewicz P, Stangel M, Maasoumy B, Witte T, Wedemeyer H, Manns MP, Jaeckel E (2022) Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis. Hepatology 75(1): 13-27.
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Weber T, Potthoff J, Bizu S, Labuhn M, Dold L, Schoofs T, Horning M, Ercanoglu MS, Kreer C, Gieselmann L, Vanshylla K, Langhans B, Janicki H, Ströh LJ, Knops E, Nierhoff D, Spengler U, Kaiser R, Bjorkman PJ, Krey T, Bankwitz D, Pfeifer N, Pietschmann T, Flyak AI, Klein F (2022) Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity 55(2): 341-354.e7.
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Wetzke M, Funken D, Lange M, Bejo L, Haid S, Monteiro JGT, Schutz K, Happle C, Schulz TF, Seidenberg J, Pietschmann T, Hansen G (2022) IRIS: Infection with RespIratory Syncytial Virus in infants-a prospective observational cohort study. BMC Pulm Med 22(1): 88.
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Adamek M, Davies J, Beck A, Jordan L, Becker AM, Mojzesz M, Rakus K, Rumiac T, Collet B, Brogden G, Way K, Bergmann SM, Zou J, Steinhagen D (2021) Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination. Front Immunol 12(n/a): 581786.
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Arnberg N, Lenman A (2021) Special Issue “Adenovirus Pathogenesis”. Viruses 13(6): 1112.
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Bankwitz D, Bahai A, Labuhn M, Doepke M, Ginkel C, Khera T, Todt D, Stroh LJ, Dold L, Klein F, Klawonn F, Krey T, Behrendt P, Cornberg M, McHardy AC, Pietschmann T (2021) Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies. Gut 70(9): 1734-1745.
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Beck J, Seitz S, Lauber C, Nassal M (2021) Conservation of the HBV RNA element epsilon in nackednaviruses reveals ancient origin of protein-primed reverse transcription. Proc Natl Acad Sci U S A 118(13).
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Behrendt P, Bremer B, Todt D, Steinmann E, Manns MP, Cornberg M, Wedemeyer H, Maasoumy B (2021) Significant compartment-specific impact of different RNA extraction methods and PCR assays on the sensitivity of hepatitis E virus detection. Liver Int 41(8): 1815-1823.
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Dong TN, Brogden G, Gerold G, Khosla M (2021) A multitask transfer learning framework for the prediction of virus-human protein-protein interactions. BMC Bioinformatics 22(1): 572.
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Faisal MR, Kellermann MY, Rohde S, Putra MY, Murniasih T, Risdian C, Mohr KI, Wink J, Praditya DF, Steinmann E, Köck M, Schupp PJ (2021) Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge Lamellodysidea herbacea. Mar Drugs 19(11): 611.
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Glebe D, Goldmann N, Lauber C, Seitz S (2021) HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals. Antiviral Res 186(n/a): 104973.
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Jo WK, Schadenhofer A, Habierski A, Kaiser FK, Saletti G, Ganzenmueller T, Hage E, Haid S, Pietschmann T, Hansen G, Schulz TF, Rimmelzwaan GF, Osterhaus Adme, Ludlow M. (2021) Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants. Proc Natl Acad Sci U S A 118(14).
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Kirui J, Abidine Y, Lenman A, Islam K, Gwon YD, Lasswitz L, Evander M, Bally M, Gerold G (2021) The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry. Cells 10(7): 1828.
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Krüger N, Rocha C, Runft S, Krüger J, Färber I, Armando F, Leitzen E, Brogden G, Gerold G, Pöhlmann S, Hoffmann M, Baumgärtner W (2021) The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection. Int J Mol Sci 22(19): 10636.
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Mhlekude B, Lenman A, Sidoyi P, Joseph J, Kruppa J, Businge CB, Mdaka ML, Konietschke F, Pich A, Gerold G, Goffinet C, Mall AS (2021) The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission. AIDS 35(13): 2105-2117.
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Nicolay W, Moeller R, Kahl S, Vondran F, Pietschmann T, Kunz S, Gerold G (2021) Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes. Cells 10(11): 3019.
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Rafie K, Lenman A, Fuchs J, Rajan A, Arnberg N, Carlson LA (2021) The structure of enteric human adenovirus 41-A leading cause of diarrhea in children. Sci Adv 7(2).
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Rajan A, Palm E, Trulsson F, Mundigl S, Becker M, Persson BD, Frängsmyr L, Lenman A (2021) Heparan Sulfate Is a Cellular Receptor for Enteric Human Adenoviruses. Viruses 13(2): 298.
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Reinecke B, Klöhn M, Brüggemann Y, Kinast V, Todt D, Stang A, Badenhorst M, Koeppel K, Guthrie A, Groner U, Puff C, de le Roi M, Baumgärtner W, Cavalleri JMV, Steinmann E (2021) Clinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis. Viruses 13(8): 1454.
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Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchón FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, Höfer A, Kühnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, Pfeffer TJ, Hilfiker A, Haverich A, Hilfiker-Kleiner D (2021) Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLOS ONE 16(8): 1-24.
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Risso-Ballester J, Galloux M, Cao J, Goffic RL, Hontonnou F, Jobart-Malfait A, Desquesnes A, Sake SM, Haid S, Du M, Zhang X, Zhang H, Wang Z, Rincheval V, Zhang Y, Pietschmann T, Eleouët JF, Rameix-Welti MA, Altmeyer R (2021) A condensate-hardening drug blocks RSV replication in vivo. Nature 595(7868): 596-599.
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Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgartner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP (2021) Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements. J Virol 95(10): e00245-21.
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Wibowo JT, Kellermann MY, Köck M, Putra MY, Murniasih T, Mohr KI, Wink J, Praditya DF, Steinmann E, Schupp PJ (2021) Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp. SV 21. Mar Drugs 19(2): 81.
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Zapatero-Belinchchon FJ, Ötjengerdes R, Sheldon J, Schulte B, Carriqui-Madronal B, Brogden G, Arroyo-Fernandez LM, Vondran FWR, Maasoumy B, von Hahn T, Gerold G (2021) Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity. Cells 10(7): 1626.
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Zapatero-Belinchon FJ, Moeller R, Lasswitz L, van Ham M, Becker M, Brogden G, Rosendal E, Bi W, Carriqui-Madronal B, Islam K, Lenman A, Gunesch AP, Kirui J, Pietschmann T, Överby AK, Jänsch L, Gerold G (2021) Fluvastatin mitigates SARS-CoV-2 infection in human lung cells. iScience 24(12): 103469.
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Zapatero-Belinchón FranciscoJosé, Carriqu\'ı-Madroñal Belén, Gerold Gisa (2021) Proximity labeling approaches to study protein complexes during virus infection. 109(n/a): 63-104.
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Alberione MP, Moeller R, Kirui J, Ginkel C, Doepke M, Stroh LJ, Machtens JP, Pietschmann T, Gerold G (2020) Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells. Med Microbiol Immunol 209(4): 499-514.
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Armando F, Gambini M, Corradi A, Becker K, Marek K, Pfankuche VM, Mergani AE, Brogden G, Buhr N, Köckritz-Blickwede M, Naim HY, Baumgärtner W, Puff C (2020) Mesenchymal to epithelial transition driven by canine distemper virus infection of canine histiocytic sarcoma cells contributes to a reduced cell motility in vitro. J Cell Mol Med 24(16): 9332-9348.
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Baird J, Tegtmeyer B, Arroyo L, Stang A, Brüggemann Y, Hazlett M, Steinmann E (2020) The association of Equine Parvovirus-Hepatitis (EqPV-H) with cases of non-biologic-associated Theiler's disease on a farm in Ontario, Canada. Vet Microbiol 242(n/a): 108575.
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Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Goffic RL, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eleouet JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T (2020) Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry. Antiviral Res 177(n/a): 104774.
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Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Stroh LJ, Miskey C, Ivics Z, Herder V, Baumgartner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T (2020) Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv 6(45).
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Carpentier A, Sheldon J, Vondran FWR, Brown RJ, Pietschmann T (2020) Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus. Gut 69(9): 1659-1666.
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Eismann H, Sieg L, Ahmed H, Teske J, Behrendt P, Friedrich L, Schumacher C, Johanning K (2020) Influence of alcohol consumption on blood coagulation in ROTEM: an in-vivo study. Korean J Anesthesiol 73(4): 334-341.
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Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Dohner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen PK, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C (2020) Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Proc Natl Acad Sci U S A 117(32): 19475-19486.
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Gerold G, Moeller R, Pietschmann T (2020) Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion. Cold Spring Harb Perspect Med 10(2): a036830.
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Glebe D, Goldmann N, Lauber C, Seitz S (2020) HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals. Antiviral Res 186(n/a): 104973.
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Gunesch AP, Zapatero-Belinchon FJ, Pinkert L, Steinmann E, Manns MP, Schneider G, Pietschmann T, Bronstrup M, von Hahn T (2020) Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis. Antimicrob Agents Chemother 64(8).
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Kamar N, Abravanel F, Behrendt P, Hofmann J, Pageaux GP, Barbet C, Moal V, Couzi L, Horvatits T, Man RADe, Cassuto E, Elsharkawy AM, Riezebos-Brilman A, Scemla A, Hillaire S, Donnelly MC, Radenne S, Sayegh J, Garrouste C, Dumortier J, Glowaki F, Matignon M, Coilly A, Figueres L, Mousson C, Minello A, Dharancy S, Rerolle JP, Lebray P, Etienne I, Perrin P, Choi M, Marion O, Izopet J, Belliere J, Cointault O, Bello ADel, Espostio L, Hebral AL, Lavayssiere L, Lhomme S, Mansuy JM, Wedemeyer H, Nickel P, Bismuth M, Stefic K, Büchler M, D'Alteroche L, Colson P, Bufton S, Ramiere C, Trimoulet P, Pischke S, Todesco E, Soussan RS, Legendre C, Mallet V, Johannessen I, Simpson K (2020) Ribavirin for Hepatitis E virus infection after organ transplantation: A large European retrospective multicenter study. Clin Infect Dis 71(5): 1204-1211.
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Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brueggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E (2020) C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol 73(3): 549-558.
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Köllmann C, Sake SM, Jones PG, Pietschmann T, Werz DB (2020) Protecting-Group-Mediated Diastereoselective Synthesis of C4'-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus. J Org Chem 85(6): 4267-4278.
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Lindqvist R, Rosendal E, Weber E, Asghar N, Schreier S, Lenman A, Johansson M, Dobler G, Bestehorn M, Kroger A, Overby AK (2020) The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection. J Neuroinflammation 17(1): 284.
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Moreira-Soto A, Arroyo-Murillo F, Sander AL, Rasche A, Corman V, Tegtmeyer B, Steinmann E, Corrales-Aguilar E, Wieseke N, Avey-Arroyo J, Drexler JF (2020) Cross-order host switches of hepatitis C-related viruses illustrated by a novel hepacivirus from sloths. Virus Evol 6(2): veaa033.
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Moreno H, Rastrojo A, Pryce R, Fedeli C, Zimmer G, Bowden TA, Gerold G, Kunz S (2020) A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover. PLoS Negl Trop Dis 14(12): 1-33.
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Palor M, Stejskal L, Mandal P, Lenman A, Alberione MP, Kirui J, Moeller R, Ebner S, Meissner F, Gerold G, Shepherd AJ, Grove J (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. J Biol Chem 295(50): 16931-16948.
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Persson BD, Lenman A, Frangsmyr L, Schmid M, Ahlm C, Pluckthun A, Jenssen H, Arnberg N (2020) Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells. J Virol 94(14).
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Praditya D, Friesland M, Gravemann U, Handke W, Todt D, Behrendt P, Müller TH, Steinmann E, Seltsam A (2020) Hepatitis E virus is effectively inactivated in platelet concentrates by ultraviolet C light. Vox Sang 115(7): 555-561.
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Prochnow H, Rox K, Birudukota NVS, Weichert L, Hotop SK, Klahn P, Mohr K, Franz S, Banda DH, Blockus S, Schreiber J, Haid S, Oeyen M, Martinez JP, Sussmuth RD, Wink J, Meyerhans A, Goffinet C, Messerle M, Schulz TF, Kroger A, Schols D, Pietschmann T, Bronstrup M (2020) Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis. J Virol 94(2).
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Todt D, Friesland M, Moeller N, Praditya D, Kinast V, Bruggemann Y, Knegendorf L, Burkard T, Steinmann J, Burm R, Verhoye L, Wahid A, Meister TL, Engelmann M, Pfankuche VM, Puff C, Vondran FWR, Baumgartner W, Meuleman P, Behrendt P, Steinmann E (2020) Robust hepatitis E virus infection and transcriptional response in human hepatocytes. Proc Natl Acad Sci U S A 117(3): 1731-1741.
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Tran HTL, Morikawa K, Anggakusuma, Zibi R, Thi VLD, Penin F, Heim MH, Quadroni M, Pietschmann T, Gouttenoire J, Moradpour D (2020) OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease. PLOS ONE 15(7): 1-18.
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Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T (2020) The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PLOS Pathog 16(6): 1-41.
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Wahlicht T, Vieyres G, Bruns SA, Meumann N, Buning H, Hauser H, Schmitz I, Pietschmann T, Wirth D (2020) Controlled Functional Zonation of Hepatocytes In Vitro by Engineering of Wnt Signaling. ACS Chem Biol 9(7): 1638-1649.
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Badenhorst M, de Heus P, Auer A, Rümenapf T, Tegtmeyer B, Kolodziejek J, Nowotny N, Steinmann E, Cavalleri JMV (2019) No evidence of mosquito involvement in the transmission of equine hepacivirus (Flaviviridae) in an epidemiological survey of Austrian horses. Viruses 11(11): 1014.
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Banda DH, Perin PM, Brown RJP, Todt D, Solodenko W, Hoffmeyer P, Sahu KK, Houghton M, Meuleman P, Müller R, Kirschning A, Pietschmann T (2019) A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors. J Hepatol 70(6): 1082-1092.
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Behrendt P, Bruning J, Todt D, Steinmann E (2019) Influence of Tattoo Ink on Hepatitis C Virus Infectiousness. Open Forum Infect Dis 6(3): ofz047.
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Chepkirui C, Cheng T, Sum WC, Matasyoh JC, Decock C, Praditya DF, Wittstein K, Steinmann E, Stadler M (2019) Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp.. J Agric Food Chem 67(31): 8468-8475.
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Costa R, Todt D, Zapatero-Belinchon F, Schenk C, Anastasiou OE, Walker A, Hertel B, Timmer L, Bojkova D, Ruckert M, Sarrazin C, Timm J, Lohmann V, Manns MP, Steinmann E, von Hahn T, Ciesek S (2019) SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations. J Hepatol 70(4): 603-614.
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Domingo E, de Avila AI, Gallego I, Sheldon J, Perales C (2019) Viral fitness: history and relevance for viral pathogenesis and antiviral interventions. Pathog Dis 77(2).
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Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rubsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hubner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, Edler von Koch F, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Rohrig E, Mikolajczyk R (2019) Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood. Int J Epidemiol 48(4): 1382-1383.
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Helfritz FA, Wanders V, Bojkova D, Kuklinski N, Westhaus S, Swoboda S, Minor T, Meuleman P, Paul A, Steinmann E, Ciesek S (2019) Infectivity and stability of hepatitis C virus in different perfusion solutions. Transpl Infect Dis n/a(n/a): e13135.
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Herrador A, Fedeli C, Radulovic E, Campbell KP, Moreno H, Gerold G, Kunz S (2019) Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus. MBio 10(2).
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Khera T, Behrendt P, Bankwitz D, Brown RJP, Todt D, Doepke M, Khan AG, Schulze K, Law J, Logan M, Hockman D, Wong JAJ-X, Dold L, Gonzalez-Motos V, Spengler U, Viejo-Borbolla A, Ströh L, Krey T, Tarr AW, Steinmann E, Manns MP, Klein F, Guzman CA, Marcotrigiano J, Houghton M, Pietschmann T (2019) Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants. J Hepatol 70(4): 593-602.
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Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Essbach C, Strnad P, Vondran FWR, Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E (2019) Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver. Cells 8(6).
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Kleinert RDV, Montoya-Diaz E, Khera T, Welsch K, Tegtmeyer B, Hoehl S, Ciesek S, Brown RJP (2019) Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus. Viruses 11(10): 960.
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Köllmann C, Wiechert SM, Jones PG, Pietschmann T, Werz DB (2019) Synthesis of 4'/5'-Spirocyclopropanated Uridine and d-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus. Org Lett 21(17): 6966-6971.
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Martin-Benlloch X, Haid S, Novodomska A, Rominger F, Pietschmann T, Davioud-Charvet E, Elhabiri M (2019) Physicochemical Properties Govern the Activity of Potent Antiviral Flavones. ACS Omega 4(3): 4871-4887.
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Meister T.L., Tegtmeyer B., Postel A., Cavalleri J.V., Todt D., Stang A., Steinmann E. (2019) Equine Parvovirus-Hepatitis Frequently Detectable in Commercial Equine Serum Pools. Viruses 11(5).
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Meister TL, Tegtmeyer B, Brüggemann Y, Sieme H, Feige K, Todt D, Stang A, Cavalleri JV, Steinmann E (2019) Characterization of Equine Parvovirus in Thoroughbred Breeding Horses from Germany. Viruses 11(10): 965.
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Moreno H, Moller R, Fedeli C, Gerold G, Kunz S (2019) Comparison of the innate immune response to pathogenic and non-pathogenic Clade B New World arenaviruses. J Virol 93(19).
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Passos V, Zillinger T, Casartelli N, Wachs AS, Xu S, Malassa A, Steppich K, Schilling H, Franz S, Todt D, Steinmann E, Sutter K, Dittmer U, Bohne J, Schwartz O, Barchet W, Goffinet C (2019) Characterization of Endogenous SERINC5 Protein as anti-HIV-1 Factor. J Virol 93(24).
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Pietschmann T, Brown RJP (2019) Hepatitis C Virus. Trends Microbiol 27(4): 379-380.
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Praditya D, Kirchhoff L, Brüning J, Rachmawati H, Steinmann J, Steinmann E (2019) Anti-infective Properties of the Golden Spice Curcumin. Front Microbiol 10:(n/a): 912.
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Sandargo B, Michehl M, Praditya D, Steinmann E, Stadler M, Surup F (2019) Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A–E from the Wrinkled Peach Mushroom, Rhodotus palmatus. Org Lett 21(9): 3286-3289.
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Schlevogt B, Kinast V, Reusch J, Kerkhoff A, Praditya D, Todt D, Schmidt HH, Steinmann E, Behrendt P (2019) Chronic Hepatitis E Virus Infection during Lymphoplasmacytic Lymphoma and Ibrutinib Treatment. Pathogens 8(3).
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Soon CF, Behrendt P, Todt D, Manns MP, Wedemeyer H, Chen MS, Cornberg M (2019) Defining virus-specific CD8+ TCR repertoires for therapeutic regeneration of T cells against chronic hepatitis E. J Hepatol 71(4): 673-684.
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Tegtmeyer B, Echelmeyer J, Pfankuche VM, Puff C, Todt D, Fischer N, Durham A, Feige K, Baumgartner W, Steinmann E, Cavalleri JV (2019) Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy. Vet Med Sci 5(3): 372-378.
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Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G (2019) Quantitative proteomics of Uukuniemi virus - host cell interactions reveals GBF1 as proviral host factor for phleboviruses. Mol Cell Proteomics 18(12): 2401-2417.
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Vieyres G, Pietschmann T (2019) HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit. Cells 8(3).
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Wibowo JT, Kellermann MY, Versluis D, Putra MY, Murniasih T, Mohr KI, Wink J, Engelmann M, Praditya DF, Steinmann E, Schupp PJ (2019) Biotechnological potential of bacteria isolated from the sea cucumber holothuria leucospilota and stichopus vastus from Lampung, Indonesia. Mar Drugs 17(11): 635.
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Zapatero-Belinchon FJ, Dietzel E, Dolnik O, Dohner K, Costa R, Hertel B, Veselkova B, Kirui J, Klintworth A, Manns MP, Pohlmann S, Pietschmann T, Krey T, Ciesek S, Gerold G, Sodeik B, Becker S, von Hahn T (2019) Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors. Viruses 11(3).
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Abere B, Samarina N, Gramolelli S, Ruckert J, Gerold G, Pich A, Schulz TF (2018) Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2alpha To Activate Productive Viral Replication. J Virol 92(17).
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Badenhorst M, Tegtmeyer B, Todt D, Guthrie A, Feige K, Campe A, Steinmann E, Cavalleri JMV (2018) First detection and frequent occurrence of Equine Hepacivirus in horses on the African continent. Vet Microbiol 223:(n/a): 51-58.
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Baier C, Haid S, Beilken A, Behnert A, Wetzke M, Brown RJP, Schmitt C, Ebadi E, Hansen G, Schulz TF, Pietschmann T, Bange FC (2018) Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease. Antimicrob Resist Infect Control 7:(n/a): 21.
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Banse P, Moeller R, Bruening J, Lasswitz L, Kahl S, Khan AG, Marcotrigiano J, Pietschmann T, Gerold G (2018) CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells. Viruses 10(4): 207.
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Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T (2018) Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: considerations for scientists and funding agencies. Virus Res 248:(n/a): 53-62.
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Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C, Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G (2018) Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. PLOS Pathog 14(7): 1-35.
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Fedeli C, Torriani G, Galan-Navarro C, Moraz ML, Moreno H, Gerold G, Kunz S (2018) Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan. J Virol 92(5).
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Franz S, Friesland M, Passos V, Todt D, Simmons G, Goffinet C, Steinmann E (2018) Susceptibility of Chikungunya Virus to Inactivation by Heat and Commercially and WHO-Recommended Biocides. J Infect Dis 218(9): 1507-1510.
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Garcia-Nicolas O, V'Kovski P, Vielle NJ, Ebert N, Zust R, Portmann J, Stalder H, Gaschen V, Vieyres G, Stoffel M, Schweizer M, Summerfield A, Engler O, Pietschmann T, Todt D, Alves MP, Thiel V, Pfaender S (2018) The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor. Antimicrob Agents Chemother 62(11).
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Happle C, Meyer-Decking L, Dreier A, Wetzke M, Gläsener S, Grychtol R, Braubach P, Jablonka A, Haid S, Jirmo AC, Habener A, Skuljec J, Hansen G (2018) Improved protocol for simultaneous analysis of leukocyte subsets and epithelial cells from murine and human lung. Exp Lung Res 44(3): 127-136.
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Helfritz FA, Bojkova D, Wanders V, Kuklinski N, Westhaus S, von Horn C, Rauen U, Gallinat A, Baba HA, Skyschally A, Swoboda S, Kinast V, Steinmann E, Heusch G, Minor T, Meuleman P, Paul A, Ciesek S (2018) Methylene Blue Treatment of Grafts during Cold Ischemia time Reduces the Risk of HCV Transmission. J Infect Dis 218(11): 1711-1721.
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Knegendorf L, Drave SA, Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M, Bremer B, Wedemeyer H., Behrendt P, Neyts J, Pietschmann T, Todt D, Steinmann E (2018) Hepatitis E virus replication and interferon responses in human placental cells. Hepatol Commun 2(2): 173-187.
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Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgartner W, Wacker F, Kalinke U, Klause Tanja, Tegtmeyer Pia-K., Becker Jennifer, Herder Vanessa, Borst Katharina, Todt Daniel, Lienenklaus Stefan, Gerhauser Ingo, Detje ClaudiaN., Geffers Robert, Langereis MartijnA., Vondran FlorianW.R., Yuan Qinggong, van Kuppeveld FrankJ.M., Ott Michael, Staeheli Peter, Steinmann Eike, Baumgärtner Wolfgang, Wacker Frank, Kalinke Ulrich (2018) Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLOS Pathog 14(8): 1-23.
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Lasswitz L, Chandra N, Arnberg N, Gerold G (2018) Glycomics and Proteomics Approaches to Investigate Early Adenovirus-Host Cell Interactions. J Mol Biol 430(13): 1863-1882.
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Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C (2018) The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. J Virol 92(14).
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Mulwa LS, Jansen R, Praditya DF, Mohr KI, Okanya PW, Wink J, Steinmann E, Stadler M (2018) Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria). Beilstein J Org Chem 14:(n/a): 1554-1562.
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Mulwa LS, Jansen R, Praditya DF, Mohr KI, Wink J, Steinmann E, Stadler M (2018) Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. Molecules 23(3): 542.
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Olsowski M, Hoffmann F, Hain A, Kirchhoff L, Theegarten D, Todt D, Steinmann E, Buer J, Rath PM, Steinmann J (2018) Exophiala dermatitidis isolates from various sources: using alternative invertebrate host organisms (Caenorhabditis elegans and Galleria mellonella) to determine virulence. Sci Rep 8(1): 12747.
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Pfaender S, Helfritz FA, Siddharta A, Todt D, Behrendt P, Heyden J, Riebesehl N, Willmann W, Steinmann J, Münch J, Ciesek S, Steinmann E (2018) Environmental Stability and Infectivity of Hepatitis C Virus (HCV) in Different Human Body Fluids. Frontiers in Microbiology 9:(n/a): 504.
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Pfankuche VM, Hahn K, Bodewes R, Hansmann F, Habierski A, Haverkamp AK, Pfaender S, Walter S, Baechlein C, Postel A, Steinmann E, Becher P, Osterhaus A, Baumgartner W, Puff C (2018) Comparison of Different In Situ Hybridization Techniques for the Detection of Various RNA and DNA Viruses. Viruses 10(7): 384.
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Sandargo B, Thongbai B, Praditya D, Steinmann E, Stadler M, Surup F (2018) Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea. Molecules 23(10).
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Seufert R, Sedlacek L, Kahl B, Hogardt M, Hamprecht A, Haase G, Gunzer F, Haas A, Grauling-Halama S, MacKenzie CR, Essig A, Stehling F, Sutharsan S, Dittmer S, Killengray D, Schmidt D, Eskandarian N, Steinmann E, Buer J, Hagen F, Meis JF, Rath PM, Steinmann J (2018) Prevalence and characterization of azole-resistant Aspergillus fumigatus in patients with cystic fibrosis: a prospective multicentre study in Germany. J Antimicrob Chemother 73(8): 2047-2053.
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Todt D, Moeller N, Praditya D, Kinast V, Friesland M, Engelmann M, Verhoye L, Sayed IM, Behrendt P, Thi VLD, Meuleman Philip, Steinmann Eike (2018) The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo. Antiviral Res 157:(n/a): 151--158.
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Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T (2017) Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity. J Hepatol 67(3): 480-489.
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Bartenschlager R, Cornberg M, Pietschmann T (2017) Maßgeschneiderte Therapie der Virushepatitis der Gegenwart und Zukunft. Der Internist 58(7): 666-674.
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Becker B, Bischoff B, Brill FHH, Steinmann E, Steinmann J (2017) Virucidal efficacy of a sonicated hydrogen peroxide system (trophon® EPR) following European and German test methods. GMS Hyg Infect Control 12:(n/a): Doc02.
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Becker B, Brill FHH, Todt D, Steinmann E, Lenz J, Paulmann D, Bischoff B, Steinmann J (2017) Virucidal efficacy of peracetic acid for instrument disinfection. Antimicrob Resist Infect Control 6:(n/a): 114.
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Behrendt P, Lüth S, Dammermann W, Drave S, Brown RJP, Todt D, Schnoor U, Steinmann E, Wedemeyer H, Pischke S, Iking-Konert C (2017) Exacerbation of hepatitis E virus infection during anti-TNFα treatment. Joint Bone Spine 84(2): 217-219.
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Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meulemann P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T (2017) Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry. Antiviral Res 147:(n/a): 19-28.
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Bruening J, Weigel B, Gerold G (2017) The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. J Immunol Res 2017(n/a): 12.
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Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C (2017) Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections. PLoS Negl Trop Dis 11(5): 1-11.
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Ducroux A, Goffinet C (2017) cGAS, an antiviral weapon: role in the recognition of HIV-1 transmitted from cell to cell. Med Sci (Paris) 33(8-9): 732-734.
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Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A (2017) Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology 14(1): 34.
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Gerold G, Bruening J, Weigel B, Pietschmann T (2017) Protein interactions during the flavivirus and hepacivirus life cycle. Mol Cell Proteomics 16(4 suppl 1): S75-S91.
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Khera T, Todt D, Vercauteren K, McClure CP, Verhoye L, Farhoudi A, Bhuju S, Geffers R, Baumert TF, Steinmann E, Meuleman P, Pietschmann T, Brown RJP (2017) Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy. Antiviral Research 139(n/a): 129 - 137.
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Kirchhoff L, Olsowski M, Zilmans K, Dittmer S, Haase G, Sedlacek L, Steinmann E, Buer J, Rath PM, Steinmann J (2017) Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents. Sci Rep 7(n/a): 42886.
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Pfaender S, Vielle NJ, Ebert N, Steinmann E, Alves MP, Thiel V (2017) Inactivation of Zika virus in human breast milk by prolonged storage or pasteurization. Virus Res 228(n/a): 58 - 60.
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Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJP, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JMV, Steinmann E (2017) Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A 114(12): E2430-E2439.
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Pietschmann T (2017) Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases. J Virol 91(2).
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Reichert C, Campe A, Walter S, Pfaender S, Welsch K, Ruddat I, Sieme H, Feige K, Steinmann E, Cavalleri JMV (2017) Frequent occurrence of nonprimate hepacivirus infections in Thoroughbred breeding horses - A cross-sectional study for the occurrence of infections and potential risk factors. Vet Microbiol 203(n/a): 315--322.
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Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, Yang J, Engelmann M, Todt D, Windisch MP, Brill FH, Steinmann J, Steinmann J, Becker S, Alves MP, Pietschmann T, Eickmann M, Thiel V, Steinmann E (2017) Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses. J Infect Dis 215(6): 902-906.
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Todt D, Schlevogt B, Deterding K, Grundhoff A, Manns MP, Wedemeyer H, Fischer N, Cornberg M, Steinmann E (2017) Successful retreatment of a patient with chronic hepatitis C genotype 2k/1b virus with ombitasvir/paritaprevir/ritonavir plus dasabuvir. J Antimicrob Chemother 72(5): 1541-1543.
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Vasiliauskaite I, Owsianka A, England P, Khan AG, Cole S, Bankwitz D, Foung SKH, Pietschmann T, Marcotrigiano J, Rey FA, Patel AH, Krey T (2017) Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. mBio 8(3).
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Walter S, Rasche A, Moreira-Soto A, Pfaender S, Bletsa M, Corman VM, Aguilar-Setien A, García-Lacy F, Hans A, Todt D, Schuler G, Shnaiderman-Torban A, Steinman A, Roncoroni C, Veneziano V, Rusenova N, Sandev N, Rusenov A, Zapryanova D, García-Bocanegra I, Jores J, Carluccio A, Veronesi MC, Cavalleri JMV, Drosten C, Lemey P, Steinmann E, Drexler JF (2017) Differential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeys. J Virol 91(1).
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Weller R, Hueging K, Brown RJP, Todt D, Joecks S, Vondran FWR, Pietschmann T (2017) Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions. J Virol 91(18).
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Anggakusuma, Brown RJ, Banda D, Todt D, Vieyres G, Steinmann E, Pietschmann T (2016) Hepaciviral NS3/4A proteases interfere with MAVS signalling of their cognate animal hosts and also with human MAVS: implications for zoonotic transmission. J Virol 90(23): 10670-10681.
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Bankwitz D, Pietschmann T (2016) Hepatitis C virus plays hide and seek with neutralizing antibodies. Hepatology 64(6): 1840-1842.
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Behrendt P, Bremer B, Todt D, Brown RJP, Heim A, Manns MP, Steinmann E, Wedemeyer H (2016) Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection. J Infect Dis 214(3): 361-368.
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Drave SA, Debing Y, Walter S, Todt D, Engelmann M, Friesland M, Wedemeyer H, Neyts J, Behrendt P, Steinmann E (2016) Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. Journal of Viral Hepatitis 23(7): 512-521.
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Gather T, Walter S, Pfaender S, Todt D, Feige K, Steinmann E, Cavalleri JM (2016) Acute and chronic infections with nonprimate hepacivirus in young horses. Vet Res 47(1): 97.
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Gather T, Walter S, Todt D, Pfaender S, Brown RJ, Postel A, Becher P, Moritz A, Hansmann F, Baumgaertner W, Feige K, Steinmann E, Cavalleri JV (2016) Vertical transmission of hepatitis C virus-like nonprimate hepacivirus in horses. J Gen Virol 97(10): 2540-2551.
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Gerold G, Bruening J, Pietschmann T (2016) Decoding protein networks during virus entry by quantitative proteomics. Virus Res 218(n/a): 25-39.
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Goffinet C (2016) Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. Curr HIV Res 14(3): 211-216.
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Heidrich B, Steinmann E, Plumeier I, Kirschner J, Sollik L, Ziegert S, Engelmann M, Lehmann P, Manns MP, Pieper DH, Wedemeyer H (2016) Frequent detection of HCV RNA and HCVcoreAg in stool of patients with chronic hepatitis C. J Clin Virol 80(n/a): 1 - 7.
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Ionidis G, Hübscher J, Jack T, Becker B, Bischoff B, Todt D, Hodasa V, Brill FHH, Steinmann E, Steinmann J (2016) Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid. BMC Infect Dis 16(1).
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Klotz U, Schmidt D, Willinger B, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria. Mycoses 59(5): 312-318.
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Krull M, Klare I, Ross B, Trenschel R, Beelen DW, Todt D, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation. Antimicrob Resist Infect Control 5(n/a): 31.
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Ludtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Gunther S, Oestereich L, Munoz-Fontela C (2016) Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes. J Infect Dis 214(suppl 3): S275-S280.
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Perin PM, Haid S, Brown RJP, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FWR, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology 63(1): 49--62.
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Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T (2016) Hepatitis C Virus Stimulates Murine CD8alpha-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog 12(7): e1005736.
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Pfaender S, von Hahn T, Steinmann J, Ciesek S, Steinmann E (2016) Prevention strategies for blood-borne viruses—in the Era of vaccines, direct acting antivirals and antiretroviral therapy. Rev Med Virol 26(5): 330-339.
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Postel A, Cavalleri JM, Pfaender S, Walter S, Steinmann E, Fischer N, Feige K, Haas L, Becher P (2016) Frequent presence of hepaci and pegiviruses in commercial equine serum pools. Vet Microbiol 182(n/a): 8 - 14.
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Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, Garcia-Dorival I, Wolfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avsic-Zupanc T, Kurth A, Meschi S, Mely S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Gunther S, Munoz-Fontela C (2016) Unique human immune signature of Ebola virus disease in Guinea. Nature 533(7601): 100-104.
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Siddharta A, Pfaender S, Malassa A, Doerrbecker J, Anggakusuma, Engelmann M, Nugraha B, Steinmann J, Todt D, Vondran FW, Mateu-Gelabert P, Goffinet C, Steinmann E (2016) Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. Sci Rep 6(n/a): 36619.
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Stohr S, Costa R, Sandmann L, Westhaus S, Pfaender S, Anggakusuma, Dazert E, Meuleman P, Vondran FW, Manns MP, Steinmann E, von Hahn T, Ciesek S (2016) Host cell mTORC1 is required for HCV RNA replication. Gut 65(12): 2017-2028.
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Todt D, Gisa A, Radonic A, Nitsche A, Behrendt P, Suneetha PV, Pischke S, Bremer B, Brown RJP, Manns MP, Cornberg M, Bock CT, Steinmann E, Wedemeyer H (2016) In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 65(10): 1733-1743.
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Todt D, Walter S, Brown RJP, Steinmann E (2016) Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations. Viruses 8(10): 283.
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Todt D., Francois C., Kusuma A, Behrendt P, Engelmann M, Knegendorf L, Vieyres G, Wedemeyer H, Hartmann R, Pietschmann T, Duverlie G, Steinmann E (2016) Antiviral activity of different interferon (sub-) types against hepatitis E virus replication. Antimicrobial Agents and Chemotherapy 60(4): 2132-2139.
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Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P (2016) Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Gut 65(12): 2029-2034.
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Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FWR, Kaderali L, Pietschmann T (2016) ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production. PLoS Pathog 12(4): e1005568.
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Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E (2016) Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7. J Virol 90(10): 5075-5089.
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Weller R, Todt D, Engelmann M, Friesland M, Wedemeyer H, Pietschmann T, Steinmann E (2016) Apolipoprotein E polymorphisms and their protective effect on Hepatitis E virus replication. Hepatology 64(6): 2274-2276.
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Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C (2016) cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Cell Host & Microbe 20(4): 443-457.
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von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A (2016) Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. MBio 7(6).
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Abd-Elshafy DN, Pietschmann T, Muller-Ladner U, Neumann E, Anggakusuma, M BahgatM, Pessler F, Behrendt P (2015) Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 5(n/a): 18043.
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Anggakusuma, Frentzen A, Gurlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Hornung V, Kuehnel F, Pietschmann T (2015) Control of HCV replication in mouse liver derived cells by MAVS-dependent production of type-I and -III interferons. J Virol 98(7): 3833-3845.
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Garcia-Risco MR, Vazquez E, Sheldon J, Steinmann E, Riebesehl N, Fornari T, Reglero G (2015) Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of the extracts. Virus Res 198(n/a): 9-14.
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Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T (2015) Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Cell Rep 12(5): 864-878.
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Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells. J Virol 89(6): 3200-3208.
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Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T (2015) Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor by using a novel lentiviral pseudotype (hRSVpp) system. J Virol 90(6): 3065-3073.
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Hedenstierna M, Weiland O, Brass A, Bankwitz D, Behrendt P, Uhnoo I, Aleman S, Cardell K, Fryden A, Norkrans G, Eilard A, Glaumann H, Pietschmann T, Sallberg M, Brenndorfer ED (2015) Long-term follow-up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure. Aliment Pharmacol Ther 41(6): 532-543.
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Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wolk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T (2015) Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. PLoS One 10(7): e0134529.
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Koutsoudakis G, Romero-Brey I, Berger C, Perez-Vilaro G, Perin PM, Vondran FW, Kalesse M, Harmrolfs K, Muller R, Martinez JP, Pietschmann T, Bartenschlager R, Bronstrup M, Meyerhans A, Diez J (2015) Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. J Hepatol 63(4): 813-821.
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Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Hepatology 62(3): 702-714.
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Lauber C, Vieyres G, Terczynska-Dyla E, Anggakusuma, Dijkman R, Gad HH, Akhtar H, Geffers R, Vondran FW, Thiel V, Kaderali L, Pietschmann T, Hartmann R (2015) Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells. Genes Immun 16(6): 414-421.
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Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Sturzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klarner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Munch J (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife 4(n/a).
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Pfaender S, Brinkmann J, Todt D, Riebesehl N, Steinmann J, Steinmann J, Pietschmann T, Steinmann E (2015) Mechanisms of viral inactivation methods against hepatitis C virus. Appl Environ Microbiol 81(5): 1616-1621.
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Pfaender S, Cavalleri JM, Walter S, Doerrbecker J, Campana B, Brown RJ, Burbelo PD, Postel A, Hahn K, Kusuma A, Riebesehl N, Baumgartner W, Becher P, Heim MH, Pietschmann T, Feige K, Steinmann E (2015) Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses. Hepatology 61(2): 448-459.
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Pfaender S, Walter S, Todt D, Behrendt P, Doerrbecker J, Woelk B, Engelmann M, Gravemann U, Seltsam A, Steinmann J, Burbelo PD, Klawonn F, Feige K, Pietschmann T, Cavalleri JM, Steinmann E (2015) Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure. J Gen Virol 96(9): 2636-2642.
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Rabenau HF, Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 493-504.
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Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2015) Reply: PCR assay for pathogen detection in ventriculostomy-related meningitis in neurosurgery patients: unanswered questions?. Infection 43(2): 251-252.
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Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, von Rheinbaben F, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P, Rabenau HF (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 491-491.
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Steinmann J, Becker B, Bischoff B, Steinmann E (2015) Alcohol hand rub or soap and water for removal of norovirus from hands – the debate continues. Journal of Hospital Infection 91(4): 371 - 372.
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Tarr AW, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, Brown RJ (2015) Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design. Viruses 7(7): 3995-4046.
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Walker A, Skibbe K, Steinmann E, Pfaender S, Kuntzen T, Megger D.A., Groten S, Sitek B, Lauer G.M., Kim A.Y., Pietschmann T, Allen T.M., Timm J. (2015) Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing. J Virol doi: 10.1128/JVI.01993-15(n/a).
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Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63(7): 1137-1149.
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Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, Haid S, Catanese MT, Zeisel MB, Nicosia A, Baumert TF, Kaderali L, Pietschmann T (2014) Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins. J Virol 88(21): 12644-12655.
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Behrendt P, Steinmann E, Manns MP, Wedemeyer H (2014) The impact of hepatitis E in the liver transplant setting. Journal of hepatology 61(6): 1418-1429.
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Brown RJ, Koutsoudakis G, Urbanowicz RA, Mirza D, Ginkel C, Riebesehl N, Calland N, Albecka A, Price L, Hudson N, Descamps V, Backx M, McClure CP, Duverlie G, Pecheur EI, Dubuisson J, Perez-Del-Pulgar S, Forns X, Steinmann E, Tarr AW, Pietschmann T, Ball JK (2014) Analysis of serine codon conservation reveals diverse phenotypic constraints on Hepatitis C Virus glycoprotein evolution. J Virol 88(1): 667-678.
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Deest M, Westhaus S, Steinmann E, Manns MP, von Hahn T, Ciesek S (2014) Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization. Antiviral Res 101(n/a): 37-44.
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Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Behrendt P, Brown RJ, Ciesek S, Wedemeyer H, Sarrazin C, Kaderali L, Pietschmann T, Steinmann E (2014) Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology 60(2): 508-520.
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Frentzen A, Anggakusuma, Guerlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kroger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T (2014) Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology 59(1): 78-88.
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Gerold G, Pietschmann T (2014) A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication. Hepatology 59(2): 363-365.
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Gerold G, Pietschmann T (2014) The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets. Dig Dis 32(5): 525-537.
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Haid S, Grethe C, Dill MT, Heim M, Kaderali L, Pietschmann T (2014) Isolate-dependent use of Claudins for cell entry by hepatitis C virus. Hepatology 59(1): 24-34.
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Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wolk B, Kaderali L, Pietschmann T (2014) Apolipoprotein E co-determines tissue-tropism of hepatitis C virus and it is crucial for viral cell-to-cell transmission by contributing to a post-envelopment step of assembly. J Virol 88(3): 1433-1446.
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Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ (2014) Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res 110c(n/a): 52-59.
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Lange M, Fiedler M, Bankwitz D, Osburn W, Viazov S, Brovko O, Zekri AR, Khudyakov Y, Nassal M, Pumpens P, Pietschmann T, Timm J, Roggendorf M, Walker A (2014) Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies. PLoS One 9(7): e102235.
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Pietschmann T (2014) In sero veritas: what serum markers teach us about HCV infection of primary human hepatocytes. Gut 63(9): 1375-1377.
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Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2014) Value of multiplex PCR using cerebrospinal fluid for the diagnosis of ventriculostomy-related meningitis in neurosurgery patients. Infection 42(2): 621-627.
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Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P (2014) Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. Hepatology 9(7): e102235.
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Vidigal PG, Dittmer S, Steinmann E, Buer J, Rath PM, Steinmann J (2014) Adaptation of Stenotrophomonas maltophilia in cystic fibrosis: Molecular diversity, mutation frequency and antibiotic resistance. Int J Med Microbiol 304(5-6): 613-619.
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Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J (2014) Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm. PLoS One 9(4): e92876.
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Vieyres G, Dubuisson J, Pietschmann T (2014) Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion. Viruses 6(3): 1149-1187.
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Behrendt P, Doerrbecker J, Riebesehl N, Wilhelm C, Ciesek S, Erichsen TJ, Steinmann J, Ott M, Manns MP, Pietschmann T, Steinmann E (2013) Stability and transmission of hepatitis C virus in different anesthetic agents. Am J Infect Control 41(10): 942-943.
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Doerrbecker J, Behrendt P, Mateu-Gelabert P, Ciesek S, Riebesehl N, Wilhelm C, Steinmann J, Pietschmann T, Steinmann E (2013) Transmission of Hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment. J Infect Dis 207(2): 281-287.
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Doerrbecker J., Meuleman P., Kang J., Riebesehl N., Wilhelm C., Friesland M., Pfaender S., Steinmann J., Pietschmann T., Steinmann E. (2013) Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. J Virol Hepat 20(7): 478-485.
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Gentzsch J, Brohm C, Steinmann E, Friesland M, Menzel N, Vieyres G, Perin PM, Frentzen A, Kaderali L, Pietschmann T (2013) Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment. PLoS pathogens 9(5): e1003355.
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Gerold G, Pietschmann T (2013) Hepatitis C virus NS5B polymerase primes innate immune signaling. Hepatology 57(3): 1275-1277.
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Goncalves Vidigal P, Schmidt D, Stehling F, Mellies U, Steinmann E, Buer J, Rath PM, Steinmann J (2013) Development of a quantitative immunofluorescence assay for detection of Stenotrophomonas maltophilia antibodies in patients with cystic fibrosis. J Cyst Fibros 12(6): 651-654.
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Hamming OJ, Terczynska-Dyla E, Vieyres G, Dijkman R, Jorgensen SE, Akhtar H, Siupka P, Pietschmann T, Thiel V, Hartmann R (2013) Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses. Embo J 32(23): 3055-3065.
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Lodermeyer V, Suhr K, Schrott N, Kolbe C, Sturzel CM, Krnavek D, Munch J, Dietz C, Waldmann T, Kirchhoff F, Goffinet C (2013) 90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1. Retrovirology 10(1): 111.
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Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kroger A (2013) Hepatitis C Virus Replication in Mouse Cells is Restricted by IFN-Dependent and -Independent Mechanisms. Gastroenterology 145(6): 1414-1423e1.
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Pfaender S, Heyden J, Friesland M, Ciesek S, Ejaz A, Steinmann J, Malarski A, Stoiber H, Tsiavaliaris G, Bader W, Jahreis G, Pietschmann T, Steinmann E (2013) Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk. J Infect Dis 208(12): 1943-1952.
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Schemuth H, Dittmer S, Lackner M, Sedlacek L, Hamprecht A, Steinmann E, Buer J, Rath PM, Steinmann J (2013) In vitro activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis. Mycoses 56(3): 297-303.
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Steinmann E, Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Hillung J, Gentzsch J, Lauber C, Brown R, Frentzen A, Pietschmann T (2013) Characterization of hepatitis C virus intra- and inter-genotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol 87(24): 13297-13306.
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Steinmann E, Gravemann U, Friesland M, Doerrbecker J, Muller TH, Pietschmann T, Seltsam A (2013) Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products. Transfusion 53(5): 1010-1018.
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Steinmann E, Pietschmann T (2013) Cell culture systems for hepatitis C virus. Curr Top Microbiol Immunol 369(n/a): 17-48.
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Steinmann J, Becker B, Bischoff B, Magulski T, Steinmann E (2013) Virucidal activity of Formulation I of the World Health Organization's alcohol-based handrubs: impact of changes in key ingredient levels and test parameters. Antimicrob Resist Infect Control 2(1): 34.
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Steinmann J, Buer J, Pietschmann T, Steinmann E (2013) Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of Green Tea. Br J Pharmacol 168(5): 1059-1073.
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Vieyres G, Brohm C, Friesland M, Gentzsch J, Wolk B, Roingeard P, Steinmann E, Pietschmann T (2013) Subcellular localization and function of an epitope-tagged p7 in hepatitis C virus-producing cells. J Virol 87(3): 1664-1678.
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Vieyres G, Pietschmann T (2013) Entry and replication of recombinant hepatitis C viruses in cell culture. Methods 59(2): 233-248.
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Westhaus S, Bankwitz D, Ernst S, Rohrmann K, Wappler I, Agne C, Luchtefeld M, Schieffer B, Sarrazin C, Manns MP, Pietschmann T, Ciesek S, von Hahn T (2013) Characterization of the inhibition of hepatitis C virus entry by in vitro generated and patient derived oxidized low density lipoprotein. Hepatology 57(5): 1716-1724.
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Zahid MN, Turek M, Xiao F, Thi VL, Guerin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F, Baumert TF, Zeisel MB (2013) The post-binding activity of scavenger receptor BI mediates initiation of hepatitis C virus infection and viral dissemination. Hepatology 57(2): 492-504.
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Barbier J, Wegner J, Benson S, Gentzsch J, Pietschmann T, Kirschning A (2012) Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition. Chemistry 18(29): 9083-9090.
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Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P, Lohmann V, Pietschmann T (2012) Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. PloS One 7(4): e36029.
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Ejaz A, Steinmann E, Banki Z, Kusuma A, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H (2012) Specific Acquisition of Functional CD59 but Not CD46 or CD55 by Hepatitis C Virus. PLoS One 7(9): e45770.
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Fofana I, Fafi-Kremer S, Carolla P, Fauvelle C, Zahid MN, Turek M, Heydmann L, Cury K, Hayer J, Combet C, Cosset FL, Pietschmann T, Hiet MS, Bartenschlager R, Habersetzer F, Doffoel M, Keck ZY, Foung SK, Zeisel MB, Stoll-Keller F, Baumert TF (2012) Mutations that Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies. Gastroenterology 143(1): 223-233.e9.
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Frentzen A, Hueging K, Bitzegeio J, Pietschmann T, Steinmann E (2012) Two methods of heterokaryon formation to discover HCV restriction factors. J Vis Exp n/a(65): e4029.
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Haid S, Novodomska A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Ponisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg A, Wong-Staal F, Davioud-Charvet E, Pietschmann T (2012) A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes. Gastroenterology 143(1): 213-222.e5.
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Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J (2012) High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. J Biol Chem 287(46): 39224-39232.
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Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, Haid S, Gentzsch J, Kaderali L, Bartenschlager R, Pietschmann T (2012) MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles. PLoS Pathog 8(7): e1002829.
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Rath PM, Saner F, Paul A, Lehmann N, Steinmann E, Buer J, Steinmann J (2012) Multiplex PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients. J Clin Microbiol 50(6): 2069-2071.
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Ruhl M, Chhatwal P, Strathmann H, Kuntzen T, Bankwitz D, Skibbe K, Walker A, Heinemann FM, Horn PA, Allen TM, Hoffmann D, Pietschmann T, Timm J (2012) Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope. J Virol 86(2): 991-1000.
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Sandmann L, Wilson M, Back D, Wedemeyer H, Manns MP, Steinmann E, Pietschmann T, von Hahn T, Ciesek S (2012) Antiretroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro. Antiviral Res 96(1): 51-58.
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Stegmann KA, Bjorkstrom NK, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, Malinski P, Dustin LB, Rice CM, Manns MP, Pietschmann T, Cornberg M, Ljunggren HG, Wedemeyer H (2012) Interferon alpha-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1. J Infect Dis 205(9): 1351-1362.
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Steinmann J, Paulmann D, Becker B, Bischoff B, Steinmann E (2012) Comparison of virucidal activity of alcohol-based hand sanitizers versus antimicrobial hand soaps in vitro and in vivo. J Hosp Infect 82(4): 277-280.
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von Hahn T, Schiene-Fischer C, Van ND, Pfander S, Karavul B, Steinmann E, Potthoff A, Strassburg C, Hamdi N, Abdelaziz AI, Sarrazin C, Muller T, Berg T, Trepo E, Wedemeyer H, Manns MP, Pietschmann T, Ciesek S (2012) Hepatocytes that Express Variants of Cyclophilin A are Resistant to HCV Infection and Replication. Gastroenterology 143(2): 439-447e1.
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Burgel B, Friesland M, Koch A, Manns MP, Wedemeyer H, Weissenborn K, Schulz-Schaeffer WJ, Pietschmann T, Steinmann E, Ciesek S (2011) Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration. J Viral Hepat 18(8): 562-570.
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Ciesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, Hamdi N, Abdelaziz AI, Strassburg CP, Wedemeyer H, Manns MP, Pietschmann T, von Hahn T (2011) Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles. J Virol 85(15): 7613-7621.
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Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry. Hepatology 54(6): 1947-1955.
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Ciesek S, von Hahn T, Manns MP (2011) Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 15(3): 597-609.
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Doerrbecker J, Friesland M, Ciesek S, Erichsen TJ, Mateu-Gelabert P, Steinmann J, Pietschmann T, Steinmann E (2011) Inactivation and survival of hepatitis C virus on inanimate surfaces. J Infect Dis 204(12): 1830-1838.
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Frentzen A, Huging K, Bitzegeio J, Friesland M, Haid S, Gentzsch J, Hoffmann M, Lindemann D, Zimmer G, Zielecki F, Weber F, Steinmann E, Pietschmann T (2011) Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog 7(4): e1002029.
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Gentzsch J, Hinkelmann B, Kaderali L, Irschik H, Jansen R, Sasse F, Frank R, Pietschmann T (2011) Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res 89(2): 136-148.
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Lupberger J, Zeisel MB, Xiao F, Thumann C, zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF (2011) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 17(5): 589-595.
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Paulmann D, Steinmann J, Becker B, Bischoff B, Steinmann E (2011) Virucidal activity of different alcohols against murine norovirus, a surrogate of human norovirus. J Hosp Infect 79(4): 378-379.
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Steinmann E, Ciesek S, Friesland M, Erichsen TJ, Pietschmann T (2011) Prolonged Survival of Hepatitis C Virus in the Anesthetic Propofol. Clin Infect Dis 53(9): 963-964.
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Steinmann J, Kaase M, Gatermann S, Popp W, Steinmann E, Damman M, Paul A, Saner F, Buer J, Path P (2011) Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. Euro Surveill 16(33): pii: 19944.
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von Hahn T, Schulze A, Chicano Wust I, Heidrich B, Becker T, Steinmann E, Helfritz FA, Rohrmann K, Urban S, Manns MP, Pietschmann T, Ciesek S (2011) The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. PLoS One 6(9): e24142.
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Bankwitz D, Steinmann E, Bitzegeio J, Ciesek S, Friesland M, Herrmann E, Zeisel MB, Baumert TF, Keck ZY, Foung SK, Pecheur EI, Pietschmann T (2010) Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84(11): 5751-5763.
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Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB, Herrmann E, Iken M, Ott M, Baumert TF, Pietschmann T (2010) Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog 6(n/a): e1000978.
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Ciesek S, Friesland M, Steinmann J, Becker B, Wedemeyer H, Manns MP, Pietschmann T, Steinmann E (2010) How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201(12): 1859-1866.
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Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA, Wappler I, Manns MP, Wedemeyer H, Pietschmann T (2010) Glucocorticosteroids increase cell entry by hepatitis C virus. Gastroenterology 138(5): 1875-1884.
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Hahn T, Steinmann E, Ciesek S, Pietschmann T (2010) Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches. Expert Rev Gastroenterol Hepatol 4(1): 63-79.
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Haid S, Windisch MP, Bartenschlager R, Pietschmann T (2010) Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line. J Virol 84(2): 964-975.
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Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS, Tellinghuisen TL, Symons J, Furman PA (2010) Development of novel therapies for hepatitis C. Antiviral Res 86(1): 79-92.
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Montserret R, Saint N, Vanbelle C, Salvay AG, Simorre JP, Ebel C, Sapay N, Renisio JG, Bockmann A, Steinmann E, Pietschmann T, Dubuisson J, Chipot C, Penin F (2010) NMR structure and ion channel activity of the p7 protein from hepatitis C virus. Biol Chem 285(41): 31446-31461.
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Stegmann KA, Bjorkstrom NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V., Fytili P., Cornberg M., Manns MP., Geffers R., Pietschmann T., Guzman CA., Ljunggren HG., Wedemeyer H. (2010) Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 138(5): 1885-1897.
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Steinmann E, Pietschmann T (2010) Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses 2(9): 2078-2095 (Review).
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Steinmann J, Becker B, Bischoff B, Paulmann D, Friesland M, Pietschmann T, Steinmann E (2010) Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization. Am J Infect Control 38(1): 66-68.
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Brohm C, Steinmann E, Friesland M, Lorenz IC, Patel A, Penin F, Bartenschlager R, Pietschmann T (2009) Characterization of determinants important for hepatitis C virus p7 function in morphogenesis using trans-complementation. J Virol 83(22): 11682-11693.
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Ciesek S, Steinmann E, Wedemeyer H, Manns MP, Neyts J, Tautz N, Madan V, Bartenschlager R, von Hahn T, Pietschmann T (2009) Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology 50(5): 1638-1645.
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Haid S, Pietschmann T, Pecheur EI (2009) Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition, and density of virus particles. Pecheur EI Haid S 284(26): 17657-17667.
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Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M (2009) A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4): 295-308.
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Pietschmann T (2009) Full-length infectious HCV chimeras. Methods Mol Biol 510(n/a): 347-359.
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Pietschmann T (2009) Regulation of hepatitis C virus replication by microRNAs. J Hepatol 50(50(3)): 441-444.
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Pietschmann T (2009) Virology: Final entry key for hepatitis C. Nature 457(7231): 797-798.
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Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R (2009) Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog 5(6): e1000475.
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Witteveldt J, Evans MJ, Bitzegeio J, Koutsoudakis G, Owsianka AM, Angus AG, Keck ZY, Foung SK, Pietschmann T, Rice CM, Patel AH (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. J Gen Virol 90(Pt 1): 48-58.
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Ciesek S, Steinmann E, Manns MP, Wedemeyer H, Pietschmann T (2008) The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis 198(7): 1091-1093.
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Jirasko V, Montserret R, Appel N, Janvier A, Eustachi L, Brohm C, Steinmann E, Pietschmann T, Penin F, Bartenschlager R (2008) Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem 283(42): 28546-28562.
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Pietschmann T, Steinmann E, Ciesek S (2008) Hepatitis C virus cell culture models--new perspectives for research and clinic. Dtsch Med Wochenschr 133(30): 1580-1584.
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Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T (2008) Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol 82(14): 7034-7046.