Experimental Virology

Viruses are vehicles that transport biological information and reprogram the functions of human, animal or plant cells in order to replicate. They are very small and usually have a very simple structure. Enveloped viruses consist only of a layer of proteins filled with genetic material and surrounded by a thin shell of lipids in which viral proteins are embedded. Nevertheless, viral pathogens such as HIV or hepatitis C virus (HCV) threaten the health of millions of people. In addition to HCV, important human pathogens in the group of the RNA viruses include respiratory syncytial virus (RSV) and SARS-CoV-2, the virus responsible for the current COVID-19 pandemic.

In our institute three research groups are working on hepatitis viruses (HCV, HEV), RSV and since 2020 also SARS-CoV-2. We combine molecular and cell biological approaches with bioinformatics and computational methods to understand viral replication mechanisms and to develop new therapeutic and preventive measures.  

 

Prof. Dr. Thomas Pietschmann is a member of the RESIST cluster of excellence

In the video he explains his research focus in RESIST

This video was provided by the RESIST cluster of excellence.

Further information about Thomas Pietschmann in RESIST can be found here.

 

News

Hard to break down

Hepatitis E virus defies alcohol-based hand disinfectants.

Joint press release by TWINCORE, Hannover Medical School and Ruhr University Bochum

Lipid-lowering drugs not a risk factor in COVID-19.

Statins do not increase infectivity or viral replication of SARS-CoV-2

A precise measure of protective immunity

New tool aims to make HCV vaccine search easier

Two murine restriction factors limiting hepatitis C infection described

Research team at TWINCORE, with international collaborators, clarifies why mice are not susceptible to infection with hepatitis C virus

 

New research group “Computational Virology” at TWINCORE

Group leader Chris Lauber funded by RESIST