TWINCORE-Seminar

Dr. Jean-François Éléouët,
Senior scientist at INRA, Unité de Virologie et Immunologie Moléculaires (VIM), Jouy-en-Josas, France.

Titel: Can structural and functional data help the design of antiviral compounds targeting the RNA polymerase complex of RSV?

Zeit: 17:00 Uhr s.t.
Ort: TWINCORE Lecture Hall (0.02)

Abstract:
The main objective of his group is to study the structure and the functioning of the RNAdependent RNA polymerase (RdRp) of Respiratory Syncytial Virus. The goal is to better understand how RSV replicates, transcribes its genes and, based on these data, to develop antiviral compounds. They have mapped and characterized protein-protein interaction domains between the different components of the RdRp complex; they try to resolve the atomic structure of these proteins in collaboration with crystallographs and NMR spectroscopists. They are searching for cellular partners of the RdRp; have developed an RSV minigenome with a luciferase reporter gene for functional analysis of the RdRp in living cells and have developed their own reverse genetics system.

The INRA Research Center at Jouy-en-Josas  is a unique space located in Ile-de-France region, offering research on food, animals, and microorganisms, affirmed and supported by mathematics. The Jouy Research Center is the largest INRA center in France: 820 permanent INRA employees work there along with 430 from other partner organizations and more than 250 on fixed-term contracts.

Ansprechpartner: <link internal-link internal link in current>Prof. Dr. Thomas Pietschmann