Publikationen

    2017

    • Wang LL, Balakrishnan A, Bigall NC, Candito D, Miethe JF, Seidel K, Xie Y, Ott M, Kirschning A (2017) A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. Chemistry 23(10): 2265-2270.

    2016

    • Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer B M, Araúzo-Bravo M J, Steinemann D, Luedde T, Schwabe R F, Manns M P, Schöler H R, Schambach A, Cantz T, Ott M, Sharma A D (2016) Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell 18(6): 797-808.

    • Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD (2016) MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun 7 11916.

    2015

    • Anggakusuma, Frentzen A, Gurlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Hornung V, Kuehnel F, Pietschmann T (2015) Control of HCV replication in mouse liver derived cells by MAVS-dependent production of type-I and -III interferons. J Virol 89(7): 3833-3845.

    • Junge N, Mingozzi F, Ott M, Baumann U (2015) Adeno-associated Virus Vector Based Gene Therapy for Monogenetic Metabolic Diseases of the Liver. J Pediatr Gastroenterol Nutr 60(4): 433-440.

    • Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD (2015) MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells. J Hepatol 62(1): 101-110.

    2014

    • Anggakusuma A, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63(7): 1137-1149.

    • Berneman-Zeitouni D, Molakandov K, Elgart M, Mor E, Fornoni A, Dominguez MR, Kerr-Conte J, Ott M, Meivar-Levy I, Ferber S (2014) The temporal and hierarchical control of transcription factors-induced liver to pancreas transdifferentiation. PLoS One 9(2): 387812.

    2013

    • Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Munch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schuttrumpf J, Muller UC, Seppen J, Ott M, Buchholz CJ (2013) Specific gene delivery to liver sinusoidal and artery endothelial cells. Blood 122(12): 2030-2038.

    • Behrendt P, Doerrbecker J, Riebesehl N, Wilhelm C, Ciesek S, Erichsen TJ, Steinmann J, Ott M, Manns MP, Pietschmann T, Steinmann E (2013) Stability and transmission of hepatitis C virus in different anesthetic agents. Am J Infect Control 41(10): 942-943.

    • Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T (2013) Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med 2(9): 641-654. * ebenfalls TWINCORE Beteiligung.

    • Norenberg A, Heinz S, Scheller K, Hewitt NJ, Braspenning J, Ott M (2013) Optimization of upcyte human hepatocytes for the in vitro micronucleus assay. Mutat Res 758(1-2): 69-79 * ebenfalls TWINCORE Beteiligung.

    • Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M (2013) Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents. Hepatology 58(1): 397-408.

    • Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T (2013) Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med 13(5): 842-855.

    • Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L (2013) A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration. Cell 153(2): 389-401.

    • Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD (2013) MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology 57(1): 299-310.

    2012

    • Bieback K, Wuchter P, Besser D, Franke W, Becker M, Ott M, Pacher M, Ma N, Stamm C, Kluter H, Muller A, Ho AD (2012) Mesenchymal stromal cells (MSCs): science and f(r)iction. J Mol Med (Berl) 90(7): 773-782.

    • Kafert-Kasting S, Schneider A, Attaran M, Priesner C, Barthold M, Perrier AL, Kriegbaum H, Ott M, Meyburg J (2012) Safety assessment of intraportal liver cell application in New Zealand white rabbits under GLP conditions. Arch Toxicol 86(9): 1413-1422.

    • Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gomez-Lechon MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A (2012) Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 21(1): 1-10.

    • Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U (2012) Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes. Gene Ther 19(4): 425-434.

    • Sharma AD, Rittelmeyer I, Cantz T, Ott M (2012) Regenerative therapies for liver diseases. Stem Cell Biology and Regenerative Medicine 2013(doi: 10.1007/978-1-62703-098-4_10): 203-231.

    • Waern JM, Yuan Q, Rudrich U, Becker PD, Schulze K, Strick-Marchand H, Huntington ND, Zacher BJ, Wursthorn K, Di Santo JP, Guzman CA, Manns MP, Ott M, Bock M (2012) Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice. Hepatology 56(4): 1479-1788.

    2011

    • Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry.. Hepatology 54(6): 1947-1955.

    • Iacob R, Rudrich U, Rothe M, Kirsch S, Maasoumy B, Narain N, Verfaillie CM, Sancho-Bru P, Iken M, Popescu I, Schambach A, Manns MP, Bock M (2011) Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors.. Stem Cell Res 6(3): 251-261.

    • Kang TW, Yevsa T, Woller N, Hoenicke L, Gereke M, Wuestefeld T, Dauch D, Hohmeyer A, Potapova A, Bruder D, Schirmacher P, Longerich T, Kubicka S, Ott M, Iken M, Luedde T, Rudalska R, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Manns MP, Tacke F (2011) Senescence surveillance of premalignant hepatocytes limits liver cancer development.. Nature 479(7374): 547-551.

    • Koenig S, Yuan Q, Krause P, Christiansen H, Rave-Fraenk M, Kafert-Kasting S, Kriegbaum H, Schneider A, Ott M, Meyburg J (2011) Regional transient portal ischemia and irradiation as preparative regimen for hepatocyte transplantation.. Cell Transplant 20(2): 303-311.

    • Sancho-Bru P, Roelandt P, Narain N, Pauwelyn K, Notelaers T, Shimizu T, Ott M, Verfaillie C (2011) Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells.. J Hepatol 54(1): 98-107.

    • Sharma AD, Narain N, Handel EM, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T (2011) MicroRNA-221 regulates FAS-induced fulminant liver failure.. Hepatology 53(5): 1651-1661.

    • Straub BK, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, Ott M, Schirmacher P, Franke WW (2011) E:N-cadherin heterodimers define a novel kind of adherens junction connecting certain endoderm-derived normal and tumor cells. J Cell Biol 195(5): 873-887.

    • Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T (2011) Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells. PLoS Biol 9(7): e1001099.

    2010

    • Asgari S, Pournasr B, Salekdeh GH, Ghodsizadeh A, Ott M, Baharvand H (2010) Induced pluripotent stem cells: a new era for hepatology. J Hepatol 53(4): 738-751.

    • Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H (2010) Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One 5(10): e13137.

    • Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB, Herrmann E, Iken M, Ott M, Baumert TF, Pietschmann T (2010) Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog 6 e1000978.

    • Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA, Wappler I, Manns MP, Wedemeyer H, Pietschmann T (2010) Glucocorticosteroids increase cell entry by hepatitis C virus.. Gastroenterology 138(5): 1875-1884.

    • Hettwer M, Reis-Fernandes MA, Iken M, Ott M, Steinberg P, Nau H (2010) Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.. Reprod Toxicol 30(1): 113-120.

    • Stange MA, Tutarel O, Pischke S, Schneider A, Strassburg CP, Becker T, Barg-Hock H, Basturk M, Wursthorn K, Cornberg M, Ott M, Greten TF, Manns MP, Wedemeyer H (2010) Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab. Z Gastroenterol 48(2): 258-263.

    2009

    • Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Norder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M (2009) Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.. Am J Pathol 175(4): 1483-1492.

    • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P (2009) Humanized mice for modeling human infectious disease: challenges, progress, and outlook.. Cell Host Microbe 6(1): 5-9. Review.

    • Meyburg J, Das AM, Hoerster F, Lindner M, Kriegbaum H, Engelmann G, Schmidt J, Ott M, Pettenazzo A, Luecke T, Bertram H, Hoffmann GF, Burlina A (2009) One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects.. Transplantation 87(5): 636-641.

    • Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M (2009) Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?. Gut 58(4): 594-603.

    2008

    • Cantz T, Manns MP, Ott M (2008) Stem cells in liver regeneration and therapy. Cell Tissue Res 331(1): 271-282 Review.

    • Dietrich CF, Ignee A, Braden B, Barreiros AP, Ott M, Hocke M (2008) Improved differentiation of pancreatic tumors using contrast-enhanced endoscopic ultrasound. Clin Gastroenterol Hepatol 6(5): 590-597 e1.

    • Haridass D, Narain N, Ott M (2008) Hepatocyte transplantation: waiting for stem cells. Curr Opin Organ Transplant 13(6): 627-632 Review.

    • Kwon HS, Ott M (2008) The ups and downs of SIRT1. Trends Biochem Sci 33(11): 517-525 Review.

    • Ott M (2008) A symphony of techniques for liver cell therapy, only applicable to rats?. J Hepatol 49(1): 6-8.

    • Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M (2008) Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplant 17(3): 313-323.