Publikationen

    2017

    • Kommerein N, Stumpp SN, Müsken M, Ehlert N, Winkel A, Häussler S, Behrens P, Buettner FFR, Stiesch M (2017) An oral multispecies biofilm model for high content screening applications. PLoS One 12(3): 1-21.

    • Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S (2017) Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. mBio 8(1).

    2016

    • Binder SC, Eckweiler D, Schulz S, Bielecka A, Nicolai T, Franke R, Haussler S, Meyer-Hermann M (2016) Functional modules of sigma factor regulons guarantee adaptability and evolvability. Sci Rep 6 22212.

    • Ghanbari A, Dehghany J, Schwebs T, Musken M, Haussler S, Meyer-Hermann M (2016) Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms. Sci Rep 6.

    • Khaledi A, Schniederjans M, Pohl S, Rainer R, Bodenhofer U, Xia B, Klawonn F, Bruchmann S, Preusse M, Eckweiler D, Dötsch A, Häussler S (2016) Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa. Antimicrob Agents and Chemother 66(8): 4722-4733.

    • Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S (2016) Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa. Environ Microbiol 18(10): 3583-3592.

    • Lorenz A, Pawar V, Häussler S, Weiss S (2016) Insights into host–pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections. FEBS Letters 590(21): 3941-3959.

    • Tata M, Wolfinger MT, Amman F, Roschanski N, Dötsch A, Sonnleitner E, Häussler S, Bläsi U (2016) RNASeq Based Transcriptional Profiling of Pseudomonas aeruginosa PA14 after Short- and Long-Term Anoxic Cultivation in Synthetic Cystic Fibrosis Sputum Medium. PLoS One 11(1): e0147811.

    • Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C (2016) cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Cell Host & Microbe 20(4): 443 - 457.

    2015

    • Bielecki P, Jensen V, Schulze W, Godeke J, Strehmel J, Eckweiler D, Nicolai T, Bielecka A, Wille T, Gerlach RG, Haussler S (2015) Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa. Nucleic Acids Res 43(13): 6413-6425.

    • Blanka A, Duvel J, Dotsch A, Klinkert B, Abraham WR, Kaever V, Ritter C, Narberhaus F, Haussler S (2015) Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition. Sci Signal 8(372): ra36.

    • Bruchmann S, Muthukumarasamy U, Pohl S, Preusse M, Bielecka A, Nicolai T, Hamann I, Hillert R, Kola A, Gastmeier P, Eckweiler D, Haussler S (2015) Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain- and sequence type-specific adaptation. Environ Microbiol 17(11): 4690-4710.

    • Casilag F, Lorenz A, Krüger J, Klawonn F, Weiss S, Häussler S (2015) The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition. Infect Immun 84(1): 162-171.

    • Dotsch A, Schniederjans M, Khaledi A, Hornischer K, Schulz S, Bielecka A, Eckweiler D, Pohl S, Haussler S (2015) The Pseudomonas aeruginosa Transcriptional Landscape Is Shaped by Environmental Heterogeneity and Genetic Variation. MBio 6(4): e00749.

    • Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch Lothar, Herberg FriedrichW., Frank Ronald, Häussler Susanne (2015) Application of synthetic peptide arrays to uncover c-di-GMP binding motifs. Journal of Bacteriology 198(1): 138-146.

    • Lassak J, Keilhauer E, Furst M, Wuichet K, Godeke J, Starosta AL, Chen JM, Sogaard-Andersen L, Rohr J, Wilson DN, Haussler S, Mann M, Jung K (2015) Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nat Chem Biol 11(4): 266-270.

    • Oumeraci T, Jensen V, Talbot SR, Hofmann W, Kostrzewa M, Schlegelberger B, von Neuhoff N, Haussler S (2015) Comprehensive MALDI-TOF Biotyping of the Non-Redundant Harvard Pseudomonas aeruginosa PA14 Transposon Insertion Mutant Library. PLoS One 10(2): e0117144.

    • Pawar V, Komor U, Kasnitz N, Bielecki P, Pils MC, Gocht B, Moter A, Rohde M, Weiss S, Haussler S (2015) In vivo efficacy of antimicrobials against biofilm producing Pseudomonas aeruginosa. Antimicrob Agents Chemother 59(8): 4974-4981.

    • Pustelny C, Komor U, Pawar V, Lorenz A, Bielecka A, Moter A, Gocht B, Eckweiler D, Grothe C, Lunsdorf H, Weiss S, Haussler S (2015) Contribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system. Infect Immun 83(1): 417-429.

    • Schulz S, Eckweiler D, Bielecka A, Nicolai T, Franke R, Dotsch A, Hornischer K, Bruchmann S, Duvel J, Haussler S (2015) Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk. PLoS Pathog 11(3): e1004744.

    • Vercammen K, Wei Q, Charlier D, Dotsch A, Haussler S, Schulz S, Salvi F, Gadda G, Spain J, Levin Rybtke M, Tolker-Nielsen T, Dingemans J, Ye L, Cornelis P (2015) Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene encoding a nitronate monooxygenase. J Bacteriol 197(6): 1026-1039.

    2014

    • Barbier M, Damron FH, Bielecki P, Suarez-Diez M, Puchalka J, Alberti S, Dos Santos VM, Goldberg JB (2014) From the Environment to the Host: Re-Wiring of the Transcriptome of Pseudomonas aeruginosa from 22 degrees C to 37 degrees C. PLoS One 9(2): e89941.

    • Bielecki P, Muthukumarasamy U, Eckweiler D, Bielecka A, Pohl S, Schanz A, Niemeyer U, Oumeraci T, von Neuhoff N, Ghigo JM, Haussler S (2014) In vivo mRNA profiling of uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene expression profiles. MBio 5(4): e01075-14.

    • Blanka A, Schulz S, Eckweiler D, Franke R, Bielecka A, Nicolai T, Casilag F, Duvel J, Abraham WR, Kaever V, Haussler S (2014) Identification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity. J Bacteriol 196(2): 345-356.

    • Borrero-de Acuna JM, Bielecka A, Haussler S, Schobert M, Jahn M, Wittmann C, Jahn D, Poblete-Castro I (2014) Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida. Microb Cell Fact 13(1): 88.

    • Brouwer S, Pustelny C, Ritter C, Klinkert B, Narberhaus F, Haussler S (2014) The PqsR and RhlR transcriptional regulators determine the level of PQS synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms. J Bacteriol 196(23): 4163-4171.

    • Cabot G, Bruchmann S, Mulet X, Zamorano L, Moya B, Juan C, Haussler S, Oliver A (2014) Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC. Antimicrob Agents Chemother 58(6): 3091-3099.

    • Eckweiler D, Bunk B, Sproer C, Overmann J, Haussler S (2014) Complete Genome Sequence of Highly Adherent Pseudomonas aeruginosa Small-Colony Variant SCV20265. Genome Announc 2(1).

    • Fleige H, Ravens S, Moschovakis GL, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R (2014) IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 211(4): 643-651.

    • Pawar V, Crull K, Komor U, Kasnitz N, Frahm M, Kocijancic D, Westphal K, Leschner S, Wolf K, Loessner H, Rohde M, Haussler S, Weiss S (2014) Murine solid tumours as a novel model to study bacterial biofilm formation in vivo. J Intern Med 276(2): 130-139.

    • Perez F, Hujer AM, Marshall SH, Ray AJ, Rather PN, Suwantarat N, Dumford, D 3rd, O'Shea P, Domitrovic TN, Salata RA, Chavda KD, Chen L, Kreiswirth BN, Vila AJ, Haussler S, Jacobs MR, Bonomo RA (2014) Extensively Drug Resistant (XDR) Pseudomonas aeruginosa Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: A New Genetic Resistance Determinant in Northeast Ohio. Antimicrob Agents Chemother 58(10): 5929-5935.

    • Pohl S, Klockgether J, Eckweiler D, Khaledi A, Schniederjans M, Chouvarine P, Tummler B, Haussler S (2014) The extensive set of accessory Pseudomonas aeruginosa genomic components. FEMS Microbiol Lett 356(2): 235-241.

    • Schmidt A, Belaaouaj A, Bissinger R, Koller G, Malleret L, D'Orazio C, Facchinelli M, Schulte-Hubbert B, Molinaro A, Holst O, Hammermann J, Schniederjans M, Meyer KC, Damkiaer S, Piacentini G, Assael B, Bruce K, Haussler S, Lipuma JJ, Seelig J, Worlitzsch D, Doring G (2014) Neutrophil elastase-mediated increase in airway temperature during inflammation. J Cyst Fibros 58(10): 5929-5935.

    • Schulz S, Haussler S (2014) Chromatin Immunoprecipitation for ChIP-chip and ChIP-seq. Methods Mol Biol 1149 591-605.

    • Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J (2014) Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm. PLoS One 9(4): e92876.

    2013

    • Ahmad I, Wigren E, Le Guyon S, Vekkeli S, Blanka A, El Mouali Y, Anwar N, Chuah ML, Lunsdorf H, Frank R, Rhen M, Liang ZX, Lindqvist Y, Romling U (2013) The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium. Mol Microbiol 90(6): 1216-1232.

    • Bielecki P, Komor U, Bielecka A, Musken M, Puchalka J, Pletz MW, Ballmann M, Martins Dos Santos VA, Weiss S, Haussler S (2013) Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites. Environ Microbiol 15(2): 570-587.

    • Bobadilla Fazzini RA, Skindersoe ME, Bielecki P, Puchalka J, Givskov M, Martins Dos Santos VA (2013) Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response. Environ Microbiol 15(1): 111-120.

    • Bruchmann S, Dotsch A, Nouri B, Chaberny IF, Haussler S (2013) Quantitative contribution of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance. Antimicrob Agents Chemother 57(3): 1361-1368.

    • Godeke J, Pustelny C, Haussler S (2013) Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase counteracts Azithromycin-mediated effects on Pseudomonas aeruginosa. Antimicrob Agents Chemother 57(4): 1617-1624.

    • Haussler S, Fuqua C (2013) Biofilms 2012: New Discoveries and Significant Wrinkles in a Dynamic Field. J Bacteriol 195(13): 2947-2958.

    • Pustelny C, Brouwer S, Musken M, Bielecka A, Dotsch A, Nimtz M, Haussler S (2013) The peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental adaptation of Pseudomonas aeruginosa PA14. Environ Microbiol 15(2): 597-609.

    2012

    • Bielecki P, Lukat P, Husecken K, Dotsch A, Steinmetz H, Hartmann RW, Muller R, Haussler S (2012) Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa. Chembiochem 13(16): 2339-2345.

    • Dotsch A, Eckweiler D, Schniederjans M, Zimmermann A, Jensen V, Scharfe M, Geffers R, Haussler S (2012) The Pseudomonas aeruginosa transcriptome in planktonic cultures and static biofilms using RNA sequencing. PloS One 7(2): e31092.

    • Duvel J, Bertinetti D, Moller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jansch L, Herberg FW, Haussler S (2012) A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. J Microbiol Methods 88(2): 229-236.

    • Komor U, Bielecki P, Loessner H, Rohde M, Wolf K, Westphal K, Weiss S, Haussler S (2012) Biofilm formation by Pseudomonas aeruginosa in solid murine tumors - a novel model system. Microbes Infect 14(11): 951-958.

    • Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Musken M, Haussler S, Steinbach A, Hartmann RW (2012) Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa. Chem Biol 19(3): 381-390.

    • Malone JG, Jaeger T, Manfredi P, Dotsch A, Blanka A, Bos R, Cornelis GR, Haussler S, Jenal U (2012) The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways. PLoS Pathog 8(6): e1002760.

    • Selezska K, Kazmierczak M, Musken M, Garbe J, Schobert M, Haussler S, Wiehlmann L, Rohde C, Sikorski J (2012) Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure. Environ Microbiol 14(8): 1952-1967.

    • Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Musken M, Haussler S, Steinbach A, Hartmann RW (2012) Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors. J Am Chem Soc 134(39): 16143-16146.

    • Wei Q, Minh PN, Dotsch A, Hildebrand F, Panmanee W, Elfarash A, Schulz S, Plaisance S, Charlier D, Hassett D, Haussler S, Cornelis P (2012) Global regulation of gene expression by OxyR in an important human opportunistic pathogen. Nucleic Acids Res 40(10): 4320-4333.

    • Zaoui C, Overhage J, Lons D, Zimmermann A, Musken M, Bielecki P, Pustelny C, Becker T, Nimtz M, Haussler S (2012) An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa. Mol Microbiol 83(3): 536-547.

    2011

    • Bielecki P, Puchalka J, Wos-Oxley ML, Loessner H, Glik J, Kawecki M, Nowak M, Tummler B, Weiss S, Dos Santos VA (2011) In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs. PLos One 6(9): e24235.

    • Schmidt J, Musken M, Becker T, Magnowska Z, Bertinetti D, Moller S, Zimmermann B, Herberg FW, Jansch L, Haussler S (2011) The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling. PLoS One 6(3): e18184.

    • Wei Q, Tarighi S, Dotsch A, Haussler S, Musken M, Wright VJ, Camara M, Williams P, Haenen S, Boerjan B, Bogaerts A, Vierstraete E, Verleyen P, Schoofs L, Willaert R, De Groote VN, Michiels J, Vercammen K, Crabbe A, Cornelis P (2011) Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa. PLoS One 6(12): e29276.

    2010

    • Dotsch A, Klawonn F, Jarek M, Scharfe M, Blocker H, Haeussler S (2010) Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. BMC Genomics 11 234.

    • Haeussler S (2010) Multicellular signalling and growth of Pseudomonas aeruginosa. Int J Med Microbiol 300(8): 544-548.

    • Haeussler S, Parsek MR (2010) Biofilms 2009: new perspectives at the heart of surface-associated microbial communities. J Bacteriol 192(12): 2941-2949.

    • Muesken M, Di Fiore S, Dotsch A, Fischer R, Haussler S (2010) Genetic determinants of Pseudomonas aeruginosa biofilm establishment. Microbiology 156(Pt 2): 431-441.

    • Muesken M, Di Fiore S, Romling U, Haussler S (2010) A 96-well-plate-based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing. Nat Protoc 5(8): 1460-1469.

    • Pommerenke C, Muesken M, Becker T, Dotsch A, Klawonn F, Haeussler S (2010) Global genotype-phenotype correlations in Pseudomonas aeruginosa. PLoS Pathog 6(8): e1001074.

    2009

    • Bohn YS, Brandes G, Rakhimova E, Horatzek S, Salunkhe P, Munder A, van Barneveld A, Jordan D, Bredenbruch F, Haussler S, Riedel K, Eberl L, Jensen PO, Bjarnsholt T, Moser C, Hoiby N, Tummler B, Wiehlmann L (2009) Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection. Mol Microbiol 71(3): 730-747.

    • Dotsch A, Becker T, Pommerenke C, Magnowska Z, Jansch L, Haeussler S (2009) Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 53(6): 2522-2531.

    • Dotsch A, Pommerenke C, Bredenbruch F, Geffers R, Haussler S (2009) Evaluation of a microarray-hybridization based method applicable for discovery of single nucleotide polymorphisms (SNPs) in the Pseudomonas aeruginosa genome. BMC Genomics 10 29.

    • Haddad A, Jensen V, Becker T, Haeussler S (2009) The Pho regulon influences biofilm formation and type three secretion in Pseudomonas aeruginosA. Environmental Microbiology reports 1(6): 488-494.

    • Moya B, Dotsch A, Juan C, Blazquez J, Zamorano L, Haussler S, Oliver A (2009) Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog 5(3): e1000353.

    • Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haeussler S, Blankenfeldt W (2009) Structure Elucidation and Preliminary Assessment of Hydrolase Activity of PqsE, the Pseudomonas Quinolone Signal (PQS) Response Protein. Biochemistry 48(43): 10298-10307.

    2008

    • Balke B, Schmoldt S, Haussler S, Suerbaum S, Heesemann J, Hogardt M (2008) A German external quality survey of diagnostic microbiology of respiratory tract infections in patients with cystic fibrosis. J Cyst Fibros 7(1): 7-14.

    • Haussler S, Becker T (2008) The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations. PLoS Pathog 4(9): e1000166.