Publikationen

Publikationen

    2017

    • Ducroux A, Goffinet C (2017) cGAS, an antiviral weapon: role in the recognition of HIV-1 transmitted from cell to cell. Med Sci (Paris) 33(8-9): 732-734.

    • Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meulemann P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T (2017) Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry. Antiviral Res 147 19-28.

    • Reichert C, Campe A, Walter S, Pfaender S, Welsch K, Ruddat I, Sieme H, Feige K, Steinmann E, Cavalleri JMV (2017) Frequent occurrence of nonprimate hepacivirus infections in Thoroughbred breeding horses - A cross-sectional study for the occurrence of infections and potential risk factors. Vet Microbiol 203 315--322.

    • Bartenschlager R, Cornberg M, Pietschmann T (2017) Maßgeschneiderte Therapie der Virushepatitis der Gegenwart und Zukunft. Der Internist 58(7): 666-674.

    • Weller R, Hueging K, Brown RJP, Todt D, Joecks S, Vondran FWR, Pietschmann T (2017) Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions. J Virol 91(18).

    • Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A (2017) Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology 14(1): 34.

    • Vasiliauskaite I, Owsianka A, England P, Khan AG, Cole S, Bankwitz D, Foung SKH, Pietschmann T, Marcotrigiano J, Rey FA, Patel AH, Krey T (2017) Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. mBio 8(3).

    • Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T (2017) Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity. J Hepatol 67(3): 480-489.

    • Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJP, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JMV, Steinmann E (2017) Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A 114(12): E2430-E2439.

    • Kirchhoff L, Olsowski M, Zilmans K, Dittmer S, Haase G, Sedlacek L, Steinmann E, Buer J, Rath PM, Steinmann J (2017) Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents. Sci Rep 7 42886.

    • Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, Yang J, Engelmann M, Todt D, Windisch MP, Brill FH, Steinmann J, Steinmann J, Becker S, Alves MP, Pietschmann T, Eickmann M, Thiel V, Steinmann E (2017) Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses. J Infect Dis 215(6): 902-906.

    • Becker B, Bischoff B, Brill FHH, Steinmann E, Steinmann J (2017) Virucidal efficacy of a sonicated hydrogen peroxide system (trophon® EPR) following European and German test methods. GMS Hyg Infect Control 12 Doc02.

    • Todt D, Schlevogt B, Deterding K, Grundhoff A, Manns MP, Wedemeyer H, Fischer N, Cornberg M, Steinmann E (2017) Successful retreatment of a patient with chronic hepatitis C genotype 2k/1b virus with ombitasvir/paritaprevir/ritonavir plus dasabuvir. J Antimicrob Chemother 72(5): 1541-1543.

    • Gerold G, Bruening J, Weigel B, Pietschmann T (2017) Protein interactions during the flavivirus and hepacivirus life cycle. Mol Cell Proteomics 16(4 suppl 1): S75-S91.

    • Khera T, Todt D, Vercauteren K, McClure CP, Verhoye L, Farhoudi A, Bhuju S, Geffers R, Baumert TF, Steinmann E, Meuleman P, Pietschmann T, Brown RJP (2017) Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy. Antiviral Research 139 129 - 137.

    • Behrendt P, Lüth S, Dammermann W, Drave S, Brown RJP, Todt D, Schnoor U, Steinmann E, Wedemeyer H, Pischke S, Iking-Konert C (2017) Exacerbation of hepatitis E virus infection during anti-TNFα treatment. Joint Bone Spine 84(2): 217-219.

    • Pfaender S, Vielle NJ, Ebert N, Steinmann E, Alves MP, Thiel V (2017) Inactivation of Zika virus in human breast milk by prolonged storage or pasteurization. Virus Res 228 58 - 60.

    • Pietschmann T (2017) Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases. J Virol 91(2).

    • Walter S, Rasche A, Moreira-Soto A, Pfaender S, Bletsa M, Corman VM, Aguilar-Setien A, García-Lacy F, Hans A, Todt D, Schuler G, Shnaiderman-Torban A, Steinman A, Roncoroni C, Veneziano V, Rusenova N, Sandev N, Rusenov A, Zapryanova D, García-Bocanegra I, Jores J, Carluccio A, Veronesi MC, Cavalleri JMV, Drosten C, Lemey P, Steinmann E, Drexler JF (2017) Differential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeys. J Virol 91(1).

    2016

    • Anggakusuma, Brown RJ, Banda D, Todt D, Vieyres G, Steinmann E, Pietschmann T (2016) Hepaciviral NS3/4A proteases interfere with MAVS signalling of their cognate animal hosts and also with human MAVS: implications for zoonotic transmission. J Virol 90(23): 10670-10681.

    • Bankwitz D, Pietschmann T (2016) Hepatitis C virus plays hide and seek with neutralizing antibodies. Hepatology 64(6): 1840-1842.

    • Behrendt P, Bremer B, Todt D, Brown RJP, Heim A, Manns MP, Steinmann E, Wedemeyer H (2016) Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection. J Infect Dis 214(3): 361-368.

    • Drave SA, Debing Y, Walter S, Todt D, Engelmann M, Friesland M, Wedemeyer H, Neyts J, Behrendt P, Steinmann E (2016) Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. Journal of Viral Hepatitis 23(7): 512-521.

    • Gather T, Walter S, Pfaender S, Todt D, Feige K, Steinmann E, Cavalleri JM (2016) Acute and chronic infections with nonprimate hepacivirus in young horses. Vet Res 47(1): 97.

    • Gather T, Walter S, Todt D, Pfaender S, Brown RJ, Postel A, Becher P, Moritz A, Hansmann F, Baumgaertner W, Feige K, Steinmann E, Cavalleri JV (2016) Vertical transmission of hepatitis C virus-like nonprimate hepacivirus in horses. J Gen Virol 97(10): 2540-2551.

    • Gerold G, Bruening J, Pietschmann T (2016) Decoding protein networks during virus entry by quantitative proteomics. Virus Res 218 25-39.

    • Goffinet C (2016) Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. Curr HIV Res 14(3): 211-216.

    • Heidrich B, Steinmann E, Plumeier I, Kirschner J, Sollik L, Ziegert S, Engelmann M, Lehmann P, Manns MP, Pieper DH, Wedemeyer H (2016) Frequent detection of HCV RNA and HCVcoreAg in stool of patients with chronic hepatitis C. J Clin Virol 80 1 - 7.

    • Ionidis G, Hübscher J, Jack T, Becker B, Bischoff B, Todt D, Hodasa V, Brill FHH, Steinmann E, Steinmann J (2016) Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid. BMC Infect Dis 16(1).

    • Klotz U, Schmidt D, Willinger B, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria. Mycoses 59(5): 312-318.

    • Krull M, Klare I, Ross B, Trenschel R, Beelen DW, Todt D, Steinmann E, Buer J, Rath PM, Steinmann J (2016) Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation. Antimicrob Resist Infect Control 5 31.

    • Perin PM, Haid S, Brown RJP, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FWR, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology 63(1): 49--62.

    • Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T (2016) Hepatitis C Virus Stimulates Murine CD8alpha-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog 12(7): e1005736.

    • Pfaender S, von Hahn T, Steinmann J, Ciesek S, Steinmann E (2016) Prevention strategies for blood-borne viruses—in the Era of vaccines, direct acting antivirals and antiretroviral therapy. Rev Med Virol 26(5): 330-339.

    • Postel A, Cavalleri JM, Pfaender S, Walter S, Steinmann E, Fischer N, Feige K, Haas L, Becher P (2016) Frequent presence of hepaci and pegiviruses in commercial equine serum pools. Vet Microbiol 182 8 - 14.

    • Siddharta A, Pfaender S, Malassa A, Doerrbecker J, Anggakusuma, Engelmann M, Nugraha B, Steinmann J, Todt D, Vondran FW, Mateu-Gelabert P, Goffinet C, Steinmann E (2016) Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. Sci Rep 6 36619.

    • Stohr S, Costa R, Sandmann L, Westhaus S, Pfaender S, Anggakusuma, Dazert E, Meuleman P, Vondran FW, Manns MP, Steinmann E, von Hahn T, Ciesek S (2016) Host cell mTORC1 is required for HCV RNA replication. Gut 65(12): 2017-2028.

    • Todt D, Gisa A, Radonic A, Nitsche A, Behrendt P, Suneetha PV, Pischke S, Bremer B, Brown RJP, Manns MP, Cornberg M, Bock CT, Steinmann E, Wedemeyer H (2016) In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 65(10): 1733-1743.

    • Todt D, Walter S, Brown RJP, Steinmann E (2016) Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations. Viruses 8(10): 283.

    • Todt D., Francois C., Kusuma A, Behrendt P, Engelmann M, Knegendorf L, Vieyres G, Wedemeyer H, Hartmann R, Pietschmann T, Duverlie G, Steinmann E (2016) Antiviral activity of different interferon (sub-) types against hepatitis E virus replication. Antimicrobial Agents and Chemotherapy 60(4): 2132-2139.

    • Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P (2016) Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Gut 65(12): 2029-2034.

    • Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FWR, Kaderali L, Pietschmann T (2016) ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production. PLoS Pathog 12(4): e1005568.

    • Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E (2016) Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7. J Virol 90(10): 5075-5089.

    • Weller R, Todt D, Engelmann M, Friesland M, Wedemeyer H, Pietschmann T, Steinmann E (2016) Apolipoprotein E polymorphisms and their protective effect on Hepatitis E virus replication. Hepatology 64(6): 2274-2276.

    • Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C (2016) cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Cell Host & Microbe 20(4): 443-457.

    • von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A (2016) Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. MBio 7(6).

    2015

    • Abd-Elshafy DN, Pietschmann T, Muller-Ladner U, Neumann E, Anggakusuma, M BahgatM, Pessler F, Behrendt P (2015) Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep 5 18043.

    • Anggakusuma, Frentzen A, Gurlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Hornung V, Kuehnel F, Pietschmann T (2015) Control of HCV replication in mouse liver derived cells by MAVS-dependent production of type-I and -III interferons. J Virol 98(7): 3833-3845.

    • Garcia-Risco MR, Vazquez E, Sheldon J, Steinmann E, Riebesehl N, Fornari T, Reglero G (2015) Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of the extracts. Virus Res 198 9-14.

    • Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T (2015) Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Cell Rep 12(5): 864-878.

    • Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells. J Virol 89(6): 3200-3208.

    • Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T (2015) Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor by using a novel lentiviral pseudotype (hRSVpp) system. J Virol 90(6): 3065-3073.

    • Hedenstierna M, Weiland O, Brass A, Bankwitz D, Behrendt P, Uhnoo I, Aleman S, Cardell K, Fryden A, Norkrans G, Eilard A, Glaumann H, Pietschmann T, Sallberg M, Brenndorfer ED (2015) Long-term follow-up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure. Aliment Pharmacol Ther 41(6): 532-543.

    • Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wolk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T (2015) Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. PLoS One 10(7): e0134529.

    • Koutsoudakis G, Romero-Brey I, Berger C, Perez-Vilaro G, Perin PM, Vondran FW, Kalesse M, Harmrolfs K, Muller R, Martinez JP, Pietschmann T, Bartenschlager R, Bronstrup M, Meyerhans A, Diez J (2015) Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. J Hepatol 63(4): 813-821.

    • Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Hepatology 62(3): 702-714.

    • Lauber C, Vieyres G, Terczynska-Dyla E, Anggakusuma, Dijkman R, Gad HH, Akhtar H, Geffers R, Vondran FW, Thiel V, Kaderali L, Pietschmann T, Hartmann R (2015) Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells. Genes Immun 16(6): 414-421.

    • Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Sturzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klarner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Munch J (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife 4.

    • Pfaender S, Brinkmann J, Todt D, Riebesehl N, Steinmann J, Steinmann J, Pietschmann T, Steinmann E (2015) Mechanisms of viral inactivation methods against hepatitis C virus. Appl Environ Microbiol 81(5): 1616-1621.

    • Pfaender S, Cavalleri JM, Walter S, Doerrbecker J, Campana B, Brown RJ, Burbelo PD, Postel A, Hahn K, Kusuma A, Riebesehl N, Baumgartner W, Becher P, Heim MH, Pietschmann T, Feige K, Steinmann E (2015) Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses. Hepatology 61(2): 448-459.

    • Pfaender S, Walter S, Todt D, Behrendt P, Doerrbecker J, Woelk B, Engelmann M, Gravemann U, Seltsam A, Steinmann J, Burbelo PD, Klawonn F, Feige K, Pietschmann T, Cavalleri JM, Steinmann E (2015) Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure. J Gen Virol 96(9): 2636-2642.

    • Rabenau HF, Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 493-504.

    • Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2015) Reply: PCR assay for pathogen detection in ventriculostomy-related meningitis in neurosurgery patients: unanswered questions?. Infection 43(2): 251-252.

    • Schwebke I, Blumel J, Eggers M, Glebe D, Rapp I, von Rheinbaben F, Sauerbrei A, Steinmann E, Steinmann J, Willkommen H, Wutzler P, Rabenau HF (2015) In Process Citation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58(4-5): 491-491.

    • Steinmann J, Becker B, Bischoff B, Steinmann E (2015) Alcohol hand rub or soap and water for removal of norovirus from hands – the debate continues. Journal of Hospital Infection 91(4): 371 - 372.

    • Tarr AW, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, Brown RJ (2015) Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design. Viruses 7(7): 3995-4046.

    • Walker A, Skibbe K, Steinmann E, Pfaender S, Kuntzen T, Megger D.A., Groten S, Sitek B, Lauer G.M., Kim A.Y., Pietschmann T, Allen T.M., Timm J. (2015) Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing. J Virol doi: 10.1128/JVI.01993-15.

    2014

    • Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63(7): 1137-1149.

    • Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, Haid S, Catanese MT, Zeisel MB, Nicosia A, Baumert TF, Kaderali L, Pietschmann T (2014) Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins. J Virol 88(21): 12644-12655.

    • Behrendt P, Steinmann E, Manns MP, Wedemeyer H (2014) The impact of hepatitis E in the liver transplant setting. Journal of hepatology 61(6): 1418-1429.

    • Brown RJ, Koutsoudakis G, Urbanowicz RA, Mirza D, Ginkel C, Riebesehl N, Calland N, Albecka A, Price L, Hudson N, Descamps V, Backx M, McClure CP, Duverlie G, Pecheur EI, Dubuisson J, Perez-Del-Pulgar S, Forns X, Steinmann E, Tarr AW, Pietschmann T, Ball JK (2014) Analysis of serine codon conservation reveals diverse phenotypic constraints on Hepatitis C Virus glycoprotein evolution. J Virol 88(1): 667-678.

    • Deest M, Westhaus S, Steinmann E, Manns MP, von Hahn T, Ciesek S (2014) Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization. Antiviral Res 101 37-44.

    • Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Behrendt P, Brown RJ, Ciesek S, Wedemeyer H, Sarrazin C, Kaderali L, Pietschmann T, Steinmann E (2014) Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology 60(2): 508-520.

    • Frentzen A, Anggakusuma, Guerlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kroger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T (2014) Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology 59(1): 78-88.

    • Gerold G, Pietschmann T (2014) A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication. Hepatology 59(2): 363-365.

    • Gerold G, Pietschmann T (2014) The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets. Dig Dis 32(5): 525-537.

    • Haid S, Grethe C, Dill MT, Heim M, Kaderali L, Pietschmann T (2014) Isolate-dependent use of Claudins for cell entry by hepatitis C virus. Hepatology 59(1): 24-34.

    • Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wolk B, Kaderali L, Pietschmann T (2014) Apolipoprotein E co-determines tissue-tropism of hepatitis C virus and it is crucial for viral cell-to-cell transmission by contributing to a post-envelopment step of assembly. J Virol 88(3): 1433-1446.

    • Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ (2014) Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res 110c 52-59.

    • Lange M, Fiedler M, Bankwitz D, Osburn W, Viazov S, Brovko O, Zekri AR, Khudyakov Y, Nassal M, Pumpens P, Pietschmann T, Timm J, Roggendorf M, Walker A (2014) Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies. PLoS One 9(7): e102235.

    • Pietschmann T (2014) In sero veritas: what serum markers teach us about HCV infection of primary human hepatocytes. Gut 63(9): 1375-1377.

    • Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J (2014) Value of multiplex PCR using cerebrospinal fluid for the diagnosis of ventriculostomy-related meningitis in neurosurgery patients. Infection 42(2): 621-627.

    • Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P (2014) Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. Hepatology 9(7): e102235.

    • Vidigal PG, Dittmer S, Steinmann E, Buer J, Rath PM, Steinmann J (2014) Adaptation of Stenotrophomonas maltophilia in cystic fibrosis: Molecular diversity, mutation frequency and antibiotic resistance. Int J Med Microbiol 304(5-6): 613-619.

    • Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J (2014) Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm. PLoS One 9(4): e92876.

    • Vieyres G, Dubuisson J, Pietschmann T (2014) Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion. Viruses 6(3): 1149-1187.

    2013

    • Behrendt P, Doerrbecker J, Riebesehl N, Wilhelm C, Ciesek S, Erichsen TJ, Steinmann J, Ott M, Manns MP, Pietschmann T, Steinmann E (2013) Stability and transmission of hepatitis C virus in different anesthetic agents. Am J Infect Control 41(10): 942-943.

    • Doerrbecker J, Behrendt P, Mateu-Gelabert P, Ciesek S, Riebesehl N, Wilhelm C, Steinmann J, Pietschmann T, Steinmann E (2013) Transmission of Hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment. J Infect Dis 207(2): 281-287.

    • Doerrbecker J., Meuleman P., Kang J., Riebesehl N., Wilhelm C., Friesland M., Pfaender S., Steinmann J., Pietschmann T., Steinmann E. (2013) Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. J Virol Hepat 20(7): 478-485.

    • Gentzsch J, Brohm C, Steinmann E, Friesland M, Menzel N, Vieyres G, Perin PM, Frentzen A, Kaderali L, Pietschmann T (2013) Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment. PLoS pathogens 9(5): e1003355.

    • Gerold G, Pietschmann T (2013) Hepatitis C virus NS5B polymerase primes innate immune signaling. Hepatology 57(3): 1275-1277.

    • Goncalves Vidigal P, Schmidt D, Stehling F, Mellies U, Steinmann E, Buer J, Rath PM, Steinmann J (2013) Development of a quantitative immunofluorescence assay for detection of Stenotrophomonas maltophilia antibodies in patients with cystic fibrosis. J Cyst Fibros 12(6): 651-654.

    • Hamming OJ, Terczynska-Dyla E, Vieyres G, Dijkman R, Jorgensen SE, Akhtar H, Siupka P, Pietschmann T, Thiel V, Hartmann R (2013) Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses. Embo J 32(23): 3055-3065.

    • Lodermeyer V, Suhr K, Schrott N, Kolbe C, Sturzel CM, Krnavek D, Munch J, Dietz C, Waldmann T, Kirchhoff F, Goffinet C (2013) 90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1. Retrovirology 10(1): 111.

    • Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kroger A (2013) Hepatitis C Virus Replication in Mouse Cells is Restricted by IFN-Dependent and -Independent Mechanisms. Gastroenterology 145(6): 1414-1423e1.

    • Pfaender S, Heyden J, Friesland M, Ciesek S, Ejaz A, Steinmann J, Malarski A, Stoiber H, Tsiavaliaris G, Bader W, Jahreis G, Pietschmann T, Steinmann E (2013) Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk. J Infect Dis 208(12): 1943-1952.

    • Schemuth H, Dittmer S, Lackner M, Sedlacek L, Hamprecht A, Steinmann E, Buer J, Rath PM, Steinmann J (2013) In vitro activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis. Mycoses 56(3): 297-303.

    • Steinmann E, Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Hillung J, Gentzsch J, Lauber C, Brown R, Frentzen A, Pietschmann T (2013) Characterization of hepatitis C virus intra- and inter-genotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol 87(24): 13297-13306.

    • Steinmann E, Gravemann U, Friesland M, Doerrbecker J, Muller TH, Pietschmann T, Seltsam A (2013) Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products. Transfusion 53(5): 1010-1018.

    • Steinmann E, Pietschmann T (2013) Cell culture systems for hepatitis C virus. Curr Top Microbiol Immunol 369 17-48.

    • Steinmann J, Becker B, Bischoff B, Magulski T, Steinmann E (2013) Virucidal activity of Formulation I of the World Health Organization's alcohol-based handrubs: impact of changes in key ingredient levels and test parameters. Antimicrob Resist Infect Control 2(1): 34.

    • Steinmann J, Buer J, Pietschmann T, Steinmann E (2013) Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of Green Tea. Br J Pharmacol 168(5): 1059-1073.

    • Vieyres G, Brohm C, Friesland M, Gentzsch J, Wolk B, Roingeard P, Steinmann E, Pietschmann T (2013) Subcellular localization and function of an epitope-tagged p7 in hepatitis C virus-producing cells. J Virol 87(3): 1664-1678.

    • Vieyres G, Pietschmann T (2013) Entry and replication of recombinant hepatitis C viruses in cell culture. Methods 59(2): 233-248.

    • Westhaus S, Bankwitz D, Ernst S, Rohrmann K, Wappler I, Agne C, Luchtefeld M, Schieffer B, Sarrazin C, Manns MP, Pietschmann T, Ciesek S, von Hahn T (2013) Characterization of the inhibition of hepatitis C virus entry by in vitro generated and patient derived oxidized low density lipoprotein. Hepatology 57(5): 1716-1724.

    • Zahid MN, Turek M, Xiao F, Thi VL, Guerin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F, Baumert TF, Zeisel MB (2013) The post-binding activity of scavenger receptor BI mediates initiation of hepatitis C virus infection and viral dissemination. Hepatology 57(2): 492-504.

    2012

    • Barbier J, Wegner J, Benson S, Gentzsch J, Pietschmann T, Kirschning A (2012) Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition. Chemistry 18(29): 9083-9090.

    • Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P, Lohmann V, Pietschmann T (2012) Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. PloS One 7(4): e36029.

    • Ejaz A, Steinmann E, Banki Z, Kusuma A, Khalid S, Lengauer S, Wilhelm C, Zoller H, Schloegl A, Steinmann J, Grabski E, Kleines M, Pietschmann T, Stoiber H (2012) Specific Acquisition of Functional CD59 but Not CD46 or CD55 by Hepatitis C Virus. PLoS One 7(9): e45770.

    • Fofana I, Fafi-Kremer S, Carolla P, Fauvelle C, Zahid MN, Turek M, Heydmann L, Cury K, Hayer J, Combet C, Cosset FL, Pietschmann T, Hiet MS, Bartenschlager R, Habersetzer F, Doffoel M, Keck ZY, Foung SK, Zeisel MB, Stoll-Keller F, Baumert TF (2012) Mutations that Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies. Gastroenterology 143(1): 223-233.e9.

    • Frentzen A, Hueging K, Bitzegeio J, Pietschmann T, Steinmann E (2012) Two methods of heterokaryon formation to discover HCV restriction factors. J Vis Exp (65): e4029.

    • Haid S, Novodomska A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Ponisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg A, Wong-Staal F, Davioud-Charvet E, Pietschmann T (2012) A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes. Gastroenterology 143(1): 213-222.e5.

    • Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J (2012) High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. J Biol Chem 287(46): 39224-39232.

    • Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, Haid S, Gentzsch J, Kaderali L, Bartenschlager R, Pietschmann T (2012) MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles. PLoS Pathog 8(7): e1002829.

    • Rath PM, Saner F, Paul A, Lehmann N, Steinmann E, Buer J, Steinmann J (2012) Multiplex PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients. J Clin Microbiol 50(6): 2069-2071.

    • Ruhl M, Chhatwal P, Strathmann H, Kuntzen T, Bankwitz D, Skibbe K, Walker A, Heinemann FM, Horn PA, Allen TM, Hoffmann D, Pietschmann T, Timm J (2012) Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope. J Virol 86(2): 991-1000.

    • Sandmann L, Wilson M, Back D, Wedemeyer H, Manns MP, Steinmann E, Pietschmann T, von Hahn T, Ciesek S (2012) Antiretroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro. Antiviral Res 96(1): 51-58.

    • Stegmann KA, Bjorkstrom NK, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, Malinski P, Dustin LB, Rice CM, Manns MP, Pietschmann T, Cornberg M, Ljunggren HG, Wedemeyer H (2012) Interferon alpha-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1. J Infect Dis 205(9): 1351-1362.

    • Steinmann J, Paulmann D, Becker B, Bischoff B, Steinmann E (2012) Comparison of virucidal activity of alcohol-based hand sanitizers versus antimicrobial hand soaps in vitro and in vivo. J Hosp Infect 82(4): 277-280.

    • von Hahn T, Schiene-Fischer C, Van ND, Pfander S, Karavul B, Steinmann E, Potthoff A, Strassburg C, Hamdi N, Abdelaziz AI, Sarrazin C, Muller T, Berg T, Trepo E, Wedemeyer H, Manns MP, Pietschmann T, Ciesek S (2012) Hepatocytes that Express Variants of Cyclophilin A are Resistant to HCV Infection and Replication. Gastroenterology 143(2): 439-447e1.

    2011

    • Burgel B, Friesland M, Koch A, Manns MP, Wedemeyer H, Weissenborn K, Schulz-Schaeffer WJ, Pietschmann T, Steinmann E, Ciesek S (2011) Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration. J Viral Hepat 18(8): 562-570.

    • Ciesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, Hamdi N, Abdelaziz AI, Strassburg CP, Wedemeyer H, Manns MP, Pietschmann T, von Hahn T (2011) Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles. J Virol 85(15): 7613-7621.

    • Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry. Hepatology 54(6): 1947-1955.

    • Ciesek S, von Hahn T, Manns MP (2011) Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 15(3): 597-609.

    • Doerrbecker J, Friesland M, Ciesek S, Erichsen TJ, Mateu-Gelabert P, Steinmann J, Pietschmann T, Steinmann E (2011) Inactivation and survival of hepatitis C virus on inanimate surfaces. J Infect Dis 204(12): 1830-1838.

    • Frentzen A, Huging K, Bitzegeio J, Friesland M, Haid S, Gentzsch J, Hoffmann M, Lindemann D, Zimmer G, Zielecki F, Weber F, Steinmann E, Pietschmann T (2011) Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog 7(4): e1002029.

    • Gentzsch J, Hinkelmann B, Kaderali L, Irschik H, Jansen R, Sasse F, Frank R, Pietschmann T (2011) Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res 89(2): 136-148.

    • Lupberger J, Zeisel MB, Xiao F, Thumann C, zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF (2011) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 17(5): 589-595.

    • Paulmann D, Steinmann J, Becker B, Bischoff B, Steinmann E (2011) Virucidal activity of different alcohols against murine norovirus, a surrogate of human norovirus. J Hosp Infect 79(4): 378-379.

    • Steinmann E, Ciesek S, Friesland M, Erichsen TJ, Pietschmann T (2011) Prolonged Survival of Hepatitis C Virus in the Anesthetic Propofol. Clin Infect Dis 53(9): 963-964.

    • Steinmann J, Kaase M, Gatermann S, Popp W, Steinmann E, Damman M, Paul A, Saner F, Buer J, Path P (2011) Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. Euro Surveill 16(33): pii: 19944.

    • von Hahn T, Schulze A, Chicano Wust I, Heidrich B, Becker T, Steinmann E, Helfritz FA, Rohrmann K, Urban S, Manns MP, Pietschmann T, Ciesek S (2011) The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. PLoS One 6(9): e24142.

    2010

    • Bankwitz D, Steinmann E, Bitzegeio J, Ciesek S, Friesland M, Herrmann E, Zeisel MB, Baumert TF, Keck ZY, Foung SK, Pecheur EI, Pietschmann T (2010) Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84(11): 5751-5763.

    • Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB, Herrmann E, Iken M, Ott M, Baumert TF, Pietschmann T (2010) Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog 6 e1000978.

    • Ciesek S, Friesland M, Steinmann J, Becker B, Wedemeyer H, Manns MP, Pietschmann T, Steinmann E (2010) How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201(12): 1859-1866.

    • Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA, Wappler I, Manns MP, Wedemeyer H, Pietschmann T (2010) Glucocorticosteroids increase cell entry by hepatitis C virus. Gastroenterology 138(5): 1875-1884.

    • Hahn T, Steinmann E, Ciesek S, Pietschmann T (2010) Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches. Expert Rev Gastroenterol Hepatol 4(1): 63-79.

    • Haid S, Windisch MP, Bartenschlager R, Pietschmann T (2010) Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line. J Virol 84(2): 964-975.

    • Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS, Tellinghuisen TL, Symons J, Furman PA (2010) Development of novel therapies for hepatitis C. Antiviral Res 86(1): 79-92.

    • Montserret R, Saint N, Vanbelle C, Salvay AG, Simorre JP, Ebel C, Sapay N, Renisio JG, Bockmann A, Steinmann E, Pietschmann T, Dubuisson J, Chipot C, Penin F (2010) NMR structure and ion channel activity of the p7 protein from hepatitis C virus. Biol Chem 285(41): 31446-31461.

    • Stegmann KA, Bjorkstrom NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V., Fytili P., Cornberg M., Manns MP., Geffers R., Pietschmann T., Guzman CA., Ljunggren HG., Wedemeyer H. (2010) Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 138(5): 1885-1897.

    • Steinmann E, Pietschmann T (2010) Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses 2(9): 2078-2095 (Review).

    • Steinmann J, Becker B, Bischoff B, Paulmann D, Friesland M, Pietschmann T, Steinmann E (2010) Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization. Am J Infect Control 38(1): 66-68.

    2009

    • Brohm C, Steinmann E, Friesland M, Lorenz IC, Patel A, Penin F, Bartenschlager R, Pietschmann T (2009) Characterization of determinants important for hepatitis C virus p7 function in morphogenesis using trans-complementation. J Virol 83(22): 11682-11693.

    • Ciesek S, Steinmann E, Wedemeyer H, Manns MP, Neyts J, Tautz N, Madan V, Bartenschlager R, von Hahn T, Pietschmann T (2009) Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology 50(5): 1638-1645.

    • Haid S, Pietschmann T, Pecheur EI (2009) Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition, and density of virus particles. Pecheur EI Haid S 284(26): 17657-17667.

    • Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M (2009) A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4): 295-308.

    • Pietschmann T (2009) Full-length infectious HCV chimeras. Methods Mol Biol 510 347-359.

    • Pietschmann T (2009) Regulation of hepatitis C virus replication by microRNAs. J Hepatol 50(50(3)): 441-444.

    • Pietschmann T (2009) Virology: Final entry key for hepatitis C. Nature 457(7231): 797-798.

    • Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R (2009) Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog 5(6): e1000475.

    • Witteveldt J, Evans MJ, Bitzegeio J, Koutsoudakis G, Owsianka AM, Angus AG, Keck ZY, Foung SK, Pietschmann T, Rice CM, Patel AH (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. J Gen Virol 90(Pt 1): 48-58.

    2008

    • Ciesek S, Steinmann E, Manns MP, Wedemeyer H, Pietschmann T (2008) The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis 198(7): 1091-1093.

    • Jirasko V, Montserret R, Appel N, Janvier A, Eustachi L, Brohm C, Steinmann E, Pietschmann T, Penin F, Bartenschlager R (2008) Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem 283(42): 28546-28562.

    • Pietschmann T, Steinmann E, Ciesek S (2008) Hepatitis C virus cell culture models--new perspectives for research and clinic. Dtsch Med Wochenschr 133(30): 1580-1584.

    • Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T (2008) Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol 82(14): 7034-7046.