Translation - in the sense of TWINCORE - is living infection research, which is composed of many individual projects. These projects are directly related to new diagnostic methods and combine therapies and basic research with clinical problems. They range from cell culture experiments, the training of researchers and translational investigators to Pharma Consulting - with the aim to bring together science and patient. In the German infection research this translational model is unique. It demonstrates how the cooperation between partners of variety disciplines can work - and how such cooperations extend the research horizon.
In science, twinning means the close co-operation between two research groups, working together on one problem from two sides. At TWINCORE these are the projects in which basic scientists meet up with clinical scientists or other basic scientists to find new paths in clinically-applied research and to pursue new diagnosis or therapy methods.
The current twinning projects at TWINCORE
In a joint project with the research Group Chemical Biology at the Helmholtz Centre for Infection Research staff in the research groups of Prof. Dr. Thomas Pietschmann (Institute for Experimental Virology ) and Dr. Florenz Sasse are searching through substance libraries for new agents to combat the hepatitis C virus. These are investigated using a high-throughput procedure on the liver cell systems developed by Thomas Pietschmann.
Together with Prof. Dr. Carlos Guzmán of the Helmholtz Centre for Infection Research, researchers at the Institute for Experimental Virology are investigating how the immune system reacts to vaccination with a devitalised hepatitis C virus. The scientists are currently examining how strongly such an immunisation affects mice, and for how long. In future they plan to investigate the vaccine on humanised mice - in order to be able to better estimate how such a vaccine could behave in humans.