New preclinical models
New therapeutic or prophylactic approaches developed in basic research need to be subjected to extensive preclinical testing prior to first being tested in humans.
At TWINCORE new models are being developed that should enable improved prediction with regard to reactions in humans.
An important point in this respect is the humanisation of mice. To this end, on the one hand, mice are treated with human cells to enable components of the human immune system to develop in the animals. On the other hand, mouse models are also being developed in which human precursor cells contribute to the formation of liver tissue. A further aspect is the genetic humanisation of mice, for example by bacterial artificial chromosome (BAC)-mediated transgenesis. Using this method, human receptors and allelic forms of them found in the human population may be expressed in order to investigate their function in an animal model.
Another subject is the investigation of effects that are mediated by constant portions of human antibodies. This subject is particularly relevant in the context of the development of new therapeutic monoclonal antibodies.