New mechanisms of pathogen inhibition

New mechanisms of pathogen inhibition

Following the triumphant march of antibiotics in the treatment of bacterial infections, over the past decades key breakthroughs have been made in the development of antiviral substances. New approaches to the inhibition of pathogen reproduction are sought at TWINCORE.

In collaboration with the HZI and the University of Hannover, biological compound libraries are being examined for antiviral and antibacterial substances. This involves the utilisation of new cell culture methods, for example permitting a targeted search for inhibitors of HCV replication.
A further core focus is the search for inhibitors of bacterial biofilm formation which occur in chronic infections. Similarly, new gene-therapy approaches are also being sought for the treatment of infectious diseases. Moreover, it is also being investigated whether pathogen-encoded immune modulators constitute potential target structures for new therapeutic approaches.

Highlights

13. February 2017

WHO handrub formulations are effective against emerging viruses

In the last few years, previously unknown viruses or viruses, which were considered eliminated, have been unveiled: last year, the World Health Organization WHO declared “A Public Health Emergency of International Concern”...


28. November 2016

Hepatitis C and HIV prophylaxis from the microwave – A powerful kitchen tool reduces viral transmission in the drug injection community

Infections with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among people who inject drugs (PWID) are a global health problem. For example, sharing of drug preparation equipment within this population...


12. September 2016

Gilead Sciences supports translational HIV research at TWINCORE and MHH

HIV is knows since 33 years and claimed around 40 million lives. Therapies are existing - healing is still not possible. Now, the "Gilead Förderprogramm Infektiologie 2016" supports scientists of TWINCORE and MHH with...


30. May 2016

Virus suppressant works like a turbo for Hepatitis E viruses

Hepatitis E virus infections seem to be an underrated risk - probably because the course of desease is characterised by a mild progression. The Robert-Koch-Institute estimates, that there are 300.000 people infected with that...


11. January 2016

Migränetabletten gegen Hepatitis C – Flunarizin hemmt den Viruseintritt in die Leberzellen

Obwohl es inzwischen wirksame Medikamente gegen Hepatitis-C-Virusinfektionen gibt, sind nach wie vor etwa 130 Millionen Menschen weltweit von einer chronischen Infektion mit dem Virus betroffen. Die Folge sind häufig schwere...