Analysis of pathogen-host interactions

Analysis of pathogen-host interactions

During long periods of co-evolution, pathogens and hosts developed complex strategies to enable survival of both the host population and the pathogen population. At the cellular level intrinsic immune mechanisms play a role.

At TWINCORE investigations are conducted to establish the influence such factors have on host- and tissue-specificity of pathogens. For several years it has been acknowledged that, in addition to the recognition of "foreign", the communication of "danger signals" via pattern recognition receptors (PRR) plays a central role in the induction of protective immunity.
The analysis of how innate immunity is triggered by stimulation of PRR and the consequences on pathogen-specific immunity are the subject of intensive investigations. In this process both acute and chronic courses of infections and their associated inflammatory reactions are examined.
Pathogens have developed various strategies to evade host immunity. Pathogen-encoded factors that modulate immune responses are sought. Furthermore, the influence of regulatory cells on the course of infection is also analysed.

Highlights

14. June 2017

Virus infections of bone marrow donors influence the outcome of transplantations

Stem cells in the bone marrow provide a life-long supply of blood and immune cells. If they display defects – either caused by hereditary diseases or blood cancer – the transplantation of bone marrow cells of a suitable donor is...


17. May 2017

Dendritic cells and epithelia cells are the main actors of the bacteria defence in the gut Bakterienabwehr im Darm

Der Darm gilt als Wiege unseres Immunsystems: Knapp ein Drittel unserer antikörperproduzierenden Zellen befinden sich in der Darmschleimhaut – sie setzen sich mit den unzähligen Mikroorganismen und Fremdstoffen auseinander, die...


09. March 2017

New perspectives for research on hepatitis C virus

The hepatitis C virus (HCV) infects around 160 million people worldwide. Although there are new therapies, HCV infection is still one of the most common causes of liver transplantation as these new drugs are very expensive and...


18. October 2016

Exploration of defence mechanisms of cytomegalovirus opens new therapeutical opportunities

Das Cytomegalovirus gehört zur Gruppe der Herpesviren und teilt deren zentrale Eigenschaften: eine erste Infektion mit dem Virus verläuft unauffällig und wird von den Patienten meist nicht einmal bemerkt. Es fliegt sozusagen...


14. October 2016

Combined strength – immune cells cooperate in HIV defence

Der – zweifelhafte – Erfolg des HI-Virus gründet auf einer ganzen Reihe Tricks, mit denen das Virus unsere Abwehr unterwandert oder  für sich selbst nutzt. In einem sehr frühen Stadium der Infektion – gleich nach dem ersten...