Hospital-acquired infections caused by antibiotic-resistant opportunistic pathogens are on the increase world-wide and pose one of the greatest challenges to modern medicine. Multi-drug resistance dramatically impacts on human health, public health and the principles and practice of clinical medicine. Management of nosocomial infections, especially those caused by multidrug-resistant gram-negative bacteria, requires a multipronged strategy that includes not only the development of new antimicrobial compounds and a rational use of antimicrobial agents, but also the implementation of effective infection control principles.
Furthermore, despite improvements in technology and healthcare services, morbidity and mortality due to chronic infections have remained unchanged over the past few decades. The emergence of a chronic infection disease burden calls for the development of modern diagnostics for biofilm resistance profiling and radically new therapeutic strategies to eradicate biofilm-associated infections.
A bridge between TWINCORE and HZI
The Molecular Bacteriology Institute at the Twincore is one of two locations of the Molecular Bacteriology department headed by Susanne Häußler. The second location is at the HZI in Braunschweig. Thus, there are two teams of researchers, two locations, two different compositions of expertise and technical infrastructure - but one project and one overarching aim: applying research to fight multi-drug resistant and chronic persistent P. aeruginosa infections. Whereas the main focus of the Twincore group is on imaging and monitoring of P. aeruginosa biofilm growth, the research focus in Braunschweig is on DNA- and RNA sequencing - with the HZI being perfectly suited for this kind of technology application. The team at the HZI also provides bioinformatics expertise to the whole Molecular Bacteriology research group.
Pseudomonas aeruginosa ist ein widerstandsfähiges Bakterium, das fast überall in der Umwelt vorkommt. Insbesondere Patienten mit Verbrennungen und Mukoviszidose-Erkrankte sind anfällig für eine chronische Infektion mit dem...
Bacteria in cystic fibrosis lungs form particularly resistant biofilms - TWINCORE scientists uncover mechanism
Cystic Fibrosis, better known as mucoviscidosis is a treacherous hereditary disease. Caused by a metabolic disorder the body secretions of patients contain too little water. One of the consequences: The mucus in the patients'...