Research Group Innate Immunity and Viral Evasion

Research Group Innate Immunity and Viral Evasion

The research group "Innate Immunity and Viral Evasion" is interested in gaining a better understanding of the interplay between host cells and viruses at the cellular and molecular level. HIV-1, the causative agent of AIDS, remains one of the most devastating viral pathogens worldwide and causes chronic immunodeficiency. Using human target cells of HIV-1, we characterize their ability to sense, with the help of the cellular pattern recognition receptors, an invading HIV-1 infection, and how efficiently this information is translated into a functional antiviral state. Vice versa, we identify and elucidate HIV-1-mediated evasion strategies of this cellular innate immunity, which explain why HIV-1 is successfully circumventing cellular defense mechanisms. Furthermore, we investigate the mode of action of cellular restriction factors, focusing on the antiviral proteins 90K and SERINC5, which can reduce the infectivity of HIV-1 particles.
Knowledge on these naturally occurring molecular weapons of human cells, and how HIV-1 has evolved to counteract them, could pave new avenues towards antiviral drugs.  In addition, together with our cooperation partners from Hannover Medical School, we are developing strategies for eradication of latently HIV-1-infected resting T-cells.
The research group "Innate Immunity and Viral Evasion" is also investigating the entry process of Chikungunya viruses. Chikungunya virus is an emerging and rapidly expanding pathogen which causes, in most of the cases, acute infections. A subset of infected persons, however, suffers from chronic joint pain and inflammation, justifying research to develop protective and/or therapeutic options which are completely missing to date. Using lentiviral pseudotypes carrying the CHIKV glycoproteins, we study means to inhibit entry of CHIKV into host cells using immunological and pharmacological approaches.

News

PhD Prize 2017 of the DGI and DZIF for Shuting Xu

Dr. Shuting Xu was awarded the Dissertation Prize 2017 of the German Center for Infection Research (DZIF)/German Society of Infectious Diseases (DGI). She obtained the award for her excellent achievements during her doctoral...


31. July 2017

16th Workshop „Immunobiology of Viral Infections“ (GfV)

Dear friends and colleagues,It is our pleasure to announce the 16th workshop of the study group “Immunobiology of Viral Infections” of the Society for Virology (GfV). This year´s workshop will be held for the second time at...


03. July 2017

Exploration Grant of the Boehringer Ingelheim Foundation for Christine Goffinet

Jun.-Prof. Christine Goffinet, Leiterin der Arbeitsgruppe Angeborene Immunität und Virale Evasion am Institut für Experimentelle Virologie, erhält für zwölf Monate den mit 80.000 € dotierten Exploration Grant der Boehringer...


16. June 2017

"Deutscher AIDS-Preis 2017" for Christine Goffinet

Jun.-Professorin Christine Goffinet, Leiterin der Arbeitsgruppe Angeborene Immunität und Virale Evasion am Institut für Experimentelle Virologie, und Ihre Mitarbeiterinnen Dr. Shuting Xu und Dr. Aurélie Ducroux erhielten am 16....


09. December 2016

DFG Priority-Project at innate sensing of HIV

How do cells sense and combat a retroviral infection? The newly funded DFG-Priority Programme „Innate Sensing and Restriction of Retroviruses“ will address this central question during the next six years. One of the currently...