Research Group Biomarkers for Infectious Diseases
The Research Group Biomarkers for Infectious Diseases aims to identify more accurate diagnostic, prognostic and predictive host biomarkers for infectious diseases and the vaccine response. The clinical aims of the group are to help select the most effective, individualized treatment as early as possible, aiming to streamline the use of anti-infectives (improve anti-infective stewardship) and to improve clinical outcome.
And the researchers try to identify individuals that are at high risk of a non-response to a given vaccination and would therefore benefit from alternative vaccination strategies, for example higher doses, more frequent applications, adjuvanted vaccines or next-generation vaccines.
The group was selected to support the mission of the CIIM and to maximize collaborations with MHH clinicians and the CRC platforms. Through the collaborations with the clinicians and the CRC Biobank the researchers have access to bio samples such as PBMCs, plasma, or cerebrospinal fluid from patients and the respective healthy controls and disease controls (disease with similar symptoms but different etiology). Their biomarker discovery approach rests on a combination of unbiased profiling of biosamples (e.g., LC-MS/MS, RNAseq) and measuring levels of specific markers for which experimental evidence suggests importance in pathophysiology and therefore differential expression in disease.
Unser Gehirn ist ein Hochsicherheitstrakt, das mit der Blut-Hirn-Schranke eine sehr effektive Barriere gegen Schadstoffe und Krankheitserreger errichtet hat. Trotzdem kann diese überwunden werden: Beispielsweise vom ...
International antibiotics study: HZI receives Euro 6m funding An increasing number of bacteria is evolving antibiotic resistance. Much-feared representatives of this steadily growing group include Staphylococci strains. At...