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Dominguez, P.; Lopez-Bravo, M.; Kalinke, U. & Ardavin, C. (in press),
'Statins inhibit iNOSmediated microbicidal potential of activated monocyte-derived dendritic cells by an IFNbeta-dependent mechanism.', Eur J Immunol
n/a
(n/a)
, n/a
.
[Kurzfassung]
[BibTeX]
[Endnote]
Poeck, H.; Dann, A.; Maihoefer, C.; Endres, S.; Kalinke, U.; Knobeloch, K.; Akira, S.; Hartmann, G. & Prinz, M. (in press),
'Engagement of cytosolic helicases amelioritas autoimmune inflammation of the CNS by IFNAR-mediated modulation of the TH17 immune response.', Nat Neurosc
n/a
(n/a)
, n/a
.
[BibTeX]
[Endnote]
Schulke, S.; Burggraf, M.; Waibler, Z.; Wangorsch, A.; Wolfheimer, S.; Kalinke, U.; Vieths, S.; Toda, M. & Scheurer, S. (in press),
'A fusion protein of flagellin and ovalbumin suppresses the T(H)2 response and prevents murine intestinal allergy.', J Allergy Clin Immunol
n/a
(n/a)
, n/a
.
[Kurzfassung]
[BibTeX]
[Endnote]
Stormer, M.; Arroyo, A.; Brachert, J.; Carrero, H.; Devine, D.; Epstein, J.; Gabriel, C.; Gelber, C.; Goodrich, R.; Hanschmann, K.; Heath, D.; Jacobs, M.; Keil, S.; de Korte, D.; Lambrecht, B.; Lee, C.; Marcelis, J.; Marschner, S.; McDonald, C.; McGuane, S.; McKee, M.; Muller, T.; Muthivhi, T.; Pettersson, A.; Radziwon, P.; Ramirez-Arcos, S.; Reesink, H.; Rojo, J.; Rood, I.; Schmidt, M.; Schneider, C.; Seifried, E.; Sicker, U.; Wendel, S.; Wood, E.; Yomtovian, R. & Montag, T. (in press),
'Establishment of the first International Repository for Transfusion-Relevant Bacteria Reference Strains: ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria.', Vox Sang
n/a
(n/a)
, n/a
.
[Kurzfassung]
[BibTeX]
[Endnote]
Buttel, I.; Voller, K. & Schneider, C. (2010),
'Immunogenicity and its Impact on Benefit/Risk Considerations in the Authorisation of Biopharmaceuticals.', Curr Drug Saf
5
(5(4))
, 287-292
.
[Kurzfassung]
[BibTeX]
[Endnote]
Frenz, T.; Waibler, Z.; Hofmann, J.; Hamdorf, M.; Lantermann, M.; Reizis, B.; Tovey, M. G.; Aichele, P.; Sutter, G. & Kalinke, U. (2010),
'Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion', Eur J Immunol
40
(40(10))
, 2769-2777
.
[Kurzfassung]
[BibTeX]
[Endnote]
Virus-induced expansion of CD8(+) T cells may be promoted by type I IFN receptor (IFNAR)-triggering of T cells, depending on the pathogen tested. We studied modified vaccinia virus Ankara (MVA), a promising vaccine vector candidate, which was derived from conventional vaccinia virus (VACV) by more than 570 consecutive in vitro passages. In adoptive transfer experiments, we verified that VACV expressing the gp33 epitope of lymphocytic choriomeningitis virus (VACV(gp33)) induced largely IFNAR-independent expansion of gp33-specific T cells. On the contrary, MVA(gp33)-induced T-cell expansion was IFNAR dependent. Interestingly, under the latter conditions, T-cell activation was IFNAR independent, whereas T-cell apoptosis was enhanced in the absence of IFNAR. To address whether MVA-induced T-cell expansion was solely affected by IFNAR-triggering of T cells, expansion of endogenous T cells was studied in conditional mice with a T-cell- or DC-specific IFNAR deletion. Interestingly, both mouse strains showed moderately reduced T-cell expansion, whereas mice with a combined T-cell- and DC-specific IFNAR ablation showed massively reduced T-cell expansion similar to that of IFNAR(-/-) mice. These results are compatible with the model that IFN-inducing viruses such as MVA confer virus-specific CD8(+) T-cell expansion by concomitant IFNAR-triggering of DC and of T cells.
Goetz, K.; Pfleiderer, M. & Schneider, C. (2010),
'First-in-human clinical trials with vaccines-what regulators want.', Nat Biotechnol
(28)
, 910-916
.
[Kurzfassung]
[BibTeX]
[Endnote]
Goossens, P.; Gijbels, M.; Zernecke, A.; Eijgelaar, W.; Vergouwe, M.; van der Made, I.; Vanderlocht, J.; Beckers, L.; Buurman, W.; Daemen, M.; Kalinke, U.; Weber, C.; Lutgens, E. & de Winther, M. (2010),
'Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions', Curr Drug Saf
5
((4))
, 287-292
.
[Kurzfassung]
[BibTeX]
[Endnote]
Goossens, P.; Gijbels, M. J.; Zernecke, A.; Eijgelaar, W.; Vergouwe, M. N.; van der Made, I.; Vanderlocht, J.; Beckers, L.; Buurman, W. A.; Daemen, M. J.; Kalinke, U.; Weber, C.; Lutgens, E. & de Winther, M. P. (2010),
'Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions', Cell Metab
12
(12(2))
, 142-153
.
[Kurzfassung]
[BibTeX]
[Endnote]
Inflammatory cytokines are well-recognized mediators of atherosclerosis. Depending on the pathological context, type I interferons (IFNs; IFNalpha and IFNbeta) exert either pro- or anti-inflammatory immune functions, but their exact role in atherogenesis has not been clarified. Here, we demonstrate that IFNbeta enhances macrophage-endothelial cell adhesion and promotes leukocyte attraction to atherosclerosis-prone sites in mice in a chemokine-dependent manner. Moreover, IFNbeta treatment accelerates lesion formation in two different mouse models of atherosclerosis and increases macrophage accumulation in the plaques. Concomitantly, absence of endogenous type I IFN signaling in myeloid cells inhibits lesion development, protects against lesional accumulation of macrophages, and prevents necrotic core formation. Finally, we show that type I IFN signaling is upregulated in ruptured human atherosclerotic plaques. Hereby, we identify type I IFNs as proatherosclerotic cytokines that may serve as additional targets for prevention or treatment.
Grabski, E.; Waibler, Z.; Schüle, S.; Kloke, B.; Sender, L.; Panitz, S.; Cichutek, K.; Schweiter, M. & Kalinke, U. (2010),
'Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems.', J Mol Biotech
.
[Kurzfassung]
[BibTeX]
[Endnote]
Ilchmann, A.; Burgdorf, S.; ScheurerZ, S.; Waibler, Z.; Nagai, R.; Wellner, A.; Yamamoto, Y.; Yamamoto, H.; Henle, T.; Kurts, C.; Kalinke, U.; Vieths, S. & Toda, M. (2010),
'Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II.', J Allergy Clin Immunol
125
(125(1))
, 175-183, e171-111
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kern, M.; Popov, A.; Scholz, K.; Schumak, B.; Dandji, D.; Limmer, A.; Eggle, D.; Sacher, T.; Zawatzky, R.; Holtappels, R.; Reddehase, M.; Hartmann, G.; Debey-Pascher, S.; Diehl, L.; Kalinke, U.; ans J Schultze, U. K. & Knolle, P. (2010),
'Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.',
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kochs, G.; Bauer, S.; Vogt, C.; Frenz, T.; Tschopp, J.; Kalinke, U. & Waibler, Z. (2010),
'Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. ', J Virol
84
(84(23))
, 12344-12350
.
[Kurzfassung]
[BibTeX]
[Endnote]
Lang, P.; Recher, M.; Honke, N.; Scheu, S.; Borkens, S.; Gailus, N.; Krings, C.; Meryk, A.; Kulawik, A.; Cervantes-Barragan, L.; Rooijen, N. V.; Kalinke, U.; Ludewig, B.; Hengartner, H.; Harris, N.; Häussinger, D.; Ohashi, P.; Zinkernagel, R. & Lang, K. (2010),
'Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.', Hepatology
51
((1))
, 25-32
.
[Kurzfassung]
[BibTeX]
[Endnote]
Moussawi, K. A.; Ghigo, E.; Kalinke, U.; Alexopoulou, L.; Mege, J. & Desnues, B. (2010),
'Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.', PLoS Pathog
6
(6(1))
, e1000722
.
[Kurzfassung]
[BibTeX]
[Endnote]
Murikinati, S.; Juttler, E.; Keinert, T.; Ridder, D.; Muhammad, S.; Waibler, Z.; Ledent, C.; Zimmer, A.; Kalinke, U. & Schwaninger, M. (2010),
'Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.', FASEB J
24
(24(3))
, 788-798
.
[Kurzfassung]
[BibTeX]
[Endnote]
Prinz, M. & Kalinke, U. (2010),
'New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.', Trends Mol Med
16
(16(8))
, 379-386
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schneider, C.; Salmikangas, P.; Jilma, B.; Flamion, B.; Todorova, L.; Paphitou, A.; Haunerova, I.; Maimets, T.; Trouvin, J.; Flory, E.; Tsiftsoglou, A.; Sarkadi, B.; Gudmundsson, K.; O'Donovan, M.; Migliaccio, G.; Ancans, J.; Maciulaitis, R.; Robert, J.; Samuel, A.; Ovelgonne, J.; Hystad, M.; Fal, A.; Lima, B.; Moraru, A.; Turcani, P.; Zorec, R.; Ruiz, S.; Akerblom, L.; Narayanan, G.; Kent, A.; Bignami, F.; Dickson, J.; Niederwieser, D.; Figuerola-Santos, M.; Reischl, I.; Beuneu, C.; Georgiev, R.; Vassiliou, M.; Pychova, A.; Clausen, M.; Methuen, T.; Lucas, S.; Schussler-Lenz, M.; Kokkas, V.; Buzas, Z.; MacAleenan, N.; Galli, M.; Line, A.; Gulbinovic, J.; Berchem, G.; Fraczek, M.; Menezes-Ferreira, M.; Vilceanu, N.; Hrubisko, M.; Marinko, P.; Timon, M.; Cheng, W.; Crosbie, G.; Meade, N.; di Paola, M.; VandenDriessche, T.; Ljungman, P.; D'Apote, L.; Oliver-Diaz, O.; Buttel, I. & Celis, P. (2010),
'Challenges with advanced therapy medicinal products and how to meet them.', Nat Rev Drug Discov
9
(9(3))
, 195-201
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schussler-Lenz, M. & Schneider, C. (2010),
'Clinical trials with advanced therapy medicinal products. ', Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
53
(53(1))
, 68-74
.
[Kurzfassung]
[BibTeX]
[Endnote]
Sender, L.; Gibbert, K.; Suezer, Y.; Radeke, H.; Kalinke, U. & Waibler, Z. (2010),
'CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals. ', Mol Immunol
47
(47(6))
, 1255-1261
.
[Kurzfassung]
[BibTeX]
[Endnote]
Aly, S.; Mages, J.; Reiling, N.; Kalinke, U.; Decker, T.; Lang, R. & Ehlers, S. (2009),
'Mycobacteria-induced granuloma necrosis depends on IRF-1', J Cell Mol Med
13
(13(8B))
, 2069-2082
.
[Kurzfassung]
[BibTeX]
[Endnote]
Anz, D.; Thaler, R.; Stephan, N.; Waibler, Z.; Trauscheid, M.; Scholz, C.; Kalinke, U.; Barchet, W.; Endres, S. & Bourquin, C. (2009),
'Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus', J Immunol
182
(182(10))
, 6044-6050
.
[Kurzfassung]
[BibTeX]
[Endnote]
Bach, P.; Tschape, J.; Kopietz, F.; Braun, G.; Baade, J.; Wiederhold, K.; Staufenbiel, M.; Prinz, M.; Deller, T.; Kalinke, U.; Buchholz, C. & Muller, U. (2009),
'Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice', J Immunol
182
(182(12))
, 7613-7624
.
[Kurzfassung]
[BibTeX]
[Endnote]
Cervantes-Barragan, L.; Kalinke, U.; Zust, R.; Konig, M.; Reizis, B.; Lopez-Macias, C.; Thiel, V. & Ludewig, B. (2009),
'Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection', J Immunol
182
(182(2))
, 1099-1106
.
[Kurzfassung]
[BibTeX]
[Endnote]
Cucak, H.; Yrlid, U.; Reizis, B.; Kalinke, U. & Johansson-Lindbom, B. (2009),
'Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells', Immunity
31
((3))
, 491-501
.
[Kurzfassung]
[BibTeX]
[Endnote]
Dauber, B.; Martinez-Sobrido, L.; Schneider, J.; Hai, R.; Waibler, Z.; Kalinke, U.; Garcia-Sastre, A. & Wolff, T. (2009),
'Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR', PLoS Pathog
5
(5(6))
, e1000473
.
[Kurzfassung]
[BibTeX]
[Endnote]
Detje, C.; Meyer, T.; Schmidt, H.; Kreuz, D.; Rose, J.; Bechmann, I.; Prinz, M. & Kalinke, U. (2009),
'Local type I IFN receptor signaling protects against virus spread within the central nervous system', J Immunol
182
(182(4))
, 2297-2304
.
[Kurzfassung]
[BibTeX]
[Endnote]
Essers, M.; Offner, S.; Blanco-Bose, W.; Waibler, Z.; Kalinke, U.; Duchosal, M. & Trumpp, A. (2009),
'IFNalpha activates dormant haematopoietic stem cells in vivo', Nature
458
((7240))
, 904-908
.
[Kurzfassung]
[BibTeX]
[Endnote]
Jahn, E. & Schneider, C. (2009),
'How to systematically evaluate immunogenicity of therapeutic proteins - regulatory considerations', N Biotechnol
25
(25(5))
, 280-286
.
[Kurzfassung]
[BibTeX]
[Endnote]
Paran, N.; Suezer, Y.; Lustig, S.; Israely, T.; Schwantes, A.; Melamed, S.; Katz, L.; Preuss, T.; Hanschmann, K.; Kalinke, U.; Erez, N.; Levin, R.; Velan, B.; Lower, J.; Shafferman, A. & Sutter, G. (2009),
'Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox', J Infect Dis
199
(199(1))
, 39-48
.
[Kurzfassung]
[BibTeX]
[Endnote]
Pilz, A.; Kratky, W.; Stockinger, S.; Simma, O.; Kalinke, U.; Lingnau, K.; von Gabain, A.; Stoiber, D.; Sexl, V.; Kolbe, T.; Rulicke, T.; Muller, M.; Decker, T.; Pilz, A.; Kratky, W.; Stockinger, S.; Simma, O.; Kalinke, U.; Lingnau, K.; von Gabain, A.; Stoiber, D.; Sexl, V.; Kolbe, T.; Rulicke, T.; Muller, M. & Decker, T. (2009),
'Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL', J Immunol
183
(183(4))
, 2286-2293
.
[Kurzfassung]
[BibTeX]
[Endnote]
Richter, C.; Juan, M.; Will, J.; Brandes, R.; Kalinke, U.; Akira, S.; Pfeilschifter, J.; Hultqvist, M.; Holmdahl, R. & Radeke, H. (2009),
'Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells', J Immunol
182
(182(7))
, 4183-4191
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schneider, C.; Papaluca, M. & Kurki, P. (2009),
'A European perspective on immunogenicity evaluation', Nat Biotechnol
27
(27(6))
, 507-508
.
[Kurzfassung]
[BibTeX]
[Endnote]
Stockinger, S.; Kastner, R.; Kernbauer, E.; Pilz, A.; Westermayer, S.; Reutterer, B.; Soulat, D.; Stengl, G.; Vogl, C.; Frenz, T.; Waibler, Z.; Taniguchi, T.; Rulicke, T.; Kalinke, U.; Muller, M. & Decker, T. (2009),
'Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes', PLoS Pathog
5
(5(3))
, e1000355
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Anzaghe, M.; Frenz, T.; Schwantes, A.; Pohlmann, C.; Ludwig, H.; Palomo-Otero, M.; Alcami, A.; Sutter, G. & Kalinke, U. (2009),
'Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components', J Virol
83
(83(4))
, 1563-1571
.
[Kurzfassung]
[BibTeX]
[Endnote]
Michallet, M.; Meylan, E.; Ermolaeva, M.; Vazquez, J.; Rebsamen, M.; Curran, J.; Poeck, H.; Bscheider, M.; Hartmann, G.; Konig, M.; Kalinke, U.; Pasparakis, M. & Tschopp, J. (2008),
'TRADD protein is an essential component of the RIG-like helicase antiviral pathway', Immunity
28
((5))
, 651-661
.
[Kurzfassung]
[BibTeX]
[Endnote]
Poeck, H.; Besch, R.; Maihoefer, C.; Renn, M.; Tormo, D.; Morskaya, S.; Kirschnek, S.; Gaffal, E.; Landsberg, J.; Hellmuth, J.; Schmidt, A.; Anz, D.; Bscheider, M.; Schwerd, T.; Berking, C.; Bourquin, C.; Kalinke, U.; Kremmer, E.; Kato, H.; Akira, S.; Meyers, R.; Hacker, G.; Neuenhahn, M.; Busch, D.; Ruland, J.; Rothenfusser, S.; Prinz, M.; Hornung, V.; Endres, S.; Tuting, T. & Hartmann, G. (2008),
'5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma', Nat Med
14
(14(11))
, 1256-1263
.
[Kurzfassung]
[BibTeX]
[Endnote]
Prinz, M.; Schmidt, H.; Mildner, A.; Knobeloch, K.; Hanisch, U.; Raasch, J.; Merkler, D.; Detje, C.; Gutcher, I.; Mages, J.; Lang, R.; Martin, R.; Gold, R.; Becher, B.; Bruck, W. & Kalinke, U. (2008),
'Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system', Immunity
28
((5))
, 675-686
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schneider, C. & Kalinke, U. (2008),
'Toward biosimilar monoclonal antibodies', Nat Biotechnol
26
(26(9))
, 985-990
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schraven, B. & Kalinke, U. (2008),
'CD28 superagonists: what makes the difference in humans?', Immunity
28
((5))
, 591-595
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Anzaghe, M.; Konur, A.; Akira, S.; Muller, W. & Kalinke, U. (2008),
'Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC', Eur J Immunol
38
(38(11))
, 3127-3137
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Sender, L.; Merten, C.; Hartig, R.; Kliche, S.; Gunzer, M.; Reichardt, P.; Kalinke, U. & Schraven, B. (2008),
'Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies', PLoS One
3
(3(3))
, e1708
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Sender, L.; Kamp, C.; Muller-Berghaus, J.; Liedert, B.; Schneider, C.; Lower, J. & Kalinke, U. (2008),
'Toward experimental assessment of receptor occupancy: TGN1412 revisited', J Allergy Clin Immunol
122
(122(5))
, 890-892
.
[Kurzfassung]
[BibTeX]
[Endnote]
Bach, P.; Kamphuis, E.; Odermatt, B.; Sutter, G.; Buchholz, C. & Kalinke, U. (2007),
'Vesicular stomatitis virus glycoprotein displaying retrovirus-like particles induce a type I IFN receptor-dependent switch to neutralizing IgG antibodies', J Immunol
178
(178(9))
, 5839-5847
.
[Kurzfassung]
[BibTeX]
[Endnote]
Blakqori, G.; Delhaye, S.; Habjan, M.; Blair, C.; Sanchez-Vargas, I.; Olson, K.; Attarzadeh-Yazdi, G.; Fragkoudis, R.; Kohl, A.; Kalinke, U.; Weiss, S.; Michiels, T.; Staeheli, P. & Weber, F. (2007),
'La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts', J Virol
81
(81(10))
, 4991-4999
.
[Kurzfassung]
[BibTeX]
[Endnote]
Demirel, O.; Waibler, Z.; Kalinke, U.; Grunebach, F.; Appel, S.; Brossart, P.; Hasilik, A.; Tampe, R. & Abele, R. (2007),
'Identification of a lysosomal peptide transport system induced during dendritic cell development', J Biol Chem
282
(282(52))
, 37836-37843
.
[Kurzfassung]
[BibTeX]
[Endnote]
Koerner, I.; Kochs, G.; Kalinke, U.; Weiss, S. & Staeheli, P. (2007),
'Protective role of beta interferon in host defense against influenza A virus', J Virol
81
(81(4))
, 2025-2030
.
[Kurzfassung]
[BibTeX]
[Endnote]
Liedert, B.; Bassus, S.; Schneider, C.; Kalinke, U. & Lower, J. (2007),
'Safety of phase I clinical trials with monoclonal antibodies in Germany--the regulatory requirements viewed in the aftermath of the TGN1412 disaster', Int J Clin Pharmacol Ther
45
(45(1))
, 1-9
.
[Kurzfassung]
[BibTeX]
[Endnote]
Osterloh, A.; Kalinke, U.; Weiss, S.; Fleischer, B. & Breloer, M. (2007),
'Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide', J Biol Chem
282
(282(7))
, 4669-4680
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schleicher, U.; Liese, J.; Knippertz, I.; Kurzmann, C.; Hesse, A.; Heit, A.; Fischer, J.; Weiss, S.; Kalinke, U.; Kunz, S. & Bogdan, C. (2007),
'NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs', J Exp Med
204
(204(4))
, 893-906
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schneider, C. & Kalinke, U. (2007),
'[After the TGN1412 incident. Principles for assessment of first-in-man trials with monoclonal antibodies by the Paul Ehrlich Institute]', Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
50
(50(10))
, 1213-1220
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Detje, C.; Bell, J. & Kalinke, U. (2007),
'Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells', Immunobiology
212
((9-10))
, 887-894
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Anzaghe, M.; Ludwig, H.; Akira, S.; Weiss, S.; Sutter, G. & Kalinke, U. (2007),
'Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses', J Virol
81
(81(22))
, 12102-12110
.
[Kurzfassung]
[BibTeX]
[Endnote]
Waibler, Z.; Kalinke, U.; Will, J.; Juan, M.; Pfeilschifter, J. & Radeke, H. (2007),
'TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells', Mol Immunol
44
(44(7))
, 1483-1489
.
[Kurzfassung]
[BibTeX]
[Endnote]
Aichele, P.; Unsoeld, H.; Koschella, M.; Schweier, O.; Kalinke, U. & Vucikuja, S. (2006),
'CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion', J Immunol
176
(176(8))
, 4525-4529
.
[Kurzfassung]
[BibTeX]
[Endnote]
Bon, A. L.; Thompson, C.; Kamphuis, E.; Durand, V.; Rossmann, C.; Kalinke, U. & Tough, D. (2006),
'Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN', J Immunol
176
(176(4))
, 2074-2078
.
[Kurzfassung]
[BibTeX]
[Endnote]
Bon, A. L.; Durand, V.; Kamphuis, E.; Thompson, C.; Bulfone-Paus, S.; Rossmann, C.; Kalinke, U. & Tough, D. (2006),
'Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming', J Immunol
176
(176(8))
, 4682-4689
.
[Kurzfassung]
[BibTeX]
[Endnote]
Buchholz, C.; Bach, P.; Nikles, D. & Kalinke, U. (2006),
'Prion protein-specific antibodies for therapeutic intervention of transmissible spongiform encephalopathies', Expert Opin Biol Ther
6
(6(3))
, 293-300
.
[Kurzfassung]
[BibTeX]
[Endnote]
Gerlach, N.; Schimmer, S.; Weiss, S.; Kalinke, U. & Dittmer, U. (2006),
'Effects of type I interferons on Friend retrovirus infection', J Virol
80
(80(7))
, 3438-3444
.
[Kurzfassung]
[BibTeX]
[Endnote]
Hinz, T.; Buchholz, C.; van der Stappen, T.; Cichutek, K. & V, U. K. (2006),
'Manufacturing and quality control of cell-based tumor vaccines: a scientific and a regulatory perspective', J Immunother
29
(29(5))
, 472-476
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, U.; Bach, P.; Konig, M. & Buchholz, C. (2006),
'Vaccination against prion diseases', Discov Med
6
(6(31))
, 29-34
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kamphuis, E.; Junt, T.; Waibler, Z.; Forster, R. & Kalinke, U. (2006),
'Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia', Blood
108
((10))
, 3253-3261
.
[Kurzfassung]
[BibTeX]
[Endnote]
Ludwig, H.; Suezer, Y.; Waibler, Z.; Kalinke, U.; Schnierle, B. & Sutter, G. (2006),
'Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara', J Gen Virol
87
(87(Pt 5))
, 1145-1155
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schneider, C.; Kalinke, U. & Lower, J. (2006),
'TGN1412--a regulator's perspective', Nat Biotechnol
24
(24(5))
, 493-496
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schule, S.; Steidl, S.; Panitz, S.; Coulibaly, C.; Kalinke, U.; Cichutek, K. & Schweizer, M. (2006),
'Selective gene transfer to T lymphocytes using coreceptor-specific [MLV(HIV)] pseudotype vectors in a transgenic mouse model', Virology
351
((1))
, 237-247
.
[Kurzfassung]
[BibTeX]
[Endnote]
Staib, C.; Suezer, Y.; Kisling, S.; Kalinke, U. & Sutter, G. (2006),
'Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara', J Gen Virol
87
(87(Pt 10))
, 2917-2921
.
[Kurzfassung]
[BibTeX]
[Endnote]
Dominguez, D.; Tournoy, J.; Hartmann, D.; Huth, T.; Cryns, K.; Deforce, S.; Serneels, L.; Camacho, I.; Marjaux, E.; Craessaerts, K.; Roebroek, A.; Schwake, M.; D'Hooge, R.; Bach, P.; Kalinke, U.; Moechars, D.; Alzheimer, C.; Reiss, K.; Saftig, P. & Strooper, B. D. (2005),
'Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice', J Biol Chem
280
(280(35))
, 30797-30806
.
[Kurzfassung]
[BibTeX]
[Endnote]
Nikles, D.; Bach, P.; Boller, K.; Merten, C.; Montrasio, F.; Heppner, F.; Aguzzi, A.; Cichutek, K.; Kalinke, U. & Buchholz, C. (2005),
'Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP', J Virol
79
(79(7))
, 4033-4042
.
[Kurzfassung]
[BibTeX]
[Endnote]
Strobl, B.; Bubic, I.; Bruns, U.; Steinborn, R.; Lajko, R.; Kolbe, T.; Karaghiosoff, M.; Kalinke, U.; Jonjic, S. & Muller, M. (2005),
'Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus', J Immunol
175
(175(6))
, 4000-4008
.
[Kurzfassung]
[BibTeX]
[Endnote]
Meier-Noorden, M.; Flindt, S.; Kalinke, U. & Hinz, T. (2004),
'A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation', Gene
338
((2))
, 197-207
.
[Kurzfassung]
[BibTeX]
[Endnote]
Hangartner, L.; Senn, B.; Ledermann, B.; Kalinke, U.; Seiler, P.; Bucher, E.; Zellweger, R.; Fink, K.; Odermatt, B.; Burki, K.; Zinkernagel, R. & Hengartner, H. (2003),
'Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.', Proc Natl Acad Sci U S A
100
(100(22))
, 12883-12888
.
[Kurzfassung]
[BibTeX]
[Endnote]
Senn, B.; Lopez-Macias, C.; Kalinke, U.; Lamarre, A.; Isibasi, A.; Zinkernagel, R. & Hengartner, H. (2003),
'Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.', Eur J Immunol
33
(33(4))
, 950-961
.
[Kurzfassung]
[BibTeX]
[Endnote]
Barchet, W.; Cella, M.; Odermatt, B.; Asselin-Paturel, C.; Colonna, M. & Kalinke, U. (2002),
'Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.', J Exp Med
195
(195(4))
, 507-516
.
[Kurzfassung]
[BibTeX]
[Endnote]
Scheu, S.; Alferink, J.; Potzel, T.; Barchet, W.; Kalinke, U. & Pfeffer, K. (2002),
'Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.', J Exp Med
195
(195(12))
, 1613-1624
.
[Kurzfassung]
[BibTeX]
[Endnote]
Heppner, F.; Arrighi, I.; Kalinke, U. & Aguzzi, A. (2001),
'Immunity against prions? ', Trends Mol Med
7
(7(11))
, 477-479
.
[Kurzfassung]
[BibTeX]
[Endnote]
Heppner, F.; Musahl, C.; Arrighi, I.; Klein, M.; Rulicke, T.; Oesch, B.; Zinkernagel, R.; Kalinke, U. & Aguzzi, A. (2001),
'Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies', Science
294
((5540))
, 178-182
.
[Kurzfassung]
[BibTeX]
[Endnote]
Klein, M.; Kaeser, P.; Schwarz, P.; Weyd, H.; Xenarios, I.; Zinkernagel, R.; Carroll, M.; Verbeek, J.; Botto, M.; Walport, M.; Molina, H.; Kalinke, U.; Acha-Orbea, H. & Aguzzi, A. (2001),
'Complement facilitates early prion pathogenesis', Nat Med
7
(7(4))
, 488-492
.
[Kurzfassung]
[BibTeX]
[Endnote]
Zinkernagel, R.; LaMarre, A.; Ciurea, A.; Hunziker, L.; Ochsenbein, A.; McCoy, K.; Fehr, T.; Bachmann, M.; Kalinke, U. & Hengartner, H. (2001),
'Neutralizing antiviral antibody responses', Adv Immunol
79
(n/a)
, 1-53
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, U.; Oxenius, A.; Lopez-Macias, C.; Zinkernagel, R. & Hengartner, H. (2000),
'Virus neutralization by germ-line vs. hypermutated antibodies', Proc Natl Acad Sci U S A
97
(97(18))
, 10126-10131
.
[Kurzfassung]
[BibTeX]
[Endnote]
Karrer, U.; Lopez-Macias, C.; Oxenius, A.; Odermatt, B.; Bachmann, M.; Kalinke, U.; Bluethmann, H.; Hengartner, H. & Zinkernagel, R. (2000),
'Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice', J Immunol
164
(164(2))
, 768-778
.
[Kurzfassung]
[BibTeX]
[Endnote]
Seiler, P.; Senn, B.; Klenerman, P.; Kalinke, U.; Hengartner, H. & Zinkernagel, R. (2000),
'Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence', J Virol
74
(74(13))
, 5896-5901
.
[Kurzfassung]
[BibTeX]
[Endnote]
Lopez-Macias, C.; Kalinke, U.; Cascalho, M.; Wabl, M.; Hengartner, H.; Zinkernagel, R. & Lamarre, A. (1999),
'Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses', J Exp Med
189
(189(11))
, 1791-1798
.
[Kurzfassung]
[BibTeX]
[Endnote]
Seiler, P.; Senn, B.; Brundler, M.; Zinkernagel, R.; Hengartner, H. & Kalinke, U. (1999),
'In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody', J Immunol
162
(162(8))
, 4536-4541
.
[Kurzfassung]
[BibTeX]
[Endnote]
Funk, G.; Barbour, A.; Hengartner, H. & Kalinke, U. (1998),
'Mathematical model of a virus-neutralizing immunglobulin response', J Theor Biol
195
(195(1))
, 41-52
.
[Kurzfassung]
[BibTeX]
[Endnote]
Seiler, P.; Kalinke, U.; Rulicke, T.; Bucher, E.; Bose, C.; Zinkernagel, R. & Hengartner, H. (1998),
'Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice', J Virol
72
(72(3))
, 2253-2258
.
[Kurzfassung]
[BibTeX]
[Endnote]
Bachmann, M.; Kalinke, U.; Althage, A.; Freer, G.; Burkhart, C.; Hoost, H.; Aguet, M.; Hengartner, H. & Zinkernagel, R. (1997),
'The role of antibody concentration and avidity in antiviral protection', Science
276
((5321))
, 2024-2027
.
[Kurzfassung]
[BibTeX]
[Endnote]
Fehr, T.; Bachmann, M.; Bucher, E.; Kalinke, U.; Padova, F. D.; Lang, A.; Hengartner, H. & Zinkernagel, R. (1997),
'Role of repetitive antigen patterns for induction of antibodies against antibodies', J Exp Med
185
(185(10))
, 1785-1792
.
[Kurzfassung]
[BibTeX]
[Endnote]
Hammami-Hauasli, N.; Kalinke, D.; Schumann, H.; Kalinke, U.; Pontz, B.; Anton-Lamprecht, I.; Pulkkinen, L.; Zimmermann, M.; Uitto, J. & Bruckner-Tuderman, L. (1997),
'A combination of a common splice site mutation and a frameshift mutation in the COL7A1 gene: absence of functional collagen VII in keratinocytes and skin', J Invest Dermatol
109
(109(3))
, 384-389
.
[Kurzfassung]
[BibTeX]
[Endnote]
Klein, M.; Frigg, R.; Flechsig, E.; Raeber, A.; Kalinke, U.; Bluethmann, H.; Bootz, F.; Suter, M.; Zinkernagel, R. & Aguzzi, A. (1997),
'A crucial role for B cells in neuroinvasive scrapie', Nature
390
((6661))
, 687-690
.
[Kurzfassung]
[BibTeX]
[Endnote]
Battegay, M.; Fiedler, P.; Kalinke, U.; Brombacher, F.; Zinkernagel, R.; Peter, H.; Kohler, G. & Eibel, H. (1996),
'Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mic', Eur J Immuno
26
(26(1))
, 250-258
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, U.; Krebber, A.; Krebber, C.; Bucher, E.; Pluckthun, A.; Zinkernagel, R. & Hengartner, H. (1996),
'Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection', Eur J Immuno
26
(26(12))
, 2801-2806
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, U.; Bucher, E.; Ernst, B.; Oxenius, A.; Roost, H.; Geley, S.; Kofler, R.; Zinkernagel, R. & Hengartner, H. (1996),
'The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis viru', Immunity
5
((6))
, 639-652
.
[Kurzfassung]
[BibTeX]
[Endnote]
Gilfillan, S.; Bachmann, M.; Trembleau, S.; Adorini, L.; Kalinke, U.; Zinkernagel, R.; Benoist, C. & Mathis, D. (1995),
'Efficient immune responses in mice lacking N-region diversity', Eur J Immunol
25
(25(11))
, 3115-3122
.
[Kurzfassung]
[BibTeX]
[Endnote]
Roost, H.; Bachmann, M.; Haag, A.; Kalinke, U.; Pliska, V.; Hengartner, H. & Zinkernagel, R. (1995),
'Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity', Proc Natl Acad Sci
92
(92(5))
, 1257-1261
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, D.; Kalinke, U.; Winberg, J.; Konig, A.; Lauharanta, J.; Christiano, A.; Uitto, J. & Bruckner-Tuderman, L. (1994),
'Collagen VII in severe recessive dystrophic epidermolysis bullosa: expression of mRNA but lack of intact protein product in skin and cutaneous cells in vitro', J Invest Dermatol
102
(102(2))
, 260-262
.
[Kurzfassung]
[BibTeX]
[Endnote]
Schonrich, G.; Kalinke, U.; Momburg, F.; Malissen, M.; Schmitt-Verhulst, A.; Malissen, B.; Hammerling, G. & Arnold, B. (1991),
'Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductio', Cell
65
((2))
, 293-304
.
[Kurzfassung]
[BibTeX]
[Endnote]
Kalinke, U.; Arnold, B. & Hammerling, G. (1990),
'Strong xenogeneic HLA response in transgenic mice after introducing an alpha 3 domain into HLA B27', Nature
348
((6302))
, 642-644
.
[Kurzfassung]
[BibTeX]
[Endnote]
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